PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32368526-7 2020 Lycopene stimulates apoptosis through intrinsic pathways, by stimulating the pro-apoptotic factor of the mitochondrial cavity such as the Bax/Bak protein (an apoptotic promotor). Lycopene 0-8 BCL2 associated X, apoptosis regulator Homo sapiens 138-141 32885410-5 2020 Lycopene also ameliorated H2 O2 -induced damage and reduced the expression of apoptotic markers, such as Bcl-2, Bax, and cleaved caspase 3. Lycopene 0-8 BCL2 associated X, apoptosis regulator Homo sapiens 112-115 31491956-6 2019 Lycopene decreased cell viability and increased apoptotic indices (DNA fragmentation, apoptosis inducing factor, cleavage of caspase-3 and caspase-9, Bax/Bcl-2 ratio). Lycopene 0-8 BCL2 associated X, apoptosis regulator Homo sapiens 150-153 28345329-0 2017 Lycopene Extracts from Different Tomato-Based Food Products Induce Apoptosis in Cultured Human Primary Prostate Cancer Cells and Regulate TP53, Bax and Bcl-2 Transcript Expression Carotenoids are the main tomato components, especially lycopene. Lycopene 0-8 BCL2 associated X, apoptosis regulator Homo sapiens 144-147 30939781-6 2019 Lycopene reduced cell viability with increases in active caspase-3 and the Bax to Bcl-2 ratio in PANC-1 cells. Lycopene 0-8 BCL2 associated X, apoptosis regulator Homo sapiens 75-78 28585698-7 2018 Transfection with FOXO3a siRNA inhibited the lycopene-induced increase in cell apoptosis, BAX and cleaved PARP expression. Lycopene 45-53 BCL2 associated X, apoptosis regulator Homo sapiens 90-93 28407181-11 2017 Moreover, lycopene could also upregulate the expression of p53 and Bax mRNAs in MCF-7 cells. Lycopene 10-18 BCL2 associated X, apoptosis regulator Homo sapiens 67-70 28407181-12 2017 In conclusion, lycopene inhibits proliferation and facilitates apoptosis of MCF-7 cells in vitro, possibly by regulating the expression of p53 and Bax. Lycopene 15-23 BCL2 associated X, apoptosis regulator Homo sapiens 147-150 31741457-4 2019 In the present study, we showed that lycopene reduces the viability of AGS cells by inducing DNA fragmentation and increasing the Bax/Bcl-2 ratio. Lycopene 37-45 BCL2 associated X, apoptosis regulator Homo sapiens 130-133 31279748-6 2019 After lycopene treatment, the protein expression of Bax (an apoptotic protein) in SKOV3 cells increased significantly, and the protein expression of Bcl-2 (an anti-apoptotic protein) decreased significantly. Lycopene 6-14 BCL2 associated X, apoptosis regulator Homo sapiens 52-55 28345329-5 2017 Using real time PCR assay, we found that lycopene promotedan upregulation of TP53 and Bax transcript expression and also downregulation of Bcl-2 expression in PCa cells. Lycopene 41-49 BCL2 associated X, apoptosis regulator Homo sapiens 86-89 27035331-5 2016 Additionally, lycopene counteracted H2O2-induced mitochondrial dysfunction, which was evidenced by suppression of mitochondrial permeability transition pore opening, attenuation of the decline of the mitochondrial membrane potential, and inhibition of the increase of Bax and decrease of Bcl-2 levels within the mitochondria. Lycopene 14-22 BCL2 associated X, apoptosis regulator Homo sapiens 268-271 26664697-7 2016 In irradiated cells, lycopene preexposure resulted in overexpression of BAX gene compared to nonexposed irradiated cells. Lycopene 21-29 BCL2 associated X, apoptosis regulator Homo sapiens 72-75 24397737-7 2014 In triple negative cells, lycopene inhibited the phosphorylation of Akt and its downstream molecule mTOR, followed by subsequent upregulation of proapoptotic Bax without affecting anti-apoptotic Bcl-xL. Lycopene 26-34 BCL2 associated X, apoptosis regulator Homo sapiens 158-161 26535076-6 2015 Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment. Lycopene 13-21 BCL2 associated X, apoptosis regulator Homo sapiens 187-213 26535076-6 2015 Furthermore, lycopene pretreatment decreased the expression of cleaved poly (ADP ribose) polymerase-1 (PARP-1) and caspase-3 and increased the expression of B-cell lymphoma 2 (Bcl-2) and Bcl-2-associated X protein (Bax), which were induced by H2O2 treatment. Lycopene 13-21 BCL2 associated X, apoptosis regulator Homo sapiens 215-218 24053141-6 2013 Using real time PCR assay, lycopene also induced apoptosis in prostate cancer cells with altered gene expression of Bax and Bcl-2. Lycopene 27-35 BCL2 associated X, apoptosis regulator Homo sapiens 116-119 18708285-12 2009 Immunocytochemical staining results revealed that lycopene and EPA could also up-regulate the expression of apoptotic proteins such as Bax and Fas ligand to suppress cell survival. Lycopene 50-58 BCL2 associated X, apoptosis regulator Homo sapiens 135-138 32718121-11 2021 Lycopene treatment significantly increased Bax expression (P < 0.0001) and decreased Bcl-2 expression (P < 0.0001) in HeLa cells. Lycopene 0-8 BCL2 associated X, apoptosis regulator Homo sapiens 43-46 32718121-13 2021 CONCLUSION: Lycopene increases the sensitization of cervical cancer cells to cisplatin via inhibition of cell viability, up-regulation of Bax expression, and down-regulation of Bcl-2 expression. Lycopene 12-20 BCL2 associated X, apoptosis regulator Homo sapiens 138-141 18095570-7 2007 CONCLUSION: Lycopene can induce apoptosis of PC-3, change the cell cycle distribution and downregulate the expression of cyclin D1 and bcl-2 and upregulate the expression of bax and then restrain cell proliferation. Lycopene 12-20 BCL2 associated X, apoptosis regulator Homo sapiens 174-177