PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25689917-10 2015 Moreover, intrarenal HO-1 level was up-regulated in the presence of lycopene. Lycopene 68-76 heme oxygenase 1 Mus musculus 21-25 33987329-0 2021 Lycopene alleviates hepatic ischemia reperfusion injury via the Nrf2/HO-1 pathway mediated NLRP3 inflammasome inhibition in Kupffer cells. Lycopene 0-8 heme oxygenase 1 Mus musculus 69-73 33987329-9 2021 Intriguingly, we identified that the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) were elevated in KCs isolated from IR-stressed mice pretreated with lycopene. Lycopene 202-210 heme oxygenase 1 Mus musculus 110-126 33987329-9 2021 Intriguingly, we identified that the protein levels of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) were elevated in KCs isolated from IR-stressed mice pretreated with lycopene. Lycopene 202-210 heme oxygenase 1 Mus musculus 128-132 33987329-10 2021 Nrf2-siRNA or HO-1-siRNA could block the autophagy activation enhanced by lycopene in KCs, resulting in the activation of the NLRP3 inflammasome and aggravated hepatic IR injury. Lycopene 74-82 heme oxygenase 1 Mus musculus 14-18 33987329-11 2021 Conclusions: Our findings demonstrated that lycopene promoted Nrf2/HO-1 pathway activation and further suppressed the NLRP3 inflammasome via enhancing KC autophagy, which alleviated hepatic IR injury. Lycopene 44-52 heme oxygenase 1 Mus musculus 67-71 26572165-10 2016 Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene. Lycopene 0-8 heme oxygenase 1 Mus musculus 53-57 26572165-10 2016 Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene. Lycopene 0-8 heme oxygenase 1 Mus musculus 84-88 26572165-10 2016 Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene. Lycopene 156-164 heme oxygenase 1 Mus musculus 53-57 26572165-10 2016 Lycopene increased the expression levels of Nrf2 and HO-1, indicating that the Nrf2/HO-1 signaling pathway may be involved in the neuroprotective effect of lycopene. Lycopene 156-164 heme oxygenase 1 Mus musculus 84-88 26572165-11 2016 The present study revealed that lycopene protects the brain from global ischemic injury, which is associated with its antiapoptotic effect and the activation of the Nrf2/HO-1 signaling pathway. Lycopene 32-40 heme oxygenase 1 Mus musculus 170-174 32813603-0 2020 Lycopene Alleviates Hepatic Hypoxia/Reoxygenation Injury Through Nrf2/HO-1 Pathway in AML12 Cell. Lycopene 0-8 heme oxygenase 1 Mus musculus 70-74 32813603-11 2020 Lycopene led to a reversed effect, with promotion on Nrf2 transfer from cytoplasm into nucleus and Nrf2/HO-1 pathway activation. Lycopene 0-8 heme oxygenase 1 Mus musculus 104-108 32813603-13 2020 Lycopene could activate Nrf2/HO-1 pathway to protect hepatic cells against H/R injury. Lycopene 0-8 heme oxygenase 1 Mus musculus 29-33 29475907-7 2018 RESULTS: Hmox1 mRNA, but not Cox2 and Nos2 mRNA, was up-regulated by 100 muM beta-carotene and lycopene, and by 0.125% TBB. Lycopene 95-103 heme oxygenase 1 Mus musculus 9-14 25385104-8 2015 Lycopene treatment, especially in the colistin plus lycopene (20 mg/kg) group, significantly downregulated the expression of NF-kappaB mRNA (P < 0.01) but upregulated the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and HO-1 mRNA (both P < 0.01) in the kidney compared with the results seen with the colistin group. Lycopene 0-8 heme oxygenase 1 Mus musculus 243-247 25385104-0 2015 Lycopene attenuates colistin-induced nephrotoxicity in mice via activation of the Nrf2/HO-1 pathway. Lycopene 0-8 heme oxygenase 1 Mus musculus 87-91 25385104-10 2015 This effect may be attributed to the antioxidative property of lycopene and its ability to activate the Nrf2/HO-1 pathway. Lycopene 63-71 heme oxygenase 1 Mus musculus 109-113 23906616-0 2014 Antineuroinflammatory effects of lycopene via activation of adenosine monophosphate-activated protein kinase-alpha1/heme oxygenase-1 pathways. Lycopene 33-41 heme oxygenase 1 Mus musculus 116-132 23906616-11 2014 Preincubation of cells with HO-1 and AMPK selective pharmacological inhibitors dramatically reversed the inhibitory effect of lycopene on LPS-induced COX-2 and prostaglandin E2 production. Lycopene 126-134 heme oxygenase 1 Mus musculus 28-32 23906616-12 2014 Transfection of microglia with HO-1 and AMPKalpha small interfering RNA (siRNA) also effectively reversed the inhibitory effect of lycopene on LPS-induced COX-2 expression. Lycopene 131-139 heme oxygenase 1 Mus musculus 31-35 23906616-14 2014 These findings suggest that lycopene-inhibited LPS-induced COX-2 expression is mediated by HO-1 activation through the AMPK pathway. Lycopene 28-36 heme oxygenase 1 Mus musculus 91-95 23906616-7 2014 In the present study, we demonstrated that lycopene inhibits LPS-induced COX-2 expression through heme oxygenase-1 (HO-1) activation. Lycopene 43-51 heme oxygenase 1 Mus musculus 98-114 23906616-7 2014 In the present study, we demonstrated that lycopene inhibits LPS-induced COX-2 expression through heme oxygenase-1 (HO-1) activation. Lycopene 43-51 heme oxygenase 1 Mus musculus 116-120 23906616-9 2014 Treatment with AMPK inhibitors effectively antagonized lycopene-stimulated HO-1 expression. Lycopene 55-63 heme oxygenase 1 Mus musculus 75-79 15549328-0 2005 Lycopene enhances UVA-induced DNA damage and expression of heme oxygenase-1 in cultured mouse embryo fibroblasts. Lycopene 0-8 heme oxygenase 1 Mus musculus 59-75 15549328-3 2005 AIM OF THE STUDY: We examined whether lycopene inhibits ultraviolet A (UVA)-induced DNA damage and the expression of heme oxygenase-1 (HO-1). Lycopene 38-46 heme oxygenase 1 Mus musculus 135-139 15549328-12 2005 In addition, lycopene enhanced UVA-induced HO-1 expression by ca. Lycopene 13-21 heme oxygenase 1 Mus musculus 43-47 15549328-15 2005 When cells were incubated with lycopene that had been pre-irradiated with UVA without subjecting the cells to further UVA irradiation, cellular DNA damage and expression of HO-1 were markedly increased, and these effects of irradiated lycopene were concentration-dependent. Lycopene 31-39 heme oxygenase 1 Mus musculus 173-177 15549328-15 2005 When cells were incubated with lycopene that had been pre-irradiated with UVA without subjecting the cells to further UVA irradiation, cellular DNA damage and expression of HO-1 were markedly increased, and these effects of irradiated lycopene were concentration-dependent. Lycopene 235-243 heme oxygenase 1 Mus musculus 173-177