PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 7902076-3 1993 It is to note that CD28 triggering led to calcium mobilization, whereas stimulation via CD2 did not. Calcium 42-49 CD2 molecule Homo sapiens 19-22 8906806-8 1996 By contrast, CD2 induces PLCgamma-1 tyrosine phosphorylation as efficiently as CD3, with a correlated inositol phosphate production and intracellular calcium increase, and even a higher production of IL-2. Calcium 150-157 CD2 molecule Homo sapiens 13-16 7662514-0 1995 Intracellular calcium levels are differentially regulated in T lymphocytes triggered by anti-CD2 and anti-CD3 monoclonal antibodies. Calcium 14-21 CD2 molecule Homo sapiens 93-96 7908759-2 1993 We found that the addition of small concentrations (1-10 microM) of Cd2+ to the low calcium bathing Ringer reduced both the control EPP amplitude and the increase in EPP amplitude that normally occurs during repetitive stimulation under low quantal conditions. Calcium 84-91 CD2 molecule Homo sapiens 68-71 7902214-0 1993 Regulation of CD2-mediated human T cell activation: anti-CD8 monoclonal antibodies inhibit CD2-mediated rise in intracellular calcium. Calcium 126-133 CD2 molecule Homo sapiens 14-17 7902214-0 1993 Regulation of CD2-mediated human T cell activation: anti-CD8 monoclonal antibodies inhibit CD2-mediated rise in intracellular calcium. Calcium 126-133 CD2 molecule Homo sapiens 91-94 7902214-6 1993 Furthermore, CD8 alpha-specific mAb inhibited the increase in intracellular ionized calcium mediated by CD2 mAbs in the CD8+ clone and in purified T cells. Calcium 84-91 CD2 molecule Homo sapiens 104-107 7679705-3 1993 ChTX blocks T cell activation induced by signals (e.g., anti-CD2, anti-CD3, ionomycin) that elicit a rise in intracellular calcium ([Ca2+]i) by preventing the elevation of [Ca2+]i in a dose-dependent manner. Calcium 123-130 CD2 molecule Homo sapiens 61-64 9070345-9 1997 These studies indicated that: (1) a portion of the overall transport of Cd2+ can be attributed to diffusion, (2) stimulation of calcium binding protein transcription by vit. Calcium 128-135 CD2 molecule Homo sapiens 72-75 7909498-7 1994 Moreover, the modulation of CD26 resulted in an increase in anti-CD3-mediated cord T cell activation through an enhancement in intracellular calcium levels, IL-2 receptor expression, and IL-2 synthesis, whereas it had no effect on cord T cell activation induced by anti-CD2 or anti-CD2 plus exogenous IL-2. Calcium 141-148 CD2 molecule Homo sapiens 28-31 1471158-3 1992 A prior incubation with wheat germ agglutinin (WGA) or certain other lectins inhibited calcium release evoked by Cd2+. Calcium 87-94 CD2 molecule Homo sapiens 113-116 1363475-4 1992 These changes were accompanied by faulty T-cell proliferation in response to anti-CD3 and anti-CD2 mAb and inhibition of CD3- and CD2-mediated rises in intracellular calcium and, to a lesser extent, inositol 1,4,5-triphosphate levels. Calcium 166-173 CD2 molecule Homo sapiens 130-133 1354231-6 1992 In contrast, anti-1A4 inhibited CD2-mediated calcium mobilization and the serine esterase activity of NK cell granules. Calcium 45-52 CD2 molecule Homo sapiens 32-35 1372020-10 1992 CD3 receptor modulation potently down-regulated CD2-induced PLC gamma 1 tyrosine phosphorylation and calcium mobilization. Calcium 101-108 CD2 molecule Homo sapiens 48-51 1706751-5 1991 In the CD2 transfectant, a combination of anti-T11(2) + anti-T11(3) monoclonal antibodies (mAbs) induced a rise in intracellular free calcium [( Ca2+]i), IL-6 production, and histamine release. Calcium 134-141 CD2 molecule Homo sapiens 7-10 1715359-5 1991 In addition, pretreatment of T cells with anti-1A4 inhibited the normally sustained intracellular calcium mobilization seen after triggering of T cells via the CD2 or CD3 pathways. Calcium 98-105 CD2 molecule Homo sapiens 160-163 1707760-5 1991 This correlation held even for the CD28/CD2 pathway which was previously shown to be calcium-independent; however by employing FACS analysis of [Ca2+]i within individual cells, a subset of cells activated via CD28/CD2 was found to respond with a measurable rise in [Ca2+]i. Calcium 85-92 CD2 molecule Homo sapiens 35-38 1707760-5 1991 This correlation held even for the CD28/CD2 pathway which was previously shown to be calcium-independent; however by employing FACS analysis of [Ca2+]i within individual cells, a subset of cells activated via CD28/CD2 was found to respond with a measurable rise in [Ca2+]i. Calcium 85-92 CD2 molecule Homo sapiens 40-43 2573636-0 1989 Phorbol esters regulate CD2- and CD3-mediated calcium responses in peripheral blood-derived human T cells. Calcium 46-53 CD2 molecule Homo sapiens 24-27 1972660-6 1990 In the wild type Jurkat cell line as well as in CD3- and CD2- variants, AlF4- can activate the G protein(s) presumably associated with phospholipase C to generate polyphosphoinositide turnover as well as an increase in cytoplasmic free calcium ions. Calcium 236-243 CD2 molecule Homo sapiens 57-60 1970938-10 1990 We also found that, after CD2 stimulation, calcium flux in T cells was normal immediately after engraftment. Calcium 43-50 CD2 molecule Homo sapiens 26-29 2575034-2 1989 Stimulation of cells via the TcR/CD3-complex or via the CD2 molecule increases inositol phosphates and cytoplasmic free calcium. Calcium 120-127 CD2 molecule Homo sapiens 56-59 1677314-1 1991 An increase in intracellular calcium concentration stimulated by anti-CD2 or CD3 antibodies has been measured with Fura-2 in P28 cells, a human CD4+ T cell clone. Calcium 29-36 CD2 molecule Homo sapiens 70-73 1677314-6 1991 It is concluded that the effects of nitrendipine on potassium channels may account for a large part of the inhibition that nitrendipine exerts on the calcium increase elicited by CD2 or CD3 stimulation. Calcium 150-157 CD2 molecule Homo sapiens 179-182 1976695-5 1990 Co-aggregation of CD2 and CD45, a tyrosine phosphatase, results in inhibition of intracellular calcium elevation and T cell proliferation. Calcium 95-102 CD2 molecule Homo sapiens 18-21 1972730-6 1990 Stimulation of transfectants CD2 FL, CD2 M1 (271-272), and CD2 M2 (278-279) with anti-T11(2) + anti-T11(3) antibodies resulted in a rise in cytosolic-free calcium [( Ca2+]i) and subsequent interleukin 2 (IL-2) secretion. Calcium 155-162 CD2 molecule Homo sapiens 37-40 1972730-6 1990 Stimulation of transfectants CD2 FL, CD2 M1 (271-272), and CD2 M2 (278-279) with anti-T11(2) + anti-T11(3) antibodies resulted in a rise in cytosolic-free calcium [( Ca2+]i) and subsequent interleukin 2 (IL-2) secretion. Calcium 155-162 CD2 molecule Homo sapiens 37-40 1968928-5 1990 Extracellular calcium appears to play a critical role because the effects of CD2 mAb were inhibited in a Ca2(+)-depleted medium. Calcium 14-21 CD2 molecule Homo sapiens 77-80 2573636-1 1989 The purpose of the present study was to examine the effect of protein kinase C (pkC) activation on calcium responses generated through the CD3 and CD2 Ag in both normal peripheral blood-derived T lymphocytes and the leukemic T cell line Jurkat. Calcium 99-106 CD2 molecule Homo sapiens 147-150 2573636-3 1989 Thus, the pkC activator phorbol-12,13-dibutyrate (Pdbu) enhances calcium responses induced via CD3 and CD2 molecules in normal T cells by accelerating the rate of elevation of intracellular calcium levels and increasing the maximum change in calcium concentration achieved. Calcium 65-72 CD2 molecule Homo sapiens 103-106 2573636-4 1989 In contrast, Pdbu inhibits both CD3- and CD2-induced calcium responses in Jurkat cells. Calcium 53-60 CD2 molecule Homo sapiens 41-44 2788303-2 1989 The binding of mitogenic lectins phytohaemagglutinin (PHA), concanavalin A (Con A) and/or of monoclonal antibodies to different receptors such as antigen receptor complex or CD2 on human T cells generates increases in the concentrations of inositol triphosphate (IP3) and cytoplasmic free calcium. Calcium 289-296 CD2 molecule Homo sapiens 174-177 2784064-15 1989 Cross-linking of CD2 as well as CD19 antigens on FL 8.2 CD2+ cells caused an increase of intracellular ionized calcium. Calcium 111-118 CD2 molecule Homo sapiens 17-20 2567337-4 1989 Anti-T11(2) plus anti-T11(3) antibody stimulation of cells expressing a full-length CD2 cDNA results in a characteristic rise in cytosolic-free calcium [( Ca2+]i), and subsequent IL-2 secretion that accompany CD2 stimulation in human T lymphocytes. Calcium 144-151 CD2 molecule Homo sapiens 84-87 2567674-3 1989 The kinetics of PKC translocation parallels the rise in intracellular calcium following both CD2 and CD3 stimulations. Calcium 70-77 CD2 molecule Homo sapiens 93-96 2564856-9 1989 Our findings provide evidence for an intrinsic functional defect in cord CD2-mediated T cell activation, which is linked to an impaired increase of free cytoplasmic calcium, as confirmed by the effectiveness of calcium ionophore A23187 in restoring a good CD2-induced cord T cell proliferation and by measurement of cellular calcium uptake after activation via the CD2 molecule. Calcium 165-172 CD2 molecule Homo sapiens 73-76 2564856-9 1989 Our findings provide evidence for an intrinsic functional defect in cord CD2-mediated T cell activation, which is linked to an impaired increase of free cytoplasmic calcium, as confirmed by the effectiveness of calcium ionophore A23187 in restoring a good CD2-induced cord T cell proliferation and by measurement of cellular calcium uptake after activation via the CD2 molecule. Calcium 211-218 CD2 molecule Homo sapiens 73-76 2564856-9 1989 Our findings provide evidence for an intrinsic functional defect in cord CD2-mediated T cell activation, which is linked to an impaired increase of free cytoplasmic calcium, as confirmed by the effectiveness of calcium ionophore A23187 in restoring a good CD2-induced cord T cell proliferation and by measurement of cellular calcium uptake after activation via the CD2 molecule. Calcium 211-218 CD2 molecule Homo sapiens 256-259 2564856-9 1989 Our findings provide evidence for an intrinsic functional defect in cord CD2-mediated T cell activation, which is linked to an impaired increase of free cytoplasmic calcium, as confirmed by the effectiveness of calcium ionophore A23187 in restoring a good CD2-induced cord T cell proliferation and by measurement of cellular calcium uptake after activation via the CD2 molecule. Calcium 211-218 CD2 molecule Homo sapiens 256-259 2564856-9 1989 Our findings provide evidence for an intrinsic functional defect in cord CD2-mediated T cell activation, which is linked to an impaired increase of free cytoplasmic calcium, as confirmed by the effectiveness of calcium ionophore A23187 in restoring a good CD2-induced cord T cell proliferation and by measurement of cellular calcium uptake after activation via the CD2 molecule. Calcium 211-218 CD2 molecule Homo sapiens 73-76 2564856-9 1989 Our findings provide evidence for an intrinsic functional defect in cord CD2-mediated T cell activation, which is linked to an impaired increase of free cytoplasmic calcium, as confirmed by the effectiveness of calcium ionophore A23187 in restoring a good CD2-induced cord T cell proliferation and by measurement of cellular calcium uptake after activation via the CD2 molecule. Calcium 211-218 CD2 molecule Homo sapiens 256-259 2564856-9 1989 Our findings provide evidence for an intrinsic functional defect in cord CD2-mediated T cell activation, which is linked to an impaired increase of free cytoplasmic calcium, as confirmed by the effectiveness of calcium ionophore A23187 in restoring a good CD2-induced cord T cell proliferation and by measurement of cellular calcium uptake after activation via the CD2 molecule. Calcium 211-218 CD2 molecule Homo sapiens 256-259 2542344-0 1989 Cholera toxin inhibits the increase in cytoplasmic free calcium induced via the CD2 pathway of human T-lymphocyte activation. Calcium 56-63 CD2 molecule Homo sapiens 80-83 2542344-1 1989 We investigated the action of cholera toxin on the intracellular ionized calcium [Ca2+]i increase induced by anti-CD2 and anti-CD3 monoclonal antibodies in the leukemic human T-cell line Jurkat. Calcium 73-80 CD2 molecule Homo sapiens 114-117 2784064-15 1989 Cross-linking of CD2 as well as CD19 antigens on FL 8.2 CD2+ cells caused an increase of intracellular ionized calcium. Calcium 111-118 CD2 molecule Homo sapiens 56-59 2564843-4 1989 Calcium mobilization in CD3- LGL induced by CLB/FcR gran I is associated with inhibition of natural killer cell (NK) killing, and inhibition of the enhanced NK killing induced by the anti-CD2 low-density monoclonal antibody, 9.1. Calcium 0-7 CD2 molecule Homo sapiens 188-191 2536766-5 1989 Before culture, the intracellular calcium mobilization in newborn NK cells induced by mAb to CD2 and CD16 did not differ from that of adult NK cells. Calcium 34-41 CD2 molecule Homo sapiens 93-96 2918858-5 1989 The CD3-CD2, CD3-CD4, CD3-CD6 and CD3-CD8 heteroconjugates each gained two to three orders of magnitude in titer in calcium mobilization compared to unconjugated CD3 or the CD3-CD3 conjugate. Calcium 116-123 CD2 molecule Homo sapiens 8-11 2461305-4 1988 However, combinations of CD2 monoclonal antibodies, that stimulated an increase in the cytoplasmic calcium concentration of the human T cell line Jurkat, failed to induce a similar signal in the transfectants. Calcium 99-106 CD2 molecule Homo sapiens 25-28 3147981-5 1988 In the presence or absence of the monocytes, CD3, as well as certain combinations of CD2 monoclonal antibodies including the D66 monoclonal antibody, were able to increase the intracellular calcium concentration as measured by Quin 2 fluorescence. Calcium 190-197 CD2 molecule Homo sapiens 85-88 3147981-6 1988 EGTA, a Ca++ chelator, completely inhibited CD2- and CD3- mediated T-cell proliferation, indicating that calcium uptake is necessary during the T-cell proliferation. Calcium 105-112 CD2 molecule Homo sapiens 44-47 2973067-2 1988 Formation of homoaggregates of CD3, CD2, or CD28 on the surface of T cells induced by crosslinking with monoclonal antibodies (mAbs) results in an increase in cytoplasmic free calcium concentration ([Ca2+]i). Calcium 176-183 CD2 molecule Homo sapiens 36-39 2444644-7 1987 Thus, when peripheral blood T cells were deprived of cell surface T3/Ti by anti-T3 modulation, anti-T11(2) plus anti-T11(3)-induced mitogenesis and transmembrane signal generation in the form of calcium mobilization were inhibited. Calcium 195-202 CD2 molecule Homo sapiens 100-103 2459194-4 1988 We show here that although purified multimeric LFA-3 is not capable of initiating transmembrane signaling events on its own, the combination of LFA-3 and the anti-CD2 mAb CD2.1 induces intracellular calcium increases, phosphatidylinositol second messenger generation and lymphokine secretion in the T cell leukemic line Jurkat. Calcium 199-206 CD2 molecule Homo sapiens 163-166 2459194-4 1988 We show here that although purified multimeric LFA-3 is not capable of initiating transmembrane signaling events on its own, the combination of LFA-3 and the anti-CD2 mAb CD2.1 induces intracellular calcium increases, phosphatidylinositol second messenger generation and lymphokine secretion in the T cell leukemic line Jurkat. Calcium 199-206 CD2 molecule Homo sapiens 171-174 2899908-3 1988 The HIV-1--infected T cells were unable to mobilize Ca2+ after stimulation with anti-CD3, whereas CD2-induced calcium mobilization remained intact. Calcium 110-117 CD2 molecule Homo sapiens 98-101 2897246-3 1988 Soluble phase anti-CD2 also inhibited accessory cell-dependent increases in intracellular free calcium concentration and cell-to-cell contact among oxidizing mitogen-treated T cells and accessory cells. Calcium 95-102 CD2 molecule Homo sapiens 19-22 2918858-2 1989 In addition to the CD3-T cell receptor complex, the CD2, CD4, CD5, CD7, CD8 and CD28 receptors mobilize cytoplasmic calcium within minutes of binding with monoclonal antibodies and additional crosslinking occurs on the cell surface. Calcium 116-123 CD2 molecule Homo sapiens 52-55 3257905-3 1988 Soluble-phase anti-CD2 also inhibited anti-CD3 and accessory cell-dependent increases in intracellular free calcium concentration. Calcium 108-115 CD2 molecule Homo sapiens 19-22 3257905-4 1988 Crosslinked anti-CD2, on the other hand, mediated an increase in the concentration of intracellular free calcium in T cells. Calcium 105-112 CD2 molecule Homo sapiens 17-20 2444644-7 1987 Thus, when peripheral blood T cells were deprived of cell surface T3/Ti by anti-T3 modulation, anti-T11(2) plus anti-T11(3)-induced mitogenesis and transmembrane signal generation in the form of calcium mobilization were inhibited. Calcium 195-202 CD2 molecule Homo sapiens 117-120 6151183-1 1984 A small and very slow inward calcium current has been identified in isolated single ventricular cells using TTX and Cd2+ to block the sodium and fast calcium currents. Calcium 29-36 CD2 molecule Homo sapiens 116-119 3084290-5 1986 It is shown that calcium mobilization can be induced in these cells by mAb to CD2 and purified PHA but not by anti-CD3 mAb. Calcium 17-24 CD2 molecule Homo sapiens 78-81 3084290-6 1986 This indicates that calcium mobilization can be induced via the CD2 molecule in NK cells not expressing CD3 and that activation through CD2 is separate from the antigen receptor CD3 pathway. Calcium 20-27 CD2 molecule Homo sapiens 64-67 2417941-2 1986 The rise in calcium mobilization induced by purified PHA (PHA-P) does not occur in a cell line which lacks CD2 expression, and can be blocked in other T cells by anti-CD2 antibodies. Calcium 12-19 CD2 molecule Homo sapiens 107-110 2417941-2 1986 The rise in calcium mobilization induced by purified PHA (PHA-P) does not occur in a cell line which lacks CD2 expression, and can be blocked in other T cells by anti-CD2 antibodies. Calcium 12-19 CD2 molecule Homo sapiens 167-170 2417941-3 1986 A combination of monoclonal antibodies to different epitopes of CD2 causes calcium mobilization and mitogenesis. Calcium 75-82 CD2 molecule Homo sapiens 64-67 3103134-1 1987 Antibodies binding to a large subset of T-cell differentiation antigens, including CD2, CD4, CD5, CD6, CD7, CD8, Tp44, and CDw18, cause an increase in the cytoplasmic calcium concentration [( Ca2+]i) after the antigens are crosslinked on the cell surface. Calcium 167-174 CD2 molecule Homo sapiens 83-86 2434339-4 1987 We show that this activation is initiated by a T11-mediated increase in the concentration of free cytoplasmic calcium ions ([Ca2+]i). Calcium 110-117 CD2 molecule Homo sapiens 47-50 6151183-1 1984 A small and very slow inward calcium current has been identified in isolated single ventricular cells using TTX and Cd2+ to block the sodium and fast calcium currents. Calcium 150-157 CD2 molecule Homo sapiens 116-119 29100878-0 2018 N-acetyl-l-cysteine and Mn2+ attenuate Cd2+-induced disturbance of the intracellular free calcium homeostasis in cultured cerebellar granule neurons. Calcium 90-97 CD2 molecule Homo sapiens 39-42 33559717-3 2021 In this study, we used a novel biomaterial based on calcium-crosslinked alginate-encapsulated bacteria to precipitate Cd2+ in polluted water. Calcium 52-59 CD2 molecule Homo sapiens 118-121 33559717-4 2021 Our results show that calcium-crosslinked alginate-encapsulated bacteria effectively removed Cd2+ ions from cadmium-polluted water. Calcium 22-29 CD2 molecule Homo sapiens 93-96 33559717-10 2021 Our results indicated that calcium-crosslinked alginate-encapsulated bacteria are suitable for depletion of Cd2+ in polluted water and for production of CdS nanoparticles. Calcium 27-34 CD2 molecule Homo sapiens 108-111 33559717-11 2021 These calcium-crosslinked alginate-encapsulated bacteria are safe for biological manipulation and can be widely used to produce CdS nanoparticles during bioremediation of Cd2+-polluted water. Calcium 6-13 CD2 molecule Homo sapiens 171-174 33559717-12 2021 KEY POINTS: Calcium-crosslinked alginate-encapsulated bacteria can effectively precipitate Cd2+ in water coupled with production of CdS quantum dots. Calcium 14-21 CD2 molecule Homo sapiens 93-96 31739390-2 2019 In this study, Brassia campestris L. was used as the experimental material and polluted soil with cadmium was used as the experimental soil sample, to explore the competition inhibition of calcium polypeptide application on the absorption of Cd2+ by Brassia campestris L. in the growth process, as well as the effect of calcium application on the growth. Calcium 189-196 CD2 molecule Homo sapiens 242-245 31739390-4 2019 There was a significantly negative correlation between Cd concentration in Brassia campestris L. and calcium application (r = -0.99, p < 0.01) when calcium polypeptide was over-applied, which indicates that the inhibition effect of Cd2+ absorption on Brassia campestris L. is mainly through competitive inhibition rather than passivation. Calcium 101-108 CD2 molecule Homo sapiens 232-235 31739390-4 2019 There was a significantly negative correlation between Cd concentration in Brassia campestris L. and calcium application (r = -0.99, p < 0.01) when calcium polypeptide was over-applied, which indicates that the inhibition effect of Cd2+ absorption on Brassia campestris L. is mainly through competitive inhibition rather than passivation. Calcium 148-155 CD2 molecule Homo sapiens 232-235 31046050-7 2019 The above results suggest that DREAM and probably other members of the neuronal calcium sensor family bind Cd2+ with an affinity that is superior to that for Ca2+ and the interactions between toxic Cd2+ and DREAM and other neuronal calcium sensors provide novel insight into the molecular mechanism of Cd2+ neurotoxicity. Calcium 80-87 CD2 molecule Homo sapiens 107-110 31046050-7 2019 The above results suggest that DREAM and probably other members of the neuronal calcium sensor family bind Cd2+ with an affinity that is superior to that for Ca2+ and the interactions between toxic Cd2+ and DREAM and other neuronal calcium sensors provide novel insight into the molecular mechanism of Cd2+ neurotoxicity. Calcium 80-87 CD2 molecule Homo sapiens 198-201 31046050-7 2019 The above results suggest that DREAM and probably other members of the neuronal calcium sensor family bind Cd2+ with an affinity that is superior to that for Ca2+ and the interactions between toxic Cd2+ and DREAM and other neuronal calcium sensors provide novel insight into the molecular mechanism of Cd2+ neurotoxicity. Calcium 80-87 CD2 molecule Homo sapiens 198-201 31046050-7 2019 The above results suggest that DREAM and probably other members of the neuronal calcium sensor family bind Cd2+ with an affinity that is superior to that for Ca2+ and the interactions between toxic Cd2+ and DREAM and other neuronal calcium sensors provide novel insight into the molecular mechanism of Cd2+ neurotoxicity. Calcium 232-239 CD2 molecule Homo sapiens 107-110 31046050-7 2019 The above results suggest that DREAM and probably other members of the neuronal calcium sensor family bind Cd2+ with an affinity that is superior to that for Ca2+ and the interactions between toxic Cd2+ and DREAM and other neuronal calcium sensors provide novel insight into the molecular mechanism of Cd2+ neurotoxicity. Calcium 232-239 CD2 molecule Homo sapiens 198-201 31046050-7 2019 The above results suggest that DREAM and probably other members of the neuronal calcium sensor family bind Cd2+ with an affinity that is superior to that for Ca2+ and the interactions between toxic Cd2+ and DREAM and other neuronal calcium sensors provide novel insight into the molecular mechanism of Cd2+ neurotoxicity. Calcium 232-239 CD2 molecule Homo sapiens 198-201 410009-0 1977 Studes of calcium absorption in man using a CD-2 whole-body counter. Calcium 10-17 CD2 molecule Homo sapiens 44-48 29100878-4 2018 Using Fluo-4 AM, measurements of intracellular calcium ions demonstrated that 24h-exposure to Cd2+ induced intensive increase of Fluo-4 fluorescence in neurons accompanied by mitochondria swelling. Calcium 47-54 CD2 molecule Homo sapiens 94-97 20813844-5 2010 IL-2-activated NK cells cultured in the absence of 2B4/CD48 or CD2/CD58 interactions were severely impaired for their ability to induce intracellular calcium mobilization and subsequent ERK activation upon tumor target exposure, suggesting that the early signaling pathway of NK receptors leading to impaired cytolysis and interferon (IFN)-gamma secretion was inhibited. Calcium 150-157 CD2 molecule Homo sapiens 63-66 19177362-6 2009 Subsequently, OptGraft is used to guide the transfer of a calcium-binding pocket from thermitase protein (PDB: 1thm) into the first domain of CD2 protein (PDB:1hng). Calcium 58-65 CD2 molecule Homo sapiens 142-145 17220479-0 2007 CD2 and TCR synergize for the activation of phospholipase Cgamma1/calcium pathway at the immunological synapse. Calcium 66-73 CD2 molecule Homo sapiens 0-3 18287277-0 2008 Rational design of a novel calcium-binding site adjacent to the ligand-binding site on CD2 increases its CD48 affinity. Calcium 27-34 CD2 molecule Homo sapiens 87-90 17220479-2 2007 We investigated the contribution of the accessory molecule CD2 to the activation of phospholipase Cgamma1 (PLCgamma1)/calcium pathway in antigen-stimulated T cells. Calcium 118-125 CD2 molecule Homo sapiens 59-62 12147347-2 2002 We have successfully engineered a series of model proteins, each containing a single EF-hand loop but with increasing numbers of Gly residues linking the EF-hand loop to a scaffold protein, cluster of differentiation 2 (CD2), to obtain the site-specific calcium-binding ability of a protein with EF-hand motifs without the interference of cooperativity. Calcium 254-261 CD2 molecule Homo sapiens 220-223 12785848-2 2003 We have introduced a de novo designed calcium-binding site into the framework of a non-calcium-binding protein, domain 1 of CD2. Calcium 38-45 CD2 molecule Homo sapiens 124-127 12785848-2 2003 We have introduced a de novo designed calcium-binding site into the framework of a non-calcium-binding protein, domain 1 of CD2. Calcium 87-94 CD2 molecule Homo sapiens 124-127 12147347-3 2002 Loop III of calmodulin with two Gly linkers in CD2 (CaM-CD2-III-5G) has metal affinities with K(d) values of 1.86 x 10(-4) and 5.8 x 10(-5) M for calcium and lanthanum, respectively. Calcium 146-153 CD2 molecule Homo sapiens 47-50 12147347-3 2002 Loop III of calmodulin with two Gly linkers in CD2 (CaM-CD2-III-5G) has metal affinities with K(d) values of 1.86 x 10(-4) and 5.8 x 10(-5) M for calcium and lanthanum, respectively. Calcium 146-153 CD2 molecule Homo sapiens 52-66 12200539-1 2002 To understand the key determinants in calcium-binding affinity, a calcium-binding site with pentagonal bipyramid geometry was designed into a non-calcium-binding protein, domain 1 of CD2. Calcium 38-45 CD2 molecule Homo sapiens 183-186 12200539-1 2002 To understand the key determinants in calcium-binding affinity, a calcium-binding site with pentagonal bipyramid geometry was designed into a non-calcium-binding protein, domain 1 of CD2. Calcium 66-73 CD2 molecule Homo sapiens 183-186 12200539-1 2002 To understand the key determinants in calcium-binding affinity, a calcium-binding site with pentagonal bipyramid geometry was designed into a non-calcium-binding protein, domain 1 of CD2. Calcium 66-73 CD2 molecule Homo sapiens 183-186 11809931-3 2001 In addition, calcium binding to the engineered CD2 variants does not result in a significant change from native CD2 conformation. Calcium 13-20 CD2 molecule Homo sapiens 47-50 11948788-6 2002 Using the established method, we have designed de novo calcium-binding sites into the scaffold of non-calcium-binding proteins CD2 and Rop. Calcium 55-62 CD2 molecule Homo sapiens 127-130 11948788-6 2002 Using the established method, we have designed de novo calcium-binding sites into the scaffold of non-calcium-binding proteins CD2 and Rop. Calcium 102-109 CD2 molecule Homo sapiens 127-130 12102281-5 2002 Computed tomography (CT) and magnetic resonance imaging (MRI) of the thoracic spine showed calcium-density masses that were in contact with the neural arches and bulged into the spinal canal at T5/T6, T7/T8, T9/T10, and T10/T11. Calcium 91-98 CD2 molecule Homo sapiens 224-227 11376005-5 2001 Structural integrity of rafts is necessary for CD2-stimulated elevation of intracellular free calcium and tyrosine phosphorylation of cellular substrates. Calcium 94-101 CD2 molecule Homo sapiens 47-50 11093148-7 2000 By contrast, CD2-induced PLCgamma-1 tyrosine phosphorylation and calcium response progressively diminished. Calcium 65-72 CD2 molecule Homo sapiens 13-16