PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
25932745-8	2015	Conversely, lycopene treatment enhanced heme oxygenase-1 (HO-1) gene expression through the activation of phosphoinositide 3-kinase (PI3K)/Akt pathway, followed by induction of the nuclear factor erythroid 2-related factor 2 (Nrf2) nuclear translocation; in addition, HO-1 silencing partially inhibited the repressive effects of lycopene on strain-induced ET-1 expression.	Lycopene	12-20	endothelin 1	Homo sapiens	356-360	
25932745-9	2015	In summary, our study showed, for the first time, that lycopene inhibits cyclic strain-induced ET-1 gene expression through the suppression of ROS generation and induction of HO-1 in HUVECs.	Lycopene	55-63	endothelin 1	Homo sapiens	95-99	
25932745-0	2015	Lycopene inhibits cyclic strain-induced endothelin-1 expression through the suppression of reactive oxygen species generation and induction of heme oxygenase-1 in human umbilical vein endothelial cells.	Lycopene	0-8	endothelin 1	Homo sapiens	40-52	
25932745-4	2015	This study investigated the effects of lycopene on cyclic strain-induced ET-1 gene expression in human umbilical vein endothelial cells (HUVECs) and identified the signal transduction pathways that are involved in this process.	Lycopene	39-47	endothelin 1	Homo sapiens	73-77	
25932745-6	2015	Lycopene inhibited strain-induced ET-1 expression through the suppression of reactive oxygen species (ROS) generation through attenuation of p22(phox) mRNA expression and NAD(P)H oxidase activity.	Lycopene	0-8	endothelin 1	Homo sapiens	34-38	
25932745-7	2015	Furthermore, lycopene inhibited strain-induced ET-1 secretion by reducing ROS-mediated extrace-llular signal-regulated kinase (ERK) phosphorylation.	Lycopene	13-21	endothelin 1	Homo sapiens	47-51