PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 31863291-6 2020 The immune infiltration-miRNA functional network analysis showed that the resting mast cell-associated miRNAs are mainly involved in the enrichment of development, mRNA metabolic process, myeloid cell differentiation, Wnt, calcium modulating, interferon, p53 pathways. Calcium 223-230 tumor protein p53 Homo sapiens 255-258 32065645-0 2020 Expression of Concern: "Cadmium Induces Intracellular Ca2+- and H2O2-Dependent Apoptosis through JNK- and p53-Mediated Pathways in Skin Epidermal Cell line". Calcium 54-58 tumor protein p53 Homo sapiens 106-109 31761381-5 2020 10ah-treatment in MGC-803 cells increased the expression of p53, phosphorylated p53 (p-p53), CDK4, p21 to cause cell cycle arrest at G2/M phase, significantly up-regulated the levels of pro-apoptosis proteins Bak, Bax, Bim while down-regulated the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1, fluctuated the intracellular reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential, activated Caspase-9 and Caspase-3 to induce apoptosis. Calcium 375-379 tumor protein p53 Homo sapiens 60-63 31761381-5 2020 10ah-treatment in MGC-803 cells increased the expression of p53, phosphorylated p53 (p-p53), CDK4, p21 to cause cell cycle arrest at G2/M phase, significantly up-regulated the levels of pro-apoptosis proteins Bak, Bax, Bim while down-regulated the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1, fluctuated the intracellular reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential, activated Caspase-9 and Caspase-3 to induce apoptosis. Calcium 375-379 tumor protein p53 Homo sapiens 80-83 31761381-5 2020 10ah-treatment in MGC-803 cells increased the expression of p53, phosphorylated p53 (p-p53), CDK4, p21 to cause cell cycle arrest at G2/M phase, significantly up-regulated the levels of pro-apoptosis proteins Bak, Bax, Bim while down-regulated the anti-apoptosis proteins Bcl-2, Bcl-xL and the levels of cyclin B1, fluctuated the intracellular reactive oxygen species (ROS), Ca2+ and mitochondrial membrane potential, activated Caspase-9 and Caspase-3 to induce apoptosis. Calcium 375-379 tumor protein p53 Homo sapiens 80-83 32668972-0 2020 Cryptotanshinone-Induced p53-Dependent Sensitization of Colon Cancer Cells to Apoptotic Drive by Regulation of Calpain and Calcium Homeostasis. Calcium 123-130 tumor protein p53 Homo sapiens 25-28 33923162-1 2021 S100P, a small calcium-binding protein, associates with the p53 protein with micromolar affinity. Calcium 15-22 tumor protein p53 Homo sapiens 60-63 33039869-11 2021 These results indicated that Cr(VI)-induced apoptosis of Hep3B cells (p53-null) was closely associated with calcium overload, and was accompanied by the activation of Ca2+/CaM/CaMKII signaling pathway. Calcium 108-115 tumor protein p53 Homo sapiens 70-73 32805233-1 2020 S100A4 is a small calcium-binding protein that exerts its biological functions by interacting with nonmuscle myosin IIA (NMIIA) and p53. Calcium 18-25 tumor protein p53 Homo sapiens 132-135 32402583-9 2020 Additionally, an intracellular calcium rise and subsequent mitochondrial membrane potential collapse, P53 phosphorylation, reduced BcL-2/Bax ratio in the mitochondrial membrane, release cytochrome c from mitochondria, leading to the subsequent activation of caspase 3 activation by H2O2 were all markedly suppressed in the presence of luteolin. Calcium 31-38 tumor protein p53 Homo sapiens 102-105 32064753-7 2020 The outcomes depicted that target genes were correlated with calcium, as well as cell proliferation, circadian entrainment, EGFR, PI3K-Akt-mTOR, and P53 signaling pathways. Calcium 61-68 tumor protein p53 Homo sapiens 149-152 29358327-8 2018 Low-level overexpression of p53 in pAVICs via an adenovirus vector did not affect pAVIC apoptosis but promoted warfarin-induced calcium deposition and expression of osteogenic markers. Calcium 128-135 tumor protein p53 Homo sapiens 28-31 30405856-7 2018 The upregulated genes were enriched in cell cycle, ECM-receptor interaction, and p53 signaling pathway, while the downregulated genes were enriched in retrograde endocannabinoid signaling, glutamatergic synapse, morphine addiction, GABAergic synapse, and calcium signaling pathway. Calcium 255-262 tumor protein p53 Homo sapiens 81-84 31442557-10 2019 It was also shown that KB promoted cytoprotective autophagy by a calcium dependent-p53 downregulation pathway. Calcium 65-72 tumor protein p53 Homo sapiens 83-86 30591679-8 2018 RNA sequencing analysis suggested that sFRP4-mediated apoptosis is via the Fas-p53 pathway by activating the Wnt calcium and reactive oxygen species pathways. Calcium 113-120 tumor protein p53 Homo sapiens 79-82 29580374-0 2018 Mitochondrial dysfunction suppresses p53 expression via calcium-mediated nuclear factor-kB signaling in HCT116 human colorectal carcinoma cells. Calcium 56-63 tumor protein p53 Homo sapiens 37-40 29580374-5 2018 The p53 expression was reduced by activation of nuclear factor-kappaB that depended on elevated levels of free calcium in HCT116/rho0 cells. Calcium 111-118 tumor protein p53 Homo sapiens 4-7 29358327-11 2018 Of note, overexpression of Slug increased osteogenic marker Runx2 expression, but not pAVIC calcium deposition, and Slug knockdown attenuated pAVIC calcification and p53-mediated pAVIC calcium deposition and expression of osteogenic markers. Calcium 185-192 tumor protein p53 Homo sapiens 166-169 29358327-9 2018 shRNA-mediated p53 knockdown attenuated the pAVIC calcium deposition and osteogenic marker expression. Calcium 50-57 tumor protein p53 Homo sapiens 15-18 26727270-1 2016 The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. Calcium 30-37 tumor protein p53 Homo sapiens 71-74 28068434-9 2017 Given that modulation of calcium signaling has been demonstrated to change sensitivity of chemotherapeutic agents to apoptotic signals, in principle, we explored the paradigm of how p53 modulation of calcium regulators in ER+ breast cancer patients impacts and influences therapeutic outcomes. Calcium 200-207 tumor protein p53 Homo sapiens 182-185 29391550-2 2018 Pulsed Hill-type dynamics involves the binding of multiple signal molecules to a receptor and occurs e.g., when transcription factor p53 orchestrates cancer prevention, during calcium signaling, and during circadian rhythms. Calcium 176-183 tumor protein p53 Homo sapiens 133-136 26727270-1 2016 The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. Calcium 30-37 tumor protein p53 Homo sapiens 86-89 26727270-1 2016 The drug pentamidine inhibits calcium-dependent complex formation with p53 ((Ca)S100B p53) in malignant melanoma (MM) and restores p53 tumor suppressor activity in vivo. Calcium 30-37 tumor protein p53 Homo sapiens 86-89 25018059-9 2014 We determined that oxLDL triggered the phosphorylation of ERK and, in turn, the activation of p53 and other apoptosis-related events, including calcium accumulation, destabilization of the mitochondrial permeability and disruption of the balance between pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins. Calcium 144-151 tumor protein p53 Homo sapiens 94-97 26341291-0 2015 Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells. Calcium 45-52 tumor protein p53 Homo sapiens 72-75 26341291-5 2015 Further, we demonstrate that this elevation of intracellular calcium modulates p53 activity and the subsequent transcription of several pro-apoptotic genes encoding PIG8, CD95, PIDD, TP53INP, RRM2B, Noxa, p21 and PUMA. Calcium 61-68 tumor protein p53 Homo sapiens 79-82 25806354-0 2015 p53 Calls upon CIA (Calcium Induced Apoptosis) to Counter Stress. Calcium 20-27 tumor protein p53 Homo sapiens 0-3 25741709-7 2015 DAVID and KEGG pathway analysis suggested that the target genes were generally involved in cell apoptosis, p53, neurotrophin, calcium, chemokine and Jak-STAT signalling pathways. Calcium 126-133 tumor protein p53 Homo sapiens 107-110 25824785-8 2015 OIT3 possibly correlated with calcium binding revealed by the annotation analyses and was regulated by a large number of transcription factors including STAT, SOX9, CREB, NF-kB, PPARG and p53. Calcium 30-37 tumor protein p53 Homo sapiens 188-191 25715001-0 2015 Inside the tumor: p53 modulates calcium homeostasis. Calcium 32-39 tumor protein p53 Homo sapiens 18-21 25823563-8 2015 These observations collectively strongly suggest that both endoplasmic reticulum stress-mediated calcium release and Bax targeting might be altering mitochondrion membrane potential which in turn could induce secondary apoptotic signals; subsequently, endoplasmic reticulum stress can also lead to nuclear localization of Nuclear factor-kappaB (NF-kappaB) which in turn favors p53 mediated apoptotic signals. Calcium 97-104 tumor protein p53 Homo sapiens 377-380 25880696-0 2015 p53 orchestrates calcium signaling in vivo. Calcium 17-24 tumor protein p53 Homo sapiens 0-3 23313430-3 2013 Calcium-dependent binding of dimeric S100B(betabeta) to p53-NRD blocks access to these PTM sites and disrupts the p53 tetramer to inhibit p53 activation. Calcium 0-7 tumor protein p53 Homo sapiens 56-59 23796514-1 2013 S100A6 is a calcium binding protein that, like some other members of the S100 protein family, is able to bind p53. Calcium 12-19 tumor protein p53 Homo sapiens 110-113 23108402-4 2013 Here we establish a role of calcium (Ca(2+)) as a messenger for p53 activation in response to 5-FU. Calcium 28-35 tumor protein p53 Homo sapiens 64-67 23976973-3 2013 Here we have shown that in cancer cells treated with anti-neoplastic drug GaQ3, p53, there is an increase in intracellular calcium levels by transcriptional regulation of a novel calcium channel gene TRPC6. Calcium 123-130 tumor protein p53 Homo sapiens 80-83 23976973-6 2013 This research work shows that p53 and its transcriptional activity is critical in regulation of calcium signaling and an increase in the intracellular calcium level might be one of the anti-cancer strategies to induce apoptosis in cancer cells. Calcium 96-103 tumor protein p53 Homo sapiens 30-33 23976973-6 2013 This research work shows that p53 and its transcriptional activity is critical in regulation of calcium signaling and an increase in the intracellular calcium level might be one of the anti-cancer strategies to induce apoptosis in cancer cells. Calcium 151-158 tumor protein p53 Homo sapiens 30-33 24801133-9 2014 Array comparative genomic hybridization detected a 1.36 Mb deletion in 8q22.3 that encompassed RRM2B and NCALD, which encode the small subunit of p53-inducible ribonucleotide reductase and neurocalcin delta in the neuronal calcium sensor family of calcium-binding proteins, respectively. Calcium 223-230 tumor protein p53 Homo sapiens 146-149 24801133-9 2014 Array comparative genomic hybridization detected a 1.36 Mb deletion in 8q22.3 that encompassed RRM2B and NCALD, which encode the small subunit of p53-inducible ribonucleotide reductase and neurocalcin delta in the neuronal calcium sensor family of calcium-binding proteins, respectively. Calcium 248-255 tumor protein p53 Homo sapiens 146-149 23976973-0 2013 p53 increases intra-cellular calcium release by transcriptional regulation of calcium channel TRPC6 in GaQ3-treated cancer cells. Calcium 29-36 tumor protein p53 Homo sapiens 0-3 23313430-3 2013 Calcium-dependent binding of dimeric S100B(betabeta) to p53-NRD blocks access to these PTM sites and disrupts the p53 tetramer to inhibit p53 activation. Calcium 0-7 tumor protein p53 Homo sapiens 114-117 23313430-3 2013 Calcium-dependent binding of dimeric S100B(betabeta) to p53-NRD blocks access to these PTM sites and disrupts the p53 tetramer to inhibit p53 activation. Calcium 0-7 tumor protein p53 Homo sapiens 114-117 23360948-0 2013 Switching p53 states by calcium: dynamics and interaction of stress systems. Calcium 24-31 tumor protein p53 Homo sapiens 10-13 23360948-2 2013 The high dose of calcium in the system activates the nitric oxide synthase, synthesizing nitric oxide which then downregulates Mdm2 and influences drastically the p53-Mdm2 network regulation, lifting the system from a normal to a stressed state. Calcium 17-24 tumor protein p53 Homo sapiens 163-166 23360948-3 2013 The increase in calcium level switches the system to different states, as identified by the different behaviours of the p53 temporal dynamics, i.e. oscillation death to sustain the oscillation state via a mixed state of dampened and oscillation death states. Calcium 16-23 tumor protein p53 Homo sapiens 120-123 22913742-3 2012 Previously, peptides derived from CapZ, p53, NDR, HDM2, and HDM4 have been shown to interact with S100B in a calcium-dependent manner. Calcium 109-116 tumor protein p53 Homo sapiens 40-43 23079576-6 2012 RESULTS: The most strongly differentially enriched pathways between breast cancers stratified by TP53 mutation status include in addition to TP53 signalling, several known cancer pathways involved in renal, prostate, pancreatic, colorectal, lung and other cancers, and signalling pathways such as calcium signalling, MAPK, ERBB and vascular endothelial growth factor (VEGF) signalling pathways. Calcium 297-304 tumor protein p53 Homo sapiens 97-101 23131771-7 2012 Interestingly, in the presence of calcium ions Annexin A2 showed increased binding with p53 IRES. Calcium 34-41 tumor protein p53 Homo sapiens 88-91 22394450-1 2012 S100A2 is an EF-hand calcium ion (Ca(2+))-binding protein that activates the tumour suppressor p53. Calcium 21-28 tumor protein p53 Homo sapiens 95-98 20547212-10 2010 Annexin V plays an important role in maintenance of calcium homeostasis which when disturbed can activate a p53-dependent cell death. Calcium 52-59 tumor protein p53 Homo sapiens 108-111 22124122-6 2012 Wnt5a and calcium ionophore activate NFATc1, NFATc2, NF-kappaB, and B cell lymphoma 6 (BCL-6) promptly and upregulate CD40 expression in GC B and Ramos cells, whereas p53 and JNK are not upregulated or activated. Calcium 10-17 tumor protein p53 Homo sapiens 167-170 22323293-10 2012 In agreement with this, increased p53 levels are necessary for a calcium-induced increase in neurons. Calcium 65-72 tumor protein p53 Homo sapiens 34-37 21063838-4 2010 The expression of apoptosis related p53 and Bcl-2 protein and the second messenger calcium were detected respectively by Western blotting, patch clamp and confocal calcium imaging. Calcium 164-171 tumor protein p53 Homo sapiens 36-39 20702634-4 2010 We show that the induction of miR-203 observed during calcium-induced differentiation of HFKs is significantly reduced in HFKs expressing E6 and in p53i HFKs. Calcium 54-61 tumor protein p53 Homo sapiens 148-151 21132089-2 2010 In such cancers, S100B binds wild-type p53 in a calcium-dependent manner, sequestering it, and promoting its degradation, resulting in the loss of p53-dependent tumor suppression activities. Calcium 48-55 tumor protein p53 Homo sapiens 39-42 19513503-5 2009 Interestingly, it was revealed that treatment with exogenous S100A4 protein reduced transcriptional activity of p53 and abrogated the modification of calcium binding affinity of S100A4 protein. Calcium 150-157 tumor protein p53 Homo sapiens 112-115 20140014-7 2010 The regulation of the p53 family by S100 is complicated and depends on the target preference of each individual S100 protein, the concentration of the proteins and calcium, as well as the splicing variation of p63 or p73. Calcium 164-171 tumor protein p53 Homo sapiens 22-25 20432164-6 2010 These data support an association between calcium and rectal tumors overall as well as specifically with TP53 mutations. Calcium 42-49 tumor protein p53 Homo sapiens 105-109 17889823-0 2007 The calcium binding protein ALG-2 binds and stabilizes Scotin, a p53-inducible gene product localized at the endoplasmic reticulum membrane. Calcium 4-11 tumor protein p53 Homo sapiens 65-68 18765292-4 2009 Here, we report, based on affinity chromatography and co-immunoprecipitation results that S100A6 interacts with p53 in the presence of calcium ions. Calcium 135-142 tumor protein p53 Homo sapiens 112-115 18620780-1 2009 BACKGROUND: In a previously published in vitro study based on top-down proteomics we found that the calcium-binding proteins S100A6 and S100A4 were affected by exposure to ionizing radiation in a p53-dependent fashion. Calcium 100-107 tumor protein p53 Homo sapiens 196-199 18783790-5 2008 This calcium-dependent conformational change opens up a hydrophobic binding pocket that is capable of binding to target proteins such as annexin A2, the tumor-suppressor protein p53 and myosin IIA. Calcium 5-12 tumor protein p53 Homo sapiens 178-181 20735960-11 2008 But the significant difference was not observed on MTT assay between CMAG2+ and its control, the reason might be due to the mutated p53, which had strong proliferation promoting effects, was also down-regulated by MAG-2"s over-expression in PLA801C, and the levels of cytoplasm calcium in CMAG2+ had 1.05 times more than that of vector control. Calcium 278-285 tumor protein p53 Homo sapiens 132-135 17514353-0 2007 Calcium-mediated activation of PI3K and p53 leads to apoptosis in thyroid carcinoma cells. Calcium 0-7 tumor protein p53 Homo sapiens 40-43 17065086-1 2006 Previously, we have found that activation of deoxycytidine kinase elicited by various DNA-damaging chemical agents could be prevented by BAPTA-AM, a cell-permeable calcium chelator or by pifithrin-alpha, a pharmacological inhibitor of p53. Calcium 164-171 tumor protein p53 Homo sapiens 235-238 17514353-5 2007 Buffering of the calcium response attenuated mitochondrial impairment, recovered the cadmium-activated Akt, p53, JNK, ERK and p38, and subsequently blocked the apoptosis. Calcium 17-24 tumor protein p53 Homo sapiens 108-111 15914462-4 2005 Both proline oxidase- and p53-induced activation of NFAT were sensitive to the calcineurin inhibitors cyclosporin A and FK-506, to scavengers of ROS, and to inhibitors of calcium mobilization. Calcium 171-178 tumor protein p53 Homo sapiens 26-29 16043423-6 2005 However, following the onset of calcium-induced differentiation, basal levels of p53 were nearly undetectable by 12 days of differentiation when global repair activity was unaffected. Calcium 32-39 tumor protein p53 Homo sapiens 81-84 16043423-7 2005 Following ultraviolet radiation, induction of p53 following ultraviolet radiation was abrogated by 6 days of calcium-induced differentiation. Calcium 109-116 tumor protein p53 Homo sapiens 46-49 15914462-7 2005 Inhibitors of calcineurin and calcium mobilization abolished proline oxidase-mediated apoptosis and reduced p53-induced apoptosis. Calcium 30-37 tumor protein p53 Homo sapiens 108-111 15093128-4 2004 This type of calcium signal promotes activation of the transcription factor CREB (cAMP response element binding protein) leading to cell cycle arrest in G1 phase via transactivation of p53/p21 signaling pathways. Calcium 13-20 tumor protein p53 Homo sapiens 185-188 15339849-3 2005 p53 deletions were associated with higher serum calcium (P = .0062) and creatinine (P = .013) levels, but there were no association with patient age, gender, beta2-microglobulin, C-reactive protein, hemoglobin, albumin or bone lytic lesions, or immunoglobulin isotype. Calcium 48-55 tumor protein p53 Homo sapiens 0-3 16248785-1 2005 S100B interacts with the p53 protein in a calcium-dependent manner and down-regulates its function as a tumor suppressor. Calcium 42-49 tumor protein p53 Homo sapiens 25-28 15456252-0 2004 Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction. Calcium 72-79 tumor protein p53 Homo sapiens 96-99 12393587-7 2002 We demonstrate that p53-dependent apoptosis results in mitochondrial damage as shown by loss of mitochondrial membrane potential, increase in intracellular calcium, and release of mitochondrial cytochrome c into the cytosol. Calcium 156-163 tumor protein p53 Homo sapiens 20-23 15581406-5 2004 In primary cultures of mesencephalon, this form of injury is mediated through release of calcium from intracellular stores (CICR), leading to loss of calcium homeostasis, oxidative stress, and activation of the transcription factor NFkappaB and the cell death protein p53. Calcium 89-96 tumor protein p53 Homo sapiens 268-271 10094469-1 1999 S100A2, a calcium binding protein of the EF-hand family, was recently identified to be inducible by etoposide, a p53 activator. Calcium 10-17 tumor protein p53 Homo sapiens 113-116 10876230-0 2000 Where cancer meets calcium--p53 crosstalk with EF-hands. Calcium 19-26 tumor protein p53 Homo sapiens 28-31 10187847-4 1999 We have confirmed a calcium-dependent interaction of the S100B with a synthetic peptide corresponding to the C-terminal region of p53 (residues 319-393 in human p53) using plasmon resonance experiments on a BIAcore system. Calcium 20-27 tumor protein p53 Homo sapiens 130-133 10187847-4 1999 We have confirmed a calcium-dependent interaction of the S100B with a synthetic peptide corresponding to the C-terminal region of p53 (residues 319-393 in human p53) using plasmon resonance experiments on a BIAcore system. Calcium 20-27 tumor protein p53 Homo sapiens 161-164 10327055-0 1999 Wild-type p53 protein shows calcium-dependent binding to F-actin. Calcium 28-35 tumor protein p53 Homo sapiens 10-13 10327055-8 1999 Here we show that, in the presence of free calcium ions, p53 binds directly to F-actin with a dissocation constant of about 10 microM. Calcium 43-50 tumor protein p53 Homo sapiens 57-60 10327055-9 1999 Thus, part of the regulatory machinery in normal cell cycling may involve p53-actin interactions regulated by calcium fluxes and the dynamic turnover of F-actin. Calcium 110-117 tumor protein p53 Homo sapiens 74-77 9685342-4 1998 p53 accumulated was degraded efficiently in vitro in the S10-0 extract (S10-0) prepared from MA1 cells in an ATP and ubiquitin-dependent manner, but not in S10-24 prepared after treatment with dexamethasone for 24 h. The p53 polyubiquitination activity in S100-0 was calcium-dependent and reduced greatly in S100-24. Calcium 267-274 tumor protein p53 Homo sapiens 0-3 10025726-9 1999 In addition, growth in normal calcium medium lowered the UVB-induced stimulation of the p53 protein and altered the normal subcellular localization pattern of p53. Calcium 30-37 tumor protein p53 Homo sapiens 88-91 10025726-9 1999 In addition, growth in normal calcium medium lowered the UVB-induced stimulation of the p53 protein and altered the normal subcellular localization pattern of p53. Calcium 30-37 tumor protein p53 Homo sapiens 159-162 9665463-2 1998 In this study we investigated by immunohistochemistry and Western blotting whether calcium and the phorbol ester 12-O-tetradecanoylphorbol-13-acetate, well characterized differentiation signals, induce p21WAF1 in cultured normal human keratinocytes and whether induction of p21WAF1 in this system depends on protein kinase C activation or functional p53. Calcium 83-90 tumor protein p53 Homo sapiens 350-353 9111352-8 1997 Conversely, activation of calpains by calcium ionophore led to a reduction of p53 in mammalian cells, and the effect was blocked by cell-permeant calpain inhibitors. Calcium 38-45 tumor protein p53 Homo sapiens 78-81 9703382-7 1998 Serum ionized calcium tended to be higher in p53-positive glands in all histopathological groups; however, the difference was only significant in nodular hyperplasias (P = 0.018). Calcium 14-21 tumor protein p53 Homo sapiens 45-48 8476634-0 1993 Retinoic acid and calcium regulation of p53, transforming growth factor-beta 1, and transforming growth factor-alpha gene expression and growth in adenovirus 12-SV40-transformed human tracheal gland epithelial cells. Calcium 18-25 tumor protein p53 Homo sapiens 40-43 8634048-6 1996 A significant correlation between p53 immunoreactivity and preparathyroidectomy calcium levels of > 1.5 mmol/L was detected (P < 0.005) although no correlation was noted between p53 immunoreactivity and higher levels of preparathyroidectomy intact parathyroid hormone (PTH) levels. Calcium 80-87 tumor protein p53 Homo sapiens 34-37 8634048-7 1996 CONCLUSION: A relationship is postulated between abnormal serum calcium regulation and p53 mutation in hypercalcaemic states associated with hyperparathyroidism. Calcium 64-71 tumor protein p53 Homo sapiens 87-90 34859139-1 2021 The calcium-independent phospholipase iPLA2beta has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Calcium 4-11 tumor protein p53 Homo sapiens 120-124 30578154-9 2019 The up-regulated miRNAs were mainly enriched in pathways as GO:0000122-negative regulation of transcription from RNA polymerase II promoter, phosphatidylinositol phosphorylation, MAPK signaling pathway, and Ras signaling pathway, etc., while the down-regulated miRNAs were enriched in pathways as, response to reactive oxygen species, p53 signaling pathway, calcium signaling pathway, etc. Calcium 358-365 tumor protein p53 Homo sapiens 335-338 34859139-1 2021 The calcium-independent phospholipase iPLA2beta has been identified as a transcriptional target of the tumor suppressor TP53 (or p53). Calcium 4-11 tumor protein p53 Homo sapiens 129-132 35500522-11 2022 One sentence summary: TRPM4 is repressed in the p53 pathway leading to reduced currents and increased calcium signaling. Calcium 102-109 tumor protein p53 Homo sapiens 48-51