PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2540167-4 1989 Cathepsin D and calpain I (low calcium-requiring form of calcium-activated neutral protease) rapidly cleaved human placental lipocortin I at Trp-12 and Lys-26, respectively. Calcium 31-38 transient receptor potential cation channel subfamily V member 4 Homo sapiens 141-147 33399853-0 2021 Cross-talk between the calcium channel TRPV4 and reactive oxygen species interlocks adhesive and degradative functions of invadosomes. Calcium 23-30 transient receptor potential cation channel subfamily V member 4 Homo sapiens 39-44 32319342-1 2021 Mutations in the calcium channel gene Transient Receptor Potential cation channel subfamily V member 4 (TRPV4) cause autosomal dominant skeletal dysplasia, with phenotypes ranging from mild to perinatal lethality. Calcium 17-24 transient receptor potential cation channel subfamily V member 4 Homo sapiens 38-102 32319342-1 2021 Mutations in the calcium channel gene Transient Receptor Potential cation channel subfamily V member 4 (TRPV4) cause autosomal dominant skeletal dysplasia, with phenotypes ranging from mild to perinatal lethality. Calcium 17-24 transient receptor potential cation channel subfamily V member 4 Homo sapiens 104-109 33629929-6 2021 Mechanistically, calcium flux induced by CBD through TRPV4 (transient receptor potential cation channel subfamily V member 4) activation played a key role in mitophagy initiation. Calcium 17-24 transient receptor potential cation channel subfamily V member 4 Homo sapiens 53-58 33651003-7 2021 In addition, a functionally-related calcium channel, the transient receptor potential vanilloid type 4 (TRPV4) channel, has recently been linked to purinergic signaling and has also been shown to mediate lung IRI. Calcium 36-43 transient receptor potential cation channel subfamily V member 4 Homo sapiens 57-102 33651003-7 2021 In addition, a functionally-related calcium channel, the transient receptor potential vanilloid type 4 (TRPV4) channel, has recently been linked to purinergic signaling and has also been shown to mediate lung IRI. Calcium 36-43 transient receptor potential cation channel subfamily V member 4 Homo sapiens 104-109 33707778-4 2021 Cellular volume regulation in healthy chondrocytes was associated with changes in anabolic gene expression, in the secretion of multiple pro-inflammatory cytokines, and in the modulation of intracellular calcium regulated by the ion-channel protein transient receptor potential cation channel subfamily V member 4 (TRPV4), which controls the phosphorylation of glycogen synthase kinase 3beta (GSK3beta), an enzyme with pleiotropic effects in osteoarthritis. Calcium 204-211 transient receptor potential cation channel subfamily V member 4 Homo sapiens 315-320 33629929-6 2021 Mechanistically, calcium flux induced by CBD through TRPV4 (transient receptor potential cation channel subfamily V member 4) activation played a key role in mitophagy initiation. Calcium 17-24 transient receptor potential cation channel subfamily V member 4 Homo sapiens 60-124 33399853-3 2021 Using genetic and reverse genetic approaches combined with biochemical and imaging techniques, we now show that the calcium channel TRPV4 colocalizes with beta1-integrins at the invadosome periphery and regulates its activation and the coupling of acto-adhesive and degradative functions. Calcium 116-123 transient receptor potential cation channel subfamily V member 4 Homo sapiens 132-137 33298523-9 2021 These findings demonstrate that Piezo1 activation by fluid shear stress initiates a calcium signal that causes TRPV4 opening which in turn is responsible for the sustained phase calcium elevation that triggers pathological events in endothelial cells. Calcium 84-91 transient receptor potential cation channel subfamily V member 4 Homo sapiens 111-116 33322037-4 2020 In this study, we exploited the availability of a selective pharmacological activator of the calcium-permeable ion channel TRPV4 to assess the direct role of calcium influx in EMT marker induction. Calcium 93-100 transient receptor potential cation channel subfamily V member 4 Homo sapiens 123-128 33322037-4 2020 In this study, we exploited the availability of a selective pharmacological activator of the calcium-permeable ion channel TRPV4 to assess the direct role of calcium influx in EMT marker induction. Calcium 158-165 transient receptor potential cation channel subfamily V member 4 Homo sapiens 123-128 33322037-6 2020 TRPV4 was an important component of the calcium influx phase induced in MDA-MB-468 breast cancer cells by the EMT inducer epidermal growth factor (EGF). Calcium 40-47 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 33298523-9 2021 These findings demonstrate that Piezo1 activation by fluid shear stress initiates a calcium signal that causes TRPV4 opening which in turn is responsible for the sustained phase calcium elevation that triggers pathological events in endothelial cells. Calcium 178-185 transient receptor potential cation channel subfamily V member 4 Homo sapiens 111-116 32979394-1 2020 Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. Calcium 147-154 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-40 32979394-1 2020 Transient potential receptor vanilloid 4 (TRPV4) is an ion channel responsible for sensing osmotic and mechanical signals, which in turn regulates calcium signaling across cell membranes. Calcium 147-154 transient receptor potential cation channel subfamily V member 4 Homo sapiens 42-47 32989042-3 2020 CD98hc knock down inhibits TRPV4-mediated calcium influx induced by mechanical forces, but not by chemical activators, thus confirming the mechanospecificity of this signaling response. Calcium 42-49 transient receptor potential cation channel subfamily V member 4 Homo sapiens 27-32 33230171-1 2020 Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that has been associated with several types of cancer. Calcium 54-61 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-40 33230171-1 2020 Transient receptor potential vanilloid 4 (TRPV4) is a calcium-permeable cation channel that has been associated with several types of cancer. Calcium 54-61 transient receptor potential cation channel subfamily V member 4 Homo sapiens 42-47 33230171-4 2020 We reported here on the findings that a high level of serum ionized calcium was significantly correlated with advanced EC progression, and among all the calcium channels, TRPV4 played an essential role, with high levels of TRPV4 expression associated with cancer progression both in vitro and in vivo. Calcium 153-160 transient receptor potential cation channel subfamily V member 4 Homo sapiens 171-176 33230171-7 2020 Overall, our findings indicated that ionized serum calcium level was significantly associated with poor outcomes and calcium channel TRPV4 should be targeted to improve therapeutic and preventive strategies in EC. Calcium 117-124 transient receptor potential cation channel subfamily V member 4 Homo sapiens 133-138 33841909-3 2021 This disorder is caused by mutations in the transient receptor potential vanilloid 4 (TRPV4) that encodes calcium-permeable, nonselective cation channels. Calcium 106-113 transient receptor potential cation channel subfamily V member 4 Homo sapiens 44-84 33841909-3 2021 This disorder is caused by mutations in the transient receptor potential vanilloid 4 (TRPV4) that encodes calcium-permeable, nonselective cation channels. Calcium 106-113 transient receptor potential cation channel subfamily V member 4 Homo sapiens 86-91 32924320-7 2020 Calcium signaling through a transient receptor potential vanilloid 4 (TRPV4) is found to regulate VIC spreading, alignment, and activation in a time dependent manner. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 28-68 32924320-7 2020 Calcium signaling through a transient receptor potential vanilloid 4 (TRPV4) is found to regulate VIC spreading, alignment, and activation in a time dependent manner. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 70-75 32871457-1 2020 Transient receptor potential V4 (TRPV4), a plasma membrane calcium channel, is implicated as a contributor to the initiation of chemotherapy-induced peripheral neuropathy (CIPN). Calcium 59-66 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-31 32871457-1 2020 Transient receptor potential V4 (TRPV4), a plasma membrane calcium channel, is implicated as a contributor to the initiation of chemotherapy-induced peripheral neuropathy (CIPN). Calcium 59-66 transient receptor potential cation channel subfamily V member 4 Homo sapiens 33-38 33475095-6 2020 However, at these CSE concentrations, calcium influx transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential vanilloid 6 (TRPV6) proteins significantly increased, whereas calcium efflux sodium-calcium exchanger (NCX1) and plasma membrane Ca2+ ATPase (PMCA1) proteins significantly decreased from those of the control cells. Calcium 38-45 transient receptor potential cation channel subfamily V member 4 Homo sapiens 53-93 33475095-6 2020 However, at these CSE concentrations, calcium influx transient receptor potential vanilloid 4 (TRPV4) and transient receptor potential vanilloid 6 (TRPV6) proteins significantly increased, whereas calcium efflux sodium-calcium exchanger (NCX1) and plasma membrane Ca2+ ATPase (PMCA1) proteins significantly decreased from those of the control cells. Calcium 38-45 transient receptor potential cation channel subfamily V member 4 Homo sapiens 95-100 32272228-5 2020 Here, we showed that NOX2 and TRPV4-dependent calcium influx is required for calcium oscillations, and that TRPV4 activation is both necessary and sufficient for sclerostin degradation. Calcium 77-84 transient receptor potential cation channel subfamily V member 4 Homo sapiens 30-35 32690264-1 2020 As a member of transient receptor potential family, the transient receptor potential vanilloid 4 (TRPV4) is a kind of nonselective calcium-permeable cation channel, which belongs to non-voltage gated Ca2+ channel. Calcium 131-138 transient receptor potential cation channel subfamily V member 4 Homo sapiens 56-96 32690264-1 2020 As a member of transient receptor potential family, the transient receptor potential vanilloid 4 (TRPV4) is a kind of nonselective calcium-permeable cation channel, which belongs to non-voltage gated Ca2+ channel. Calcium 131-138 transient receptor potential cation channel subfamily V member 4 Homo sapiens 98-103 32272228-0 2020 TRPV4 calcium influx controls sclerostin protein loss independent of purinergic calcium oscillations. Calcium 6-13 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 31778738-6 2020 Vanilloid transient potential (TRPV) channel inhibitor Ruthenium Red, but not a voltage-dependent calcium channel (VDCC) inhibitor nifedipine, efficiently stunted Ca2+ entry, and comparable abrogation was reproduced in cells treated with TRPV4-selective inhibitor RN-1734 or transfected with TRPV4-specific siRNA. Calcium 163-167 transient receptor potential cation channel subfamily V member 4 Homo sapiens 238-243 32272228-2 2020 We have recently shown that the osteocyte responds to fluid shear stress via the microtubule network-dependent activation of NADPH oxidase 2 (NOX2)-generated reactive oxygen species and subsequent opening of TRPV4 cation channels, leading to calcium influx, activation of CaMKII, and rapid sclerostin protein downregulation. Calcium 242-249 transient receptor potential cation channel subfamily V member 4 Homo sapiens 208-213 32272228-5 2020 Here, we showed that NOX2 and TRPV4-dependent calcium influx is required for calcium oscillations, and that TRPV4 activation is both necessary and sufficient for sclerostin degradation. Calcium 46-53 transient receptor potential cation channel subfamily V member 4 Homo sapiens 30-35 32401673-2 2020 We argue for inhibition of the transient receptor potential vanilloid 4 (TRPV4) calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. Calcium 80-87 transient receptor potential cation channel subfamily V member 4 Homo sapiens 31-71 32401673-2 2020 We argue for inhibition of the transient receptor potential vanilloid 4 (TRPV4) calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. Calcium 80-87 transient receptor potential cation channel subfamily V member 4 Homo sapiens 73-78 32401673-2 2020 We argue for inhibition of the transient receptor potential vanilloid 4 (TRPV4) calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. Calcium 80-87 transient receptor potential cation channel subfamily V member 4 Homo sapiens 175-180 32401673-2 2020 We argue for inhibition of the transient receptor potential vanilloid 4 (TRPV4) calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. Calcium 80-87 transient receptor potential cation channel subfamily V member 4 Homo sapiens 175-180 32202681-4 2020 Water transport is activated and, IP3 R, TRPA1, TRPV4, and Aquaporin-4 are all involved in shaping the dynamics of infrared pulse-evoked intracellular calcium signal. Calcium 151-158 transient receptor potential cation channel subfamily V member 4 Homo sapiens 48-53 32281947-4 2020 describe roles for the mechanically activated plasma membrane calcium channels Piezo1 and transient receptor potential vanilloid subfamily 4 (TRPV4) in acinar cells. Calcium 62-69 transient receptor potential cation channel subfamily V member 4 Homo sapiens 90-140 31918271-14 2020 We concluded that tyrosine-phosphorylated claudin-7 affects the TRPV4-modulated intestinal epithelial barrier, TRPV4-mediated calcium influx, and the protein expression of TRPV4 in human colonic cells. Calcium 126-133 transient receptor potential cation channel subfamily V member 4 Homo sapiens 111-116 31918271-14 2020 We concluded that tyrosine-phosphorylated claudin-7 affects the TRPV4-modulated intestinal epithelial barrier, TRPV4-mediated calcium influx, and the protein expression of TRPV4 in human colonic cells. Calcium 126-133 transient receptor potential cation channel subfamily V member 4 Homo sapiens 111-116 31918271-15 2020 We suggest that tyrosine-phosphorylated claudin-7 affects the TRPV4-modulated intestinal epithelial barrier, which might be related to TRPV4 expression and TRPV4-mediated calcium influx. Calcium 171-178 transient receptor potential cation channel subfamily V member 4 Homo sapiens 62-67 31624352-4 2020 Here, we show that ablation of Kidins220 in primary cultured astrocytes induced defects in calcium (Ca2+) signaling that were linked to altered store-operated Ca2+ entry and strong overexpression of the transient receptor potential channel TRPV4. Calcium 91-98 transient receptor potential cation channel subfamily V member 4 Homo sapiens 240-245 31624352-4 2020 Here, we show that ablation of Kidins220 in primary cultured astrocytes induced defects in calcium (Ca2+) signaling that were linked to altered store-operated Ca2+ entry and strong overexpression of the transient receptor potential channel TRPV4. Calcium 100-104 transient receptor potential cation channel subfamily V member 4 Homo sapiens 240-245 31628683-4 2020 The blockage of AQP2, or its physically-associated calcium channel TRPV4, significantly reduced lamellipodia NHE1 activity. Calcium 51-58 transient receptor potential cation channel subfamily V member 4 Homo sapiens 67-72 31628683-6 2020 Our data suggest that AQP2 modulates the activity of NHE1 through its calcium channel partner TRPV4, thereby determining pH-dependent actin polymerization, providing mechanical stability to delineate lamellipodia structure and defining the efficiency of cell migration. Calcium 70-77 transient receptor potential cation channel subfamily V member 4 Homo sapiens 94-99 32714108-2 2020 We argue for inhibition of the TRPV4 calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema, and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. Calcium 37-44 transient receptor potential cation channel subfamily V member 4 Homo sapiens 31-36 32714108-2 2020 We argue for inhibition of the TRPV4 calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema, and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. Calcium 37-44 transient receptor potential cation channel subfamily V member 4 Homo sapiens 132-137 32714108-2 2020 We argue for inhibition of the TRPV4 calcium-permeable ion channel as a strategy to address this issue, based on the rationale that TRPV4 inhibition is protective in various preclinical models of lung edema, and that TRPV4 hyperactivation potently damages the alveolo-capillary barrier, with lethal outcome. Calcium 37-44 transient receptor potential cation channel subfamily V member 4 Homo sapiens 132-137 31778738-7 2020 Interestingly, PTH-driven Ca2+ through TRPV4 significantly inhibited MG63 cell migration through a mechanism requiring extracellular Ca2+. Calcium 26-30 transient receptor potential cation channel subfamily V member 4 Homo sapiens 39-44 31778738-7 2020 Interestingly, PTH-driven Ca2+ through TRPV4 significantly inhibited MG63 cell migration through a mechanism requiring extracellular Ca2+. Calcium 133-137 transient receptor potential cation channel subfamily V member 4 Homo sapiens 39-44 31778738-9 2020 Altogether, our results indicate that single treatment with PTH (1-34) promotes extracellular calcium entry through TRPV4 channels in MG-63 cells through a cAMP/PKA-dependent mechanism, and that this influx affects cell migration. Calcium 94-101 transient receptor potential cation channel subfamily V member 4 Homo sapiens 116-121 31791130-0 2020 Roles of TRPV4 and piezo channels in stretch-evoked Ca2+ response in chondrocytes. Calcium 52-56 transient receptor potential cation channel subfamily V member 4 Homo sapiens 9-14 32051870-4 2020 Recently, we observed that APAP promotes cell migration through TRPV4; in this study, we examined the effect of APAP on Ca2+-channel activity of TRPV4. Calcium 120-124 transient receptor potential cation channel subfamily V member 4 Homo sapiens 145-150 32051870-8 2020 GSK-induced [Ca2+]i elevation was only observed in HeLa-mTRPV4 cells compared to that in the control HeLa cells, indicating the specific action of GSK on TRPV4. Calcium 13-17 transient receptor potential cation channel subfamily V member 4 Homo sapiens 57-62 31664615-2 2019 TRPV4 (transient receptor potential vanilloid 4) is a highly Ca2+-selective channel in vascular endothelium. Calcium 61-65 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 31903884-7 2020 Ca2+entry across membranes is mediated by different channels, including transient receptor potential (TRP) channels, some of which (e.g., TRPA1, TRPM2, TRPV1, and TRPV4) can be activated by oxidative stress and have a role in the induction of peripheral pain. Calcium 0-3 transient receptor potential cation channel subfamily V member 4 Homo sapiens 163-168 31914645-7 2020 TRPV4 activation generated greater Ca2+ rise than purinergic activation in urothelial cells. Calcium 35-39 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 31606530-6 2019 Furthermore, we found that substrate stiffening reduced the expression and activity of the calcium channel TRPV4, which subsequently enhanced ET-1 expression by inhibiting miR-6740-5p. Calcium 91-98 transient receptor potential cation channel subfamily V member 4 Homo sapiens 107-112 31664615-2 2019 TRPV4 (transient receptor potential vanilloid 4) is a highly Ca2+-selective channel in vascular endothelium. Calcium 61-65 transient receptor potential cation channel subfamily V member 4 Homo sapiens 7-47 31411921-4 2019 TRPV4 is a nonselective, calcium-permeable cation channel present in CP epithelia reported to be activated by cytokines and inflammatory mediators. Calcium 25-32 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 31622498-5 2019 By a combination of multiple approaches, including short-circuit current recordings, bulk and single cell RNA sequencing, intracellular Ca2+ imaging, and RNA interference, we found that Eact is actually an activator of the Ca2+ -permeable TRPV4 channel and that the modest effect of this compound in bronchial epithelial cells is due to a separate expression of TMEM16A and TRPV4 in different cell types. Calcium 223-227 transient receptor potential cation channel subfamily V member 4 Homo sapiens 239-244 31622498-5 2019 By a combination of multiple approaches, including short-circuit current recordings, bulk and single cell RNA sequencing, intracellular Ca2+ imaging, and RNA interference, we found that Eact is actually an activator of the Ca2+ -permeable TRPV4 channel and that the modest effect of this compound in bronchial epithelial cells is due to a separate expression of TMEM16A and TRPV4 in different cell types. Calcium 223-227 transient receptor potential cation channel subfamily V member 4 Homo sapiens 374-379 30979791-9 2019 Importantly, protein level identification of the calcium ion channel TRPV4 suggests the importance of eccrine sweat glands in re-epithelialization of wounds and prevention of dehydration. Calcium 49-56 transient receptor potential cation channel subfamily V member 4 Homo sapiens 69-74 30442652-4 2019 TRPA1, TRPM2, and TRPM8 are nonselective Ca2+-permeable cation channels which regulate calcium pathways under oxidative stress, whereas TRPV4 can be activated by oxidative, osmotic, and thermal stress as well as different fatty acid metabolites. Calcium 87-94 transient receptor potential cation channel subfamily V member 4 Homo sapiens 136-141 29604963-0 2018 STIM1 and TRPV4 regulate fluid flow-induced calcium oscillation at early and late stages of osteoclast differentiation. Calcium 44-51 transient receptor potential cation channel subfamily V member 4 Homo sapiens 10-15 31191204-1 2019 TRPV4, a nonselective calcium permeable ion channel, is expressed broadly in many organs including bone and neurons. Calcium 22-29 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 30674675-0 2019 TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. Calcium 15-22 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 31212298-4 2019 RESULTS: The TRPV4 antagonist RN-1734, but not HC-067047, inhibited the cytoplasmic calcium response to histamine in P-STS cells. Calcium 84-91 transient receptor potential cation channel subfamily V member 4 Homo sapiens 13-18 31212298-5 2019 However, also pre-incubation with the TRPV4 agonist RN-1747 strongly inhibited the calcium response to histamine in P-STS as well as HeLa cells. Calcium 83-90 transient receptor potential cation channel subfamily V member 4 Homo sapiens 38-43 29582401-1 2018 Transient receptor potential vanilloid type 4 (TRPV4) was originally described as a calcium-permeable nonselective cation channel. Calcium 84-91 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-45 29582401-1 2018 Transient receptor potential vanilloid type 4 (TRPV4) was originally described as a calcium-permeable nonselective cation channel. Calcium 84-91 transient receptor potential cation channel subfamily V member 4 Homo sapiens 47-52 29582401-2 2018 TRPV4 is now recognized as a polymodal ionotropic receptor: it is a broadly expressed, nonselective cation channel (permeable to calcium, potassium, magnesium, and sodium) that plays an important role in a multitude of physiological processes. Calcium 129-136 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 29888402-5 2018 By testing with different neurotoxins, and micropillar substrate deflections with electrophysical recordings, it is found that acute magnetomechanical stimulation induces calcium influx in DRG neurons primarily via endogenous, mechanosensitive TRPV4 and PIEZO2 channels. Calcium 171-178 transient receptor potential cation channel subfamily V member 4 Homo sapiens 244-249 30692637-0 2019 VPAC1 couples with TRPV4 channel to promote calcium-dependent gastric cancer progression via a novel autocrine mechanism. Calcium 44-51 transient receptor potential cation channel subfamily V member 4 Homo sapiens 19-24 30881453-13 2019 Furthermore, TRPV4 mediated cell apoptosis of melanoma via phosphorylation of AKT and was involved in calcium regulation. Calcium 102-109 transient receptor potential cation channel subfamily V member 4 Homo sapiens 13-18 30665695-2 2019 Here, we reproduce a weak magnetically mediated calcium response in HEK cells expressing a previously published TRPV4-ferritin fusion protein. Calcium 48-55 transient receptor potential cation channel subfamily V member 4 Homo sapiens 112-117 30728775-8 2019 Further, we show that the density of TRPV4 at the plasma membrane decreased within 20 min, as they translocate to the recycling endosomes and that the surface density is dependent on the release of calcium from the intracellular stores and is controlled via a PI3K, PKC, and RhoA signaling pathway. Calcium 198-205 transient receptor potential cation channel subfamily V member 4 Homo sapiens 37-42 30446509-3 2018 In this study, we identify transient receptor potential vanilloid isoform 4 (TRPV4) and TWIK-related potassium channel-1 (TREK-1) as key molecular determinants of TM membrane potential, pressure sensitivity, calcium homeostasis, and transcellular permeability. Calcium 208-215 transient receptor potential cation channel subfamily V member 4 Homo sapiens 27-75 30446509-3 2018 In this study, we identify transient receptor potential vanilloid isoform 4 (TRPV4) and TWIK-related potassium channel-1 (TREK-1) as key molecular determinants of TM membrane potential, pressure sensitivity, calcium homeostasis, and transcellular permeability. Calcium 208-215 transient receptor potential cation channel subfamily V member 4 Homo sapiens 77-82 29899501-0 2018 The TRPV4 channel links calcium influx to DDX3X activity and viral infectivity. Calcium 24-31 transient receptor potential cation channel subfamily V member 4 Homo sapiens 4-9 29848824-5 2018 Calcium signaling is an initial step in chondrocyte mechanotransduction that has been linked to many cellular processes, and recent studies found that calcium ion channels distinctively mechanically activated by physiological or pathological mechanical loading through transient receptor potential vanilloid 4(TRPV4)or Piezo ion channels. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 310-315 29491434-5 2018 We demonstrate that TRPV4 is required for MSC mechanotransduction, mediating oscillatory fluid shear induced calcium signaling and early osteogenic gene expression. Calcium 109-116 transient receptor potential cation channel subfamily V member 4 Homo sapiens 20-25 28949006-0 2017 Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 23-28 29038158-5 2017 CFA, calcium nanoparticles, and calcium salts also activated transient receptor potential vanilloid-1 (TRPV1) and transient receptor potential ankyrin-1 (TRPA1), but not TRPV4. Calcium 32-39 transient receptor potential cation channel subfamily V member 4 Homo sapiens 170-175 28951460-0 2017 Calcium Promotes Human Gastric Cancer via a Novel Coupling of Calcium-Sensing Receptor and TRPV4 Channel. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 91-96 28949006-2 2017 In retinal microvascular endothelial cells, TRPV4 channels regulate calcium homeostasis, cytoskeletal signalling and the organization of adherens junctional contacts. Calcium 68-75 transient receptor potential cation channel subfamily V member 4 Homo sapiens 44-49 28949006-3 2017 Intracellular calcium increases induced by TRPV4 agonists include a significant contribution from calcium release from internal stores. Calcium 14-21 transient receptor potential cation channel subfamily V member 4 Homo sapiens 43-48 28949006-3 2017 Intracellular calcium increases induced by TRPV4 agonists include a significant contribution from calcium release from internal stores. Calcium 98-105 transient receptor potential cation channel subfamily V member 4 Homo sapiens 43-48 28949006-7 2017 Using immunohistochemistry, calcium imaging, electrophysiology, impedance measurements and vascular permeability assays, we show that the transient receptor potential isoform 4 (TRPV4) plays a major role in Ca2+ /cation signalling, cytoskeletal remodelling and barrier function in retinal microvasculature in vitro and in vivo. Calcium 28-35 transient receptor potential cation channel subfamily V member 4 Homo sapiens 178-183 28863406-7 2017 The magnitude of the SFK response to hyposmotic solution was reduced by a TRPV4 antagonist HC067047 added to prevent TRPV4-mediated calcium entry, and by a cytoplasmic Ca2+ chelator BAPTA-AM. Calcium 132-139 transient receptor potential cation channel subfamily V member 4 Homo sapiens 74-79 28863406-7 2017 The magnitude of the SFK response to hyposmotic solution was reduced by a TRPV4 antagonist HC067047 added to prevent TRPV4-mediated calcium entry, and by a cytoplasmic Ca2+ chelator BAPTA-AM. Calcium 132-139 transient receptor potential cation channel subfamily V member 4 Homo sapiens 117-122 28863406-13 2017 The findings point to cAMP as a link between TRPV4 channel-mediated calcium entry, SFK activation, and a subsequent increase of Na,K-ATPase activity. Calcium 68-75 transient receptor potential cation channel subfamily V member 4 Homo sapiens 45-50 28414187-4 2017 Metatropic dysplasia is a rare osteochondrodysplasia due to mutations in the TRPV4 gene: TRPV4 is a cation channel, non-selectively permeable to calcium, encoded by a gene on chromosome 12q24.11; it is widely expressed and involved in many different physiological processes through responses to several different stimuli (physical, chemical, and hormonal) in ciliated epithelial cells. Calcium 145-152 transient receptor potential cation channel subfamily V member 4 Homo sapiens 77-82 28414187-4 2017 Metatropic dysplasia is a rare osteochondrodysplasia due to mutations in the TRPV4 gene: TRPV4 is a cation channel, non-selectively permeable to calcium, encoded by a gene on chromosome 12q24.11; it is widely expressed and involved in many different physiological processes through responses to several different stimuli (physical, chemical, and hormonal) in ciliated epithelial cells. Calcium 145-152 transient receptor potential cation channel subfamily V member 4 Homo sapiens 89-94 27765747-15 2016 Activation of TRPV4 channels appears to cause calcium events that result in the opening of eBK channels, endothelial hyperpolarization, and subsequent vasodilation. Calcium 46-53 transient receptor potential cation channel subfamily V member 4 Homo sapiens 14-19 27869310-4 2017 Ca2+ imaging experiments showed that TRPV4 activation with GSK1016790A produced an influx of calcium that was blunted by the specific TRPV4 blocker RN-1734. Calcium 93-100 transient receptor potential cation channel subfamily V member 4 Homo sapiens 37-42 27869310-4 2017 Ca2+ imaging experiments showed that TRPV4 activation with GSK1016790A produced an influx of calcium that was blunted by the specific TRPV4 blocker RN-1734. Calcium 93-100 transient receptor potential cation channel subfamily V member 4 Homo sapiens 134-139 27765747-6 2016 Calcium influx through TRPV4 may activate these endothelial BK channels (eBK). Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 23-28 27496898-7 2016 Also, TRPV4-induced calcium mobilization and inflammatory responses were enhanced in cystic fibrosis transmembrane conductance regulator-deficient cellular and animal models, suggesting that TRPV4 is a promising target for the development of new anti-inflammatory treatments for diseases such as CF. Calcium 20-27 transient receptor potential cation channel subfamily V member 4 Homo sapiens 6-11 27765747-9 2016 H2S (1 muM) increased TRPV4-dependent (1.8-fold) localized calcium events in EC of pressurized arteries loaded with fluo-4 and Oregon Green. Calcium 59-66 transient receptor potential cation channel subfamily V member 4 Homo sapiens 22-27 27765747-10 2016 In pressurized EC tubes, H2S (1 muM) and the TRPV4 activator, GSK101679A (30 nM), increased calcium events 1.8- and 1.5-fold, respectively. Calcium 92-99 transient receptor potential cation channel subfamily V member 4 Homo sapiens 45-50 27330106-8 2016 CONCLUSIONS: These findings identify a novel TRPV4 mutation implicating TRPV4 and altered calcium homeostasis in the pathogenesis of osteonecrosis while reinforcing the importance of TRPV4 in bone diseases and vascular endothelium. Calcium 90-97 transient receptor potential cation channel subfamily V member 4 Homo sapiens 45-50 27496898-7 2016 Also, TRPV4-induced calcium mobilization and inflammatory responses were enhanced in cystic fibrosis transmembrane conductance regulator-deficient cellular and animal models, suggesting that TRPV4 is a promising target for the development of new anti-inflammatory treatments for diseases such as CF. Calcium 20-27 transient receptor potential cation channel subfamily V member 4 Homo sapiens 191-196 27510430-0 2016 TRPV4 regulates calcium homeostasis, cytoskeletal remodeling, conventional outflow and intraocular pressure in the mammalian eye. Calcium 16-23 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 27003252-0 2016 TRPV4 is endogenously expressed in vertebrate spermatozoa and regulates intracellular calcium in human sperm. Calcium 86-93 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 27434269-5 2016 Western blot, live-cell calcium imaging, and qRT-PCR were used to investigate whether osmolarity changes or tumour necrosis factor alpha (TNFalpha) regulate TRPV4 expression, and how altered TRPV4 expression influences calcium signalling and pro-inflammatory cytokine expression. Calcium 219-226 transient receptor potential cation channel subfamily V member 4 Homo sapiens 191-196 27434269-7 2016 Increased TRPV4 expression increased the calcium flux following TRPV4 activation and increased interleukin-1beta (IL-1beta) and IL-6 gene expression in IVD cells. Calcium 41-48 transient receptor potential cation channel subfamily V member 4 Homo sapiens 10-15 27434269-7 2016 Increased TRPV4 expression increased the calcium flux following TRPV4 activation and increased interleukin-1beta (IL-1beta) and IL-6 gene expression in IVD cells. Calcium 41-48 transient receptor potential cation channel subfamily V member 4 Homo sapiens 64-69 27252279-1 2016 Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol 2: 695-702, 2000) and Liedtke (Cell 103: 525-535, 2000). Calcium 59-66 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-45 27252279-1 2016 Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol 2: 695-702, 2000) and Liedtke (Cell 103: 525-535, 2000). Calcium 59-66 transient receptor potential cation channel subfamily V member 4 Homo sapiens 47-52 26842013-6 2016 Calcium imaging was used to detect the TRPV4-mediated Ca(2+) influx in cortical neurons. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 39-44 25572823-6 2015 TRPV4-dependent calcium signalling and prostanoid production was studied in cultured human umbilical vein endothelial cells (HUVECs). Calcium 16-23 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 26289129-7 2016 Our findings implicate calcium-sensitive TRPV4 translocation in the regulation of endothelial responses to mechanical stimulation. Calcium 23-30 transient receptor potential cation channel subfamily V member 4 Homo sapiens 41-46 26413835-4 2016 Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium. Calcium 6-13 transient receptor potential cation channel subfamily V member 4 Homo sapiens 202-242 26413835-4 2016 Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium. Calcium 118-125 transient receptor potential cation channel subfamily V member 4 Homo sapiens 202-242 26413835-4 2016 Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium. Calcium 118-125 transient receptor potential cation channel subfamily V member 4 Homo sapiens 244-249 26413835-4 2016 Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium. Calcium 118-125 transient receptor potential cation channel subfamily V member 4 Homo sapiens 202-242 26413835-4 2016 Using calcium imaging, we show that AQP-mediated fast swelling kinetics also significantly increases the amplitude of calcium transients inhibited by Gadolinium and Ruthenium Red, two inhibitors of the transient receptor potential vanilloid 4 (TRPV4) channels, and prevented by removing extracellular calcium. Calcium 118-125 transient receptor potential cation channel subfamily V member 4 Homo sapiens 244-249 26413835-6 2016 All together our study provides evidence that (1) AQP influenced swelling kinetics is the main trigger for RVD and in mediating calcium signaling after hypotonic stimulus together with TRPV4, and (2) calcium influx from the extracellular space and/or TRPV4 are not essential for RVD to occur in astrocytes. Calcium 200-207 transient receptor potential cation channel subfamily V member 4 Homo sapiens 251-256 26490071-2 2015 TRPV4 is selectively permeable to calcium. Calcium 34-41 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 26490071-3 2015 Activation of the TRPV4 channel induces an increase in intracellular calcium concentration and plays an important role under physiological and pathological conditions. Calcium 69-76 transient receptor potential cation channel subfamily V member 4 Homo sapiens 18-23 25577546-0 2015 Modeling of TRPV4-C1 -mediated calcium signaling in vascular endothelial cells induced by fluid shear stress and ATP. Calcium 31-38 transient receptor potential cation channel subfamily V member 4 Homo sapiens 12-17 26202725-6 2015 This approach was used to examine the shear-induced calcium signalling of HEK-293 cells expressing a mechanosensitive ion channel, transient receptor potential vaniloid type 4 (TRPV4), when exposed to the full physiological range of shear stress. Calcium 52-59 transient receptor potential cation channel subfamily V member 4 Homo sapiens 131-175 26202725-6 2015 This approach was used to examine the shear-induced calcium signalling of HEK-293 cells expressing a mechanosensitive ion channel, transient receptor potential vaniloid type 4 (TRPV4), when exposed to the full physiological range of shear stress. Calcium 52-59 transient receptor potential cation channel subfamily V member 4 Homo sapiens 177-182 26029358-2 2015 Flow-induced intracellular calcium ion (Ca(2+)) increases in kidney epithelia depend on primary cilia and primary cilium-localized Ca(2+)-permeable channels polycystin-2 (PC2) and transient receptor potential vanilloid 4 (TRPV4). Calcium 27-34 transient receptor potential cation channel subfamily V member 4 Homo sapiens 180-220 26029358-2 2015 Flow-induced intracellular calcium ion (Ca(2+)) increases in kidney epithelia depend on primary cilia and primary cilium-localized Ca(2+)-permeable channels polycystin-2 (PC2) and transient receptor potential vanilloid 4 (TRPV4). Calcium 27-34 transient receptor potential cation channel subfamily V member 4 Homo sapiens 222-227 26381274-2 2016 Transient Receptor Potential Vanilloid 4 (TRPV4) channels are an important route for calcium entry that operates in a variety of cells and intervenes in a number of functions. Calcium 85-92 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-40 26381274-2 2016 Transient Receptor Potential Vanilloid 4 (TRPV4) channels are an important route for calcium entry that operates in a variety of cells and intervenes in a number of functions. Calcium 85-92 transient receptor potential cation channel subfamily V member 4 Homo sapiens 42-47 26381274-3 2016 In this study, the expression and operation of TRPV4 channels in human cultured adipocytes was evaluated using RT-PCR, Western blotting, the whole-cell patch-clamp technique and fluorescence measurements to characterize these channels and determine intracellular calcium responses. Calcium 263-270 transient receptor potential cation channel subfamily V member 4 Homo sapiens 47-52 26358221-5 2015 By using immunohistochemistry and calcium microfluorimetry, we showed that odontoblast-like cells express TRPA1 and TRPV4 and that these channels were activated by hypotonicity-induced membrane stretch. Calcium 34-41 transient receptor potential cation channel subfamily V member 4 Homo sapiens 116-121 26249260-0 2015 A mutation in TRPV4 results in altered chondrocyte calcium signaling in severe metatropic dysplasia. Calcium 51-58 transient receptor potential cation channel subfamily V member 4 Homo sapiens 14-19 26249260-3 2015 We analyzed the effect of a novel TRPV4 mutation c.2398G>A, p.Gly800Asp on intracellular calcium ([Ca(2+) ]i ) regulation in chondrocytes and compared this response to chondrocytes with a frequently observed mutation, c.2396C>T, p.Pro799Leu. Calcium 92-99 transient receptor potential cation channel subfamily V member 4 Homo sapiens 34-39 26408614-7 2015 The levels of free calcium ion in the stretch-treated HBMEC was significantly decreased in the presence of TRPV4 specific inhibitor (P<0.001), but there was no difference in calcium levels between the stretch and the control or unspecific inhibitor group (P=0.072 or 0.308). Calcium 19-26 transient receptor potential cation channel subfamily V member 4 Homo sapiens 107-112 26408614-9 2015 : CONCLUSION: The eNOS expression is up-regulated under the condition of mechanic stretch, which is related to the activation of TRPV4, resulting in the influx of calcium. Calcium 164-171 transient receptor potential cation channel subfamily V member 4 Homo sapiens 130-135 25959969-7 2015 Furthermore, we show that an endocardial calcium response and the flow-responsive klf2a promoter are modulated by the oscillatory flow through Trpv4, a mechanosensitive ion channel specifically expressed in the endocardium during heart valve development. Calcium 41-48 transient receptor potential cation channel subfamily V member 4 Homo sapiens 143-148 24405281-6 2014 Poly-lactic-co-glycolic acid NPs (300 nm) released RR for 150 hours in vitro, and blocked TRPV4-mediated calcium signaling in cells up to 7 days after phagocytosis. Calcium 105-112 transient receptor potential cation channel subfamily V member 4 Homo sapiens 90-95 24906497-0 2015 Sensitisation of TRPV4 by PAR2 is independent of intracellular calcium signalling and can be mediated by the biased agonist neutrophil elastase. Calcium 63-70 transient receptor potential cation channel subfamily V member 4 Homo sapiens 17-22 25809269-0 2015 Stochastic model of endothelial TRPV4 calcium sparklets: effect of bursting and cooperativity on EDH. Calcium 38-45 transient receptor potential cation channel subfamily V member 4 Homo sapiens 32-37 25622169-2 2015 The TRPV4 gene is located on 12q24.11, coding a cation channel with nonselective permeability to calcium; it is expressed and involved in many physiological processes through responses to different stimuli. Calcium 97-104 transient receptor potential cation channel subfamily V member 4 Homo sapiens 4-9 25120148-3 2014 As calcium-permeable TRPV4 has recently been identified as UVB-receptor in skin keratinocytes, where it regulates skin tissue injury and pain after UVB overexposure, it is discussed whether TRPV4 downregulation can also be found in other non-UVB-exposed cancers. Calcium 3-10 transient receptor potential cation channel subfamily V member 4 Homo sapiens 21-26 25120148-3 2014 As calcium-permeable TRPV4 has recently been identified as UVB-receptor in skin keratinocytes, where it regulates skin tissue injury and pain after UVB overexposure, it is discussed whether TRPV4 downregulation can also be found in other non-UVB-exposed cancers. Calcium 3-10 transient receptor potential cation channel subfamily V member 4 Homo sapiens 190-195 24779362-5 2014 EXPERIMENTAL APPROACH: Responses of non-transfected and TRPV4-transfected HEK293 cells to agonists of PAR2 (trypsin and SLIGRL) and TRPV4 channels (GSK1016790A) were determined using calcium imaging. Calcium 183-190 transient receptor potential cation channel subfamily V member 4 Homo sapiens 56-61 23314072-0 2013 Osteoblastic differentiation enhances expression of TRPV4 that is required for calcium oscillation induced by mechanical force. Calcium 79-86 transient receptor potential cation channel subfamily V member 4 Homo sapiens 52-57 24577120-1 2014 Point mutations in the calcium-permeable TRPV4 ion channel have been identified as the cause of autosomal-dominant human motor neuropathies, arthropathies, and skeletal malformations of varying severity. Calcium 23-30 transient receptor potential cation channel subfamily V member 4 Homo sapiens 41-46 24561067-7 2014 WT MLC1 also favors recycling to the plasma-membrane of the TRPV4 cation channel which cooperates with MLC1 to activate calcium influx in astrocytes during hyposmotic stress. Calcium 120-127 transient receptor potential cation channel subfamily V member 4 Homo sapiens 60-65 24034343-0 2014 TRPV4-mediated calcium influx and ciliary activity in human native airway epithelial cells. Calcium 15-22 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 24034343-7 2014 Responses to pharmacological modulation of TRPV4 were assessed with calcium imaging and CBF measurements. Calcium 68-75 transient receptor potential cation channel subfamily V member 4 Homo sapiens 43-48 24034343-8 2014 The TRPV4 agonist GSK1016790A produced concentration-dependent calcium responses in TRPV4-expressing HEK293, BEAS2B and 16HBE cells, and the TRPV4 antagonist HC067047 caused a rightward shift of the GSK1016790A concentration-response curves. Calcium 63-70 transient receptor potential cation channel subfamily V member 4 Homo sapiens 4-9 24034343-8 2014 The TRPV4 agonist GSK1016790A produced concentration-dependent calcium responses in TRPV4-expressing HEK293, BEAS2B and 16HBE cells, and the TRPV4 antagonist HC067047 caused a rightward shift of the GSK1016790A concentration-response curves. Calcium 63-70 transient receptor potential cation channel subfamily V member 4 Homo sapiens 84-89 24034343-8 2014 The TRPV4 agonist GSK1016790A produced concentration-dependent calcium responses in TRPV4-expressing HEK293, BEAS2B and 16HBE cells, and the TRPV4 antagonist HC067047 caused a rightward shift of the GSK1016790A concentration-response curves. Calcium 63-70 transient receptor potential cation channel subfamily V member 4 Homo sapiens 84-89 24034343-9 2014 Nasal epithelial cells responded to the TRPV4 agonist GSK1016790A with increased intracellular calcium signals and increased CBF, followed by cessation of ciliary beating and cell death. Calcium 95-102 transient receptor potential cation channel subfamily V member 4 Homo sapiens 40-45 24034343-11 2014 We conclude that TRPV4 is expressed in human primary nasal epithelial cells and modulates epithelial calcium levels and CBF. Calcium 101-108 transient receptor potential cation channel subfamily V member 4 Homo sapiens 17-22 23977387-10 2013 In addition EGF increased cell proliferation in cilia (-) cell that was dependent upon TRPP2\TRPV4 channel mediated increase in intracellular calcium. Calcium 142-149 transient receptor potential cation channel subfamily V member 4 Homo sapiens 93-98 24509911-4 2014 Chloride currents induced by a TRPV4 activator (GSK1016790A) were markedly increased in an extracellular calcium-dependent manner in HEK293T cells expressing TRPV4 with ANO1, but not with ANO4, ANO6, or ANO10, the mRNAs of which were expressed in the choroid plexus. Calcium 105-112 transient receptor potential cation channel subfamily V member 4 Homo sapiens 31-36 24509911-4 2014 Chloride currents induced by a TRPV4 activator (GSK1016790A) were markedly increased in an extracellular calcium-dependent manner in HEK293T cells expressing TRPV4 with ANO1, but not with ANO4, ANO6, or ANO10, the mRNAs of which were expressed in the choroid plexus. Calcium 105-112 transient receptor potential cation channel subfamily V member 4 Homo sapiens 158-163 23314072-3 2013 As mechanical force would affect signaling events in cells, we focused on a calcium channel, TRPV4 regarding its role in the effects of force stimuli on calcium in osteoblasts. Calcium 76-83 transient receptor potential cation channel subfamily V member 4 Homo sapiens 93-98 23314072-7 2013 In these osteoblasts, a TRPV4-selective agonist, 4alpha-PDD, enhanced calcium signaling and the effects of 4alpha-PDD were enhanced in differentiated osteoblasts compared to the control cells. Calcium 70-77 transient receptor potential cation channel subfamily V member 4 Homo sapiens 24-29 23314072-9 2013 In contrast, TRPV4 deficiency suppressed calcium oscillation significantly even when the cells were subjected to fluid flow. Calcium 41-48 transient receptor potential cation channel subfamily V member 4 Homo sapiens 13-18 23314072-10 2013 These data suggest that TRPV4 is involved in the flow-induced calcium signaling in osteoblasts. Calcium 62-69 transient receptor potential cation channel subfamily V member 4 Homo sapiens 24-29 23333822-2 2013 In this study, we show that TRPV4 activated by 4alpha-phorbol 12,13-didecanoate (4alphaPDD) and hypo-osmotic stimulation (HOS) is a regulator of intracellular calcium ([Ca(2+)](i)) in human brain capillary endothelial cells (HBCEs), and its activation can partially regulate cell proliferation of HBCEs. Calcium 159-166 transient receptor potential cation channel subfamily V member 4 Homo sapiens 28-33 23457335-1 2013 The Ca(2+)-permeable transient receptor potential vanilloid subtype 4 (TRPV4) channel mediates crucial physiological functions, such as calcium signaling, temperature sensing, and maintaining cell volume and energy homeostasis. Calcium 136-143 transient receptor potential cation channel subfamily V member 4 Homo sapiens 21-69 23457335-1 2013 The Ca(2+)-permeable transient receptor potential vanilloid subtype 4 (TRPV4) channel mediates crucial physiological functions, such as calcium signaling, temperature sensing, and maintaining cell volume and energy homeostasis. Calcium 136-143 transient receptor potential cation channel subfamily V member 4 Homo sapiens 71-76 23142541-8 2013 Finally, TGF-beta1 treated fibroblasts exhibited enhanced TRPV4 expression and TRPV4-mediated calcium influx compared to untreated controls. Calcium 94-101 transient receptor potential cation channel subfamily V member 4 Homo sapiens 79-84 23253200-4 2013 In these cells, gating of individual TRPV4 channels within a four-channel cluster provides elementary calcium influx (calcium sparklets) to open calcium-activated potassium channels and promote vasodilation. Calcium 102-109 transient receptor potential cation channel subfamily V member 4 Homo sapiens 37-42 23253200-4 2013 In these cells, gating of individual TRPV4 channels within a four-channel cluster provides elementary calcium influx (calcium sparklets) to open calcium-activated potassium channels and promote vasodilation. Calcium 118-125 transient receptor potential cation channel subfamily V member 4 Homo sapiens 37-42 22762361-6 2012 The role of annexin A2 in the regulation of TRPV4 activity in DRG was further verified by measurement of intracellular free calcium concentrations ([Ca(2+)](i)) and substance P (SP) release. Calcium 124-131 transient receptor potential cation channel subfamily V member 4 Homo sapiens 44-49 20657843-3 2010 METHODOLOGY AND PRINCIPAL FINDINGS: We investigated the interaction of TRPV4 with cytoskeletal components biochemically, cell biologically by observing morphological changes of DRG-neurons and DRG-neuron-derived F-11 cells, as well as functionally with calcium imaging. Calcium 253-260 transient receptor potential cation channel subfamily V member 4 Homo sapiens 71-76 22492652-11 2012 TRPV4-mediated calcium entry was examined in Fura-2-loaded cultured lens epithelium. Calcium 15-22 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 22492652-12 2012 Hyposmotic solution and GSK both increased cytoplasmic calcium that was prevented by TRPV4 antagonists. Calcium 55-62 transient receptor potential cation channel subfamily V member 4 Homo sapiens 85-90 22492652-15 2012 The results point to TRPV4-mediated calcium entry that causes a cytoplasmic calcium increase which is an essential early step in the mechanism used by the lens to sense and respond to hyposmotic stress. Calcium 36-43 transient receptor potential cation channel subfamily V member 4 Homo sapiens 21-26 22492652-15 2012 The results point to TRPV4-mediated calcium entry that causes a cytoplasmic calcium increase which is an essential early step in the mechanism used by the lens to sense and respond to hyposmotic stress. Calcium 76-83 transient receptor potential cation channel subfamily V member 4 Homo sapiens 21-26 21454511-3 2011 Both gain and loss of calcium channel activity of the mutant TRPV4 have been suggested. Calcium 22-29 transient receptor potential cation channel subfamily V member 4 Homo sapiens 61-66 21454511-4 2011 Here, we show that the three previously reported TRPV4 mutant channels have a physiological localization and display an increased calcium channel activity, leading to increased cytotoxicity in three different cell types. Calcium 130-137 transient receptor potential cation channel subfamily V member 4 Homo sapiens 49-54 21454511-7 2011 These data support the hypothesis that a "gain of function" mechanism, possibly leading to increased intracellular calcium influx, underlies the pathogenesis of the TRPV4-linked axonal neuropathies, and may have immediate implications for designing rational therapies. Calcium 115-122 transient receptor potential cation channel subfamily V member 4 Homo sapiens 165-170 22617546-3 2012 TRPV4 encodes a calcium-permeable non-selective cation channel of uncertain biological function. Calcium 16-23 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 22556255-2 2012 We identified local calcium (Ca(2+)) signals ("sparklets") in the vascular endothelium of resistance arteries that represent Ca(2+) influx through single TRPV4 cation channels. Calcium 20-27 transient receptor potential cation channel subfamily V member 4 Homo sapiens 154-159 21964829-1 2011 Dominant mutations in the receptor calcium channel gene TRPV4 have been associated with a family of skeletal dysplasias (metatropic dysplasia, pseudo-Morquio type 2, spondylometaphyseal dysplasia, Kozlowski type, brachyolmia, and familial digital arthropathy) as well as with dominantly inherited neuropathies (hereditary motor and sensory neuropathy 2C, scapuloperoneal spinal muscular atrophy, and congenital distal spinal muscular atrophy). Calcium 35-42 transient receptor potential cation channel subfamily V member 4 Homo sapiens 56-61 21964574-4 2011 Calcium influx in response to the synthetic TRPV4 agonists GSK1016790A and 4alphaPDD was significantly reduced, and mutant channels did not respond to hypotonic stress. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 44-49 21245013-0 2011 TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. Calcium 15-22 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 19278577-12 2010 In addition, the function of TRPV4 as ion channel was evaluated by calcium imaging and P substance release before and after siRNA treatment. Calcium 67-74 transient receptor potential cation channel subfamily V member 4 Homo sapiens 29-34 18783312-4 2009 Activation of calcium entry through store-operated calcium entry channels, most notably TRPC1 and TRPC4, increases lung endothelial cell permeability, as does activation of calcium entry through the TRPV4 channel. Calcium 14-21 transient receptor potential cation channel subfamily V member 4 Homo sapiens 199-204 20043876-9 2010 Substitution of Ser824 with aspartic acid, mimicking phosphorylation at this site, increased TRPV4-mediated calcium influx in resting and in stimulated cells, underlining the importance of this residue in TRPV4 regulation. Calcium 108-115 transient receptor potential cation channel subfamily V member 4 Homo sapiens 93-98 19695100-10 2009 Augmented relevance of TRPV1 and TRPV4 as inflammatory conditions persist would provide calcium mediated cell signaling required for pathophysiological responses of synoviocytes in inflammatory pain states. Calcium 88-95 transient receptor potential cation channel subfamily V member 4 Homo sapiens 33-38 20037587-6 2010 Functional analysis revealed that increased calcium channel activity is a distinct property of both SPSMA- and CMT2C-causing mutant proteins. Calcium 44-51 transient receptor potential cation channel subfamily V member 4 Homo sapiens 111-116 20037587-7 2010 Our findings link mutations in TRPV4 to altered calcium homeostasis and peripheral neuropathies, implying a pathogenic mechanism and possible options for therapy for these disorders. Calcium 48-55 transient receptor potential cation channel subfamily V member 4 Homo sapiens 31-36 19232556-0 2009 Mutations in the gene encoding the calcium-permeable ion channel TRPV4 produce spondylometaphyseal dysplasia, Kozlowski type and metatropic dysplasia. Calcium 35-42 transient receptor potential cation channel subfamily V member 4 Homo sapiens 65-70 8286349-2 1994 In the present study three forms of human annexin I truncated in the amino terminus at residue Trp-12, Lys-26, or Lys-29 exhibit dramatic differences in their sensitivities to calcium in a chromaffin granule aggregation assay, while the [Ca2+](1/2)max values for binding of the truncated proteins to granule membranes are similar. Calcium 176-183 transient receptor potential cation channel subfamily V member 4 Homo sapiens 95-101 18751967-0 2008 Calcium elevation in mouse pancreatic beta cells evoked by extracellular human islet amyloid polypeptide involves activation of the mechanosensitive ion channel TRPV4. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 161-166 18458941-3 2008 Reverse transcriptase polymerase chain reaction, intracellular calcium imaging and whole-cell patch-clamp experiments using HBE cells demonstrated the presence of TRPV4 messenger and Ca(2+) entry, and outwardly rectifying cationic currents elicited by the TRPV4 specific activator 4alpha-phorbol 12,13-didecanoate (4alphaPDD). Calcium 63-70 transient receptor potential cation channel subfamily V member 4 Homo sapiens 163-168 17699550-5 2007 Application of known activators of TRPV4, including 4alpha-PDD and hypotonic medium, induced strong calcium influx in M-1 cells and TRPV4-transfected HEK-293 cells but not in nontransfected cells. Calcium 100-107 transient receptor potential cation channel subfamily V member 4 Homo sapiens 35-40 17699550-6 2007 Applying increased flow/shear stress in a parallel plate chamber induced calcium influx in both M-1 and TRPV4-transfected HEK cells but not in nontransfected HEK cells. Calcium 73-80 transient receptor potential cation channel subfamily V member 4 Homo sapiens 104-109 17699550-7 2007 Furthermore, in loss-of-function studies employing small interference (si)RNA knockdown techniques, transfection of both M-1 and TRPV4-transfected HEK cells with siRNA specific for TRPV4, but not an inappropriate siRNA, led to a time-dependent decrease in TRPV4 expression that was accompanied by a loss of stimuli-induced calcium influx to flow and hypotonicity. Calcium 323-330 transient receptor potential cation channel subfamily V member 4 Homo sapiens 129-134 17699550-7 2007 Furthermore, in loss-of-function studies employing small interference (si)RNA knockdown techniques, transfection of both M-1 and TRPV4-transfected HEK cells with siRNA specific for TRPV4, but not an inappropriate siRNA, led to a time-dependent decrease in TRPV4 expression that was accompanied by a loss of stimuli-induced calcium influx to flow and hypotonicity. Calcium 323-330 transient receptor potential cation channel subfamily V member 4 Homo sapiens 181-186 17699550-7 2007 Furthermore, in loss-of-function studies employing small interference (si)RNA knockdown techniques, transfection of both M-1 and TRPV4-transfected HEK cells with siRNA specific for TRPV4, but not an inappropriate siRNA, led to a time-dependent decrease in TRPV4 expression that was accompanied by a loss of stimuli-induced calcium influx to flow and hypotonicity. Calcium 323-330 transient receptor potential cation channel subfamily V member 4 Homo sapiens 181-186 17613724-0 2007 The contribution of TRPV4-mediated calcium signaling to calcium homeostasis in endothelial cells. Calcium 35-42 transient receptor potential cation channel subfamily V member 4 Homo sapiens 20-25 17613724-0 2007 The contribution of TRPV4-mediated calcium signaling to calcium homeostasis in endothelial cells. Calcium 56-63 transient receptor potential cation channel subfamily V member 4 Homo sapiens 20-25 17613724-6 2007 We observed the induction of large calcium signals following mechanical stress, altered extracellular temperature, and the selective TRPV4 activator 4-alpha -PDD. Calcium 35-42 transient receptor potential cation channel subfamily V member 4 Homo sapiens 133-138 17613724-7 2007 These effects were diminished in the presence of the TRPV4 inhibitor miconazole, suggesting the involvement of this channel in mediating endothelial calcium signals. Calcium 149-156 transient receptor potential cation channel subfamily V member 4 Homo sapiens 53-58 16368742-3 2006 HEK293 cells transiently transfected with the mutant TRPV4(N651Q) exhibited increased calcium entry in response to hypotonic stress relative to wild-type TRPV4 transfectants. Calcium 86-93 transient receptor potential cation channel subfamily V member 4 Homo sapiens 53-58 12151520-4 2002 In response to warm temperatures, TRPV4 mediates large inward currents in Xenopus oocytes and both inward currents and calcium influx into human embryonic kidney 293 cells. Calcium 119-126 transient receptor potential cation channel subfamily V member 4 Homo sapiens 34-39 18355916-1 2008 TRPV4 is a non-selective cation channel with moderate calcium permeability, which is activated by exposure to hypotonicity. Calcium 54-61 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 21204498-5 2007 We recently characterized two different TRP-homologous cation channels, TRPV4 and TRPM3, as proteins mediating calcium entry in cells upon extracellular application of hypotonic solutions [3, 4]. Calcium 111-118 transient receptor potential cation channel subfamily V member 4 Homo sapiens 72-77 16899456-3 2006 We screened a library of extracts from 50 Chinese herbal plants using a calcium-imaging assay to find compounds active on TRPV3 and TRPV4 channels. Calcium 72-79 transient receptor potential cation channel subfamily V member 4 Homo sapiens 132-137 8286349-3 1994 Cleavage at Trp-12 causes a 3-fold decrease in calcium sensitivity in the membrane aggregation assay, while cleavage at Lys-26 causes a 4-fold enhancement of calcium sensitivity. Calcium 47-54 transient receptor potential cation channel subfamily V member 4 Homo sapiens 12-18 34321341-1 2021 Neuronal calcium sensor 1 (NCS1), a calcium-binding protein, and transient receptor potential V4 (TRPV4), a plasma membrane calcium channel, are fundamental in the regulation of calcium homeostasis. Calcium 124-131 transient receptor potential cation channel subfamily V member 4 Homo sapiens 65-96 33805168-1 2021 The growth factor TGFbeta and the mechanosensitive calcium-permeable cation channel TRPV4 are both important for the development and maintenance of many tissues. Calcium 51-58 transient receptor potential cation channel subfamily V member 4 Homo sapiens 84-89 33805168-5 2021 The increase was prevented by pharmacological TRPV4 inhibition or knockdown and is calcium/CamKII dependent. Calcium 83-90 transient receptor potential cation channel subfamily V member 4 Homo sapiens 46-51 21938744-3 2012 Since the calcium permeable nonselective cation channel TRPV4 plays a crucial role in the response to mechanical and osmotic perturbations in a wide range of cell types, the aim of this work was to test the hypothesis that the increase in intracellular calcium concentration and the subsequent rapid RVD, only observed in the presence of AQP2, could be due to a specific activation of TRPV4. Calcium 10-17 transient receptor potential cation channel subfamily V member 4 Homo sapiens 56-61 21938744-3 2012 Since the calcium permeable nonselective cation channel TRPV4 plays a crucial role in the response to mechanical and osmotic perturbations in a wide range of cell types, the aim of this work was to test the hypothesis that the increase in intracellular calcium concentration and the subsequent rapid RVD, only observed in the presence of AQP2, could be due to a specific activation of TRPV4. Calcium 10-17 transient receptor potential cation channel subfamily V member 4 Homo sapiens 385-390 21938744-3 2012 Since the calcium permeable nonselective cation channel TRPV4 plays a crucial role in the response to mechanical and osmotic perturbations in a wide range of cell types, the aim of this work was to test the hypothesis that the increase in intracellular calcium concentration and the subsequent rapid RVD, only observed in the presence of AQP2, could be due to a specific activation of TRPV4. Calcium 253-260 transient receptor potential cation channel subfamily V member 4 Homo sapiens 56-61 21938744-6 2012 Blocking of TRPV4 by ruthenium red abolished calcium influx as well as RVD, identifying TRPV4 as a necessary component in volume regulation. Calcium 45-52 transient receptor potential cation channel subfamily V member 4 Homo sapiens 12-17 34321341-1 2021 Neuronal calcium sensor 1 (NCS1), a calcium-binding protein, and transient receptor potential V4 (TRPV4), a plasma membrane calcium channel, are fundamental in the regulation of calcium homeostasis. Calcium 124-131 transient receptor potential cation channel subfamily V member 4 Homo sapiens 98-103 34321341-1 2021 Neuronal calcium sensor 1 (NCS1), a calcium-binding protein, and transient receptor potential V4 (TRPV4), a plasma membrane calcium channel, are fundamental in the regulation of calcium homeostasis. Calcium 178-185 transient receptor potential cation channel subfamily V member 4 Homo sapiens 65-96 34321341-1 2021 Neuronal calcium sensor 1 (NCS1), a calcium-binding protein, and transient receptor potential V4 (TRPV4), a plasma membrane calcium channel, are fundamental in the regulation of calcium homeostasis. Calcium 178-185 transient receptor potential cation channel subfamily V member 4 Homo sapiens 98-103 34321341-5 2021 Calcium fluxes through TRPV4 correlated with the magnitude of TRPV4 currents and these calcium fluxes depended on NCS1 expression levels. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 23-28 34321341-5 2021 Calcium fluxes through TRPV4 correlated with the magnitude of TRPV4 currents and these calcium fluxes depended on NCS1 expression levels. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 62-67 34321341-5 2021 Calcium fluxes through TRPV4 correlated with the magnitude of TRPV4 currents and these calcium fluxes depended on NCS1 expression levels. Calcium 87-94 transient receptor potential cation channel subfamily V member 4 Homo sapiens 62-67 35150133-0 2022 DDR1 associates with TRPV4 in cell-matrix adhesions to enable calcium-regulated myosin activity and collagen compaction. Calcium 62-69 transient receptor potential cation channel subfamily V member 4 Homo sapiens 21-26 34087722-9 2021 Importantly, in TRPV4 transfected HEK293 cells, GSK101 induced calcium response was also significantly inhibited by cimifugin pretreatment. Calcium 63-70 transient receptor potential cation channel subfamily V member 4 Homo sapiens 16-21 34194559-5 2021 TRPV1 and TRPV4 are likely related to the inhibition of inflammatory reactions, neurotoxicity and cell apoptosis, thus promoting nerve growth and regulation of intracellular calcium ions (Ca2+). Calcium 174-181 transient receptor potential cation channel subfamily V member 4 Homo sapiens 10-15 35385164-3 2022 We aimed to investigate the role of mechanosensitive calcium channel Transient Receptor Potential Vanilloid type 4 (TRPV4) in stiffness induced myofibroblast activation. Calcium 53-60 transient receptor potential cation channel subfamily V member 4 Homo sapiens 69-114 35385164-3 2022 We aimed to investigate the role of mechanosensitive calcium channel Transient Receptor Potential Vanilloid type 4 (TRPV4) in stiffness induced myofibroblast activation. Calcium 53-60 transient receptor potential cation channel subfamily V member 4 Homo sapiens 116-121 35090355-8 2022 In addition, NiONPs exposure altered calcium homeostasis inducing an increased cytosolic calcium concentration ((Ca2+)i) that was significantly reduced by the extracellular calcium chelator EGTA and the TRPV4 inhibitor HC-067047. Calcium 89-96 transient receptor potential cation channel subfamily V member 4 Homo sapiens 203-208 35256051-9 2022 Multimodal transient receptor potential vanilloid 4 (TRPV4) channels were identified as key mediators of thermo-mechanotransduction process, which becomes ineffective without external calcium sources. Calcium 184-191 transient receptor potential cation channel subfamily V member 4 Homo sapiens 53-58 35323756-3 2022 Q-PCR, Western blot, FACS analyses and fluorescence single-cell calcium imaging confirmed TRPV4 gene and protein overexpression in lentivirally transduced 12V4 cells derived from their parent HCEC-12 line. Calcium 64-71 transient receptor potential cation channel subfamily V member 4 Homo sapiens 90-95 35456964-1 2022 TRPV4 (transient receptor potential vanilloid 4), a calcium permeable TRP ion channel, is known to play a key role in endocytosis. Calcium 52-59 transient receptor potential cation channel subfamily V member 4 Homo sapiens 0-5 35456964-1 2022 TRPV4 (transient receptor potential vanilloid 4), a calcium permeable TRP ion channel, is known to play a key role in endocytosis. Calcium 52-59 transient receptor potential cation channel subfamily V member 4 Homo sapiens 7-47 35456964-5 2022 We further identified interactions between TRPV4 and folding/vesicle trafficking proteins, which were triggered by calcium entry through activated TRPV4. Calcium 115-122 transient receptor potential cation channel subfamily V member 4 Homo sapiens 43-48 35456964-5 2022 We further identified interactions between TRPV4 and folding/vesicle trafficking proteins, which were triggered by calcium entry through activated TRPV4. Calcium 115-122 transient receptor potential cation channel subfamily V member 4 Homo sapiens 147-152 35170874-1 2022 OBJECTIVE: Distinct dominant mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically cause nonoverlapping diseases of either the neuromuscular or skeletal systems. Calcium 46-53 transient receptor potential cation channel subfamily V member 4 Homo sapiens 76-81 35170874-1 2022 OBJECTIVE: Distinct dominant mutations in the calcium-permeable ion channel TRPV4 (transient receptor potential vanilloid 4) typically cause nonoverlapping diseases of either the neuromuscular or skeletal systems. Calcium 46-53 transient receptor potential cation channel subfamily V member 4 Homo sapiens 83-123 35170874-10 2022 INTERPRETATION: These findings demonstrate that the degree of baseline calcium elevation correlates with development of mixed phenotypes and sensitivity to pharmacologic channel inhibition, observations that will be critical for the design of future clinical trials for TRPV4 channelopathies. Calcium 71-78 transient receptor potential cation channel subfamily V member 4 Homo sapiens 270-275 35069237-8 2021 Calcium imaging using channel agonists/antagonists provided evidence for functional expression of TRPA1, TRPV2, TRPV4, Piezo1, but not of TRPV1 or TRPM8. Calcium 0-7 transient receptor potential cation channel subfamily V member 4 Homo sapiens 112-117