PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 11225995-2 2000 The function of CD20 is unknown, although it is thought to be involved in B-cell activation, regulation of B-cell growth, and transmembrane calcium flux. Calcium 140-147 keratin 20 Homo sapiens 16-20 18474602-3 2008 CD20 is a B cell-restricted tetraspanning protein organized in the plasma membrane as multimeric molecular complexes involved in BCR-activated calcium entry. Calcium 143-150 keratin 20 Homo sapiens 0-4 18474602-8 2008 These data provide new evidence of the involvement of CD20 in signaling downstream of the BCR and, together with the previously described involvement of CD20 in calcium influx, the first evidence of physical coupling of the BCR to a calcium entry pathway. Calcium 161-168 keratin 20 Homo sapiens 153-157 18474602-8 2008 These data provide new evidence of the involvement of CD20 in signaling downstream of the BCR and, together with the previously described involvement of CD20 in calcium influx, the first evidence of physical coupling of the BCR to a calcium entry pathway. Calcium 233-240 keratin 20 Homo sapiens 54-58 18474602-8 2008 These data provide new evidence of the involvement of CD20 in signaling downstream of the BCR and, together with the previously described involvement of CD20 in calcium influx, the first evidence of physical coupling of the BCR to a calcium entry pathway. Calcium 233-240 keratin 20 Homo sapiens 153-157 18426802-0 2008 Induction of cytosolic calcium flux by CD20 is dependent upon B Cell antigen receptor signaling. Calcium 23-30 keratin 20 Homo sapiens 39-43 18426802-3 2008 In the current study, anti-CD20 mAb-induced calcium signaling was investigated. Calcium 44-51 keratin 20 Homo sapiens 27-31 18426802-6 2008 Inhibitor analysis revealed that the signaling cascade employed by CD20 was strikingly similar to that utilized by the BCR, with inhibitors of Syk, Src, and PI3K, but not EGTA, p38, or ERK1/2, completely ablating calcium flux. Calcium 213-220 keratin 20 Homo sapiens 67-71 18426802-9 2008 Collectively, these data indicate that CD20 induces cytosolic calcium flux through its ability to associate with and "hijack" the signaling potential of the BCR. Calcium 62-69 keratin 20 Homo sapiens 39-43 15730389-0 2005 Rituxan (anti-CD20 antibody)-induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis. Calcium 91-98 keratin 20 Homo sapiens 14-18 15730389-0 2005 Rituxan (anti-CD20 antibody)-induced translocation of CD20 into lipid rafts is crucial for calcium influx and apoptosis. Calcium 91-98 keratin 20 Homo sapiens 54-58 15730389-4 2005 CD20 is a B-lymphocyte specific integral membrane protein, proposed to function as a store-operated calcium channel, which is activated upon receptor-stimulated calcium depletion of intracellular stores. Calcium 100-107 keratin 20 Homo sapiens 0-4 15649140-1 2005 CD20 is a B-lymphocyte-specific integral membrane protein, implicated in the regulation of transmembrane calcium conductance, cell-cycle progression and B-lymphocyte proliferation. Calcium 105-112 keratin 20 Homo sapiens 0-4 15649140-7 2005 This review outlines recent biochemical studies characterizing the role of CD20 in calcium signalling in B-lymphocytes and evaluates an engagement of lipid rafts in the regulation of CD20-mediated calcium conductivity. Calcium 83-90 keratin 20 Homo sapiens 75-79 15649140-7 2005 This review outlines recent biochemical studies characterizing the role of CD20 in calcium signalling in B-lymphocytes and evaluates an engagement of lipid rafts in the regulation of CD20-mediated calcium conductivity. Calcium 197-204 keratin 20 Homo sapiens 183-187 14976189-1 2004 CD20 is a B cell-specific membrane protein that functions in store-operated calcium entry and serves as a useful target for antibody-mediated therapeutic depletion of B cells. Calcium 76-83 keratin 20 Homo sapiens 0-4 12938216-7 2003 Paradoxically, one functional consequence of CD20 down-regulation was enhanced calcium signaling upon CD20 cross-linking. Calcium 79-86 keratin 20 Homo sapiens 45-49 12938216-7 2003 Paradoxically, one functional consequence of CD20 down-regulation was enhanced calcium signaling upon CD20 cross-linking. Calcium 79-86 keratin 20 Homo sapiens 102-106 12938216-8 2003 These observations support the notion that CD20 engages downstream signaling pathways that alter calcium homeostasis rather than functioning as a calcium channel itself, such signal transduction is enhanced upon CD20 internalization, and CD40 is a regulator of CD20-mediated signaling. Calcium 97-104 keratin 20 Homo sapiens 43-47 12938216-8 2003 These observations support the notion that CD20 engages downstream signaling pathways that alter calcium homeostasis rather than functioning as a calcium channel itself, such signal transduction is enhanced upon CD20 internalization, and CD40 is a regulator of CD20-mediated signaling. Calcium 97-104 keratin 20 Homo sapiens 212-216 12938216-8 2003 These observations support the notion that CD20 engages downstream signaling pathways that alter calcium homeostasis rather than functioning as a calcium channel itself, such signal transduction is enhanced upon CD20 internalization, and CD40 is a regulator of CD20-mediated signaling. Calcium 97-104 keratin 20 Homo sapiens 212-216 1382718-3 1992 Because we showed earlier that the CD20 molecule is consistently hyperphosphorylated in hairy cells and because previous studies showed that CD20 is involved in regulating intracytoplasmic free calcium concentrations ([Ca2+]i) in normal B lymphocytes, we measured [Ca2+]i in tumor cell samples from patients with HCL and studied the effect of IFN-alpha on this parameter. Calcium 194-201 keratin 20 Homo sapiens 35-39 10753604-0 2000 Clustered CD20 induced apoptosis: src-family kinase, the proximal regulator of tyrosine phosphorylation, calcium influx, and caspase 3-dependent apoptosis. Calcium 105-112 keratin 20 Homo sapiens 10-14 7680616-9 1993 The ability of anti-IgM to mobilize intracellular calcium was reduced in sIgM down-regulated cells, suggesting that B cells activation through the antigen receptor may be negatively regulated by CD20 and positively by IL-4. Calcium 50-57 keratin 20 Homo sapiens 195-199 7743602-4 1994 The synergistic interaction of CD40 signals with PMA or CD20 show differential requirements for CD40 crosslinking and different sensitivity to cyclosporine A, suggesting that CD40 receptor may use different effector mechanisms for synergy with calcium-dependent CD20 signals or with calcium-independent signals from PMA. Calcium 244-251 keratin 20 Homo sapiens 56-60 7743602-4 1994 The synergistic interaction of CD40 signals with PMA or CD20 show differential requirements for CD40 crosslinking and different sensitivity to cyclosporine A, suggesting that CD40 receptor may use different effector mechanisms for synergy with calcium-dependent CD20 signals or with calcium-independent signals from PMA. Calcium 244-251 keratin 20 Homo sapiens 262-266 7743602-4 1994 The synergistic interaction of CD40 signals with PMA or CD20 show differential requirements for CD40 crosslinking and different sensitivity to cyclosporine A, suggesting that CD40 receptor may use different effector mechanisms for synergy with calcium-dependent CD20 signals or with calcium-independent signals from PMA. Calcium 283-290 keratin 20 Homo sapiens 56-60 7743602-4 1994 The synergistic interaction of CD40 signals with PMA or CD20 show differential requirements for CD40 crosslinking and different sensitivity to cyclosporine A, suggesting that CD40 receptor may use different effector mechanisms for synergy with calcium-dependent CD20 signals or with calcium-independent signals from PMA. Calcium 283-290 keratin 20 Homo sapiens 262-266 1382718-3 1992 Because we showed earlier that the CD20 molecule is consistently hyperphosphorylated in hairy cells and because previous studies showed that CD20 is involved in regulating intracytoplasmic free calcium concentrations ([Ca2+]i) in normal B lymphocytes, we measured [Ca2+]i in tumor cell samples from patients with HCL and studied the effect of IFN-alpha on this parameter. Calcium 194-201 keratin 20 Homo sapiens 141-145 31793167-5 2020 We found that IGF2R and the store-operated Ca2+ channel CD20 share a common hydrophobic binding motif that stabilizes their association. Calcium 43-47 keratin 20 Homo sapiens 56-60 32847969-0 2020 Calcium channel blockers impair the antitumor activity of anti-CD20 monoclonal antibodies by blocking EGR-1 induction. Calcium 0-7 keratin 20 Homo sapiens 63-67 32847969-3 2020 EGR-1 induction results from an increased calcium influx induced by anti-CD20 antibodies. Calcium 42-49 keratin 20 Homo sapiens 73-77 32847969-5 2020 Inhibition of the calcium flux with calcium channel blockers (CCBs) abolished EGR-1 induction and impaired the efficacy of anti-CD20 antibodies in preclinical in vitro and in vivo models. Calcium 18-25 keratin 20 Homo sapiens 128-132 32847969-8 2020 In addition, our findings show that calcium influx is required for anti-CD20-mediated tumor cell death and suggest that simultaneous administration of calcium channel blocking agents could be deleterious in patients receiving anti-CD20 based immunotherapy. Calcium 36-43 keratin 20 Homo sapiens 72-76 32847969-8 2020 In addition, our findings show that calcium influx is required for anti-CD20-mediated tumor cell death and suggest that simultaneous administration of calcium channel blocking agents could be deleterious in patients receiving anti-CD20 based immunotherapy. Calcium 36-43 keratin 20 Homo sapiens 231-235 32847969-8 2020 In addition, our findings show that calcium influx is required for anti-CD20-mediated tumor cell death and suggest that simultaneous administration of calcium channel blocking agents could be deleterious in patients receiving anti-CD20 based immunotherapy. Calcium 151-158 keratin 20 Homo sapiens 72-76 32847969-8 2020 In addition, our findings show that calcium influx is required for anti-CD20-mediated tumor cell death and suggest that simultaneous administration of calcium channel blocking agents could be deleterious in patients receiving anti-CD20 based immunotherapy. Calcium 151-158 keratin 20 Homo sapiens 231-235 31793167-7 2020 Remarkably, anti-IGF2R induced CD20 phosphorylation, leading to the activation of sarcoplasmic/endoplasmic reticulum Ca2+ -ATPase (SERCA) and removal of intracellular Ca2+ . Calcium 117-121 keratin 20 Homo sapiens 31-35 31793167-7 2020 Remarkably, anti-IGF2R induced CD20 phosphorylation, leading to the activation of sarcoplasmic/endoplasmic reticulum Ca2+ -ATPase (SERCA) and removal of intracellular Ca2+ . Calcium 167-171 keratin 20 Homo sapiens 31-35 22982241-0 2012 Expression of CD20 reveals a new store-operated calcium entry modulator in skeletal muscle. Calcium 48-55 keratin 20 Homo sapiens 14-18 19952958-4 2010 Intracellular calcium release was triggered via a signaling pathway distinct from the lipid raft-dependent and src family kinase-dependent pathway that is activated by CD20 hypercrosslinking or B-cell receptor association. Calcium 14-21 keratin 20 Homo sapiens 168-172 22130422-11 2012 CONCLUSIONS: We propose that CD20 dissociation from the BCR signalosome is pivotal to BCR-mediated calcium mobilization in the cytosol. Calcium 99-106 keratin 20 Homo sapiens 29-33 19153665-5 2009 Here, we show that a CD20-related signaling pathway able to induce an increase in [Ca(2+)](i) is differently activated after brain derived neurotrophic factor (BDNF) stimulation of normal and dystrophic blood-derived CD133(+) stem cells, supporting the assumption of a "CD20-related calcium impairment" affecting dystrophic cells. Calcium 283-290 keratin 20 Homo sapiens 21-25 20641565-1 2004 Although the exact cellular functions of CD20 are not known, it is believed to play a role in B cell growth, activation, and maintenance of cellular calcium homeostasis (1). Calcium 149-156 keratin 20 Homo sapiens 41-45 20641768-1 2004 Although the exact cellular functions of CD20 are not known, it is believed to play a role in B cell growth, activation, and maintenance of cellular calcium homeostasis (1). Calcium 149-156 keratin 20 Homo sapiens 41-45 19153665-3 2009 The CD20 antigen plays a role in the modulation of intracellular calcium homeostasis through signaling pathways activation. Calcium 65-72 keratin 20 Homo sapiens 4-8