PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
15358683-11	2004	Our findings suggest that numerous alterations in protein expression and phosphorylation state occurred upon ablation of PLN and that a complex functional relationship among proteins involved in calcium handling, myofibrils, and energy production may exist to coordinately maintain the hyperdynamic cardiac contractile performance of the PLN-KO mouse in the long term.	Calcium	195-202	phospholamban	Mus musculus	121-124	
31185731-11	2019	Complexome profiling and Stimulated Emission Depletion imaging revealed that PLN is present in the PPP1R3A-RyR2 interaction, suggesting the existence of a previously unknown SR nanodomain composed of both RyR2 and PLN/sarco/endoplasmic reticulum calcium ATPase-2a macromolecular complexes.	Calcium	246-253	phospholamban	Mus musculus	77-80	
35297759-2	2022	PLN interacts with sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and regulates calcium uptake, which is modulated by the protein kinase A (PKA)-dependent phosphorylation of PLN during the fight-or-flight response.	Calcium	81-88	phospholamban	Mus musculus	0-3	
35297759-2	2022	PLN interacts with sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) and regulates calcium uptake, which is modulated by the protein kinase A (PKA)-dependent phosphorylation of PLN during the fight-or-flight response.	Calcium	81-88	phospholamban	Mus musculus	175-178	
32555305-1	2020	Phospholamban (PLN) plays a role in cardiomyocyte calcium handling as primary inhibitor of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA).	Calcium	50-57	phospholamban	Mus musculus	15-18	
10603985-1	1998	Accumulating evidence points to the critical role of phospholamban (PLB) regulation of the cardiac sarcoplasmic reticulum (SR) calcium ATPase in influencing the kinetics of calcium handling within the cardiac myocyte under normal and pathological conditions.	Calcium	127-134	phospholamban	Mus musculus	68-71	
29150445-2	2018	However, because global HAX-1 deletion causes early lethality, how much endogenous HAX-1 contributes to PLN"s inhibitory activity on calcium cycling is unknown.	Calcium	133-140	phospholamban	Mus musculus	104-107	
30806861-10	2018	These results suggest that the abnormal increase in PLN in the ipsilateral fast-twitch fibers may be involved in decreased SERCA activity, SR calcium content, peak calcium transients, and contractile forces of denervated muscles.	Calcium	142-149	phospholamban	Mus musculus	52-55	
29150445-1	2018	The antiapoptotic protein HAX-1 (HS-associated protein X-1) localizes to sarcoplasmic reticulum (SR) in the heart and interacts with the small membrane protein phospholamban (PLN), inhibiting the cardiac sarco/endoplasmic reticulum calcium ATPase 2a (SERCA2a) in the regulation of overall calcium handling and heart muscle contractility.	Calcium	232-239	phospholamban	Mus musculus	175-178	
29150445-6	2018	The enhanced calcium cycling in the HAX-1-depleted heart was mediated through increases in the calcium affinity of SERCA2a and reduced PLN-SERCA2a binding.	Calcium	13-20	phospholamban	Mus musculus	135-138	
21840315-2	2011	In this study, we sought to permanently alter calcium fluxes via phospholamban (PLN) gene deletion in Tm180 mice in order to sustain long-term improvements in cardiac function and adverse cardiac remodeling/hypertrophy.	Calcium	46-53	phospholamban	Mus musculus	80-83	
23800848-5	2013	The other model was a gene knockout of phospholamban (PLN KO), a regulator of calcium uptake in the sarcoplasmic reticulum of cardiomyocytes; these hearts exhibit hypercontractility with no pathological abnormalities.	Calcium	78-85	phospholamban	Mus musculus	54-57	
27811197-1	2017	BACKGROUND: Phospholamban (PLN) inhibition enhances calcium cycling and is a potential novel therapy for heart failure (HF).	Calcium	52-59	phospholamban	Mus musculus	27-30	
27642167-0	2016	Phospholamban is concentrated in the nuclear envelope of cardiomyocytes and involved in perinuclear/nuclear calcium handling.	Calcium	108-115	phospholamban	Mus musculus	0-13	
18064719-11	2008	Down-regulation of PLN led to enhanced cell shortening and relaxation and to a decrease in the time constant of calcium decay, signs of improved contractility and calcium handling.	Calcium	112-119	phospholamban	Mus musculus	19-22	
18064719-11	2008	Down-regulation of PLN led to enhanced cell shortening and relaxation and to a decrease in the time constant of calcium decay, signs of improved contractility and calcium handling.	Calcium	163-170	phospholamban	Mus musculus	19-22	
16461894-5	2006	In these cardiomyocytes, isoproterenol restored calcium dynamics to the levels seen in PLN KO.	Calcium	48-55	phospholamban	Mus musculus	87-90