PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33586683-3 2021 Here, we show that pCF remodels with aging and a high-fat diet and that the size and function of this depot are controlled by alcohol dehydrogenase 1 (ADH1), an enzyme that oxidizes retinol into retinaldehyde. Retinaldehyde 195-208 alcohol dehydrogenase 1 (class I) Mus musculus 126-149 33586683-3 2021 Here, we show that pCF remodels with aging and a high-fat diet and that the size and function of this depot are controlled by alcohol dehydrogenase 1 (ADH1), an enzyme that oxidizes retinol into retinaldehyde. Retinaldehyde 195-208 alcohol dehydrogenase 1 (class I) Mus musculus 151-155 33586683-8 2021 Mechanistically, we found that the ADH1/retinaldehyde pathway works by driving PGC-1alpha nuclear translocation and promoting mitochondrial fusion and biogenesis in the pCF depot. Retinaldehyde 40-53 alcohol dehydrogenase 1 (class I) Mus musculus 35-39 33586683-9 2021 Together, these data demonstrate that pCF is a critical regulator of cardiometabolic fitness and that retinaldehyde and its generating enzyme ADH1 act as critical regulators of adipocyte remodeling in the pCF depot. Retinaldehyde 102-115 alcohol dehydrogenase 1 (class I) Mus musculus 142-146 33586686-9 2021 ADH1 appears to regulate the mitochondrial content of paracardial fat, a mechanism mediated by retinaldehyde. Retinaldehyde 95-108 alcohol dehydrogenase 1 (class I) Mus musculus 0-4 12604205-8 2003 Collectively, these genetic findings indicate that metabolism of retinol to retinaldehyde is not tissue-restricted as it is catalyzed by ubiquitously-expressed ADH3 (a low activity form) as well as by tissue-specifically expressed ADH1 and ADH4 (high activity forms). Retinaldehyde 76-89 alcohol dehydrogenase 1 (class I) Mus musculus 231-235 12851412-3 2003 Whereas Adh1 plays a dominant role in the first step of the clearance pathway (oxidation of retinol to retinaldehyde), it is unknown what controls the second step (oxidation of retinaldehyde to RA). Retinaldehyde 103-116 alcohol dehydrogenase 1 (class I) Mus musculus 8-12 8018987-1 1994 The Adh-1 gene product, ADH-A2, the only known murine class I alcohol dehydrogenase, is able to oxidize retinol (vitamin A) into retinaldehyde, the first enzymatic step in the conversion of retinol into its biologically active metabolite retinoic acid. Retinaldehyde 129-142 alcohol dehydrogenase 1 (class I) Mus musculus 4-9 8018987-1 1994 The Adh-1 gene product, ADH-A2, the only known murine class I alcohol dehydrogenase, is able to oxidize retinol (vitamin A) into retinaldehyde, the first enzymatic step in the conversion of retinol into its biologically active metabolite retinoic acid. Retinaldehyde 129-142 alcohol dehydrogenase 1 (class I) Mus musculus 24-30 8018987-1 1994 The Adh-1 gene product, ADH-A2, the only known murine class I alcohol dehydrogenase, is able to oxidize retinol (vitamin A) into retinaldehyde, the first enzymatic step in the conversion of retinol into its biologically active metabolite retinoic acid. Retinaldehyde 129-142 alcohol dehydrogenase 1 (class I) Mus musculus 54-83