PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18818727-3	2008	We analyze the effects of the two signaling molecules complement factors 5a (C5a) and uridine diphosphate (UDP) on the intracellular second messenger calcium to elucidate the principles that govern the processing of multiple signals by GPCRs.	Calcium	150-157	hemolytic complement	Mus musculus	77-80	
18818727-6	2008	When the model is also used as a tool in the design of experiments, it predicts a synergistic region in the calcium peak height dose response that results when cells are simultaneously stimulated by C5a and UDP.	Calcium	108-115	hemolytic complement	Mus musculus	199-202	
18818727-7	2008	An analysis of the model reveals a potential mechanism for crosstalk between the Galphai-coupled C5a receptor and the Galphaq-coupled UDP receptor signaling systems that results in synergistic calcium release.	Calcium	193-200	hemolytic complement	Mus musculus	97-100	
18559098-6	2008	Likewise, C5a induced intracellular calcium fluxes solely in activated MC.	Calcium	36-43	hemolytic complement	Mus musculus	10-13	
18411281-0	2008	Signaling and cross-talk by C5a and UDP in macrophages selectively use PLCbeta3 to regulate intracellular free calcium.	Calcium	111-118	hemolytic complement	Mus musculus	28-31	
17996333-0	2008	Estrogen enhances expression of the complement C5a receptor and the C5a-agonist evoked calcium influx in hormone secreting neurons of the hypothalamus.	Calcium	87-94	hemolytic complement	Mus musculus	47-50	
17996333-0	2008	Estrogen enhances expression of the complement C5a receptor and the C5a-agonist evoked calcium influx in hormone secreting neurons of the hypothalamus.	Calcium	87-94	hemolytic complement	Mus musculus	68-71	
15255929-2	2004	This correlated to an attenuated calcium signaling of complement (C5a) and purinergic (UTP) receptors as well as to the capacity for effective production of cytokines-chemokines.	Calcium	33-40	hemolytic complement	Mus musculus	66-69	
15983374-6	2005	Similarly, C5a-mediated actin polymerization, C5a- and UTP-stimulated intracellular calcium mobilization, and the stimulation of cAMP formation by isoproterenol were all eliminated in the absence of the Gbeta-subunits.	Calcium	84-91	hemolytic complement	Mus musculus	46-49	
15255929-8	2004	However, both the elevation in basal [Ca2+]i as well as the suppression of C5a- and UTP-evoked calcium signals are selectively and dose-dependently reversed by tyrphostin AG126, a PTK inhibitor that, moreover, blocks inducible nitric oxide and cytokine-chemokine release.	Calcium	95-102	hemolytic complement	Mus musculus	75-78	
14699051-5	2004	Similarly, the C5a-mediated calcium response of single cells is either absent or significantly delayed and weakened by G beta(2) knockdown.	Calcium	28-35	hemolytic complement	Mus musculus	15-18	
8809827-8	1996	The C5a-induced motility reaction was accompanied by an increase in intracellular calcium ([Ca2+]i) as measured by a Fluo-3 based imaging system.	Calcium	82-89	hemolytic complement	Mus musculus	4-7	
1712820-5	1991	Release induced by rC5a was calcium-dependent, and peaked at 30 degrees C. These results indicate that functional heterogeneity exists between the CMC and the PMC of BALB/c mice, that C5a is a relevant stimulus for characterization of this heterogeneity, and that CMC from these animals can serve as a convenient in vitro model for the study of human C5a-mast cell interactions.	Calcium	28-35	hemolytic complement	Mus musculus	20-23