PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 22309082-9 2012 Lycopene-mediated inhibition of MMP-9 was reversed by mevalonate and associated with a reduced expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase. Lycopene 0-8 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 109-166 26548547-1 2016 This study initially aimed to depict the molecular rationale evolving the role of lycopene in inhibiting the enzymatic activity of beta-hydroxy-beta-methylglutaryl-CoA (HMG-CoA) reductase via in vitro and in silico analysis. Lycopene 82-90 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 131-187 21208793-7 2011 These results imply a potential role of lycopene in attenuating foam cell formation and, therefore, in preventing atherosclerosis by a cascade mechanism involving inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, RhoA inactivation and subsequent increase in PPARgamma and liver X receptor alpha activities and enhancement of ABCA1 and cav-1 expressions. Lycopene 40-48 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 177-224 20699249-4 2010 Incubation of the Ras-activated prostatic carcinoma LNCaP cells with a 24 h lycopene treatment (2.5-10 muM) dose dependently reduced intracellular total cholesterol by decreasing 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase expression and by inactivating Ras, as evidenced by its translocation from cell membranes to cytosol. Lycopene 76-84 3-hydroxy-3-methylglutaryl-CoA reductase Homo sapiens 179-236