PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
22309082-9	2012	Lycopene-mediated inhibition of MMP-9 was reversed by mevalonate and associated with a reduced expression of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase.	Lycopene	0-8	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	109-166	
26548547-1	2016	This study initially aimed to depict the molecular rationale evolving the role of lycopene in inhibiting the enzymatic activity of beta-hydroxy-beta-methylglutaryl-CoA (HMG-CoA) reductase via in vitro and in silico analysis.	Lycopene	82-90	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	131-187	
21208793-7	2011	These results imply a potential role of lycopene in attenuating foam cell formation and, therefore, in preventing atherosclerosis by a cascade mechanism involving inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase, RhoA inactivation and subsequent increase in PPARgamma and liver X receptor alpha activities and enhancement of ABCA1 and cav-1 expressions.	Lycopene	40-48	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	177-224	
20699249-4	2010	Incubation of the Ras-activated prostatic carcinoma LNCaP cells with a 24 h lycopene treatment (2.5-10 muM) dose dependently reduced intracellular total cholesterol by decreasing 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase expression and by inactivating Ras, as evidenced by its translocation from cell membranes to cytosol.	Lycopene	76-84	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	179-236