PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 26136560-3 2015 MARCKS and MLP-1 are regulated by changes in cytosolic calcium; increasing calcium promotes dissociation of MARCKS from the membrane, but the calcium-regulatory mechanisms are unclear. Calcium 55-62 myristoylated alanine rich protein kinase C substrate Homo sapiens 0-6 8313612-5 1994 This protein, myristoylated alanine-rich C kinase substrate ("MARCKS"), is implicated in synaptic neurotransmission, calcium regulation, and cytoskeletal restructuring. Calcium 117-124 myristoylated alanine rich protein kinase C substrate Homo sapiens 14-69 1846353-4 1991 Bombesin induces the same extent of phosphorylation of MARCKS protein, the major cellular substrate for protein kinase C, irrespective of the medium calcium concentration for at least 4 h. Moreover, diverse cellular responses elicited by bombesin, including c-fos expression, activation of microtubule-associated protein 2 kinase and S6 kinase, glucose uptake, and protein synthesis but not the release of arachidonic acid and its metabolites, are induced similarly at either 0.03 or 3.0 mM calcium. Calcium 491-498 myristoylated alanine rich protein kinase C substrate Homo sapiens 55-61 26136560-3 2015 MARCKS and MLP-1 are regulated by changes in cytosolic calcium; increasing calcium promotes dissociation of MARCKS from the membrane, but the calcium-regulatory mechanisms are unclear. Calcium 75-82 myristoylated alanine rich protein kinase C substrate Homo sapiens 108-114 26136560-3 2015 MARCKS and MLP-1 are regulated by changes in cytosolic calcium; increasing calcium promotes dissociation of MARCKS from the membrane, but the calcium-regulatory mechanisms are unclear. Calcium 75-82 myristoylated alanine rich protein kinase C substrate Homo sapiens 108-114 23704996-0 2013 MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis. Calcium 47-54 myristoylated alanine rich protein kinase C substrate Homo sapiens 0-6 23704996-4 2013 Calcium- and phorbol ester-triggered acrosomal exocytosis in permeabilized sperm was abrogated by different anti-MARCKS antibodies raised against two different domains, indicating that the protein participates in acrosomal exocytosis. Calcium 0-7 myristoylated alanine rich protein kinase C substrate Homo sapiens 113-119 23704996-9 2013 We found that PIP2 and adenophostin, a potent IP3-receptor agonist, rescued MARCKS inhibition in permeabilized sperm, suggesting that MARCKS inhibits acrosomal exocytosis by sequestering PIP2 and, indirectly, MARCKS regulates the intracellular calcium mobilization. Calcium 244-251 myristoylated alanine rich protein kinase C substrate Homo sapiens 134-140 23704996-9 2013 We found that PIP2 and adenophostin, a potent IP3-receptor agonist, rescued MARCKS inhibition in permeabilized sperm, suggesting that MARCKS inhibits acrosomal exocytosis by sequestering PIP2 and, indirectly, MARCKS regulates the intracellular calcium mobilization. Calcium 244-251 myristoylated alanine rich protein kinase C substrate Homo sapiens 134-140 23704996-10 2013 In non-permeabilized sperm, a permeable peptide of MARCKS ED also inhibited acrosomal exocytosis when stimulated by a natural agonist such as progesterone, and pharmacological inducers such as calcium ionophore and phorbol ester. Calcium 193-200 myristoylated alanine rich protein kinase C substrate Homo sapiens 51-57 23704996-11 2013 The preincubation of human sperm with the permeable MARCKS ED abolished the increase in calcium levels caused by progesterone, demonstrating that MARCKS regulates calcium mobilization. Calcium 88-95 myristoylated alanine rich protein kinase C substrate Homo sapiens 52-58 23704996-11 2013 The preincubation of human sperm with the permeable MARCKS ED abolished the increase in calcium levels caused by progesterone, demonstrating that MARCKS regulates calcium mobilization. Calcium 88-95 myristoylated alanine rich protein kinase C substrate Homo sapiens 146-152 23704996-11 2013 The preincubation of human sperm with the permeable MARCKS ED abolished the increase in calcium levels caused by progesterone, demonstrating that MARCKS regulates calcium mobilization. Calcium 163-170 myristoylated alanine rich protein kinase C substrate Homo sapiens 52-58 23704996-11 2013 The preincubation of human sperm with the permeable MARCKS ED abolished the increase in calcium levels caused by progesterone, demonstrating that MARCKS regulates calcium mobilization. Calcium 163-170 myristoylated alanine rich protein kinase C substrate Homo sapiens 146-152 10771116-0 2000 Modulation of calcium-evoked [3H]noradrenaline release from permeabilized cerebrocortical synaptosomes by the MARCKS protein, calmodulin and the actin cytoskeleton. Calcium 14-21 myristoylated alanine rich protein kinase C substrate Homo sapiens 110-116 7767386-1 1995 Several proteins that are important components of the calcium/phospholipid second messenger system (e.g. phospholipase C, protein kinase C, myristoylated alanine-rich C kinase substrate (MARCKS) and pp60src) contain clusters of basic residues that can interact with acidic lipids on the cytoplasmic surface of plasma membranes. Calcium 54-61 myristoylated alanine rich protein kinase C substrate Homo sapiens 140-185 9819217-10 1998 With the IFC we show that calcium can regulate the translocation of the MARCKS effector peptide between the membrane and calmodulin (CaM) in the bulk. Calcium 26-33 myristoylated alanine rich protein kinase C substrate Homo sapiens 72-78 9112755-0 1997 Calcium binding and conformational properties of calmodulin complexed with peptides derived from myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP). Calcium 0-7 myristoylated alanine rich protein kinase C substrate Homo sapiens 97-142 9112755-0 1997 Calcium binding and conformational properties of calmodulin complexed with peptides derived from myristoylated alanine-rich C kinase substrate (MARCKS) and MARCKS-related protein (MRP). Calcium 0-7 myristoylated alanine rich protein kinase C substrate Homo sapiens 144-150