PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 6483108-6 1984 Calcium accumulated in mitochondria of basal dendrites and in the soma of pyramidal neurons in CA1 and CA3. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 95-98 6481633-0 1984 Low-calcium field burst discharges of CA1 pyramidal neurones in rat hippocampal slices. Calcium 4-11 carbonic anhydrase 1 Rattus norvegicus 38-41 6202691-5 1984 (1980) Biochemistry 19, 2396-2404) showed a rapid increase in free cytosol calcium concentration [( Ca]i) when histamine release was induced. Calcium 75-82 carbonic anhydrase 1 Rattus norvegicus 100-104 6089047-0 1984 GABA and baclofen reduce changes in extracellular free calcium in area CA1 of rat hippocampal slices. Calcium 55-62 carbonic anhydrase 1 Rattus norvegicus 71-74 7110639-3 1982 After status epilepticus, mitochondrial calcium deposits increased, particularly in the swollen mitochondria of the pyramidal cell bodies and basal dendrites of CA3 and CA1 neurones. Calcium 40-47 carbonic anhydrase 1 Rattus norvegicus 169-172 6328954-3 1984 In hippocampal slices from rats a mechanism for this modulation is described, on pyramidal neurones of the CA 1 area: Strong excitations induced by intracellular current injection, ionophoretic administration of glutamate or synaptic stimulation normally restrict themselves by the activation of the calcium-dependent potassium current (gK(Ca) ). Calcium 300-307 carbonic anhydrase 1 Rattus norvegicus 107-111 6843893-0 1983 Aspartate and glutamate induced reductions in extracellular free calcium and sodium concentration in area CA1 of "in vitro" hippocampal slices of rats. Calcium 65-72 carbonic anhydrase 1 Rattus norvegicus 106-109 7284771-2 1981 The results indicate that tetanic stimulation of the Schaffer-commissural input produces a significant increase in the uptake and retention of calcium which parallels LTP of the CA1 population spike response. Calcium 143-150 carbonic anhydrase 1 Rattus norvegicus 178-181 32272151-5 2020 We verified that the blockade of AMPA receptors (AMPAr) and L-VDCCs calcium channels impaired ORM consolidation and reconsolidation when administered into CA1 immediately after sample phase or reactivation phase and that these impairments were blocked by the administration of AMPAr agonist and of neurotrophin BDNF. Calcium 68-75 carbonic anhydrase 1 Rattus norvegicus 155-158 29313229-1 2018 A neuroprotective and nootropic drug Noopept increased the frequency of spontaneous calcium transients in neurons of CA1 radial layer in cultured rat hippocampal slices. Calcium 84-91 carbonic anhydrase 1 Rattus norvegicus 117-120 30242046-3 2018 Here, we show that muscarinic M1 receptor (M1R) and type 1 metabotropic glutamate receptor (mGluR1) signaling pathways, which are known to inhibit SK channels and thereby disinhibit NMDA receptors, converge to facilitate spine calcium transients during the induction of long-term potentiation (LTP) at hippocampal Schaffer collateral synapses onto CA1 pyramidal neurons of male rats. Calcium 227-234 carbonic anhydrase 1 Rattus norvegicus 348-351 28039042-0 2017 Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing CA1 pyramidal neurons. Calcium 30-37 carbonic anhydrase 1 Rattus norvegicus 120-123 28039042-0 2017 Role of low-voltage-activated calcium current and extracellular calcium in controlling the firing pattern of developing CA1 pyramidal neurons. Calcium 64-71 carbonic anhydrase 1 Rattus norvegicus 120-123 27560991-2 2016 In the present work, we characterized the cDNAs of four Paracoccidioides CAs (CA1, CA2, CA3, and CA4). Calcium 73-76 carbonic anhydrase 1 Rattus norvegicus 78-81 27604243-1 2017 Aberrant calcium influx is a common feature following ischemic reperfusion (I/R) in transient global cerebral ischemia (GCI) and causes delayed neuronal cell death in the CA1 region of the hippocampus. Calcium 9-16 carbonic anhydrase 1 Rattus norvegicus 171-174 26021702-7 2015 Furthermore, we demonstrate that the reduction of glutamatergic transmission by serotonin is likely to be mediated via a decrease of calcium influx into presynaptic terminals of CA1 pyramidal cells. Calcium 133-140 carbonic anhydrase 1 Rattus norvegicus 178-181 22593048-8 2012 These results indicate that synaptic plasticity in stratum radiatum of CA1 can be homeostatically regulated by the cell-wide history of synaptic activity through a calcium-dependent but action potential-independent mechanism. Calcium 164-171 carbonic anhydrase 1 Rattus norvegicus 71-74 25924998-4 2015 Biochemical and electrophysiological approaches showed that MNNG exposure caused an increased expression and function of the calcium permeable alpha-amino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) channels in the CA1 but not in the CA3 hippocampal region. Calcium 125-132 carbonic anhydrase 1 Rattus norvegicus 224-227 24674276-0 2014 Intracellular calcium elevation during plateau potentials mediated by extrasynaptic NMDA receptor activation in rat hippocampal CA1 pyramidal neurons is primarily due to calcium entry through voltage-gated calcium channels. Calcium 14-21 carbonic anhydrase 1 Rattus norvegicus 128-131 24674276-0 2014 Intracellular calcium elevation during plateau potentials mediated by extrasynaptic NMDA receptor activation in rat hippocampal CA1 pyramidal neurons is primarily due to calcium entry through voltage-gated calcium channels. Calcium 170-177 carbonic anhydrase 1 Rattus norvegicus 128-131 23637181-0 2013 Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons. Calcium 8-15 carbonic anhydrase 1 Rattus norvegicus 36-39 23637181-2 2013 Using CCD and two-photon calcium imaging techniques on CA1 pyramidal neurons from young and aged rats, we show that calcium influx across the plasma membrane increases with aging, and that this change is countered by increased intracellular calcium buffering. Calcium 116-123 carbonic anhydrase 1 Rattus norvegicus 55-58 23637181-2 2013 Using CCD and two-photon calcium imaging techniques on CA1 pyramidal neurons from young and aged rats, we show that calcium influx across the plasma membrane increases with aging, and that this change is countered by increased intracellular calcium buffering. Calcium 116-123 carbonic anhydrase 1 Rattus norvegicus 55-58 23637181-4 2013 Our results demonstrate that calcium overload occurs regularly in aging CA1 pyramidal neurons under physiological conditions. Calcium 29-36 carbonic anhydrase 1 Rattus norvegicus 72-75 25707258-0 2014 [The key role of calcium in the mechanism of deprivational potentiation of population responses in hippocampal CA1 neurons]. Calcium 17-24 carbonic anhydrase 1 Rattus norvegicus 111-114 25707258-1 2014 We investigated a role of calcium in the mechanisms of deprivational potentiation (DeP) of the popspikes amplitude of CA1 neurons that was induced in consequence of long (60 min) interruption of rare test stimulation (0.05 Hz) of Schaffer collaterals in rat hippocampal slices. Calcium 26-33 carbonic anhydrase 1 Rattus norvegicus 118-121 19589863-2 2009 A well-documented example concerns corticosteroid effects on high-voltage activated (L type) calcium currents in the hippocampal CA1 area. Calcium 93-100 carbonic anhydrase 1 Rattus norvegicus 129-132 21697385-4 2011 In the CA1 region of the hippocampus from rats, we found that bulk loading of calcium indicator dyes only reports on calcium signals within the soma and in the most proximal processes, leaving ~90% of the area of an astrocyte and its extensive processes unsampled. Calcium 78-85 carbonic anhydrase 1 Rattus norvegicus 7-10 21156150-0 2010 Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons. Calcium 8-15 carbonic anhydrase 1 Rattus norvegicus 113-116 21156150-0 2010 Nuclear calcium sensors reveal that repetition of trains of synaptic stimuli boosts nuclear calcium signaling in CA1 pyramidal neurons. Calcium 92-99 carbonic anhydrase 1 Rattus norvegicus 113-116 21156150-4 2010 Here, we used stereotaxic delivery to the rat brain of recombinant adeno-associated viruses encoding nuclear-targeted calcium sensors to assess nuclear calcium transients in CA1 pyramidal neurons after stimulation of the Schaffer collaterals. Calcium 118-125 carbonic anhydrase 1 Rattus norvegicus 174-177 21156150-4 2010 Here, we used stereotaxic delivery to the rat brain of recombinant adeno-associated viruses encoding nuclear-targeted calcium sensors to assess nuclear calcium transients in CA1 pyramidal neurons after stimulation of the Schaffer collaterals. Calcium 152-159 carbonic anhydrase 1 Rattus norvegicus 174-177 20685930-10 2010 Taken together, these findings support synaptic, calcium permeable AMPARs at a subset of synapses onto CA1 pyramidal neurons exclusively at P5-7. Calcium 49-56 carbonic anhydrase 1 Rattus norvegicus 103-106 19475649-1 2010 Synaptically activated calcium release from internal stores in CA1 pyramidal neurons is generated via metabotropic glutamate receptors by mobilizing IP(3). Calcium 23-30 carbonic anhydrase 1 Rattus norvegicus 63-66 20128049-0 2010 Icariin inhibits the increased inward calcium currents induced by amyloid-beta(25-35) peptide in CA1 pyramidal neurons of neonatal rat hippocampal slice. Calcium 38-45 carbonic anhydrase 1 Rattus norvegicus 97-100 21917800-2 2011 We used functional multineuron calcium imaging to monitor the spike outputs from thousands of CA1 neurons in response to the stimulation of two independent sites of the dentate gyrus in rat hippocampal networks ex vivo. Calcium 31-38 carbonic anhydrase 1 Rattus norvegicus 94-97 19628026-10 2010 DHPG induced calcium responses in CA1 interneurons as in CA3, and the responses were partially inhibited by MPEP treatment. Calcium 13-20 carbonic anhydrase 1 Rattus norvegicus 34-37 17228340-0 2007 Brief RU 38486 treatment normalizes the effects of chronic stress on calcium currents in rat hippocampal CA1 neurons. Calcium 69-76 carbonic anhydrase 1 Rattus norvegicus 105-108 18339118-6 2008 The NO and intracellular calcium ([Ca2+]i) levels in the CA1 region of hippocampal slices were measured by electrochemical microsenor and spectrofluorometry, respectively. Calcium 25-32 carbonic anhydrase 1 Rattus norvegicus 57-60 19215725-0 2009 Impaired presynaptic cytosolic and mitochondrial calcium dynamics in aged compared to young adult hippocampal CA1 synapses ameliorated by calcium chelation. Calcium 49-56 carbonic anhydrase 1 Rattus norvegicus 110-113 19215725-0 2009 Impaired presynaptic cytosolic and mitochondrial calcium dynamics in aged compared to young adult hippocampal CA1 synapses ameliorated by calcium chelation. Calcium 138-145 carbonic anhydrase 1 Rattus norvegicus 110-113 18684909-9 2008 Testing for other SK channel functions in CA1, we found that field excitatory postsynaptic potentials mediated by NMDARs were enhanced by apamin, supporting the idea that dendritic SK channels are activated by NMDAR-dependent calcium influx. Calcium 226-233 carbonic anhydrase 1 Rattus norvegicus 42-45 17996205-4 2008 The levels of endogenous NO and intracellular calcium in the CA1 region of the hippocampal slices were measured respectively by electrochemical microsensors and spectrofluorometry. Calcium 46-53 carbonic anhydrase 1 Rattus norvegicus 61-64 17690146-0 2007 Priming of intracellular calcium stores in rat CA1 pyramidal neurons. Calcium 25-32 carbonic anhydrase 1 Rattus norvegicus 47-50 17228340-2 2007 In the present study, we examined (i) whether unpredictable stress during 21 days affects calcium (Ca) currents of CA1 pyramidal neurons recorded on day 22; and (ii) if so, whether this change is normalized by treatment with the glucocorticoid receptor-antagonist RU 38486 during days 18-21. Calcium 90-97 carbonic anhydrase 1 Rattus norvegicus 115-118 17228340-8 2007 In conclusion, the data indicate that chronic stress, RU 38486 treatment as well as acute rises in corticosterone level strongly modulate calcium influx into CA1 neurons. Calcium 138-145 carbonic anhydrase 1 Rattus norvegicus 158-161 17223275-4 2007 In this study, the intracellular Ca2+ increase of hippocampal CA1 neurons, induced by the protocol of timing between pre- and post-synaptic excitation (i.e. STDP protocol), was measured spatially by using optical imaging to investigate how the triggering of STDP is dependent on intracellular calcium concentration. Calcium 293-300 carbonic anhydrase 1 Rattus norvegicus 62-65 17494711-9 2007 Together, the present results suggest that ischemia-induced inhibition of L-type calcium currents may give rise to delayed death of neurons in the CA1 region, possibly via oxidation mechanisms. Calcium 81-88 carbonic anhydrase 1 Rattus norvegicus 147-150 17272348-0 2007 Dendritic signals from rat hippocampal CA1 pyramidal neurons during coincident pre- and post-synaptic activity: a combined voltage- and calcium-imaging study. Calcium 136-143 carbonic anhydrase 1 Rattus norvegicus 39-42 16457957-0 2006 Lead inhibited N-methyl-D-aspartate receptor-independent long-term potentiation involved ryanodine-sensitive calcium stores in rat hippocampal area CA1. Calcium 109-116 carbonic anhydrase 1 Rattus norvegicus 148-151 17097230-1 2007 The CA1 region of the rat hippocampal slice generates spontaneous electrographic seizures (field bursts) when exposed to ACSF containing < or = 0.2 mM calcium. Calcium 154-161 carbonic anhydrase 1 Rattus norvegicus 4-7 16457957-3 2006 The present study was carried out to investigate whether the alterations of N-methyl-d-aspartate (NMDA) receptor-independent LTP following lead exposure involve internal calcium stores in hippocampus CA1 synapses. Calcium 170-177 carbonic anhydrase 1 Rattus norvegicus 200-203 16457957-10 2006 Taken together, these results demonstrated that lead inhibited NMDA receptor-independent LTP by action on calcium release and uptake by ryanodine-sensitive stores in rat hippocampal area CA1. Calcium 106-113 carbonic anhydrase 1 Rattus norvegicus 187-190 15211157-0 2004 Small physiologic changes in calcium and magnesium alter excitability and burst firing of CA1 pyramidal cells in rat hippocampal slices. Calcium 29-36 carbonic anhydrase 1 Rattus norvegicus 90-93 16483552-1 2006 During a period of acute ischemia in vivo or oxygen-glucose deprivation (OGD) in vitro, CA1 neurons depolarize, swell and become overloaded with calcium. Calcium 145-152 carbonic anhydrase 1 Rattus norvegicus 88-91 16039651-3 2006 Resting calcium, in presynaptic axonal terminals in the CA1 stratum radiatum area, was elevated in aged slices. Calcium 8-15 carbonic anhydrase 1 Rattus norvegicus 56-59 16385225-1 2005 BACKGROUND: Activation of Kupffer cells by lipopolysaccharide (LPS) plays a pivotal role in the onset of pathophysiological events that occur during endotoxemia and intracellular calcium ([Ca]i) is involved in LPS-stimulated cytokine production. Calcium 179-186 carbonic anhydrase 1 Rattus norvegicus 189-193 12686387-0 2003 Differential alterations of the inactivation properties of high voltage activated calcium currents in area CA1 and CA3 of the rat following photothrombotic lesion. Calcium 82-89 carbonic anhydrase 1 Rattus norvegicus 107-110 12865167-0 2003 Effect of hypoxia on calcium channels depends on extracellular calcium in CA1 hippocampal neurons. Calcium 21-28 carbonic anhydrase 1 Rattus norvegicus 74-77 12686387-3 2003 The whole-cell patch-clamp technique was used to investigate calcium current properties of hippocampal neurons (CA1 and CA3) 7 days after infarct induction. Calcium 61-68 carbonic anhydrase 1 Rattus norvegicus 112-115 12591156-2 2003 Calcium currents through L-type voltage-sensitive calcium channels (L-VSCCs) are increased in CA1 neurons of the hippocampus of aged rats. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 94-97 12735631-13 2003 Perfusion of DHPG reduced three calcium-dependent responses in CA3 pyramidal neurons, which are presynaptic to CA1 neurons. Calcium 32-39 carbonic anhydrase 1 Rattus norvegicus 111-114 12591156-3 2003 We have recently shown that expression of the calcium conducting L-VSCC subunit alpha(1D) (Ca(v)1.3) is selectively increased in area CA1 of aged rats. Calcium 46-53 carbonic anhydrase 1 Rattus norvegicus 134-137 12425941-1 2002 Calcium currents through the L-type voltage-sensitive calcium channel (L-VSCC) are increased in neurons of area CA1 of the hippocampus in aged rats and rabbits. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 112-115 11484817-7 2001 These findings modify the GluR2 hypothesis in so far as only a subset of, but not all, hippocampal CA1 and CA3 pyramidal neurons may die due to reduced GluR2 levels with consecutive calcium overload through calcium-permeable AMPA receptors. Calcium 182-189 carbonic anhydrase 1 Rattus norvegicus 99-102 12205182-0 2002 Spatial segregation and interaction of calcium signalling mechanisms in rat hippocampal CA1 pyramidal neurons. Calcium 39-46 carbonic anhydrase 1 Rattus norvegicus 88-91 12270046-0 2002 Differential and long-lasting alterations of high-voltage activated calcium currents in CA1 and dentate granule neurons after status epilepticus. Calcium 68-75 carbonic anhydrase 1 Rattus norvegicus 88-91 12270046-2 2002 Whole-cell voltage-clamp recordings in dissociated CA1 neurons of LT rats showed a decrease in the sustained HVA calcium current amplitude and a faster inactivation of the current both in rats that had experienced a status epilepticus (post-SE rats) and those in which the stimulation did not lead to SE (non-SE rats). Calcium 113-120 carbonic anhydrase 1 Rattus norvegicus 51-54 12163539-0 2002 Extrusion of intracellular calcium ion after in vitro ischemia in the rat hippocampal CA1 region. Calcium 27-34 carbonic anhydrase 1 Rattus norvegicus 86-89 11750920-0 2002 Effect of phenytoin on sodium and calcium currents in hippocampal CA1 neurons of phenytoin-resistant kindled rats. Calcium 34-41 carbonic anhydrase 1 Rattus norvegicus 66-69 11535677-2 2001 In area CA1 calcium influx through N-methyl-D-aspartate receptors (NMDARs; nmdaLTP) and/or L-type voltage-dependent calcium channels (vdccLTP) results in distinct forms of LTP. Calcium 12-19 carbonic anhydrase 1 Rattus norvegicus 8-11 11553300-1 2001 Adrenal corticosteroid hormones modulate voltage-gated calcium currents in rat CA1 hippocampal neurons. Calcium 55-62 carbonic anhydrase 1 Rattus norvegicus 79-82 11484817-7 2001 These findings modify the GluR2 hypothesis in so far as only a subset of, but not all, hippocampal CA1 and CA3 pyramidal neurons may die due to reduced GluR2 levels with consecutive calcium overload through calcium-permeable AMPA receptors. Calcium 207-214 carbonic anhydrase 1 Rattus norvegicus 99-102 11373474-6 2001 The effect of anesthetics on NMDA receptors was determined by measuring the NMDA-mediated changes in intracellular calcium in the CA1 pyramidal layer with a calcium indicator, fura-2. Calcium 115-122 carbonic anhydrase 1 Rattus norvegicus 130-133 11373474-6 2001 The effect of anesthetics on NMDA receptors was determined by measuring the NMDA-mediated changes in intracellular calcium in the CA1 pyramidal layer with a calcium indicator, fura-2. Calcium 157-164 carbonic anhydrase 1 Rattus norvegicus 130-133 10684874-3 2000 With two-photon microscopy we investigate action potential-induced calcium dynamics in spines from rat CA1 pyramidal neurons in slices. Calcium 67-74 carbonic anhydrase 1 Rattus norvegicus 103-106 11306194-0 2001 Characteristics of protective effects of NMDA antagonist and calcium channel antagonist on ischemic calcium accumulation in rat hippocampal CA1 region. Calcium 61-68 carbonic anhydrase 1 Rattus norvegicus 140-143 10822152-6 2000 It is concluded that ventral hippocampus CA1 area has a specific deficit in STP, which is related to the important presynaptic role of calcium and is consistent with a relatively higher transmitter release probability. Calcium 135-142 carbonic anhydrase 1 Rattus norvegicus 41-44 11113507-0 2000 Kinetic parameters of calcium currents in maturing acutely isolated CA1 cells. Calcium 22-29 carbonic anhydrase 1 Rattus norvegicus 68-71 11113507-1 2000 Calcium currents were recorded in CA1 hippocampal cells from immature (P(4-10)) and older (P(22-55)) rats, using whole-cell voltage clamp techniques. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 34-37 10899202-4 2000 We, therefore, tested the hypothesis that low-calcium bursting induced in the CA1 region of transverse and longitudinal hippocampal slices should be highly sensitive to exogenous electric fields. Calcium 46-53 carbonic anhydrase 1 Rattus norvegicus 78-81 10899202-11 2000 These results suggest that DC fields modulate and suppress low-calcium activity by directly polarizing CA1 pyramidal cells. Calcium 63-70 carbonic anhydrase 1 Rattus norvegicus 103-106 10726208-7 2000 During the second postnatal week, in the presence of bicuculline, calcium signals associated with interictal discharges evoked by stimulation of glutamatergic fibres propagated along the well-defined three-synaptic pathway from the dentate gyrus to the CA1 hippocampal area. Calcium 66-73 carbonic anhydrase 1 Rattus norvegicus 253-256 10065988-1 1999 A rapid fluorescence imaging system was developed and utilised to investigate the time-course of intracellular calcium concentration ([Ca2+]i) gradients generated by action potentials in CA1-CA3 pyramidal cells within brain slices of the rat hippocampus. Calcium 111-118 carbonic anhydrase 1 Rattus norvegicus 187-190 10618149-11 2000 Consistent with the frequency-dependent spike broadening, calcium imaging experiments from single CA1 pyramidal neurones revealed that high frequency Schaffer collateral stimulation resulted in a prolonged elevation of dendritic [Ca2+]i transients only in antisense-treated neurones. Calcium 58-65 carbonic anhydrase 1 Rattus norvegicus 98-101 10562341-0 1999 Calcium dependence of depolarization-induced suppression of inhibition in rat hippocampal CA1 pyramidal neurons. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 90-93 10515989-1 1999 In hippocampal CA1 pyramidal cells, intracellular calcium increases are required for induction of long-term potentiation (LTP), an activity-dependent synaptic plasticity. Calcium 50-57 carbonic anhydrase 1 Rattus norvegicus 15-18 10515989-4 1999 We investigated postnatal development of intracellular calcium dynamics in the proximal apical dendrites of CA1 pyramidal cells by whole cell patch-clamp recordings and calcium imaging with the Ca(2+) indicator fura-2. Calcium 55-62 carbonic anhydrase 1 Rattus norvegicus 108-111 10482734-0 1999 Changes in the calcium dependence of glutamate transmission in the hippocampal CA1 region after brief hypoxia-hypoglycemia. Calcium 15-22 carbonic anhydrase 1 Rattus norvegicus 79-82 10482734-4 1999 Reducing calcium influx, by applying a nonspecific calcium channel blocker Co2+ or lowering external Ca2+, attenuated CA1 synaptic potentials much less in challenged slices than in controls. Calcium 9-16 carbonic anhydrase 1 Rattus norvegicus 118-121 11324580-3 1998 With this improvement of labeling and the use of the confocal laser scanning microscope (Leica Lasetechnik GmbH), changes of calcium fluorescence intensity in CA1 pyramidal cells of rat hippocampal slices on the models of mimic epilepsy (induced by penicillin or glutamate) or hypoglycemia/hypoxia were studied in vitro. Calcium 125-132 carbonic anhydrase 1 Rattus norvegicus 159-162 9920654-0 1999 Differential modulation of synaptic transmission by calcium chelators in young and aged hippocampal CA1 neurons: evidence for altered calcium homeostasis in aging. Calcium 52-59 carbonic anhydrase 1 Rattus norvegicus 100-103 9739984-5 1998 Since mGluR5 is the only metabotropic glutamate receptor subtype coupled to inositide turnover in field CA1, we conclude that the postsynaptic calcium store necessary for the induction of homosynaptic LTD is gated by IP3, through activation of mGluR5 coupled to phospholipase C. Calcium 143-150 carbonic anhydrase 1 Rattus norvegicus 104-107 9878884-0 1999 Protein tyrosine kinase inhibitors reduce high-voltage activating calcium currents in CA1 pyramidal neurones from rat hippocampal slices. Calcium 66-73 carbonic anhydrase 1 Rattus norvegicus 86-89 9878884-1 1999 We have investigated the effects of protein tyrosine kinases (PTKs) inhibitors on high-threshold voltage activating (HVA) calcium currents in CA1 pyramidal neurones, whole-cell patch-clamp recorded from rat hippocampal slices. Calcium 122-129 carbonic anhydrase 1 Rattus norvegicus 142-145 10211022-4 1998 Concentrations of [Ca2+]i in the pyramidal cell layer of the CA1 region were measured using a calcium indicator dye, fura-2. Calcium 94-101 carbonic anhydrase 1 Rattus norvegicus 61-64 11324580-4 1998 The results showed that in magnesium free artificial CSF, the intracellular calcium level of the CA1 pyramidal cells increased following application of glutamate or penicillin. Calcium 76-83 carbonic anhydrase 1 Rattus norvegicus 97-100 9554954-9 1998 Glutamate receptor-mediated calcium changes in CA1 during hypoxia were 33% and 62% of the total calcium change in PND 3-7 and PND 18-22 CA1, respectively. Calcium 28-35 carbonic anhydrase 1 Rattus norvegicus 47-50 9554954-9 1998 Glutamate receptor-mediated calcium changes in CA1 during hypoxia were 33% and 62% of the total calcium change in PND 3-7 and PND 18-22 CA1, respectively. Calcium 28-35 carbonic anhydrase 1 Rattus norvegicus 136-139 9554954-9 1998 Glutamate receptor-mediated calcium changes in CA1 during hypoxia were 33% and 62% of the total calcium change in PND 3-7 and PND 18-22 CA1, respectively. Calcium 96-103 carbonic anhydrase 1 Rattus norvegicus 47-50 9554954-9 1998 Glutamate receptor-mediated calcium changes in CA1 during hypoxia were 33% and 62% of the total calcium change in PND 3-7 and PND 18-22 CA1, respectively. Calcium 96-103 carbonic anhydrase 1 Rattus norvegicus 136-139 9554954-10 1998 We conclude that survival of CA1 neurons in PND 3-7 slices following hypoxic stress is associated with smaller increases and enhanced recovery of [Ca2+]i, less accumulation of glutamate, and less glutamate receptor-mediated calcium influx than in PND 18-22 slices. Calcium 224-231 carbonic anhydrase 1 Rattus norvegicus 29-32 9813494-0 1997 [Effect of adenosine on intracellular free calcium in cultured rat hippocampal CA1 neurons during anoxia]. Calcium 43-50 carbonic anhydrase 1 Rattus norvegicus 79-82 9490842-2 1998 By applying fura-2-based fluorometric calcium imaging to neonatal rat hippocampal slices we identified a developmentally regulated spontaneous neuronal activity in the CA1 region of the hippocampus. Calcium 38-45 carbonic anhydrase 1 Rattus norvegicus 168-171 9473603-2 1998 All of these depolarizing agents elicited a decrease in pHi and an elevation of intracellular calcium ([Ca2+]i) in the CA1 pyramidal cell layer. Calcium 94-101 carbonic anhydrase 1 Rattus norvegicus 119-122 9263588-0 1997 Development of HVA and LVA calcium currents in pyramidal CA1 neurons in the hippocampus of the rat. Calcium 27-34 carbonic anhydrase 1 Rattus norvegicus 57-60 9263588-1 1997 High voltage activated (HVA) and low voltage activated (LVA) calcium currents were recorded in acutely dissociated CA1 hippocampal pyramidal neurons of the rat during the first three postnatal weeks as well as in adults. Calcium 61-68 carbonic anhydrase 1 Rattus norvegicus 115-118 9153649-0 1997 Corticosteroid effects on sodium and calcium currents in acutely dissociated rat CA1 hippocampal neurons. Calcium 37-44 carbonic anhydrase 1 Rattus norvegicus 81-84 9217967-0 1997 Characterisation of the role of calcium in AlF4-induced long-term potentiation in area CA1 of rat hippocampus. Calcium 32-39 carbonic anhydrase 1 Rattus norvegicus 87-90 9217967-1 1997 We investigated calcium influx in the long lasting potentiation induced in area CA1 of rat hippocampus by brief bath application of the G-protein activator A1F4-(NaF/AlCl3). Calcium 16-23 carbonic anhydrase 1 Rattus norvegicus 80-83 9027871-0 1997 Removal of extracellular calcium after conditioning stimulation disrupts long-term potentiation in the CA1 region of rat hippocampal slices. Calcium 25-32 carbonic anhydrase 1 Rattus norvegicus 103-106 8815908-0 1996 Aging changes in voltage-gated calcium currents in hippocampal CA1 neurons. Calcium 31-38 carbonic anhydrase 1 Rattus norvegicus 63-66 9120579-0 1997 Mediation by intracellular calcium-dependent signals of hypoxic hyperpolarization in rat hippocampal CA1 neurons in vitro. Calcium 27-34 carbonic anhydrase 1 Rattus norvegicus 101-104 8923523-0 1996 Calcium currents in pyramidal CA1 neurons in vitro after kindling epileptogenesis in the hippocampus of the rat. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 30-33 8901621-0 1996 Polyunsaturated fatty acids modulate sodium and calcium currents in CA1 neurons. Calcium 48-55 carbonic anhydrase 1 Rattus norvegicus 68-71 8815908-1 1996 Previous current-clamp studies in rat hippocampal slice CA1 neurons have found aging-related increases in long-lasting calcium (Ca)-dependent and Ca-mediated potentials. Calcium 119-126 carbonic anhydrase 1 Rattus norvegicus 56-59 8853085-6 1996 Glutamate receptor activity was determined by the change in cytosolic calcium concentration in CA1 neurons in the presence and absence of 100 nM dexmedetomidine during administration of N-methyl-D-aspartate (100 microM) and during simulated ischemic penumbra conditions (PO2 = 20 mmHg, glutamate 3 mM). Calcium 70-77 carbonic anhydrase 1 Rattus norvegicus 95-98 8899608-0 1996 Calcium dependence of LTP induced by 2-deoxyglucose in CA1 neurons. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 55-58 8890325-0 1996 Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. Calcium 30-37 carbonic anhydrase 1 Rattus norvegicus 62-65 7791901-3 1995 Using two-photon microscopy to image fluorescence with high resolution in strongly scattering tissue, we measured calcium dynamics in spines from CA1 pyramidal neurons in slices of rat hippocampus. Calcium 114-121 carbonic anhydrase 1 Rattus norvegicus 146-149 8883886-2 1996 Like long-term potentiation (LTP), homosynaptic LTD in area CA1 of the hippocampus appears to require NMDA receptor activation, changes in postsynaptic calcium concentration and phospholipase A2 (PLA2) activation. Calcium 152-159 carbonic anhydrase 1 Rattus norvegicus 60-63 8761327-1 1996 This paper briefly reviews more than 10 years of our studies on brain aging and voltage-activated calcium (Ca) currents in rat hippocampal CA1 neurons. Calcium 98-105 carbonic anhydrase 1 Rattus norvegicus 139-142 7472451-2 1995 We have used whole-cell recordings in an in vitro calcium-free model of epilepsy to record spikelets from CA1 neurons of the rat hippocampus. Calcium 50-57 carbonic anhydrase 1 Rattus norvegicus 106-109 8887976-4 1996 Change of cytosolic calcium in CA1 neurons during application of N-methyl-D-aspartate (NMDA) was measured, as were calcium changes during simulated ischemia (hypoxia, NaCN, iodoacetate) of hypoxia plus high glutamate concentration (pO2 = 25 mmHg, 3 mM glutamate). Calcium 20-27 carbonic anhydrase 1 Rattus norvegicus 31-34 8887976-6 1996 The selective alpha 2-agonist mivazerol (1 microM) decreased NMDA receptor-mediated calcium changes in hippocampal CA1 neurons by 28% (p = 0.0079). Calcium 84-91 carbonic anhydrase 1 Rattus norvegicus 115-118 8887976-7 1996 With hypoxia and 3 mM glutamate, 1 microM mivazerol reduced early peak calcium changes in CA1 neurons by 57% (p = 0.0007). Calcium 71-78 carbonic anhydrase 1 Rattus norvegicus 90-93 8635565-4 1996 Changes in the expression of the calcium binding protein parvalbumin were present in the CA1, CA3, and DG regions of the hippocampus in both sham-treated and anoxic rats exposed to enrichment. Calcium 33-40 carbonic anhydrase 1 Rattus norvegicus 89-92 8924028-2 1996 In addition, the effects of N-methyl-D-asparate (NMDA) ionotropic and metabotropic glutamate receptor (mGluR) antagonists on the induction and the establishment or maintenance of enhanced synaptic efficacy of CA1 pyramidal neurons due to high-calcium exposure were also tested. Calcium 243-250 carbonic anhydrase 1 Rattus norvegicus 209-212 8924028-3 1996 Elevation of the calcium concentration from 1.3-4 mM in the medium bathing hippocampal slices produced a long-lasting (80 over 90 min) increase in the slope of the CA1 somatic excitatory postsynaptic potential and the amplitude of the population spike (PS). Calcium 17-24 carbonic anhydrase 1 Rattus norvegicus 164-167 8777900-3 1995 As important differences exist in calcium dependent potentials in the CA1 and CA3 hippocampal cells, we compared the membrane properties of hippocampal CA3 cells in GEPRs and Sprague-Dawley (SD) rats. Calcium 34-41 carbonic anhydrase 1 Rattus norvegicus 70-73 7617733-0 1995 Modulation of free intracellular calcium levels [(Ca++)i] in brain and spinal cord of morphine-tolerant rats and mice. Calcium 33-40 carbonic anhydrase 1 Rattus norvegicus 50-56 7820606-0 1994 Calcium-dependent hyperexcitability of hippocampal CA1 pyramidal cells in an in vitro slice after ethanol withdrawal of the rat. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 51-54 7790911-0 1995 Effects of estradiol and progesterone on voltage-gated calcium and potassium conductances in rat CA1 hippocampal neurons. Calcium 55-62 carbonic anhydrase 1 Rattus norvegicus 97-100 8983996-1 1995 Calcium currents in CA1 neurons from rat hippocampus were studied with the whole-cell, patch-clamp technique. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 20-23 8983996-5 1995 It is suggested that activation of guanine nucleotide-binding proteins by NaF leads to a long-lasting attenuation of HVA calcium current run-down in hippocampal CA1 cells. Calcium 121-128 carbonic anhydrase 1 Rattus norvegicus 161-164 7508895-5 1994 The results showed that 10 nM gastrin induced a transient rise in intracellular calcium (Ca++)i followed by a sustained phase which was dependent upon a Ca++ influx operating through nifedipine-dependent and -independent Ca++ channels. Calcium 80-87 carbonic anhydrase 1 Rattus norvegicus 89-95 7523654-1 1994 Lindane (gamma-hexachlorocyclohexane) is an organochlorine pesticide that increases intracellular free calcium ([Ca++]i) in several tissues. Calcium 103-110 carbonic anhydrase 1 Rattus norvegicus 113-119 8190261-0 1994 Kindling-induced long-lasting enhancement of calcium current in hippocampal CA1 area of the rat: relation to calcium-dependent inactivation. Calcium 45-52 carbonic anhydrase 1 Rattus norvegicus 76-79 8190261-0 1994 Kindling-induced long-lasting enhancement of calcium current in hippocampal CA1 area of the rat: relation to calcium-dependent inactivation. Calcium 109-116 carbonic anhydrase 1 Rattus norvegicus 76-79 7953638-0 1994 Corticosteroid receptor-dependent modulation of calcium currents in rat hippocampal CA1 neurons. Calcium 48-55 carbonic anhydrase 1 Rattus norvegicus 84-87 7952275-1 1994 In the CA1 hippocampal region low-frequency (1-2 Hz) afferent activation leads to a long-term depression of excitatory synaptic potentials that is induced by calcium influx through postsynaptic N-methyl-D-aspartate receptor channels. Calcium 158-165 carbonic anhydrase 1 Rattus norvegicus 7-10 7909958-2 1994 The induction of LTD in hippocampal CA1 pyramidal neurons in neonatal rats is shown to depend on postsynaptic calcium ion entry through L-type voltage-gated calcium channels paired with the activation of metabotropic glutamate receptors. Calcium 110-117 carbonic anhydrase 1 Rattus norvegicus 36-39 8397354-0 1993 Bicuculline increases the intracellular calcium response of CA1 hippocampal neurons to synaptic stimulation. Calcium 40-47 carbonic anhydrase 1 Rattus norvegicus 60-63 8229202-0 1993 Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage. Calcium 14-21 carbonic anhydrase 1 Rattus norvegicus 55-58 8229202-0 1993 Intracellular calcium levels and calcium fluxes in the CA1 region of the rat hippocampal slice during in vitro ischemia: relationship to electrophysiological cell damage. Calcium 33-40 carbonic anhydrase 1 Rattus norvegicus 55-58 7690067-3 1993 Elevating extracellular potassium concentration (50 mM, 1 min) evoked the calcium-dependent release of both ASP (approximately 50% increase) and GLU (approximately 200% increase) from hippocampal slices and from minislices of area CA1. Calcium 74-81 carbonic anhydrase 1 Rattus norvegicus 231-234 8397354-1 1993 Intracellular calcium levels were measured by ratio imaging of Fura-2-injected CA1 pyramidal neurons during repetitive electrical stimulation of the Schaffer collaterals in rat hippocampal slices. Calcium 14-21 carbonic anhydrase 1 Rattus norvegicus 79-82 8380674-1 1993 Delayed selective nerve cell death as seen in the hippocampal CA1 area of gerbils after transient forebrain ischemia goes along with neuronal hyperactivity and an early demonstrable accumulation of calcium in circumscribed groups of nerve cells. Calcium 198-205 carbonic anhydrase 1 Rattus norvegicus 62-65 8353606-1 1993 GABA evoked a reversible rise of free intracellular calcium concentration ([Ca]i) in cultured rat hippocampal neurons, detected with Fluo-3 fluorescence in a confocal laser scanning microscope. Calcium 52-59 carbonic anhydrase 1 Rattus norvegicus 76-80 8380675-8 1993 Recently, we have measured glutamate and calcium in CA1 of denervated rats during 10 min of ischemia, and it turns out that there is almost no extracellular glutamate release or lowering of calcium in contrast to ischemic animals with intact innervation. Calcium 41-48 carbonic anhydrase 1 Rattus norvegicus 52-55 8388316-4 1993 Elevated calcium induced in the CA1 area of both animal species a long-term potentiation (LTP)-like response. Calcium 9-16 carbonic anhydrase 1 Rattus norvegicus 32-35 8490735-4 1993 On the contrary, in the conditioned response the latency to induce a 50% amplitude decrease of CA1 population spikes was significantly increased (p < 0.01) at 4 mM calcium, 15-ms interpulse interval with respect to experiments with 2 mM calcium, at 15- or 30-ms interpulse intervals. Calcium 167-174 carbonic anhydrase 1 Rattus norvegicus 95-98 8490735-4 1993 On the contrary, in the conditioned response the latency to induce a 50% amplitude decrease of CA1 population spikes was significantly increased (p < 0.01) at 4 mM calcium, 15-ms interpulse interval with respect to experiments with 2 mM calcium, at 15- or 30-ms interpulse intervals. Calcium 240-247 carbonic anhydrase 1 Rattus norvegicus 95-98 8093716-2 1993 In order to determine whether anoxia increases Ca2+i in adult and neonatal neurons, we monitored calcium in CA1 hippocampal neurons using the calcium-sensitive probe fluo-3 and confocal microscopy. Calcium 97-104 carbonic anhydrase 1 Rattus norvegicus 108-111 8096697-1 1993 In the CA1 region of the hippocampus, ischemia or high-frequency stimulation of the glutamatergic input induces neuronal calcium uptake that is reflected as a decrease of the extracellular concentration of calcium ([Ca2+]ec. Calcium 121-128 carbonic anhydrase 1 Rattus norvegicus 7-10 8096697-1 1993 In the CA1 region of the hippocampus, ischemia or high-frequency stimulation of the glutamatergic input induces neuronal calcium uptake that is reflected as a decrease of the extracellular concentration of calcium ([Ca2+]ec. Calcium 206-213 carbonic anhydrase 1 Rattus norvegicus 7-10 8096697-3 1993 By using calcium-sensitive microelectrodes, [Ca2+]ec was concomitantly recorded in stratum pyramidale (SP) and stratum radiatum (SR) of the CA1 in adult Wistar rats, before, during, and for 6 h after transient forebrain ischemia. Calcium 9-16 carbonic anhydrase 1 Rattus norvegicus 140-143 8096697-8 1993 In summary, during ischemia the uptake of calcium into CA1 pyramidal cells started in the dendrites and preceded that in the cell bodies. Calcium 42-49 carbonic anhydrase 1 Rattus norvegicus 55-58 12106415-6 1992 The calcium-induced increase in [3H]AMPA binding is different among various brain structures, being larger in area CA1 of the hippocampus and in the superficial layers of the cerebral cortex. Calcium 4-11 carbonic anhydrase 1 Rattus norvegicus 115-118 1324252-0 1992 Enhanced calcium uptake by CA1 pyramidal cell dendrites in the postischemic phase despite subnormal evoked field potentials: excitatory amino acid receptor dependency and relationship to neuronal damage. Calcium 9-16 carbonic anhydrase 1 Rattus norvegicus 27-30 1331856-0 1992 Enhancement of calcium currents in rat hippocampal CA1 neurons induced by kindling epileptogenesis. Calcium 15-22 carbonic anhydrase 1 Rattus norvegicus 51-54 1357588-5 1992 Calcium entry through dihydropyridine-sensitive Ca2+ channels may be a critical step for induction of N-methyl-D-aspartate receptor-independent long-term potentiation in area CA1 [Grover L. M. and Teyler T.J. (1990) Nature 347, 477-479]. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 175-178 1324252-1 1992 After 6-12 h of recovery from transient cerebral ischemia, the pyramidal cells of the hippocampal CA1 region take up excessive amounts of calcium upon electrical stimulation, which has been suggested to be important for the development of delayed neuronal death. Calcium 138-145 carbonic anhydrase 1 Rattus norvegicus 98-101 1324252-8 1992 There was a significant correlation between the degree of stimulated calcium uptake at 6 h postischemia and the extent of CA1 damage evaluated 7 days after the ischemic insult (r = 0.849; p less than 0.001). Calcium 69-76 carbonic anhydrase 1 Rattus norvegicus 122-125 1324252-13 1992 In conclusion, the uptake of calcium into CA1 pyramidal cells during electrical stimulation was enhanced already 4 h after ischemia in spite of the fact that other measures of excitability were subnormal. Calcium 29-36 carbonic anhydrase 1 Rattus norvegicus 42-45 1324252-14 1992 This calcium uptake correlated to the extent of CA1 pyramidal cell damage and was dependent on both NMDA and non-NMDA receptor activation. Calcium 5-12 carbonic anhydrase 1 Rattus norvegicus 48-51 2046027-1 1991 Hippocampal pyramidal neurons of the CA1 region express 5-hydroxytryptamine (serotonin, 5-HT) receptors which, upon activation, elicit a slow membrane depolarization and a decrease in the calcium-activated afterhyperpolarization present in these cells. Calcium 188-195 carbonic anhydrase 1 Rattus norvegicus 37-40 1297926-3 1992 After 24 hours of postischemic recirculation enhancement of intracellular (pre- and postsynaptic parts) and extracellular (synaptic clefts) calcium deposits was found in great proportion of synapses in CA1 sector. Calcium 140-147 carbonic anhydrase 1 Rattus norvegicus 202-205 1931486-9 1991 There appeared to be a clear correlation between ischemia-induced glutamate accumulation and the decrease in extracellular calcium since both changes were prevented in the denervated CA1 (the destruction of glutamatergic innervation from CA3 protects CA1 pyramidal neurons from ischemic damage). Calcium 123-130 carbonic anhydrase 1 Rattus norvegicus 183-186 1931486-9 1991 There appeared to be a clear correlation between ischemia-induced glutamate accumulation and the decrease in extracellular calcium since both changes were prevented in the denervated CA1 (the destruction of glutamatergic innervation from CA3 protects CA1 pyramidal neurons from ischemic damage). Calcium 123-130 carbonic anhydrase 1 Rattus norvegicus 251-254 1931486-10 1991 By contrast, blockade of N-methyl-D-aspartate (NMDA) receptors with the glutamate antagonist APV was only partially effective in preventing the ischemia-induced calcium changes in CA1. Calcium 161-168 carbonic anhydrase 1 Rattus norvegicus 180-183 1656303-5 1991 High calcium (+3mM) solutions prevented the depressant activity of increasing concentrations of both U-54494A and U-50488H on the amplitude of CA1 population spikes. Calcium 5-12 carbonic anhydrase 1 Rattus norvegicus 143-146 1713990-5 1991 This increment of ri, which was suppressed by verapamil (10(-5) M), indicates that when the inward movement of calcium through surface cell membrane is appreciably enhanced, the increase in free (Ca)i counteracts the effect of cyclic AMP on ri. Calcium 111-118 carbonic anhydrase 1 Rattus norvegicus 196-200 1860054-1 1991 The calcium-dependent gamma-aminobutyric acid (GABA) and glutamate release from rat hippocampal CA1 slices, evoked by a 1-min depolarization with 50 mM K+, was investigated in different stages of kindling epileptogenesis. Calcium 4-11 carbonic anhydrase 1 Rattus norvegicus 96-99 1900528-1 1991 To clarify the mechanism of contractive effects in arteries caused by oxyhemoglobin, changes in the concentration of cytosolic calcium [( Ca++]i) before and after exposure to oxyhemoglobin were measured in vitro in cultured vascular smooth-muscle cells obtained from rat aorta. Calcium 127-134 carbonic anhydrase 1 Rattus norvegicus 138-144 1900528-9 1991 These results indicate that oxyhemoglobin-induced [Ca++]i elevation is caused by the influx of extracellular calcium, which is independent of the verapamil-blocked voltage-gated calcium channel. Calcium 109-116 carbonic anhydrase 1 Rattus norvegicus 51-57 2158068-0 1990 Effects of changes in extracellular potassium, magnesium and calcium concentration on synaptic transmission in area CA1 and the dentate gyrus of rat hippocampal slices. Calcium 61-68 carbonic anhydrase 1 Rattus norvegicus 116-119 1884753-3 1991 The density and intensity of immunoreactivity for both of these calcium-binding proteins was greatest in CA2 as compared to CA1 and CA3. Calcium 64-71 carbonic anhydrase 1 Rattus norvegicus 124-127 2055416-0 1991 Effects of some calcium antagonists and of calcium concentration changes on CA1 paired pulse inhibition in rat hippocampal slices. Calcium 43-50 carbonic anhydrase 1 Rattus norvegicus 76-79 2055416-2 1991 In rat hippocampal slices, the lowering of the calcium concentration (from 2 to 1 mM) or diltiazem (200 microM) or CdCl2 (50 microM) significantly (P less than 0.01) increased the amplitude and shifted the stimulus-response curve of the secondary population spikes, due to paired pulse CA1 stimulation to the left. Calcium 47-54 carbonic anhydrase 1 Rattus norvegicus 286-289 2146781-0 1990 Mechanisms of intracellular calcium accumulation in the CA1 region of rat hippocampus during anoxia in vitro. Calcium 28-35 carbonic anhydrase 1 Rattus norvegicus 56-59 2054627-1 1991 We examined the effect of elevating intracellular calcium ([Ca2+]i) on responses to iontophoretically applied N-methyl-D-aspartate (NMDA), and quisqualate in CA1 neurons of the hippocampal slice. Calcium 50-57 carbonic anhydrase 1 Rattus norvegicus 158-161 1846413-0 1991 Calcium antagonist effects on low-threshold (T-type) calcium current in rat isolated hippocampal CA1 pyramidal neurons. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 97-100 1846413-0 1991 Calcium antagonist effects on low-threshold (T-type) calcium current in rat isolated hippocampal CA1 pyramidal neurons. Calcium 53-60 carbonic anhydrase 1 Rattus norvegicus 97-100 2226619-1 1990 Administration of serotonin (5-hydroxytryptamine, 5-HT) to pyramidal cells of the CA1 region of the hippocampus results in a hyperpolarizing response which is followed by a rebound depolarization and a decrease in the calcium-activated afterhyperpolarization (AHP). Calcium 218-225 carbonic anhydrase 1 Rattus norvegicus 82-85 2357543-2 1990 Following the induction of LTP at the Schaffer collateral/commissural synapses in the CA1 subfield of the rat hippocampal slice, there was a significant decrease (30%) in the percentage of synaptic vesicles containing calcium deposits. Calcium 218-225 carbonic anhydrase 1 Rattus norvegicus 86-89 35501152-0 2022 In Vivo Multi-Day Calcium Imaging of CA1 Hippocampus in Freely Moving Rats Reveals a High Preponderance of Place Cells with Consistent Place Fields. Calcium 18-25 carbonic anhydrase 1 Rattus norvegicus 37-40 2337778-1 1990 Calcium (Ca) spike potentials were investigated in cesium-loaded, tetrodotoxin (TTX)-treated CA1 pyramidal cells in hippocampal slices from young-mature and aged rats. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 93-96 2302557-0 1990 Effects of extracellular potassium concentration and postsynaptic membrane potential on calcium-induced potentiation in area CA1 of rat hippocampus. Calcium 88-95 carbonic anhydrase 1 Rattus norvegicus 125-128 2302557-1 1990 Long-lasting potentiation can be induced in area CA1 of hippocampus by a relatively brief (7-10 min) exposure to a higher (4.0 mM) than normal (2.0 mM) extracellular calcium concentration. Calcium 166-173 carbonic anhydrase 1 Rattus norvegicus 49-52 35501152-5 2022 In this paper, we present the first (to our knowledge) in vivo calcium imaging from CA1 hippocampus in freely moving male rats. Calcium 63-70 carbonic anhydrase 1 Rattus norvegicus 84-87 2710411-5 1989 We now report that pharmacological blockade of intraneuronal calcium release with 20 microM dantrolene-sodium (dantrium) completely blocks the induction of LTP in the CA1 region of the rat hippocampal slice. Calcium 61-68 carbonic anhydrase 1 Rattus norvegicus 167-170 2554221-0 1989 Hippocampal CA1 pyramidal cells of rats have four voltage-dependent calcium conductances. Calcium 68-75 carbonic anhydrase 1 Rattus norvegicus 12-15 2757265-1 1989 Direct measurements of free intracellular calcium (Ca)i are needed for an understanding of the regulation of contractility. Calcium 42-49 carbonic anhydrase 1 Rattus norvegicus 51-55 2573906-1 1989 A transient increase (10 min) in extracellular calcium concentration (4 mM) causes a long-lasting (greater than 2 hr) enhancement of population spike responses evoked by radiatum fibers to CA1 pyramidal neurons in rat hippocampal slices. Calcium 47-54 carbonic anhydrase 1 Rattus norvegicus 189-192 2725017-4 1989 Calcium-free, 10 mM magnesium artificial cerebrospinal fluid (ACSF) was shown to protect CA1 pyramidal cells against anoxic damage. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 89-92 2565393-4 1989 Low calcium bursting consists of repetitive spiking evoked by antidromic stimulation of the CA1 pyramidal neurons and can be suppressed by adenosine. Calcium 4-11 carbonic anhydrase 1 Rattus norvegicus 92-95 2741168-4 1989 Cytosolic free calcium concentration [( Ca++]i) in quiescent SMCs, measured by using quin 2, was 178 +/- 18 nM (n = 15). Calcium 15-22 carbonic anhydrase 1 Rattus norvegicus 40-46 2550263-4 1989 The adenosine (50 microM)-mediated hyperpolarization and decrease in input resistance as well as the adenosine-mediated inhibition of low calcium-induced bursting in pyramidal CA1 neurons were virtually abolished. Calcium 138-145 carbonic anhydrase 1 Rattus norvegicus 176-179 2710411-6 1989 This drug inhibits calcium release from the sarcoplasmic reticulum and also diminishes the rise in intraneuronal calcium ion concentrations elicited by NMDA receptor activation in cultured CA1 pyramidal cells. Calcium 113-120 carbonic anhydrase 1 Rattus norvegicus 189-192 2467962-2 1989 The relationship between receptor-mediated increases in the intracellular free calcium concentration [( Ca]i) and the stimulation of ion fluxes involved in fluid secretion was examined in the rat parotid acinar cell. Calcium 79-86 carbonic anhydrase 1 Rattus norvegicus 104-108 2885709-2 1987 To initially validate the technique, the calcium channel activator maitotoxin effectively increased intracellular free calcium [( Ca++]i). Calcium 41-48 carbonic anhydrase 1 Rattus norvegicus 130-136 2725698-8 1989 After 7 days of postischemic recovery, neuronal damage was significantly reduced by the calcium antagonist in hippocampal CA1 sector at all doses tested, the most prominent effects being observed with the lowest dose. Calcium 88-95 carbonic anhydrase 1 Rattus norvegicus 122-125 2772839-13 1989 However, the prominent Tau2 staining in dendrites of the CA1 region provides anatomical support for the hypothesis that taurine may be released from dendrites in the CA1 region and may function as a neuromodulator of calcium flux in these pyramidal neurons. Calcium 217-224 carbonic anhydrase 1 Rattus norvegicus 57-60 2848046-0 1988 Calcium uptake evoked by electrical stimulation is enhanced postischemically and precedes delayed neuronal death in CA1 of rat hippocampus: involvement of N-methyl-D-aspartate receptors. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 116-119 2848046-1 1988 Extracellular calcium concentration changes in the CA1 of the hippocampus during burst activity were measured during postischemic reflow, and the involvement of N-methyl-D-aspartate (NMDA) receptors was evaluated. Calcium 14-21 carbonic anhydrase 1 Rattus norvegicus 51-54 2848046-8 1988 Six to eight hours after ischemia, a threefold enhancement of extracellular calcium decreases was found in the dendritic layers of the CA1. Calcium 76-83 carbonic anhydrase 1 Rattus norvegicus 135-138 2839527-4 1988 The results showed significant accumulation of calcium and loss of potassium after 3 and 4 days of recovery in the CA1 sector, which developed neuronal necrosis, but not in the CA3 sector, which showed only occasional damage. Calcium 47-54 carbonic anhydrase 1 Rattus norvegicus 115-118 3033029-4 1987 Spontaneous burst firing of CA1 pyramidal cells in low calcium, high magnesium medium was reduced, indicating a partially postsynaptic inhibitory action of NPY on their dendrites. Calcium 55-62 carbonic anhydrase 1 Rattus norvegicus 28-31 3805166-6 1987 More conspicuous neuronal death was observed after 72 h. The results thus demonstrate that net accumulation of calcium in regio superior of the hippocampus precedes marked necrosis of CA1 pyramidal cells. Calcium 111-118 carbonic anhydrase 1 Rattus norvegicus 184-187 3454083-1 1987 The effect of lidocaine seizures on cellular accumulation of calcium was studied in hippocampal subfields CA1 and CA3 and the dentate gyrus of rats, using the combined oxalate-pyroantimonate method. Calcium 61-68 carbonic anhydrase 1 Rattus norvegicus 106-109 3454083-7 1987 Calcium uptake was most prominent in the CA3 sector but was also present in the CA1 subfield as well as the dentate gyrus. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 80-83 3801004-1 1986 We have developed an accurate and sensitive system for the measurement of cytoplasmic free calcium concentrations ([Ca++]i) of a single cell by using UV-laser and Indo-1. Calcium 91-98 carbonic anhydrase 1 Rattus norvegicus 116-122 3082623-1 1986 The calcium concentration, [Ca]i, in single rat peritoneal mast cells was measured by means of the new Ca indicator dye fura-2. Calcium 4-11 carbonic anhydrase 1 Rattus norvegicus 28-32 3025432-0 1986 Calcium and long-term transmission damage following anoxia in dentate gyrus and CA1 regions of the rat hippocampal slice. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 80-83 2426636-1 1986 In rat hippocampal slices which were superfused with low calcium (0.2 mM) medium, stimulation of the alvear fibers elicited an extracellularly recorded antidromic population spike in CA1 pyramidal neurons which was followed by 2-4 afterpotentials. Calcium 57-64 carbonic anhydrase 1 Rattus norvegicus 183-186 4075183-1 1985 The change in the total calcium content of the rat hippocampus was investigated quantitatively and the sites of the accumulated calcium in the CA1 region were demonstrated cytochemically by the oxalate-pyroantimonate technique 4 h following intraperitoneal kainic acid administration. Calcium 128-135 carbonic anhydrase 1 Rattus norvegicus 143-146 2866099-0 1985 Calcium and unit response decrement to locally applied glutamate on rat hippocampal CA1 neurons. Calcium 0-7 carbonic anhydrase 1 Rattus norvegicus 84-87