PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
7020769-1	1981	Insulin and its analogues displaced membrane-bound calcium within a physiological range of insulin concentration, in proportion to both biological potency and ability to displace porcine 125 I-labelled insulin from the insulin receptor.	Calcium	51-58	insulin receptor	Homo sapiens	219-235	
1653112-0	1991	High levels of cytosolic free calcium inhibit dephosphorylation of insulin receptor and glycogen synthase.	Calcium	30-37	insulin receptor	Homo sapiens	67-83	
3555257-0	1986	The role of calcium and calmodulin in insulin receptor function in the adipocyte.	Calcium	12-19	insulin receptor	Homo sapiens	38-54	
6419784-1	1984	Calcium (Ca2+) increased insulin-receptor binding in both membrane and solubilised receptor preparations.	Calcium	0-7	insulin receptor	Homo sapiens	25-41	
5434-9	1976	Divalent cations (calcium and magnesium) appear to stabilize the insulin-receptor interaction, since higher degrees of receptor occupancy were required to achieve a given rate of dissociation of 125I-insulin.	Calcium	18-25	insulin receptor	Homo sapiens	65-81	
31856878-3	2019	To explore this issue, the present study aimed to investigate the effects of glutamate-evoked increases in intracellular free Ca2+ concentrations [Ca2+]i and mitochondrial depolarisations, two key factors associated with excitotoxicity, on the insulin-induced activation of the insulin receptor (IR) and components of the Akt/ mammalian target of rapamycin (mTOR) pathway in primary cultures of rat cortical neurons.	Calcium	126-130	insulin receptor	Homo sapiens	278-294	
31856878-3	2019	To explore this issue, the present study aimed to investigate the effects of glutamate-evoked increases in intracellular free Ca2+ concentrations [Ca2+]i and mitochondrial depolarisations, two key factors associated with excitotoxicity, on the insulin-induced activation of the insulin receptor (IR) and components of the Akt/ mammalian target of rapamycin (mTOR) pathway in primary cultures of rat cortical neurons.	Calcium	126-130	insulin receptor	Homo sapiens	296-298	
27695899-2	2016	We have previously developed an in vitro model using HepG2 liver-derived cells, which mimics changes in sIR levels in plasma from diabetic patients and shows that calcium-dependent proteases cleave IR extracellularly (a process known as shedding).	Calcium	163-170	insulin receptor	Homo sapiens	105-107	
9421413-1	1998	The present study was conducted to examine the ability of insulin receptor to activate the calcium signaling system in Chinese hamster ovary (CHO) cells expressing human insulin receptor (CHO-IR cells).	Calcium	91-98	insulin receptor	Homo sapiens	170-186