PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 17240368-7 2007 Experiments using small molecule inhibitors indicate that dorsal migration of fin core cells depends on calcium signaling through calcium/calmodulin-dependent kinase II (CaMKII). Calcium 104-111 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 130-168 17240368-7 2007 Experiments using small molecule inhibitors indicate that dorsal migration of fin core cells depends on calcium signaling through calcium/calmodulin-dependent kinase II (CaMKII). Calcium 104-111 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 170-176 17202341-7 2007 The experiments designed to further understand the molecules involved in the calcium signaling suggested that calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK played a role in extracellular Tat-induced IL-10 expression in primary human monocytes. Calcium 77-84 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 125-163 17202341-7 2007 The experiments designed to further understand the molecules involved in the calcium signaling suggested that calmodulin and calmodulin-dependent protein kinase-II (CaMK-II)-activated p38 MAPK played a role in extracellular Tat-induced IL-10 expression in primary human monocytes. Calcium 77-84 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 165-172 16819989-1 2006 The activation of nucleotide receptors-- both ionotropic, P2X, and most of metabotropic, P2Y-- increases intracellular calcium concentration, resulting in calcium/calmodulin-dependent protein kinase II (CaMKII) activation. Calcium 119-126 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 155-201 17119905-0 2007 CaMKII, an emerging molecular driver for calcium homeostasis, arrhythmias, and cardiac dysfunction. Calcium 41-48 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 16966599-0 2006 Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums. Calcium 95-103 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-43 16966599-0 2006 Ca2+/calmodulin-dependent protein kinase II (CaMKII) is activated by calmodulin with two bound calciums. Calcium 95-103 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 45-51 16971505-2 2006 A decrease in calcium/calmodulin-dependent protein kinase II (CaMK-II) activity has been shown to occur with the development of SREDs in a hippocampal neuronal culture model of acquired epilepsy, and altered calcium (Ca(2+)) homeostasis has been implicated in the development of SREDs. Calcium 14-21 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 62-69 16763042-6 2006 We show that the calcium-dependent effect on postsynaptic quantal size is mediated by group 1 metabotropic glutamate receptors, acting via CaMKII (Ca2+/calmodulin-dependent protein kinase II) and PKC. Calcium 17-24 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 139-145 16763042-6 2006 We show that the calcium-dependent effect on postsynaptic quantal size is mediated by group 1 metabotropic glutamate receptors, acting via CaMKII (Ca2+/calmodulin-dependent protein kinase II) and PKC. Calcium 17-24 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 147-190 16819989-1 2006 The activation of nucleotide receptors-- both ionotropic, P2X, and most of metabotropic, P2Y-- increases intracellular calcium concentration, resulting in calcium/calmodulin-dependent protein kinase II (CaMKII) activation. Calcium 119-126 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 203-209 16054650-15 2006 There was an increase in CaMKII activity at 1 and 5 min time points in both the PDGF and PDGF + VEGF treatment groups suggesting that extracellular calcium influx is sufficient for CaMKII activation. Calcium 148-155 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 25-31 16519936-1 2006 A mechanism by which Ca(2+)/CaM-dependent protein kinase (CaMKII) is autophosphorylated by changes in extracellular calcium in the absence of detectable changes in cytoplasmic [Ca(2+)] has been identified. Calcium 116-123 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 58-64 16437222-4 2006 Three main calcium-triggered regulatory pathways acting through calcineurin, Ca(2+)-calmodulin-dependent protein kinases (CaMK) and Ca(2+)-dependent protein kinase C, transduce alterations in cytosolic calcium concentration to target genes. Calcium 11-18 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 77-120 16437222-4 2006 Three main calcium-triggered regulatory pathways acting through calcineurin, Ca(2+)-calmodulin-dependent protein kinases (CaMK) and Ca(2+)-dependent protein kinase C, transduce alterations in cytosolic calcium concentration to target genes. Calcium 11-18 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 122-126 16437222-4 2006 Three main calcium-triggered regulatory pathways acting through calcineurin, Ca(2+)-calmodulin-dependent protein kinases (CaMK) and Ca(2+)-dependent protein kinase C, transduce alterations in cytosolic calcium concentration to target genes. Calcium 202-209 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 77-120 16437222-4 2006 Three main calcium-triggered regulatory pathways acting through calcineurin, Ca(2+)-calmodulin-dependent protein kinases (CaMK) and Ca(2+)-dependent protein kinase C, transduce alterations in cytosolic calcium concentration to target genes. Calcium 202-209 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 122-126 16630823-4 2006 When neurons are stimulated by membrane depolarization, calcium signaling mediated by CaMKII induces dissociation of KIF4 from PARP-1, resulting in upregulation of PARP-1 activity, which supports neuron survival. Calcium 56-63 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 86-92 16054650-15 2006 There was an increase in CaMKII activity at 1 and 5 min time points in both the PDGF and PDGF + VEGF treatment groups suggesting that extracellular calcium influx is sufficient for CaMKII activation. Calcium 148-155 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 181-187 16325572-3 2005 (2005) report the structure of the catalytic and regulatory domains of CaMKII, a protein kinase important in the cellular response to changes in intracellular calcium ion concentration. Calcium 159-166 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 71-77 16242409-1 2005 Calcium entry through postsynaptic NMDA-Rs and subsequent activation of CaMKII trigger synaptic plasticity in many brain regions. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 72-78 16275756-7 2005 In contrast, activity of the tethered CaMKII remains fully Ca2+/CaM dependent, explaining its ability to operate as a calcium spike frequency detector. Calcium 118-125 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 38-44 16153422-4 2005 The purpose of this study is to clarify the source of the calcium, and determine if it is responsible for the formation of focal adhesion-like complexes during oxidative stress through the activation of calcium/calmodulin dependent protein kinase II (CaMK II). Calcium 58-65 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 251-258 16153422-13 2005 As a result, bound calcium dissociates, resulting in the activation of CaMK II and the formation of focal adhesion-like complexes. Calcium 19-26 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 71-78 15944130-1 2005 Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Calcium 147-154 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-46 15944388-3 2005 Protein synthesis-dependent late-phase LTP (L-LTP) in the hippocampus requires calcium influx through the NMDA-type glutamate receptor (NMDA-R) to activate CaMKII as well as concomitant inhibition of PP1 mediated by protein kinase A. Calcium 79-86 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 156-162 15923644-5 2005 In this study, our results suggest that the calcium signaling pathway, in particular calmodulin (CaM) and CaM-dependent protein kinase II (CaMK-II), is involved in TNF-alpha- but not LPS-induced CD44 expression. Calcium 44-51 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 106-137 15923644-5 2005 In this study, our results suggest that the calcium signaling pathway, in particular calmodulin (CaM) and CaM-dependent protein kinase II (CaMK-II), is involved in TNF-alpha- but not LPS-induced CD44 expression. Calcium 44-51 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 139-146 15944130-1 2005 Calcium/calmodulin-dependent protein kinase II (CaMKII) has been described as a biochemical switch that is turned on by increases in intracellular calcium to mediate synaptic plasticity. Calcium 147-154 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 48-54 15649892-8 2005 Collectively, these data provide evidence that CaMKII is a regulator of PKR-dependent p38 and eIF2alpha phosphorylation in response to ER calcium depletion by TZDs. Calcium 138-145 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 47-53 15582994-2 2005 CaMKII displays calcium-dependent binding to proteins in vitro and translocation to synaptic sites after glutamatergic activity in neurons. Calcium 16-23 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 15363387-3 2004 report that differential activations of CaMKII and calcineurin (CaN) act as the read out for distinct patterns of intracellular calcium signals and a switch between attraction and repulsion. Calcium 128-135 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 40-46 15582994-1 2005 Ca2+/calmodulin-dependent protein kinase II (CaMKII) acts in diverse cell types by phosphorylating proteins with key calcium-dependent functions such as synaptic plasticity, electrical excitability, and neurotransmitter synthesis. Calcium 117-124 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-43 15582994-1 2005 Ca2+/calmodulin-dependent protein kinase II (CaMKII) acts in diverse cell types by phosphorylating proteins with key calcium-dependent functions such as synaptic plasticity, electrical excitability, and neurotransmitter synthesis. Calcium 117-124 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 45-51 15787701-9 2005 Increased calcium influx at higher firing rates, by activating tryptophan hydroxylase via CaMKII and PKA, can work together with tryptophan to enhance negative feedback control of the output of the serotonergic system. Calcium 10-17 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 90-96 15602756-8 2005 The decreased growth of NF1 MPNST cell lines after treatment with a CAMKII inhibitor is consistent with the view that aberrant activation of the calcium-signaling pathway by PDGF-BB contributes to the formation of MPNST in NF1 patients. Calcium 145-152 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 68-74 12954639-2 2003 In this study, we demonstrate that integrin stimulation by fibronectin (FN), besides activating the Ras/Erk pathway, generates an auxiliary calcium signal that activates calmodulin and the Ca2+/calmodulin-dependent protein kinase II (CaMKII). Calcium 140-147 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 189-232 15235326-9 2004 Two signals that show promise are changes in the energy charge (acting through AMP activated kinase [AMPK]) and changes in intracellular calcium (acting through calcineurin [a calcium-calmodulin activated phosphatase] and calcium-calmodulin activated kinase [CAMK]). Calcium 137-144 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 259-263 14766423-3 2004 This calcium signaling acitivity is sufficient to activate calcium sensitive enzymes like protein kinase C (PKC), calcium-calmodulin dependent kinase II (CamKII) or calcineurin (CaCN). Calcium 5-12 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 114-152 14766423-3 2004 This calcium signaling acitivity is sufficient to activate calcium sensitive enzymes like protein kinase C (PKC), calcium-calmodulin dependent kinase II (CamKII) or calcineurin (CaCN). Calcium 5-12 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 154-160 14766423-3 2004 This calcium signaling acitivity is sufficient to activate calcium sensitive enzymes like protein kinase C (PKC), calcium-calmodulin dependent kinase II (CamKII) or calcineurin (CaCN). Calcium 59-66 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 114-152 14766423-3 2004 This calcium signaling acitivity is sufficient to activate calcium sensitive enzymes like protein kinase C (PKC), calcium-calmodulin dependent kinase II (CamKII) or calcineurin (CaCN). Calcium 59-66 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 154-160 12954639-2 2003 In this study, we demonstrate that integrin stimulation by fibronectin (FN), besides activating the Ras/Erk pathway, generates an auxiliary calcium signal that activates calmodulin and the Ca2+/calmodulin-dependent protein kinase II (CaMKII). Calcium 140-147 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 234-240 10341733-10 1999 This suggests that CaMKII acts as a switch in the transduction of the calcium signal triggering mammalian egg activation. Calcium 70-77 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 19-25 14499348-2 2003 Calmodulin is a ubiquitous protein that translates intracellular calcium signals and activates several enzymes including calcium/calmodulin-dependent protein kinase II (CaMKII). Calcium 65-72 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 169-175 12865664-15 2003 Therefore, CaMK inhibition of endothelial cells, characteristic of sustained increases in intracellular calcium, appears to result in a dysregulated proadhesive phenotype. Calcium 104-111 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 11-15 12695877-4 2003 The induction of Fos expression was blocked by tetrodotoxin, BAPTA and KN-93, thus showing that it is activity- and calcium-dependent and requires the activation of a calmodulin-dependent kinase (CaMK). Calcium 116-123 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 167-194 12695877-4 2003 The induction of Fos expression was blocked by tetrodotoxin, BAPTA and KN-93, thus showing that it is activity- and calcium-dependent and requires the activation of a calmodulin-dependent kinase (CaMK). Calcium 116-123 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 196-200 12695877-5 2003 Together, these results suggest that haloperidol induces Fos expression in dopaminergic neurons through a D2 receptor-independent increase in intracellular calcium, leading to CaMK activation. Calcium 156-163 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 176-180 12609872-7 2003 These results provide independent evidences for the mechanism of AMPA receptor regulation by CaM-KII and further strengthens the idea how calcium-dependent phosphorylation of AMPA receptors can contribute to the plasticity at central glutamatergic synapses. Calcium 138-145 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 93-100 12089357-3 2002 Calcium pathways depend on calmodulin kinase II (CAMKII) activity, and calcium-independent pathways are accounted for in part by MAPK activation (Rap1/B-Raf/MAPK-ERK kinase/ERK1/2), demonstrated by the use of molecular and pharmacological tools. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 27-47 12089357-3 2002 Calcium pathways depend on calmodulin kinase II (CAMKII) activity, and calcium-independent pathways are accounted for in part by MAPK activation (Rap1/B-Raf/MAPK-ERK kinase/ERK1/2), demonstrated by the use of molecular and pharmacological tools. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 49-55 11867691-4 2002 It is interesting that the addition of synthetic HIV-1 Tat, which we demonstrated to inhibit phagocytosis and calcium influx in DC, blocks the activation of CAMKII elicited via beta(3) integrin, which is involved in apoptotic body engulfment by DC. Calcium 110-117 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 157-163 11106872-5 2001 The autonomous (calcium-independent) activity of CaMKII was assayed for the first time after antidepressant treatment, and found to be increased in synaptic vesicles of all three areas. Calcium 16-23 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 49-55 10764765-1 2000 Calcium influx through the N-methyl-d-aspartate (NMDA)-type glutamate receptor and activation of calcium/calmodulin-dependent kinase II (CaMKII) are critical events in certain forms of synaptic plasticity. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 137-143 10851169-1 2000 Calcium signaling is crucial for several aspects of plasticity at glutamatergic synapses, and studies over the past two to three years have identified key functions for Ca(2+)/calmodulin-dependent protein kinases II and IV (CaM-KII and CaM-KIV). Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 224-231 10798500-1 2000 Activation of calcium/calmodulin-dependent protein kinase II (CaMKII) by calmodulin following calcium entry into the cell is important for long-term potentiation (LTP). Calcium 14-21 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 62-68 10798500-4 2000 Calcium could bind to calmodulin and calmodulin to CaMKII. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 51-57 10798500-8 2000 Calmodulin trapping and CaMKII activation were highly dependent on tetanus frequency (particularly between 10 and 100 Hz) and were highly sensitive to relatively small changes in the calcium signal. Calcium 183-190 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 24-30 12928489-0 2003 An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling. Calcium 131-138 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 18-61 12811739-5 2003 Calmodulin-dependent kinase II (CaMKII) may act as a switch in the transduction of the calcium signal. Calcium 87-94 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-30 12811739-5 2003 Calmodulin-dependent kinase II (CaMKII) may act as a switch in the transduction of the calcium signal. Calcium 87-94 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 32-38 11397138-6 2001 This is regulated by calmodulin-dependent protein kinase II (CaMKII) and calcineurin, which are both dependent on the intracellular calcium concentration. Calcium 132-139 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 61-67 10999834-11 2000 In addition, CaMKII and cPKCs seem to be potential modulators or mediators of these calcium effects on CRF secretion. Calcium 84-91 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 13-19 10827168-7 2000 Expression of the membrane-targeted CaMKII-binding domain of densin-180 confers membrane localization to coexpressed CaMKII without requiring calcium mobilization, suggesting that densin-180 plays a role in the constitutive association of CaMKII with PSDs. Calcium 142-149 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 36-42 9068842-3 1996 Inhibiting calmodulin or CaMKII, blocked the retraction that was also impaired in low calcium Ringer. Calcium 86-93 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 25-31 9712652-8 1998 Expression of a constitutively active CaMKII produces dendritic exocytosis in the absence of calcium stimulus, and this exocytosis is blocked by nocodazole, an inhibitor of microtubule polymerization that also blocks CEDE. Calcium 93-100 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 38-44 9153188-1 1997 Calcium/calmodulin-dependent protein kinase II (CaMKII) undergoes calcium-dependent autophosphorylation, generating a calcium-independent form that may serve as a molecular substrate for memory. Calcium 66-73 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-46 9153188-1 1997 Calcium/calmodulin-dependent protein kinase II (CaMKII) undergoes calcium-dependent autophosphorylation, generating a calcium-independent form that may serve as a molecular substrate for memory. Calcium 66-73 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 48-54 9153188-1 1997 Calcium/calmodulin-dependent protein kinase II (CaMKII) undergoes calcium-dependent autophosphorylation, generating a calcium-independent form that may serve as a molecular substrate for memory. Calcium 118-125 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-46 9153188-1 1997 Calcium/calmodulin-dependent protein kinase II (CaMKII) undergoes calcium-dependent autophosphorylation, generating a calcium-independent form that may serve as a molecular substrate for memory. Calcium 118-125 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 48-54 9153188-2 1997 Here we show that calcium-independent CaMKII specifically binds to isolated postsynaptic densities (PSDs), leading to enhanced phosphorylation of many PSD proteins including the alpha-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA)-type glutamate receptor. Calcium 18-25 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 38-44 9128183-1 1997 The relationship between intracellular free calcium ([Ca2+]i) and the activation of protein kinase C (PKC) and Ca2+/calmodulin-dependent protein kinase II (CaMKII) was investigated in the NSC-19 motoneuron cell line. Calcium 44-51 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 111-154 8662902-2 1996 Our studies focused on the calcium-dependent chloride conductance (gClCa) that was activated either by mobilizing intracellular calcium (Cai) stores with thapsigargin or by introduction of the autonomous, autophosphorylated calmodulin-dependent protein kinase II (CaMKII) into the cell via the patch pipette. Calcium 27-34 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 224-262 8662902-2 1996 Our studies focused on the calcium-dependent chloride conductance (gClCa) that was activated either by mobilizing intracellular calcium (Cai) stores with thapsigargin or by introduction of the autonomous, autophosphorylated calmodulin-dependent protein kinase II (CaMKII) into the cell via the patch pipette. Calcium 27-34 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 264-270 1708204-0 1991 CaMKII mediates stimulation of chloride conductance by calcium in T84 cells. Calcium 55-62 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 7535051-8 1995 It is concluded that calcium-dependent activation of chloride currents in Mz-ChA-1 cells is coupled to a CaMKII-dependent process. Calcium 21-28 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 105-111 8120627-9 1994 Calcium transients in these fine processes were reduced by up to 90% by NMDA receptor blockade, possibly accounting for the profound sensitivity of CaMK to this treatment. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 148-152 33590296-3 2021 Ca2+/calmodulin-dependent protein kinase II-delta (CaMKIIdelta) is a well-recognized key molecule in calcium dysregulation in cardiomyocytes. Calcium 101-108 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 51-62 33805168-5 2021 The increase was prevented by pharmacological TRPV4 inhibition or knockdown and is calcium/CamKII dependent. Calcium 83-90 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 91-97 34389294-9 2021 These results indicated that PHD might activate the CaMKII pathway through the TRPA1 ion channel, inducing the release of calcium from the sarcoplasmic reticulum through ryanodine receptor 2 (RyR2), activating AMPK to initiate the protective effects of hypoxia in cardiomyocytes. Calcium 122-129 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 52-58 34301850-0 2021 A physiologic rise in cytoplasmic calcium ion signal increases pannexin1 channel activity via a C-terminus phosphorylation by CaMKII. Calcium 34-41 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 126-132 33968186-5 2021 The present review aimed to determine whether activated CaMKII induces early afterdepolarizations and delayed afterdepolarizations that result in VA by regulating sodium, potassium and calcium ions. Calcium 185-192 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 56-62 35336076-1 2022 Ca2+/calmodulin-dependent protein kinase II (CaMKII), which is involved in the calcium signaling pathway, is an important regulator of cancer cell proliferation, motility, growth, and metastasis. Calcium 79-86 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 45-51 2848818-8 1988 These results indicate a complex mechanism through which autophosphorylation of CaM-KII may regulate its activity in response to transient fluctuations in intracellular calcium. Calcium 169-176 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 80-87 34051268-4 2021 Here, I review evidences that at mature synapses the elevated calcium levels activate primarily calcium/calmodulin-dependent kinase II (CaMKII) and cause its autophophorylation. Calcium 62-69 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 96-134 33711790-1 2021 CaMKII is a protein kinase whose function is regulated by the binding of the Calcium/Calmodulin complex (Ca2+/CaM). Calcium 77-84 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 34051268-4 2021 Here, I review evidences that at mature synapses the elevated calcium levels activate primarily calcium/calmodulin-dependent kinase II (CaMKII) and cause its autophophorylation. Calcium 62-69 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 136-142 34051268-5 2021 CaMKII autophosphorylation leads to calcium-independent activity of the kinase, so that kinase signaling can outlast NMDA receptor-dependent calcium influx. Calcium 36-43 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 34051268-5 2021 CaMKII autophosphorylation leads to calcium-independent activity of the kinase, so that kinase signaling can outlast NMDA receptor-dependent calcium influx. Calcium 141-148 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 33510801-5 2021 RNA-seq results indicated calcium ion handling and negative regulation of apoptotic process were vital processes and DHI and TMZ obviously reduced the expression of CaMK II and inhibited cleaved caspase-3 and Bax. Calcium 26-33 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 165-172 32678848-7 2020 The scaffolding molecule, Ng, when present in significant concentration, limits the availability of free calmodulin (CaM), the protein which activates CaMKII in the presence of calcium. Calcium 177-184 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 151-157 33192276-5 2020 Additionally, the BHBA-activated L-type calcium channel subsequently triggered the activation of Ca2+/CaMKII/CREB signaling, and promoted the binding of p-CREB and CBP to Bdnf promoters. Calcium 40-47 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 102-108 32678848-8 2020 We show that Ng plays an important modulatory role in CaMKII phosphorylation following a surge of high calcium concentration. Calcium 103-110 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 54-60 32678848-9 2020 We find a non-intuitive dependence of this effect on CaM concentration that results from the different affinities of CaM for CaMKII depending on the number of calcium ions bound to the former. Calcium 159-166 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 125-131 32678848-12 2020 We also study the effect of multiple calcium spikes on CaMKII holoenzyme autophosphorylation, and show that in the presence of phosphatase, CaMKII behaves as a leaky integrator of calcium signals, a result that has been recently observed in vivo. Calcium 37-44 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 140-146 32678848-12 2020 We also study the effect of multiple calcium spikes on CaMKII holoenzyme autophosphorylation, and show that in the presence of phosphatase, CaMKII behaves as a leaky integrator of calcium signals, a result that has been recently observed in vivo. Calcium 180-187 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 140-146 32678848-13 2020 Our models predict that the parameters of this leaky integrator are finely tuned through the interactions of Ng, CaM, CaMKII, and PP1, providing a mechanism to precisely control the sensitivity of synapses to calcium signals. Calcium 209-216 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 118-124 32017318-8 2020 Meanwhile, CASR activation increased the level of the [Ca2+ ]i effector p-CAMKII, and the presence of KN-93, an inhibitor of CAMKII, significantly reduced the CASR-mediated increasement of pronuclear formation rate. Calcium 55-59 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 74-80 32272228-2 2020 We have recently shown that the osteocyte responds to fluid shear stress via the microtubule network-dependent activation of NADPH oxidase 2 (NOX2)-generated reactive oxygen species and subsequent opening of TRPV4 cation channels, leading to calcium influx, activation of CaMKII, and rapid sclerostin protein downregulation. Calcium 242-249 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 272-278 32017318-10 2020 Altogether, these findings provide a new pathway of egg activation about CASR, as the extracellular Ca2+ effector, promotes egg activation via its downstream effector and upstream regulator CAMKII. Calcium 100-104 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 190-196 32149607-6 2020 Our results show how the responsiveness of CaMKII holoenzymes to calcium signals can be tuned by varying the relative levels of isoforms with long and short linkers. Calcium 65-72 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 43-49 32238193-5 2020 Under low calcium conditions, a subpopulation (40%) of synapses stood out with no CaMKII labeling at the PSD, indicating that localization of CaMKII at the PSD is sensitive to calcium levels. Calcium 176-183 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 142-148 32238193-8 2020 Median distance of label for CaMKII to postsynaptic membrane was higher in low calcium samples (68-77 nm), than in control (59-63 nm) and stimulated samples (49-53 nm). Calcium 79-86 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 29-35 32238193-5 2020 Under low calcium conditions, a subpopulation (40%) of synapses stood out with no CaMKII labeling at the PSD, indicating that localization of CaMKII at the PSD is sensitive to calcium levels. Calcium 10-17 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 142-148 31622781-5 2020 OBJECTIVE: To determine whether CaMKII-dependent phosphorylation at Ser571 on Nav1.5 increases atrial INa,L, leading to aberrant atrial Ca2+ cycling, altered electrophysiology and increased AF risk. Calcium 136-140 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 32-38 32101357-10 2020 Increased cytosolic calcium leads to activation of calmodulin-dependent protein kinase II/histone deacetylase 4 (CaMKII/HDAC4) signalling and upregulation of the foetal genes ANP and BNP, indicating cardiac remodelling. Calcium 20-27 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 113-119 31622781-12 2020 CONCLUSION: These studies identify CaMKII-dependent regulation of Nav1.5 as an important upstream event in Ca2+ handling defects and abnormal impulse generation in the setting of AF. Calcium 107-111 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 35-41 31863769-3 2020 Ca2+/calmodulin-dependent protein kinase II(CaMKII) has been reported involved in remifentanil-induced hyperalgesia (RIH) in previous studies, but the relationship between CaMKII and dezocine in RIH is still unclear. Calcium 0-4 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 41-51 31863769-3 2020 Ca2+/calmodulin-dependent protein kinase II(CaMKII) has been reported involved in remifentanil-induced hyperalgesia (RIH) in previous studies, but the relationship between CaMKII and dezocine in RIH is still unclear. Calcium 0-4 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 44-50 31733625-2 2019 The L-type calcium channel Cav1.2 can drive nuclear activity by either the ERK-CREB pathway, the Ca2+/calmodulin-dependent protein kinase II (CaMKII) cascade, or via the Ca2+-dependent protein phosphatase calcineurin. Calcium 11-18 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 97-140 32049957-12 2020 Neurogranin suppresses basal CaN activity, thus increasing the chance of CaMKII trans-autophosphorylation at high-frequency calcium spikes. Calcium 124-131 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 73-79 31625188-4 2019 Specifically, we found that Ca2+ /calmodulin-dependent protein kinase II (CaMKII), a transducer of the Wnt/Ca2+ pathway, regulates TNTs in a neuronal cell line and in primary neurons. Calcium 28-32 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 74-80 31625188-4 2019 Specifically, we found that Ca2+ /calmodulin-dependent protein kinase II (CaMKII), a transducer of the Wnt/Ca2+ pathway, regulates TNTs in a neuronal cell line and in primary neurons. Calcium 107-111 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 74-80 31748680-11 2020 In conclusion, we found that VEGF increases atrial fibroblast activity through CaMKII signaling by enhancing Ca2+ entry. Calcium 109-113 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 79-85 31733625-2 2019 The L-type calcium channel Cav1.2 can drive nuclear activity by either the ERK-CREB pathway, the Ca2+/calmodulin-dependent protein kinase II (CaMKII) cascade, or via the Ca2+-dependent protein phosphatase calcineurin. Calcium 11-18 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 142-148 31134625-2 2019 Influx of extracellular calcium (Ca2+ ) is one of the first phenomena that occur following axonal injury, and calcium/calmodulin-dependent protein kinase II (CaMKII), a target substrate for calcium ions, regulates the status of cytoskeletal proteins such as F-actin. Calcium 24-31 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 158-164 31614133-0 2019 CAIII expression in skeletal muscle is regulated by Ca2+-CaMKII-MEF2C signaling. Calcium 52-56 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 57-63 31614133-8 2019 This study demonstrates that the Ca2+-CaMKII-MEF2C signaling pathway is the key factor involved in regulating CAIII expression in skeletal muscle. Calcium 33-37 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 38-44 31134625-2 2019 Influx of extracellular calcium (Ca2+ ) is one of the first phenomena that occur following axonal injury, and calcium/calmodulin-dependent protein kinase II (CaMKII), a target substrate for calcium ions, regulates the status of cytoskeletal proteins such as F-actin. Calcium 110-117 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 158-164 31650167-6 2019 Moreover, propofol attenuated the expression of HIF-1alpha, the phosphorylation of AKT and Ca2+/calmodulin-dependent protein kinase II (CaMKII), and the Ca2+ concentration in TECs. Calcium 91-95 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 136-142 31752398-7 2019 Cellular mechanisms in the dorsal striatum in hM4D-CNO animals reveal enhanced expression of D1R and Ca2+/calmodulin-dependent kinase II (CaMKII). Calcium 101-105 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 138-144 29410121-2 2018 Aberrant calcium handling, including increased activation of calcium/calmodulin-dependent protein kinase II (CaMKII), contributes to arrhythmia development during HF. Calcium 9-16 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 61-107 30420417-3 2018 Parasites ensure efficient calcium homeostasis through gene products, such as the calmodulin-dependent kinases (CaMK), the main focus of this review. Calcium 27-34 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 82-110 30420417-3 2018 Parasites ensure efficient calcium homeostasis through gene products, such as the calmodulin-dependent kinases (CaMK), the main focus of this review. Calcium 27-34 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 112-116 30420417-6 2018 Whereas calcium regulators, including CaMK, are well characterised in mammalian systems, knowledge of their functional properties in parasites is increasing but is still in its infancy. Calcium 8-15 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 38-42 29966860-7 2018 We report a novel method for intracellular calcium sensing that utilizes the calcium dependent stable interaction between CaM kinase II (CaMKII) and its ligands such as the NMDA receptor subunit GluN2B. Calcium 43-50 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 122-135 29966860-7 2018 We report a novel method for intracellular calcium sensing that utilizes the calcium dependent stable interaction between CaM kinase II (CaMKII) and its ligands such as the NMDA receptor subunit GluN2B. Calcium 43-50 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 137-143 29966860-7 2018 We report a novel method for intracellular calcium sensing that utilizes the calcium dependent stable interaction between CaM kinase II (CaMKII) and its ligands such as the NMDA receptor subunit GluN2B. Calcium 77-84 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 122-135 29966860-7 2018 We report a novel method for intracellular calcium sensing that utilizes the calcium dependent stable interaction between CaM kinase II (CaMKII) and its ligands such as the NMDA receptor subunit GluN2B. Calcium 77-84 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 137-143 29966860-8 2018 The CaMKII-GluN2B complex formed persists as a memory of the transient increase in calcium. Calcium 83-90 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 4-10 29966860-9 2018 In a cell-based assay system GFP-alpha-CaMKII expressed in the cytosol responds to calcium by translocating towards GluN2B sequence motif exogenously expressed on mitochondria or endoplasmic reticulum. Calcium 83-90 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 39-45 31455737-2 2019 Calcium signals cause calcium-calmodulin to activate CaMKII, which leads to remodeling of the actin filament (F-actin) network in the spine. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 53-59 31455737-8 2019 This observation therefore provides a simple mechanism by which the structural dynamics of CaMKII establishes the link between calcium signaling and the morphological plasticity of dendritic spines. Calcium 127-134 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 91-97 31221819-13 2019 In conclusion, CaMKII down-regulation/proteasome inhibition/cytosolic calcium up-regulation/cathepsin B activation/trypsinogen activation axis was present in pancreatic acinar cells injury under nicardipine treatment. Calcium 70-77 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 15-21 30753871-1 2019 Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. Calcium 124-131 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-46 30753871-1 2019 Calcium/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase that transmits calcium signals in various cellular processes. Calcium 124-131 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 48-54 30753871-2 2019 CaMKII is activated by calcium-bound calmodulin (Ca2+/CaM) through a direct binding mechanism involving a regulatory C-terminal alpha-helix in CaMKII. Calcium 23-30 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 30753871-2 2019 CaMKII is activated by calcium-bound calmodulin (Ca2+/CaM) through a direct binding mechanism involving a regulatory C-terminal alpha-helix in CaMKII. Calcium 23-30 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 143-149 30244813-6 2018 A calcium chelator, BAPTA-AM, inhibited calcium ionophore A23187-induced CaMKII phosphorylation but not 24S-OHC-induced CaMKII phosphorylation. Calcium 2-9 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 73-79 30244813-6 2018 A calcium chelator, BAPTA-AM, inhibited calcium ionophore A23187-induced CaMKII phosphorylation but not 24S-OHC-induced CaMKII phosphorylation. Calcium 40-47 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 73-79 30159114-9 2018 Therefore, the miR-214/CaMKII axis regulates oxidative stress-related injury in CSCs, such as apoptosis, calcium homeostasis disequilibrium, and excessive ROS accumulation. Calcium 105-112 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 23-29 29410121-2 2018 Aberrant calcium handling, including increased activation of calcium/calmodulin-dependent protein kinase II (CaMKII), contributes to arrhythmia development during HF. Calcium 9-16 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 109-115 28869833-7 2018 As the consequence of calcium oscillation, Ca/calmodulin-dependent protein kinases II (CaMKII) was signaled and subsequently inhibited cofilin activity via phosphorylated modification. Calcium 22-29 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 43-85 29534965-8 2018 The expression of CaMKII, an important effector molecule of calcium signaling, did not alter in response to radiation. Calcium 60-67 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 18-24 28869833-7 2018 As the consequence of calcium oscillation, Ca/calmodulin-dependent protein kinases II (CaMKII) was signaled and subsequently inhibited cofilin activity via phosphorylated modification. Calcium 22-29 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 87-93 28102477-5 2017 In this review we outline the intracellular cardiac calcium dynamics and relate pathophysiological signalling, induced by disturbed calcium handling, with activation of calmodulin dependent kinase II (CaMKII) and calcineurin A (CnA). Calcium 52-59 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 169-199 29038242-4 2017 We found that CaV1.3 but not CaV1.2 channels exhibit a long-duration calcium-dependent facilitation (L-CDF) that lasts up to 8 s following a brief 50 Hz stimulus train, but only when coexpressed with densin and CaMKII. Calcium 69-76 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 211-217 29038242-8 2017 The results are important in revealing a CaV1.3-densin-CaMKII interaction that extends the contribution of CaV1.3 calcium influx to a time frame well beyond a brief input train.SIGNIFICANCE STATEMENT CaV1 L-type calcium channels play a key role in regulating the output of central neurons by providing calcium influx during repetitive inputs. Calcium 114-121 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 55-61 29038242-8 2017 The results are important in revealing a CaV1.3-densin-CaMKII interaction that extends the contribution of CaV1.3 calcium influx to a time frame well beyond a brief input train.SIGNIFICANCE STATEMENT CaV1 L-type calcium channels play a key role in regulating the output of central neurons by providing calcium influx during repetitive inputs. Calcium 212-219 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 55-61 29038242-9 2017 This study identifies a long-duration calcium-dependent facilitation (L-CDF) of CaV1.3 channels that depends on the scaffolding protein densin and CaMKII and that outlasts a depolarizing stimulus by seconds. Calcium 38-45 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 147-153 29017032-6 2017 During nutrient deprivation, glucagon-mediated increase in calcium (Ca2+) levels, via calmodulin kinase II (CaMKII) phosphorylation, inhibits proximal GRASP localization to LDs. Calcium 59-66 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 86-106 29017032-6 2017 During nutrient deprivation, glucagon-mediated increase in calcium (Ca2+) levels, via calmodulin kinase II (CaMKII) phosphorylation, inhibits proximal GRASP localization to LDs. Calcium 59-66 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 108-114 28573491-10 2017 Additionally, MAPK, PKC, PI3K or CAMKII inhibitors also are involved in the modulation of intracellular calcium signaling. Calcium 104-111 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 33-39 28521133-1 2017 CaMKII plays a critical role in decoding calcium (Ca2+) signals to initiate long-lasting synaptic plasticity. Calcium 41-48 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 28160495-4 2017 Calcium-calmodulin-dependent protein kinase II (CaMKII) is an interesting candidate as this protein can be activated by calcium influx through NMDARs. Calcium 120-127 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-46 28160495-4 2017 Calcium-calmodulin-dependent protein kinase II (CaMKII) is an interesting candidate as this protein can be activated by calcium influx through NMDARs. Calcium 120-127 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 48-54 29262619-1 2017 Background: Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent L-type calcium channel (LTCC) current (ICa) remodeling is an important contributor to the disruption of calcium homeostasis in heart failure (HF). Calcium 82-89 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 12-55 29262619-1 2017 Background: Ca2+/calmodulin-dependent protein kinase II (CaMKII)-dependent L-type calcium channel (LTCC) current (ICa) remodeling is an important contributor to the disruption of calcium homeostasis in heart failure (HF). Calcium 82-89 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 57-63 29262619-12 2017 Conclusions: Kv4.3 expression in HF ventricle can effectively reverse ICa remodeling via inhibition of the membrane-associated CaMKII, pointing to Kv4.3 restoration as a potential therapeutic approach for the disordered calcium regulation in HF. Calcium 220-227 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 127-133 28102477-5 2017 In this review we outline the intracellular cardiac calcium dynamics and relate pathophysiological signalling, induced by disturbed calcium handling, with activation of calmodulin dependent kinase II (CaMKII) and calcineurin A (CnA). Calcium 52-59 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 201-207 28102477-5 2017 In this review we outline the intracellular cardiac calcium dynamics and relate pathophysiological signalling, induced by disturbed calcium handling, with activation of calmodulin dependent kinase II (CaMKII) and calcineurin A (CnA). Calcium 132-139 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 169-199 28102477-5 2017 In this review we outline the intracellular cardiac calcium dynamics and relate pathophysiological signalling, induced by disturbed calcium handling, with activation of calmodulin dependent kinase II (CaMKII) and calcineurin A (CnA). Calcium 132-139 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 201-207 27599716-5 2016 Calcium influx induced by Abeta up-regulated the activation of Akt through CaMKII resulting in changes to the phosphorylation level of Drp1 in a time-dependent manner. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 75-81 28220073-3 2017 The discovery that the calcium and redox sensor, cardiac Ca/calmodulin-dependent protein kinase II (CaMKII) enhances both the late Na (INa-L) and the late ICa,L in patients at high risk of VT/VF provided a new and a rational AAD target. Calcium 23-30 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 57-98 28220073-3 2017 The discovery that the calcium and redox sensor, cardiac Ca/calmodulin-dependent protein kinase II (CaMKII) enhances both the late Na (INa-L) and the late ICa,L in patients at high risk of VT/VF provided a new and a rational AAD target. Calcium 23-30 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 100-106 27917108-3 2016 We demonstrate that CaM and CaMKII binding to Cx36 is calcium-dependent, with Cx36 able to engage with CaM outside of the gap junction plaque. Calcium 54-61 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 28-34 26650851-1 2016 RATIONALE: Calcium/calmodulin-dependent protein kinase II (CaMKII) is activated in heart failure (HF) and can contribute to arrhythmias induced by beta-adrenergic receptor-mediated sarcoplasmic reticulum calcium leak. Calcium 204-211 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 59-65 26762270-2 2016 Emergent evidence suggests that CaMKII may play an important role in promoting atrial fibrillation (AF) by targeting a diverse array of proteins involved in membrane excitability, cell survival, calcium homeostasis, matrix remodelling, inflammation, and metabolism. Calcium 195-202 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 32-38 27582424-12 2016 CONCLUSIONS: Cardiac arrest and reperfusion lead to CaMKII activation and calcium long-term potentiation, which support cardiomyocyte contractility in the face of impaired postarrest myofilament calcium sensitivity. Calcium 195-202 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 52-58 27584878-1 2016 In reward learning, the integration of NMDA-dependent calcium and dopamine by striatal projection neurons leads to potentiation of corticostriatal synapses through CaMKII/PP1 signaling. Calcium 54-61 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 164-170 27584878-2 2016 In order to elicit the CaMKII/PP1-dependent response, the calcium and dopamine inputs should arrive in temporal proximity and must follow a specific (dopamine after calcium) order. Calcium 58-65 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 23-29 27584878-2 2016 In order to elicit the CaMKII/PP1-dependent response, the calcium and dopamine inputs should arrive in temporal proximity and must follow a specific (dopamine after calcium) order. Calcium 165-172 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 23-29 26719529-6 2016 Blocking CamK activity abolished gene reactivation and cancer cell killing by these drugs, showing that triggering calcium fluxes is an essential component of their epigenetic mechanism of action. Calcium 115-122 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 9-13 26603284-3 2015 CaMKII dysregulation may therefore be a modulator of toxicity in Alzheimer"s disease, a dementia characterised by aberrant calcium signalling, synapse and neuronal loss, and impaired memory. Calcium 123-130 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 23657616-8 2013 In the case of all three kinase inhibitors, the IC50 for calcium current inhibition falls near that of CaMKII inhibition. Calcium 57-64 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 103-109 25215889-6 2014 Animals injected with a cGMP analogue, calcium ionophore or cAMP analogue prior to 1-trial conditioning exhibited 1-day retention, and co-injection of a CaMKII inhibitor impaired induction of LTM by the cGMP analogue or that by the calcium ionophore but not that by the cAMP analogue, suggesting that CaMKII is downstream of cGMP production and Ca(2+) influx and upstream of cAMP production in biochemical cascades for LTM formation. Calcium 232-239 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 153-159 24469321-8 2014 In conclusion, the present study demonstrated a novel signaling pathway by which AhR agonists elevated intracellular calcium levels, which activated CaMKII, leading to increased MMP-1 expression through MAPK pathways in bronchial epithelial cell lines. Calcium 117-124 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 149-155 24653208-9 2014 This role of CaMKII requires it to have kinase activity as well as an activating calcium signal released from internal ER stores via the ryanodine receptor. Calcium 81-88 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 13-19 24473075-2 2014 We now report that CaMKII has a remarkable property, which is that activation of the holoenzyme triggers the exchange of subunits between holoenzymes, including unactivated ones, enabling the calcium-independent phosphorylation of new subunits. Calcium 192-199 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 19-25 24064350-5 2013 Also, IGF-1 induced calcium-dependent molecules such as Calmodulin Kinase II (CaMK II), Extracellular signal-regulated Kinases (ERK), Protein Kinase C (PKC). Calcium 20-27 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 56-76 24064350-5 2013 Also, IGF-1 induced calcium-dependent molecules such as Calmodulin Kinase II (CaMK II), Extracellular signal-regulated Kinases (ERK), Protein Kinase C (PKC). Calcium 20-27 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 78-85 23583761-6 2013 Formation of these CaMKII-polyribosome aggregates requires the presence of both tatCN21 and calcium, and was augmented upon exposure to high K(+) or NMDA. Calcium 92-99 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 19-25 26287635-1 2015 Oxidative stress and calcium (Ca(2+))/calmodulin (CaM)-dependent protein kinase II (CaMKII) both play important roles in the pathogenesis of cardiac disease. Calcium 21-28 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 84-90 26086598-4 2015 The model tracks the response of calmodulin and CaMKII to calcium influx in synapses. Calcium 58-65 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 48-54 25815641-2 2015 Recently, calcium (Ca(2+))/calmodulin(CaM)-dependent protein kinase II (CaMKII) has emerged as a critical regulator of Na(V)1.5 function through phosphorylation of multiple residues including S516, T594, and S571, and these phosphorylation events may be important for the genesis of acquired arrhythmias, which occur in heart failure. Calcium 10-17 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 72-78 25859219-6 2015 Short (milliseconds or seconds) and long (minutes) term influences of calcium are discussed including direct regulation of ion channels and NCX, and control of the activity of calcium-dependent enzymes (including CaMKII, AC1, and AC8). Calcium 70-77 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 213-219 25277075-5 2014 It has been reported that chronic stress mediates alterations in several calcium-related components involved in BDNF synthesis, including CAMKII, CAMKIV and cAMP-response element-binding protein (CREB), and glutamatergic neurotransmission through N-Methyl-D-Aspartate receptors (NMDAR). Calcium 73-80 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 138-144 24530899-2 2014 One putative sensor for both calcium and oxidative stress in the heart is CaMKII, a calcium activated kinase that has recently been shown to also be regulated by oxidation. Calcium 29-36 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 74-80 24530899-4 2014 Additionally, oxidative activation of CaMKII is suggested in subcellular domains where calcium and ROS signaling intersect, such as mitochondria. Calcium 87-94 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 38-44 24672485-3 2014 CaMKII senses intracellular calcium (Ca(2) (+)) changes, oxidation status, and hyperglycemia to phosphorylate substrates that regulate Ca(2) (+)-sensitive proteins, such as L-type Ca(2) (+) channels, phospholamban, and cardiac ryanodine receptors (RyR2). Calcium 28-35 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 24624086-0 2014 Calcium dysregulation in atrial fibrillation: the role of CaMKII. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 58-64 24117889-10 2014 This is the first demonstration that beta-catenin is a phosphorylation target of CaMKII and represents a novel mechanism by which calcium signals could regulate beta-catenin-dependent transcription. Calcium 130-137 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 81-87 23748539-5 2013 A ROS-induced calcium (Ca 2+)-calmodulin-dependent protein kinase II (CaMKII) hyperactivity can cause diastolic Ca2+ overload secondary to the activation of the late sodium (Na+) current (INaL). Calcium 14-21 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 70-76 23357406-1 2013 L-type calcium channels are modulated by a host of mechanisms that include voltage, calcium ions (Ca(2+) dependent inactivation and facilitation), cytosolic proteins (CAM, CAMKII, PKA, PKC, etc. Calcium 7-14 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 172-178 23543737-4 2013 Furthermore, CaMKII inhibition in astrocytes is associated with the rapid onset of intracellular calcium oscillations. Calcium 97-104 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 13-19 23543737-8 2013 Extracellular ATP accumulation associated with CaMKII inhibition contributes both to calcium oscillations within astrocytes and ultimately cortical neuron toxicity. Calcium 85-92 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 47-53 23207595-9 2013 I propose that CaMKII-mediated facilitation of glutamatergic transmission strengthens emergent synchronous activity within preBotC that is then maintained by periodic surges of calcium during the bursts. Calcium 177-184 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 15-21 23632248-4 2013 These structures, when combined with other data, allow informed speculation about how CaMKII escapes calcium-dependence when calcium spikes exceed threshold frequencies. Calcium 101-108 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 86-92 23632248-4 2013 These structures, when combined with other data, allow informed speculation about how CaMKII escapes calcium-dependence when calcium spikes exceed threshold frequencies. Calcium 125-132 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 86-92 22578382-2 2012 Among the enzymes responding to calcium increase, Ca2+/calmodulin-dependent protein kinase II (CaMKII) has been involved in anergy with a still poorly characterized role. Calcium 32-39 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 50-93 23019322-1 2012 InsP(3)-mediated calcium release through the type 2 inositol 1,4,5-trisphosphate receptor (InsP(3)R2) in cardiac myocytes results in the activation of associated CaMKII, thus enabling the kinase to act on downstream targets, such as histone deacetylases 4 and 5 (HDAC4 and HDAC5). Calcium 17-24 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 162-168 22908225-10 2012 These results suggest that increased intracellular calcium and subsequent activation of CaMKII play a key role in regulating the stress-induced increase in cellular O-GlcNAc levels. Calcium 51-58 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 88-94 23362283-4 2013 This calcium flux triggered the activation of Ca(2+)-calmodulin-dependent protein kinase II (CaMKII). Calcium 5-12 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 46-91 23362283-4 2013 This calcium flux triggered the activation of Ca(2+)-calmodulin-dependent protein kinase II (CaMKII). Calcium 5-12 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 93-99 22578382-2 2012 Among the enzymes responding to calcium increase, Ca2+/calmodulin-dependent protein kinase II (CaMKII) has been involved in anergy with a still poorly characterized role. Calcium 32-39 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 95-101 22578382-11 2012 Our data for the first time suggest a distinct role of CaMKII in the induction of anergy in T lymphocytes, by differential regulation of IL-10 and IL-2 gene transcription suggest MEF2 as a molecular target which can integrate different calcium signals. Calcium 236-243 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 55-61 22253441-0 2012 Calcium/calmodulin-dependent protein kinase II (CaMKII) inhibition induces neurotoxicity via dysregulation of glutamate/calcium signaling and hyperexcitability. Calcium 120-127 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 48-54 22427672-0 2012 Substrate-selective and calcium-independent activation of CaMKII by alpha-actinin. Calcium 24-31 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 58-64 22503562-0 2012 Calcium signaling through CaMKII regulates hepatic glucose production in fasting and obesity. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 26-32 22503562-2 2012 Here, we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo. Calcium 21-28 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 45-51 22503562-2 2012 Here, we show that a calcium-sensing enzyme, CaMKII, is activated in a calcium- and IP3R-dependent manner by cAMP and glucagon in primary hepatocytes and by glucagon and fasting in vivo. Calcium 71-78 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 45-51 22253441-2 2012 Calcium/calmodulin-dependent kinase II (CaMKII), a multifunctional serine/threonine protein kinase in neurons, is believed to regulate neurotransmission and synaptic plasticity in response to calcium signaling produced by neuronal activity. Calcium 192-199 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-38 22253441-2 2012 Calcium/calmodulin-dependent kinase II (CaMKII), a multifunctional serine/threonine protein kinase in neurons, is believed to regulate neurotransmission and synaptic plasticity in response to calcium signaling produced by neuronal activity. Calcium 192-199 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 40-46 22253441-6 2012 Thus, this neurotoxicity is consistent with apoptotic mechanisms, a conclusion that is further supported by dysregulated calcium signaling with CaMKII inhibition. Calcium 121-128 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 144-150 22253441-9 2012 Enzymatic buffering of extracellular glutamate and antagonism of the NMDA subtype of glutamate receptors prevent the calcium dysregulation and neurotoxicity associated with prolonged CaMKII inhibition. Calcium 117-124 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 183-189 22334212-2 2012 LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). Calcium 25-32 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 56-102 22334212-2 2012 LTP induction results in calcium entry, which activates calcium/calmodulin-dependent protein kinase II (CaMKII). Calcium 25-32 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 104-110 22234611-7 2012 Calcium- and calmodulin-dependent protein kinase II (CaMKII) is required downstream of Wnt-induced calcium signaling for postcrossing callosal axon growth and guidance. Calcium 99-106 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 13-51 22234611-7 2012 Calcium- and calmodulin-dependent protein kinase II (CaMKII) is required downstream of Wnt-induced calcium signaling for postcrossing callosal axon growth and guidance. Calcium 99-106 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 53-59 22234611-8 2012 Taken together, these results suggest that growth and guidance of postcrossing callosal axons by Wnt-Ryk-calcium signaling involves axon repulsion through CaMKII. Calcium 105-112 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 155-161 22412364-3 2012 In long-term potentiation (LTP), a cellular and molecular model for memory, post-synaptic calcium ion (Ca2+) flux activates the hexagonal Ca2+-calmodulin dependent kinase II (CaMKII), a dodacameric holoenzyme containing 2 hexagonal sets of 6 kinase domains. Calcium 90-97 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 138-173 22412364-3 2012 In long-term potentiation (LTP), a cellular and molecular model for memory, post-synaptic calcium ion (Ca2+) flux activates the hexagonal Ca2+-calmodulin dependent kinase II (CaMKII), a dodacameric holoenzyme containing 2 hexagonal sets of 6 kinase domains. Calcium 90-97 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 175-181 22962589-0 2012 Calcium input frequency, duration and amplitude differentially modulate the relative activation of calcineurin and CaMKII. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 115-121 22962589-4 2012 Calcium input activates both calcineurin and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) at all frequencies, but increased frequencies shift the relative activation from calcineurin to CaMKII. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 45-90 22962589-4 2012 Calcium input activates both calcineurin and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) at all frequencies, but increased frequencies shift the relative activation from calcineurin to CaMKII. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 92-98 22962589-4 2012 Calcium input activates both calcineurin and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) at all frequencies, but increased frequencies shift the relative activation from calcineurin to CaMKII. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 196-202 22962589-6 2012 At a given frequency, the quantity of CaMKII activated is proportional to the total amount of calcium. Calcium 94-101 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 38-44 22962589-7 2012 Thus, an input of a small amount of calcium at high frequencies can induce the same activation of CaMKII as a larger amount, at lower frequencies. Calcium 36-43 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 98-104 22962589-8 2012 Finally, the extent of activation of CaMKII signals with high calcium frequency is further controlled by other factors, including the availability of calmodulin, and by the potency of phosphatase inhibitors. Calcium 62-69 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 37-43 25215041-1 2012 BACKGROUND: Calcium calmodulin-dependent kinase II (CaMKII) can be more active in patients with left ventricular hypertrophy (LVH), which in turn causes phosphorylation of ryanodine receptors, resulting in inactivation and the instability of intracellular calcium homeostasis. Calcium 256-263 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 20-50 25215041-1 2012 BACKGROUND: Calcium calmodulin-dependent kinase II (CaMKII) can be more active in patients with left ventricular hypertrophy (LVH), which in turn causes phosphorylation of ryanodine receptors, resulting in inactivation and the instability of intracellular calcium homeostasis. Calcium 256-263 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 52-58 21316454-2 2011 While activation of calcium-calmodulin (CaM)-dependent protein kinase II (CaMKII) is a key event in calcium signaling, its role in excitotoxicity is controversial. Calcium 20-27 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 74-80 21642394-7 2011 The ability of CAMKII to increase Nox5 activity was also observed with fixed calcium concentrations in an isolated enzyme activity assay. Calcium 77-84 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 15-21 21884935-1 2011 Calcium/calmodulin-dependent kinase II (CaMKII) forms a highly conserved dodecameric assembly that is sensitive to the frequency of calcium pulse trains. Calcium 132-139 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-38 21884935-1 2011 Calcium/calmodulin-dependent kinase II (CaMKII) forms a highly conserved dodecameric assembly that is sensitive to the frequency of calcium pulse trains. Calcium 132-139 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 40-46 21486818-4 2011 Pharmacological inhibition of CaMKII activity induced measurable changes in LTCC current density and subsequent changes in cardiomyocyte calcium signalling in less than 24 h. The effect of CaMKII on the alpha1C-subunit gene (Cacna1c) promoter was abolished by deletion of the downstream regulatory element (DRE), which binds transcriptional repressor DREAM/calsenilin/KChIP3. Calcium 137-144 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 30-36 21486818-5 2011 Imaging DREAM-GFP (green fluorescent protein)-expressing cardiomyocytes showed that CaMKII potentiates the calcium-induced nuclear translocation of DREAM. Calcium 107-114 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 84-90 21486818-7 2011 By mathematical modelling we demonstrate that the LTCC downregulation through the Ca2+-CaMKII-DREAM cascade constitutes a physiological feedback mechanism enabling cardiomyocytes to adjust the calcium intrusion through LTCCs to the amount of intracellular calcium detected by CaMKII. Calcium 193-200 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 87-93 21486818-7 2011 By mathematical modelling we demonstrate that the LTCC downregulation through the Ca2+-CaMKII-DREAM cascade constitutes a physiological feedback mechanism enabling cardiomyocytes to adjust the calcium intrusion through LTCCs to the amount of intracellular calcium detected by CaMKII. Calcium 193-200 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 276-282 21486818-7 2011 By mathematical modelling we demonstrate that the LTCC downregulation through the Ca2+-CaMKII-DREAM cascade constitutes a physiological feedback mechanism enabling cardiomyocytes to adjust the calcium intrusion through LTCCs to the amount of intracellular calcium detected by CaMKII. Calcium 256-263 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 87-93 21486818-7 2011 By mathematical modelling we demonstrate that the LTCC downregulation through the Ca2+-CaMKII-DREAM cascade constitutes a physiological feedback mechanism enabling cardiomyocytes to adjust the calcium intrusion through LTCCs to the amount of intracellular calcium detected by CaMKII. Calcium 256-263 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 276-282 21343908-1 2011 Calcium/calmodulin-dependent protein kinase II (CaMKII) interprets information conveyed by the amplitude and frequency of calcium transients by a controlled transition from an autoinhibited basal intermediate to an autonomously active phosphorylated intermediate (De Koninck and Schulman, 1998). Calcium 122-129 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-46 21343908-1 2011 Calcium/calmodulin-dependent protein kinase II (CaMKII) interprets information conveyed by the amplitude and frequency of calcium transients by a controlled transition from an autoinhibited basal intermediate to an autonomously active phosphorylated intermediate (De Koninck and Schulman, 1998). Calcium 122-129 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 48-54 20668654-2 2010 LTP triggers high-frequency calcium pulses that result in the activation of Calcium/Calmodulin (CaM)-dependent kinase II (CaMKII). Calcium 28-35 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 122-128 21148163-4 2011 CaMKII dissociation from Kv4.3-CaMKII units caused a significant increase in CaMKII autophosphorylation and L-type calcium current (I(Ca)) facilitation. Calcium 115-122 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 21148163-4 2011 CaMKII dissociation from Kv4.3-CaMKII units caused a significant increase in CaMKII autophosphorylation and L-type calcium current (I(Ca)) facilitation. Calcium 115-122 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 31-37 21148163-4 2011 CaMKII dissociation from Kv4.3-CaMKII units caused a significant increase in CaMKII autophosphorylation and L-type calcium current (I(Ca)) facilitation. Calcium 115-122 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 31-37 20974637-3 2011 The ubiquitous calcium-binding proteins, calmodulin and calmodulin-dependent protein kinase II (CaMKII), have well-established roles in regulated exocytosis in neurons and neuroendocrine cells. Calcium 15-22 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 56-94 20974637-3 2011 The ubiquitous calcium-binding proteins, calmodulin and calmodulin-dependent protein kinase II (CaMKII), have well-established roles in regulated exocytosis in neurons and neuroendocrine cells. Calcium 15-22 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 96-102 20974637-8 2011 An increased extracellular calcium level acutely lowered the amount of active phosphorylated CaMKII (pCaMKII) in adenoma cells in vitro, indicating the physiological importance of this pathway. Calcium 27-34 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 93-99 20844140-6 2010 Furthermore we found that calcium-dependent AChR recycling is mediated by Ca(2+)/calmodulin-dependent kinase II (CaMKII). Calcium 26-33 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 74-111 20844140-6 2010 Furthermore we found that calcium-dependent AChR recycling is mediated by Ca(2+)/calmodulin-dependent kinase II (CaMKII). Calcium 26-33 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 113-119 21064217-1 2010 Learning, memory and long-term potentiation (LTP) are supported by factors including post-synaptic calcium ion flux activating and transforming the hexagonal calcium-calmodulin kinase II (CaMKII) holoenzyme. Calcium 99-106 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 158-186 21064217-1 2010 Learning, memory and long-term potentiation (LTP) are supported by factors including post-synaptic calcium ion flux activating and transforming the hexagonal calcium-calmodulin kinase II (CaMKII) holoenzyme. Calcium 99-106 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 188-194 21064217-2 2010 Upon calcium-induced activation, up to six kinase domains extend upward, and up to six kinase domains extend downward from the CaMKII association domain, the fully activated holoenzyme resembling a robotic insect 20 nanometers in length. Calcium 5-12 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 127-133 20810541-6 2010 A likely mechanism for the calcium-mediated effects is activation of CaMKII, a calcium-dependent MAP4K. Calcium 27-34 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 69-75 20810541-6 2010 A likely mechanism for the calcium-mediated effects is activation of CaMKII, a calcium-dependent MAP4K. Calcium 79-86 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 69-75 20810541-9 2010 All features of GW7845-induced cell death, except loss of mitochondrial membrane potential, were suppressed by CaMKII inhibitors (KN93 and AIP-II), suggesting the activation of multiple calcium-driven pathways. Calcium 186-193 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 111-117 20810541-13 2010 Thus, we show that early B cells are susceptible to calcium-triggered cell death through a CaMKII/MAPK-dependent pathway. Calcium 52-59 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 91-97 20668654-3 2010 CaMKII acts as a molecular switch because it remains active for a long time after the return to basal calcium levels, which is a unique property required for CaMKII function. Calcium 102-109 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-6 20668654-3 2010 CaMKII acts as a molecular switch because it remains active for a long time after the return to basal calcium levels, which is a unique property required for CaMKII function. Calcium 102-109 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 158-164 20392834-2 2010 Calcium-dependent signaling through calcium/calmodulin-dependent kinase II (CaMKII) and ERK1/2 activation plays an important role in the regulation of VSMC proliferation by agents such as alpha-adrenergic receptor agonists. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 36-74 20392834-2 2010 Calcium-dependent signaling through calcium/calmodulin-dependent kinase II (CaMKII) and ERK1/2 activation plays an important role in the regulation of VSMC proliferation by agents such as alpha-adrenergic receptor agonists. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 76-82 20567760-6 2010 For at least some stimuli, calcium release leads to activation of calmodulin kinase II (CaMKII), apoptosis signaling kinase 1 (ASK1) and JNK. Calcium 27-34 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 66-86 20567760-6 2010 For at least some stimuli, calcium release leads to activation of calmodulin kinase II (CaMKII), apoptosis signaling kinase 1 (ASK1) and JNK. Calcium 27-34 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 88-94 20195498-2 2010 The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA, which are activated by calcium-dependent signaling processes and other intracellular signaling pathways. Calcium 152-159 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 113-119 20107130-8 2010 One reason LTP induction protocols may require tetanic or repeated burst stimulation is that there is a need to overcome inherent variability to provide sufficiently large calcium signals through NMDA receptor channels; with meaningful physiological stimuli, noise may allow the calcium signal to exceed threshold for CaMKII activation when it might not do so otherwise. Calcium 279-286 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 318-324 20139089-13 2010 These data suggest that CaMKII is a molecular link translating intracellular calcium changes, which are intrinsically associated with glioma migration, to changes in ClC-3 conductance required for cell movement. Calcium 77-84 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 24-30 20530430-5 2010 The pre-treatment with inhibitors of mitogen-activated/extracellular regulated kinase (MEK1), protein kinase C (PKC) or Ca(2+)/calmodulin-dependent kinase II (CaMKII) blocked the toxic effects of toxin Bc2 and EqTx-II, suggesting that calcium entry, activation of MEK1, PKC and CaMKII pathways are involved in the cytotoxicity induced by these cytolysins. Calcium 235-242 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 120-157 20530430-5 2010 The pre-treatment with inhibitors of mitogen-activated/extracellular regulated kinase (MEK1), protein kinase C (PKC) or Ca(2+)/calmodulin-dependent kinase II (CaMKII) blocked the toxic effects of toxin Bc2 and EqTx-II, suggesting that calcium entry, activation of MEK1, PKC and CaMKII pathways are involved in the cytotoxicity induced by these cytolysins. Calcium 235-242 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 159-165 20195498-5 2010 The model describes the interactions of calcium and cAMP signaling pathways and is based on published biochemical measurements of two key synaptic signaling molecules, PKA and CaMKII. Calcium 40-47 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 176-182 19959817-10 2010 p38 phosphorylation was stimulated by the calcium ionophore A23187 and by capsaicin, and the response to both agonists was reduced by a CaM inhibitor and by CaM-KII inhibitors, indicating that calcium induced activation of CaM and CaM-KII results in P38 phosphorylation. Calcium 193-200 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 157-164 19961909-3 2010 Expression of an inhibitory peptide of CaMKII, Ala, in muscle cells enhanced the density of GluRIIA, which is a major and calcium-permeable subunit of GluR, at synapses of third instar larval NMJs. Calcium 122-129 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 39-45 19959817-10 2010 p38 phosphorylation was stimulated by the calcium ionophore A23187 and by capsaicin, and the response to both agonists was reduced by a CaM inhibitor and by CaM-KII inhibitors, indicating that calcium induced activation of CaM and CaM-KII results in P38 phosphorylation. Calcium 193-200 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 231-238 20052460-7 2010 The expression of calcium downstream effectors calcineurin and phosphorylated calmodulin kinase II (CaMKII) were significantly suppressed by scutellarin. Calcium 18-25 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 78-98 20052460-7 2010 The expression of calcium downstream effectors calcineurin and phosphorylated calmodulin kinase II (CaMKII) were significantly suppressed by scutellarin. Calcium 18-25 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 100-106 19782748-5 2010 Moreover, inhibition of calcium effectors using calmodulin antagonist (W7) or Ca(2+)/calmodulin-dependent kinase II (CaMK-II) inhibitor (KN-93) abolished PGF potentiation of Butaprost-mediated cAMP release. Calcium 24-31 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 78-115 19997488-1 2009 Calmodulin kinase II (CaMKII) mediates critical signaling pathways responsible for divergent functions in the heart including calcium cycling, hypertrophy and apoptosis. Calcium 126-133 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 0-20 20685575-4 2010 In this review, we will summarize new insights into the role of enhanced CaMKII in sarcoplasmic reticulum calcium leak and atrial arrhythmogenesis during atrial fibrillation. Calcium 106-113 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 73-79 19997488-1 2009 Calmodulin kinase II (CaMKII) mediates critical signaling pathways responsible for divergent functions in the heart including calcium cycling, hypertrophy and apoptosis. Calcium 126-133 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 22-28 19638347-5 2009 In addition, the regulation of the proteasome is dependent upon external calcium entry in part through N-methyl-D-aspartate receptors and L-type voltage-gated calcium channels and requires the activity of calcium/calmodulin-dependent protein kinase II (CaMKII). Calcium 73-80 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 253-259 19625651-4 2009 TREM-2-dependent calcium signals are required for RANK-mediated activation of calcium/calmodulin-dependent protein kinase (CaMK)II and downstream MEK and ERK MAPKs that are important for osteoclastogenesis. Calcium 17-24 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 123-130 18669651-1 2008 Calmodulin plays a vital role in mediating bidirectional synaptic plasticity by activating either calcium/calmodulin-dependent protein kinase II (CaMKII) or protein phosphatase 2B (PP2B) at different calcium concentrations. Calcium 98-105 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 146-152 18769913-3 2008 Our model takes exact phosphorylation patterns of CaMKII holoenzymes into account, and is valid at physiologically relevant conditions where the concentrations of calcium and calmodulin are not saturating. Calcium 163-170 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 50-56 18769913-4 2008 Our results strongly suggest that even when bound to less than fully calcium-bound calmodulin, CaMKII is in the active state, and indicate that the autophosphorylation of T286 by an active non-phosphorylated CaMKII subunit is significantly faster than by an autophosphorylated CaMKII subunit. Calcium 69-76 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 95-101 18769913-5 2008 These results imply that CaMKII can be efficiently activated at significantly lower calcium concentrations than previously thought, which may explain how CaMKII gets activated at calcium concentrations existing at synapses in vivo. Calcium 84-91 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 25-31 18769913-5 2008 These results imply that CaMKII can be efficiently activated at significantly lower calcium concentrations than previously thought, which may explain how CaMKII gets activated at calcium concentrations existing at synapses in vivo. Calcium 84-91 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 154-160 18769913-5 2008 These results imply that CaMKII can be efficiently activated at significantly lower calcium concentrations than previously thought, which may explain how CaMKII gets activated at calcium concentrations existing at synapses in vivo. Calcium 179-186 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 25-31 18769913-5 2008 These results imply that CaMKII can be efficiently activated at significantly lower calcium concentrations than previously thought, which may explain how CaMKII gets activated at calcium concentrations existing at synapses in vivo. Calcium 179-186 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 154-160 19089983-6 2009 To investigate the underlying mechanism of activation, calcium-dependent titrations of isolated domains of CaM binding to CaMKIIp were monitored using fluorescence anisotropy. Calcium 55-62 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 122-129 19089983-7 2009 The binding affinity of CaMKIIp for the domains of CaM increased upon saturation with calcium, with the C-domain having a 35-fold greater affinity than the N-domain. Calcium 86-93 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 24-31 19089983-9 2009 Investigation of the thermodynamic linkage between saturation of individual calcium-binding sites and CaM-domain binding to CaMKIIp showed that calcium binding to Sites III and IV was sufficient to recapitulate the behavior of (Ca(2+))(4)-CaM. Calcium 76-83 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 124-131 19089983-9 2009 Investigation of the thermodynamic linkage between saturation of individual calcium-binding sites and CaM-domain binding to CaMKIIp showed that calcium binding to Sites III and IV was sufficient to recapitulate the behavior of (Ca(2+))(4)-CaM. Calcium 144-151 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 124-131 18818394-1 2008 Calcium and its major downstream effector, calcium/calmodulin-dependent protein kinase II (CaMKII), are found to be important for the functions of immune cells. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 43-89 18818394-1 2008 Calcium and its major downstream effector, calcium/calmodulin-dependent protein kinase II (CaMKII), are found to be important for the functions of immune cells. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 91-97 18818394-8 2008 The cross-talk with the calcium/CaMKII pathway is needed for full activation of TLR signaling in macrophages. Calcium 24-31 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 32-38 18088385-2 2008 Following Ca activation, CaMKII autophosphorylates, gaining a calcium-independent autonomous activity that reflects a molecular memory of having previously come into contact with calcium. Calcium 62-69 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 25-31 17609678-2 2008 Calcium influx activates calcium-calmodulin-dependent protein kinases such as CaMKII. Calcium 0-7 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 78-84 18261747-7 2008 Indeed the drug prevented calcium-induced CaMKII autophosphorylation which, in turn, led to decreased NFkappaB activation. Calcium 26-33 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 42-48 18088385-2 2008 Following Ca activation, CaMKII autophosphorylates, gaining a calcium-independent autonomous activity that reflects a molecular memory of having previously come into contact with calcium. Calcium 179-186 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 25-31 18166396-8 2008 This raises the postsynaptic calcium concentration in the dendritic spine leading to the autophosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII). Calcium 29-36 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 112-158 18166396-8 2008 This raises the postsynaptic calcium concentration in the dendritic spine leading to the autophosphorylation of calcium/calmodulin-dependent protein kinase II (CaMKII). Calcium 29-36 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 160-166 18052535-1 2007 The calcium/calmodulin-dependent protein kinase II (CaMKII) plays a key role in the induction of long-term postsynaptic modifications following calcium entry. Calcium 4-11 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 52-58 18052535-6 2007 As previously shown, two stable states of the CaMKII phosphorylation level exist at resting intracellular calcium concentration, and high calcium transients can switch the system from the weakly phosphorylated (DOWN) to the highly phosphorylated (UP) state of the CaMKII (similar to a LTP event). Calcium 106-113 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 46-52 18052535-6 2007 As previously shown, two stable states of the CaMKII phosphorylation level exist at resting intracellular calcium concentration, and high calcium transients can switch the system from the weakly phosphorylated (DOWN) to the highly phosphorylated (UP) state of the CaMKII (similar to a LTP event). Calcium 138-145 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 46-52 18052535-6 2007 As previously shown, two stable states of the CaMKII phosphorylation level exist at resting intracellular calcium concentration, and high calcium transients can switch the system from the weakly phosphorylated (DOWN) to the highly phosphorylated (UP) state of the CaMKII (similar to a LTP event). Calcium 138-145 calcium/calmodulin dependent protein kinase II gamma Homo sapiens 264-270