PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
24689792-6	2014	This >1000-fold selectivity for CA IX over off-target CAs is unprecedented for classical primary sulfonamide CA inhibitors.	Calcium	57-60	carbonic anhydrase 9	Homo sapiens	35-40	
29517989-4	2018	In addition to the role that these CAs play in the regulation of pH, recent proteome-wide analyses have revealed the presence of a complex CAIX interactome in cancer cells with roles in metabolite transport, tumor cell migration and invasion.	Calcium	35-38	carbonic anhydrase 9	Homo sapiens	139-143	
29928486-2	2018	Novel fluorinated CA IX inhibitors exhibited up to 50 pM affinity towards the recombinant human CA IX, selectivity over other CAs, and direct binding to Zn(II) in the active site of CA IX inducing novel conformational changes as determined by X-ray crystallography.	Calcium	126-129	carbonic anhydrase 9	Homo sapiens	18-23	
29928486-2	2018	Novel fluorinated CA IX inhibitors exhibited up to 50 pM affinity towards the recombinant human CA IX, selectivity over other CAs, and direct binding to Zn(II) in the active site of CA IX inducing novel conformational changes as determined by X-ray crystallography.	Calcium	126-129	carbonic anhydrase 9	Homo sapiens	96-101	
29928486-2	2018	Novel fluorinated CA IX inhibitors exhibited up to 50 pM affinity towards the recombinant human CA IX, selectivity over other CAs, and direct binding to Zn(II) in the active site of CA IX inducing novel conformational changes as determined by X-ray crystallography.	Calcium	126-129	carbonic anhydrase 9	Homo sapiens	96-101	
25254302-4	2014	Seven compounds inhibited CA IX with low nM Ki values of 1-2 nM and also exhibited permeability profiles to preferentially target the binding of extracellular CA IX over cytosolic CAs.	Calcium	180-183	carbonic anhydrase 9	Homo sapiens	26-31	
9524195-8	1998	Furthermore, MN/CA IX has a completely conserved active site domain of CAs suggesting that it could also participate in carbon dioxide/bicarbonate homeostasis.	Calcium	71-74	carbonic anhydrase 9	Homo sapiens	16-21	
19140703-2	2009	A surface layer with the composition Ca9(HPO4)2(PO4)4F2 is formed, which is suggested to form as one calcium atom is replaced by two protons.	Calcium	101-108	carbonic anhydrase 9	Homo sapiens	37-40	
12162334-6	2002	Upon immersion in aqueous solutions these nanoapatites loose phosphate, K+ and Na+ so that in an open system they are transformed into calcium deficient hydroxyapatite Ca9(HPO4)(PO4)5OH within about 2 months.	Calcium	135-142	carbonic anhydrase 9	Homo sapiens	168-171	
14567991-6	2003	Calcium switch-triggered disruption and reconstitution of cell contacts resulted in relocalization of both CA IX and E-cadherin to cytoplasm and back to plasma membrane.	Calcium	0-7	carbonic anhydrase 9	Homo sapiens	107-112