PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
31647782-7	2019	Instead, activation of the 5HT2C receptor by serotonin treatment led to activation of IP3-sensitive channels and Ca2+ mobilization from intracellular storage, leading to insulin secretion.	Calcium	113-117	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	27-41	
34553421-0	2021	RNA editing of 5-HT2C R impairs insulin secretion of pancreatic beta cells via altered store-operated calcium entry.	Calcium	102-109	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	15-21	
27189964-8	2016	By single-cell calcium imaging, we found that serotonin and WAY-161,503 induced robust calcium transients, which were also blunted by both 5-HT2CR antagonists.	Calcium	15-22	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	139-146	
27189964-8	2016	By single-cell calcium imaging, we found that serotonin and WAY-161,503 induced robust calcium transients, which were also blunted by both 5-HT2CR antagonists.	Calcium	87-94	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	139-146	
9825734-5	1998	Although the 5-HT2A receptor site was predominant, the smaller component of 5-HT2C receptors alone was sufficient to mediate a maximal calcium response.	Calcium	135-142	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	76-82	
31127052-6	2019	Consistent with this, loss of the BBSome reduced cell surface expression of the 5-HT2CR, interfered with serotonin-evoked increase in intracellular calcium and membrane potential, and blunted the anorectic and weight-reducing responses evoked by the 5-HT2cR agonist, lorcaserin.	Calcium	148-155	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	80-87	
26999672-3	2017	Amacrine cells generate 5HT and about half of RGCs respond to 5HTR2C agonism with calcium elevation.	Calcium	82-89	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	62-68	
15705738-4	2005	In functional studies, WAY-163909 stimulated the mobilization of intracellular calcium in CHO cells stably expressing the human 5-HT(2C) receptor with an EC(50) value of 8 nM, and E(max) relative to 5-HT of 90%.	Calcium	79-86	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	128-145	
34553421-10	2021	Moreover, 5-HT2C R edited isoforms displayed reduced endoplasmic reticulum (ER) calcium release and store-operated calcium entry (SOCE) activation, probably through inhibition of stromal interaction molecule 1 trafficking under PA treatment.	Calcium	80-87	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	10-16	
34553421-10	2021	Moreover, 5-HT2C R edited isoforms displayed reduced endoplasmic reticulum (ER) calcium release and store-operated calcium entry (SOCE) activation, probably through inhibition of stromal interaction molecule 1 trafficking under PA treatment.	Calcium	115-122	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	10-16	
34553421-11	2021	Altogether, our results show that PA-mediated editing of 5-HT2C R modulates GSIS through alteration of ER calcium release and SOCE activation in pancreatic MIN6 beta cells.	Calcium	106-113	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	57-63