PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33864571-12 2021 Our findings indicate that upregulated SOCC and IP3R channels and subsequent elevated cytoplasmic calcium signaling in hepatocyte fatty lesions inhibits hepatocyte autophagy through (TRPC1/IP3R)/ERK/(FOXO/mTORC1) signaling pathways, causes lipid accumulation and degeneration in hepatocytes, and promotes NAFLD occurrence and development. Calcium 98-105 mitogen-activated protein kinase 1 Homo sapiens 195-198 33610907-4 2021 Using a Piezo1-specific activator, Yoda1, we identified that calcium entry induced by Yoda1 resulted in phosphorylation of JNK, p38, and ERK, thereby activating the mitogen-activated protein kinase (MAPK) pathway, in a dose- and time-dependent manner. Calcium 61-68 mitogen-activated protein kinase 1 Homo sapiens 137-140 32392404-5 2020 The effect of calcium on ERK localization was examined using immunofluorescent staining and Western blotting. Calcium 14-21 mitogen-activated protein kinase 1 Homo sapiens 25-28 33248235-6 2021 The screening of calcium targets revealed that calpain activation and an increase in phosphorylated extracellular signal-regulated kinase (p-ERK) were calcium dependent during 6-OHDA-induced axonal degeneration in vitro. Calcium 17-24 mitogen-activated protein kinase 1 Homo sapiens 141-144 33248235-6 2021 The screening of calcium targets revealed that calpain activation and an increase in phosphorylated extracellular signal-regulated kinase (p-ERK) were calcium dependent during 6-OHDA-induced axonal degeneration in vitro. Calcium 151-158 mitogen-activated protein kinase 1 Homo sapiens 141-144 31945349-9 2020 The calcium-mediated transient up-regulation of Sema3A expression was significantly suppressed by mitogen-activated protein kinase [MAPK]/extracellular signal-regulated kinase [ERK] (MEK) 1/2 or AP-1 inhibitors. Calcium 4-11 mitogen-activated protein kinase 1 Homo sapiens 132-136 31945349-10 2020 These results demonstrate that the calcium-mediated transient up-regulation of Sema3A in NHEKs is involved in the MEK/ERK and AP-1 signaling axis. Calcium 35-42 mitogen-activated protein kinase 1 Homo sapiens 118-121 32392404-7 2020 Varying calcium concentrations significantly modified the repertoire of ERK2-interacting proteins, of which many were identified. Calcium 8-15 mitogen-activated protein kinase 1 Homo sapiens 72-76 32088216-11 2020 Finally, we demonstrated that the STIM1-mediated increase in cytosolic calcium levels induced apoptosis through the ERK pathway. Calcium 71-78 mitogen-activated protein kinase 1 Homo sapiens 116-119 32088216-12 2020 SIGNIFICANCE: Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. Calcium 105-112 mitogen-activated protein kinase 1 Homo sapiens 123-126 31814223-8 2020 Inhibition of ERK signaling specifically down-regulated the expression of calcium-permeable AMPAR subunits, GluA1 and GluA4, and up-regulated calcium-impermeable AMPAR subunit GluA2 implying differential regulation of the expression of calcium-permeable AMPA receptor subunits of glioblastoma. Calcium 74-81 mitogen-activated protein kinase 1 Homo sapiens 14-17 31954174-6 2020 Furthermore, this complex interacts with S1P receptors on the feto-placental endothelium and activates specifically extracellular signal-regulated protein kinases 1 and 2 (ERK) and phospholipase C (PLC) downstream signaling, promotes endothelial cell proliferation and calcium flux. Calcium 269-276 mitogen-activated protein kinase 1 Homo sapiens 172-175 31814223-8 2020 Inhibition of ERK signaling specifically down-regulated the expression of calcium-permeable AMPAR subunits, GluA1 and GluA4, and up-regulated calcium-impermeable AMPAR subunit GluA2 implying differential regulation of the expression of calcium-permeable AMPA receptor subunits of glioblastoma. Calcium 142-149 mitogen-activated protein kinase 1 Homo sapiens 14-17 31814223-10 2020 Corollary, these findings suggest that the AMPAR enhances invasion of glioblastoma, and ERK signaling modulates the differential expression of calcium permeable AMPA receptor phenotype that might play crucial role in the invasive propensity of glioblastoma cells. Calcium 143-150 mitogen-activated protein kinase 1 Homo sapiens 88-91 31814223-8 2020 Inhibition of ERK signaling specifically down-regulated the expression of calcium-permeable AMPAR subunits, GluA1 and GluA4, and up-regulated calcium-impermeable AMPAR subunit GluA2 implying differential regulation of the expression of calcium-permeable AMPA receptor subunits of glioblastoma. Calcium 142-149 mitogen-activated protein kinase 1 Homo sapiens 14-17 31350035-10 2020 CONCLUSIONS: LRP1 regulates cardiac hypertrophy via the PKCalpha-ERK dependent signaling pathway resulting in the alteration of intracellular calcium levels, demonstrating that LRP1 might be a potential therapeutic target for cardiac hypertrophy. Calcium 142-149 mitogen-activated protein kinase 1 Homo sapiens 65-68 31755615-14 2020 Taken together, our data suggested that EP4 activated PI3K and then induced Ca2+ influx from the extracellular space via Orai1, resulting in ERK phosphorylation and promoting cell migration. Calcium 76-80 mitogen-activated protein kinase 1 Homo sapiens 141-144 31798406-13 2019 Conclusion: In the 0.5 T group, high-frequency rTMS can induce autophagy through NMDAR-Ca2+-ERK-mTOR signaling in BMSCs. Calcium 87-91 mitogen-activated protein kinase 1 Homo sapiens 92-95 31733625-2 2019 The L-type calcium channel Cav1.2 can drive nuclear activity by either the ERK-CREB pathway, the Ca2+/calmodulin-dependent protein kinase II (CaMKII) cascade, or via the Ca2+-dependent protein phosphatase calcineurin. Calcium 11-18 mitogen-activated protein kinase 1 Homo sapiens 75-78 30186110-7 2018 (3) Phosphorylation of m-calpain has been significantly enhanced during seizure onset, which was partly mediated by the calcium independent MAPK/ERK signaling pathway activation. Calcium 120-127 mitogen-activated protein kinase 1 Homo sapiens 145-148 31233447-4 2019 Oncostatin M also increased intracellular calcium concentrations that act upstream of Akt and ERK. Calcium 42-49 mitogen-activated protein kinase 1 Homo sapiens 94-97 31807353-3 2019 Treatments with MTA, propolis or combined increased the phosphorylation of extracellular signal-regulated kinases (ERK), one of mitogen-activated protein kinases signaling cascades during odontogenic differentiation of DPSCs (p < 0.05), and U0126, an inhibitor of ERK, decreased calcium deposits (p < 0.05). Calcium 282-289 mitogen-activated protein kinase 1 Homo sapiens 75-113 31807353-3 2019 Treatments with MTA, propolis or combined increased the phosphorylation of extracellular signal-regulated kinases (ERK), one of mitogen-activated protein kinases signaling cascades during odontogenic differentiation of DPSCs (p < 0.05), and U0126, an inhibitor of ERK, decreased calcium deposits (p < 0.05). Calcium 282-289 mitogen-activated protein kinase 1 Homo sapiens 115-118 30639849-7 2019 At the mechanistic level, we demonstrated that this effect was calcium dependent and was synergic with inhibition of the ERK pathway. Calcium 63-70 mitogen-activated protein kinase 1 Homo sapiens 121-124 30052933-1 2018 The calcium-sensing receptor (CaSR) is a homodimeric G-protein-coupled receptor that signals via intracellular calcium (Ca2+i) mobilisation and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK) to regulate extracellular calcium (Ca2+e) homeostasis. Calcium 4-11 mitogen-activated protein kinase 1 Homo sapiens 163-204 30052933-1 2018 The calcium-sensing receptor (CaSR) is a homodimeric G-protein-coupled receptor that signals via intracellular calcium (Ca2+i) mobilisation and phosphorylation of extracellular signal-regulated kinase 1/2 (ERK) to regulate extracellular calcium (Ca2+e) homeostasis. Calcium 4-11 mitogen-activated protein kinase 1 Homo sapiens 206-209 28827782-6 2017 Mechanistically, we show that elevated extracellular calcium inhibits C/EBPbeta activity through hyperactivation of ERK, a process that is independent of intracellular calcium levels and reversibly halts differentiation. Calcium 53-60 mitogen-activated protein kinase 1 Homo sapiens 116-119 29581896-3 2018 By phorbol ester/calcium ionophore stimulation, for example, a real-time complex formation of ectopic IkappaBalpha/ERK/WWOX occurs as measured by FRET microscopy, indicative of an ongoing functional signaling. Calcium 17-24 mitogen-activated protein kinase 1 Homo sapiens 115-118 29644008-8 2018 The activity of SHC, AKT, ERK, P90RSK and JNK were enhanced after calcium treatment of CaSR-transfected cells. Calcium 66-73 mitogen-activated protein kinase 1 Homo sapiens 26-29 28864773-4 2017 Here, we report that MAPK1-interacting and spindle-stabilizing (MISS)-like (MISSL), a previously uncharacterized protein, interacts with ALG-2 in a calcium-dependent manner. Calcium 148-155 mitogen-activated protein kinase 1 Homo sapiens 21-26 29654770-8 2018 Taken together the findings support the notion that TRPV1 functions as a plasma membrane ion channel that, when activated, permits the entry of extracellular calcium into the lens epithelium, leading to activation of PKC, ERK1/2 and p38 MAPK. Calcium 158-165 mitogen-activated protein kinase 1 Homo sapiens 233-236 29601810-11 2018 RIR-2 specifically modulates fMLP-mediated neutrophil superoxide anion production and cathepsin G release by inhibiting the interaction between Gbeta-protein with downstream signaling which subsequently interferes with the activation of intracellular calcium, PLCgamma2, AKT, p38, PKC, ERK, p47ph x and p40phox. Calcium 251-258 mitogen-activated protein kinase 1 Homo sapiens 286-289 29346769-5 2018 However, if the calcium signal surpasses the threshold for CaMKII activation, then an ultrasensitive "on switch" activates an extracellular signal-regulated kinase (ERK)-based positive feedback loop that triggers LTD instead. Calcium 16-23 mitogen-activated protein kinase 1 Homo sapiens 126-163 29346769-5 2018 However, if the calcium signal surpasses the threshold for CaMKII activation, then an ultrasensitive "on switch" activates an extracellular signal-regulated kinase (ERK)-based positive feedback loop that triggers LTD instead. Calcium 16-23 mitogen-activated protein kinase 1 Homo sapiens 165-168 29464016-0 2018 Inhibition of the NEDD8 conjugation pathway induces calcium-dependent compensatory activation of the pro-survival MEK/ERK pathway in acute lymphoblastic leukemia. Calcium 52-59 mitogen-activated protein kinase 1 Homo sapiens 118-121 28583863-8 2017 Most importantly, we found that a novel TRPC1-regulated extracellular signal-regulated kinase 1/2 (ERK1/2) pathway exclusively contributed to calcium-induced NFkappaB activation. Calcium 142-149 mitogen-activated protein kinase 1 Homo sapiens 56-97 26305625-9 2015 The results showed that the RasGAP protein could be further cleaved, leading to the activation of the Ras/Raf/MEK (mitogen/extracellular signal-regulated kinase)/ERK pathway and that CVB3 infection could result in an increase in the concentration of calcium in the cytoplasm, resulting in mitochondrial damage, a decrease in the concentration of ATP and activation of the AMPK (AMP-activated protein kinase)/MEK/ERK pathway. Calcium 250-257 mitogen-activated protein kinase 1 Homo sapiens 162-165 28592272-10 2017 BET stimulated ERK signaling, key pathway involved in osteoblastogenesis and calcium signaling. Calcium 77-84 mitogen-activated protein kinase 1 Homo sapiens 15-18 28324742-2 2017 This increased proliferation is induced by the stretch-activated channel Piezo1 and involves calcium-triggered ERK signalling. Calcium 93-100 mitogen-activated protein kinase 1 Homo sapiens 111-114 27864646-0 2017 Low-level laser irradiation modulates brain-derived neurotrophic factor mRNA transcription through calcium-dependent activation of the ERK/CREB pathway. Calcium 99-106 mitogen-activated protein kinase 1 Homo sapiens 135-138 27224899-9 2016 In response to the calcium flow, ERK, P38 and PKCbeta were activated and COX-2 expression was increased. Calcium 19-26 mitogen-activated protein kinase 1 Homo sapiens 33-36 27123007-0 2016 Enhanced Proliferation of Porcine Bone Marrow Mesenchymal Stem Cells Induced by Extracellular Calcium is Associated with the Activation of the Calcium-Sensing Receptor and ERK Signaling Pathway. Calcium 94-101 mitogen-activated protein kinase 1 Homo sapiens 172-175 28169521-6 2017 AY77 (Isox-Cha-Chg-NH2) was a more potent calcium-biased agonist (EC50 40 nM, Ca2+; EC50 2 muM, ERK1/2), while its analogue AY254 (Isox-Cha-Chg-A-R-NH2) was an ERK-biased agonist (EC50 2 nM, ERK1/2; EC50 80 nM, Ca2+). Calcium 42-49 mitogen-activated protein kinase 1 Homo sapiens 96-99 26505315-0 2016 Diquafosol promotes corneal epithelial healing via intracellular calcium-mediated ERK activation. Calcium 65-72 mitogen-activated protein kinase 1 Homo sapiens 82-85 26527685-0 2016 Structural Basis of Ribosomal S6 Kinase 1 (RSK1) Inhibition by S100B Protein: MODULATION OF THE EXTRACELLULAR SIGNAL-REGULATED KINASE (ERK) SIGNALING CASCADE IN A CALCIUM-DEPENDENT WAY. Calcium 163-170 mitogen-activated protein kinase 1 Homo sapiens 96-133 26305625-9 2015 The results showed that the RasGAP protein could be further cleaved, leading to the activation of the Ras/Raf/MEK (mitogen/extracellular signal-regulated kinase)/ERK pathway and that CVB3 infection could result in an increase in the concentration of calcium in the cytoplasm, resulting in mitochondrial damage, a decrease in the concentration of ATP and activation of the AMPK (AMP-activated protein kinase)/MEK/ERK pathway. Calcium 250-257 mitogen-activated protein kinase 1 Homo sapiens 412-415 25474595-1 2014 in human neutrophils are through inhibiting P38 MAPK, JNK, and calcium pathways. Calcium 63-70 mitogen-activated protein kinase 1 Homo sapiens 48-52 26209520-10 2015 The model demonstrates that the spatial profile of activation for ERK-MAPK signaling components across the epidermis may be maintained in a cell-autonomous fashion by an underlying spatial gradient in calcium signaling. Calcium 201-208 mitogen-activated protein kinase 1 Homo sapiens 66-69 26209520-12 2015 Using mathematical modelling we have demonstrated that spatially varying calcium signaling components across the epidermis may be sufficient to maintain the spatial profile of ERK-MAPK signaling cascade components in a cell-autonomous manner. Calcium 73-80 mitogen-activated protein kinase 1 Homo sapiens 176-179 26080881-8 2015 CONCLUSION: The transient calcium flux initiated by estrogen has an effect on the activation of ERK signal pathway in endometrial carcinoma cells. Calcium 26-33 mitogen-activated protein kinase 1 Homo sapiens 96-99 25796184-3 2015 The increased intracellular calcium concentration resulting from increased cytoplasmic phosphorylated ERK facilitates movement of ER-anchored calcium sensors to the PM. Calcium 28-35 mitogen-activated protein kinase 1 Homo sapiens 102-105 25796184-3 2015 The increased intracellular calcium concentration resulting from increased cytoplasmic phosphorylated ERK facilitates movement of ER-anchored calcium sensors to the PM. Calcium 142-149 mitogen-activated protein kinase 1 Homo sapiens 102-105 24416790-6 2014 They suggest that the PC1 function on JAK2 and ERK signaling pathways might be regulated by calpains in response to the changes in intracellular calcium concentration. Calcium 145-152 mitogen-activated protein kinase 1 Homo sapiens 47-50 24723666-0 2014 Calcium influx, but not intracellular calcium release, supports PACAP-mediated ERK activation in HEK PAC1 receptor cells. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 79-82 24627490-0 2014 Complex formation between S100B protein and the p90 ribosomal S6 kinase (RSK) in malignant melanoma is calcium-dependent and inhibits extracellular signal-regulated kinase (ERK)-mediated phosphorylation of RSK. Calcium 103-110 mitogen-activated protein kinase 1 Homo sapiens 134-171 23686305-7 2014 Intracellular calcium chelation also inhibited EGF-induced activation of signal transducer and activator of transcription 3 (STAT3), while preserving other signal transduction pathways such as Akt and extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation. Calcium 14-21 mitogen-activated protein kinase 1 Homo sapiens 201-242 25078118-6 2014 Inhibition of p38 suppressed cell death and inhibited osteogenic differentiation (calcium deposition, alkaline phosphatase activity, and marker gene expression) providing further support for the close coupling of osteodifferentiation and cell death. Calcium 82-89 mitogen-activated protein kinase 1 Homo sapiens 14-17 24723666-7 2014 Omission of calcium from the external solution, but not thapsigargin pretreatment, significantly blunted PACAP-stimulated ERK phosphorylation. Calcium 12-19 mitogen-activated protein kinase 1 Homo sapiens 122-125 24723666-9 2014 In contrast, following Pitstop 2 pretreatment to block endocytic mechanisms, PACAP activated ERK only when calcium was present in the external solution. Calcium 107-114 mitogen-activated protein kinase 1 Homo sapiens 93-96 24723666-10 2014 We conclude that the endosome signaling pathway is largely calcium-independent whereas calcium influx appears necessary for the PLC/DAG/PKC component of PACAP-induced ERK activation. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 167-170 25175224-7 2014 Additionally, statistically significant differences (p<0.05) have been found in the calcium deposition in si-FGFR transfection and ERK inhibitor between CS and beta-TCP; these variations indicated that ERK/MAPK signaling is involved in the silicon-induced odontogenic differentiation of hDPCs. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 205-208 25175224-7 2014 Additionally, statistically significant differences (p<0.05) have been found in the calcium deposition in si-FGFR transfection and ERK inhibitor between CS and beta-TCP; these variations indicated that ERK/MAPK signaling is involved in the silicon-induced odontogenic differentiation of hDPCs. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 209-213 25018059-9 2014 We determined that oxLDL triggered the phosphorylation of ERK and, in turn, the activation of p53 and other apoptosis-related events, including calcium accumulation, destabilization of the mitochondrial permeability and disruption of the balance between pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins. Calcium 144-151 mitogen-activated protein kinase 1 Homo sapiens 58-61 24809457-3 2014 In the current study, we found that exogenous Gal-3 slightly delays, while prolonging tyrosine phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) in HeLa cells through a calcium-sensitive and PKC-dependent signaling pathway. Calcium 189-196 mitogen-activated protein kinase 1 Homo sapiens 114-155 23328481-3 2013 miR-708 targets the endoplasmic reticulum protein neuronatin to decrease intracellular calcium level, resulting in reduction of activation of ERK and FAK, decreased cell migration, and impaired metastases. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 142-145 24064350-5 2013 Also, IGF-1 induced calcium-dependent molecules such as Calmodulin Kinase II (CaMK II), Extracellular signal-regulated Kinases (ERK), Protein Kinase C (PKC). Calcium 20-27 mitogen-activated protein kinase 1 Homo sapiens 88-126 23683282-11 2013 CONCLUSIONS: This study showed that calcium ions released from MTA play an important role in odontoblastic differentiation of HDPCs via modulation of ERK and JNK activation. Calcium 36-43 mitogen-activated protein kinase 1 Homo sapiens 150-153 24392181-2 2013 This study explores the biological functions of ERK pathway in cardiomyocytes hypoxia/reoxygenation injury and clarifies the mechanisms by which F2 ameliorates cardiomyocytes hypoxia/reoxygenation injury through the extracellular-calcium-dependent and -independent ERK1/2-related pathways. Calcium 230-237 mitogen-activated protein kinase 1 Homo sapiens 48-51 24392181-12 2013 Altogether, ERK activation in extracellular-calcium-containing and extracellular-calcium-free hypoxia/reoxygenation leads to cardiomyocytes damage. Calcium 44-51 mitogen-activated protein kinase 1 Homo sapiens 12-15 24392181-12 2013 Altogether, ERK activation in extracellular-calcium-containing and extracellular-calcium-free hypoxia/reoxygenation leads to cardiomyocytes damage. Calcium 81-88 mitogen-activated protein kinase 1 Homo sapiens 12-15 22543706-8 2012 E-cadherin-mediated calcium-dependent cell-cell adhesion of SKOV-3 cells resulted in a rapid increase of P-ERK, but did not modify the expression of ERK protein. Calcium 20-27 mitogen-activated protein kinase 1 Homo sapiens 107-110 21368299-8 2011 Using Ingenuity pathways analysis software to identify signaling pathways involved in trophoblast differentiation or function, we discovered that many genes are involved in WNT/beta-catenin, ERK/MAPK, NFKB, and calcium signaling pathways, suggesting potential roles for these families in trophoblast development. Calcium 211-218 mitogen-activated protein kinase 1 Homo sapiens 191-194 22449977-4 2012 Finally, the E2-induced effects could also be significantly suppressed by BAPTA or U0126, indicating involvement of calcium/ERK signaling. Calcium 116-123 mitogen-activated protein kinase 1 Homo sapiens 124-127 21506533-1 2011 The extracellular signal-regulated protein kinase, ERK2, fully activated by phosphorylation and without a His(6) tag, shows little tendency to dimerize with or without either calcium or magnesium ions when analyzed by light scattering or analytical ultracentrifugation. Calcium 175-182 mitogen-activated protein kinase 1 Homo sapiens 51-55 21135065-9 2011 The CASR(T888M) mutant exhibited enhanced sensitivity to extracellular calcium concentration, both for intracellular calcium (Ca(2+)(i)) mobilization and for ERK phosphorylation, despite having unaltered levels of cell surface expression. Calcium 71-78 mitogen-activated protein kinase 1 Homo sapiens 158-161 21163523-9 2011 Here we discuss the possible mechanisms by which the MAPKs ERK1 and ERK2, activated by synaptically evoked calcium influx, can signal to the nucleus and regulate gene transcription. Calcium 107-114 mitogen-activated protein kinase 1 Homo sapiens 68-72 21311105-8 2011 To clarify the signal transduction pathways related to the regulation of the viral genes by alloferon, we confirmed that the calcium influx into BCBL-1 was apparently inhibited by alloferon, which preceded the suppression of the phosphorylation of ERK and the activation of AP-1 by TPA. Calcium 125-132 mitogen-activated protein kinase 1 Homo sapiens 248-251 19893321-7 2010 7betaOHC produced an increase in extracellular signal-regulated kinase (ERK) phosphorylation that was blocked by inhibitors of store-operated calcium entry 2-aminoethoxydiphenyl borate and gadolinium. Calcium 142-149 mitogen-activated protein kinase 1 Homo sapiens 33-70 20033237-6 2010 Either knockdown of the taurine transporter (TAUT) or treatment with the ERK-specific inhibitor PD98059 blocked the activation of ERK by taurine and abolished taurine-induced Axl/Gas6 expression and calcium deposition reduction in beta-GP-induced VSMC calcification model. Calcium 199-206 mitogen-activated protein kinase 1 Homo sapiens 73-76 20484116-4 2010 Here, we demonstrate that the ligation of TREM2 activated phosphatidylinositol 3-kinase (PI3K), extracellular signal-regulated kinase 1 (ERK1) and ERK2, and the guanine nucleotide exchange factor Vav3; induced the mobilization of intracellular calcium (Ca(2+)) and the reorganization of actin; and prevented apoptosis. Calcium 244-251 mitogen-activated protein kinase 1 Homo sapiens 96-135 20484116-4 2010 Here, we demonstrate that the ligation of TREM2 activated phosphatidylinositol 3-kinase (PI3K), extracellular signal-regulated kinase 1 (ERK1) and ERK2, and the guanine nucleotide exchange factor Vav3; induced the mobilization of intracellular calcium (Ca(2+)) and the reorganization of actin; and prevented apoptosis. Calcium 244-251 mitogen-activated protein kinase 1 Homo sapiens 137-141 20346918-0 2010 Elevated extracellular calcium increases expression of bone morphogenetic protein-2 gene via a calcium channel and ERK pathway in human dental pulp cells. Calcium 23-30 mitogen-activated protein kinase 1 Homo sapiens 115-118 20738419-8 2011 The IPP-induced calcium mobilization and NFAT translocation were necessary to activate Vgamma2Vdelta2 effector functions; interleukin-2, acting on the MEK/Erk pathway, regulated the strength of these responses. Calcium 16-23 mitogen-activated protein kinase 1 Homo sapiens 155-158 20854900-12 2010 These results, for the first time, reveal that DEHP induces apoptosis in hepatocytes via the activation of the ERK/NF-kappaB signaling pathway, in which calcium ions and hydrogen peroxide act as the pivotal mediators of the apoptotic signaling. Calcium 153-160 mitogen-activated protein kinase 1 Homo sapiens 111-114 19700217-5 2010 The release of calcium triggered the production of ROS, which further enhances calcium overloading and subsequently activates p38, JNK and ERK1/2. Calcium 15-22 mitogen-activated protein kinase 1 Homo sapiens 126-129 19893321-7 2010 7betaOHC produced an increase in extracellular signal-regulated kinase (ERK) phosphorylation that was blocked by inhibitors of store-operated calcium entry 2-aminoethoxydiphenyl borate and gadolinium. Calcium 142-149 mitogen-activated protein kinase 1 Homo sapiens 72-75 19893321-9 2010 The results suggest that 7betaOHC promotes HUVECs survival and proliferation by a mechanism independent of ROS production and involving calcium-dependent activation of ERK. Calcium 136-143 mitogen-activated protein kinase 1 Homo sapiens 168-171 19438323-5 2009 Inhibition of ERK activation by PD98059, a specific inhibitor of the ERK signaling pathway, blocked the osteogenic differentiation in a dose-dependent manner, as revealed by an ALP activity assay, extracellular calcium deposition detection, osteocalcin (OCN) secretion examination, and real-time polymerase chain reaction (PCR) analysis for expression of osteogenesis-relative genes: core binding factor alpha 1, collagen type I, ALP, and OCN. Calcium 211-218 mitogen-activated protein kinase 1 Homo sapiens 14-17 19477952-3 2009 VEGF-induced ERK2/1 activation was mediated by VEGFR2, but not VEGFR1, and was linked to intracellular calcium, protein kinase C, and Raf-1. Calcium 103-110 mitogen-activated protein kinase 1 Homo sapiens 13-17 19576918-7 2009 Additionally, blocking calcium entry with EGTA resulted in suppression of PDGF-induced Erk activation. Calcium 23-30 mitogen-activated protein kinase 1 Homo sapiens 87-90 19560418-0 2009 KSR2 is a calcineurin substrate that promotes ERK cascade activation in response to calcium signals. Calcium 84-91 mitogen-activated protein kinase 1 Homo sapiens 46-49 19625651-4 2009 TREM-2-dependent calcium signals are required for RANK-mediated activation of calcium/calmodulin-dependent protein kinase (CaMK)II and downstream MEK and ERK MAPKs that are important for osteoclastogenesis. Calcium 17-24 mitogen-activated protein kinase 1 Homo sapiens 154-157 19057895-6 2009 Indeed, ERK2 activity was very sensitive to PKC inhibition and calcium chelation and insensitive to tyrosine kinase and PI-3-kinase inhibition. Calcium 63-70 mitogen-activated protein kinase 1 Homo sapiens 8-12 19333000-4 2009 In the calcium-ERK autophagy and apoptosis pathway, cadmium stimulates calcium release from the endoplasmic reticulum, which activates ERK leading to predominantly autophagic cell death and a minor level of apoptotic cell death. Calcium 7-14 mitogen-activated protein kinase 1 Homo sapiens 15-18 19333000-4 2009 In the calcium-ERK autophagy and apoptosis pathway, cadmium stimulates calcium release from the endoplasmic reticulum, which activates ERK leading to predominantly autophagic cell death and a minor level of apoptotic cell death. Calcium 7-14 mitogen-activated protein kinase 1 Homo sapiens 135-138 19333000-4 2009 In the calcium-ERK autophagy and apoptosis pathway, cadmium stimulates calcium release from the endoplasmic reticulum, which activates ERK leading to predominantly autophagic cell death and a minor level of apoptotic cell death. Calcium 71-78 mitogen-activated protein kinase 1 Homo sapiens 15-18 19333000-4 2009 In the calcium-ERK autophagy and apoptosis pathway, cadmium stimulates calcium release from the endoplasmic reticulum, which activates ERK leading to predominantly autophagic cell death and a minor level of apoptotic cell death. Calcium 71-78 mitogen-activated protein kinase 1 Homo sapiens 135-138 18776917-11 2008 trans-Resveratrol potently inhibited p38 and ERK1/2 activation after calcium ionophore and CB and C5a activation. Calcium 69-76 mitogen-activated protein kinase 1 Homo sapiens 37-40 19138669-8 2009 These findings demonstrate that p38 MAPK and ERK1/2, but not JNK, are involved in apoptosis of cCGNs induced by copper, and p38 and ERK may be the downstream effectors of ROS and calcium signaling. Calcium 179-186 mitogen-activated protein kinase 1 Homo sapiens 124-127 18785111-5 2008 Blocking the enzyme activity of NQO1 with dicoumarol, a known NQO1 inhibitor, or preventing an increase in intracellular calcium levels using BAPTA-AM, an intracellular calcium chelator, substantially inhibited MAPK phosphorylation, abolished the activation of calpain, caspase-12 and caspase-7, and provided significant protection of beta-lapachone-treated cells. Calcium 121-128 mitogen-activated protein kinase 1 Homo sapiens 211-215 18837011-4 2008 Here, we show that one calcium activated signaling pathway, extracellular signal-regulated kinase (ERK), showed differential activity in cortical neurons. Calcium 23-30 mitogen-activated protein kinase 1 Homo sapiens 60-97 18837011-4 2008 Here, we show that one calcium activated signaling pathway, extracellular signal-regulated kinase (ERK), showed differential activity in cortical neurons. Calcium 23-30 mitogen-activated protein kinase 1 Homo sapiens 99-102 17641674-6 2007 Inhibition of the extracellular signal-regulated kinase (ERK) 2 eliminated the palytoxin-induced rise in calcium and intracellular acidification, whereas inhibition of MEK greatly attenuated the palytoxin effect on calcium without modifying the PLT-evoked intracellular acidification. Calcium 105-112 mitogen-activated protein kinase 1 Homo sapiens 18-63 18215419-0 2008 17beta-estradiol rapidly mobilizes intracellular calcium from ryanodine-receptor-gated stores via a PKC-PKA-Erk-dependent pathway in the human eccrine sweat gland cell line NCL-SG3. Calcium 49-56 mitogen-activated protein kinase 1 Homo sapiens 108-111 18406603-3 2008 Although estrogen"s transcriptional effects occur through classical nuclear steroid receptors (ERs), recent studies reveal the existence of a novel 7-transmembrane G protein-coupled receptor, GPR30, which responds to estrogen and tamoxifen stimulation with rapid cellular signaling including ERK activation, PI3K activation, calcium mobilization and cAMP production. Calcium 325-332 mitogen-activated protein kinase 1 Homo sapiens 292-295 17551669-6 2007 The intracellular calcium chelator, BAPTA-AM, was shown to block PGE2-induced Erk and EGFR phosphorylation. Calcium 18-25 mitogen-activated protein kinase 1 Homo sapiens 78-81 17551669-8 2007 Our findings suggest that in human cholangiocarcinoma cells, PGE2-enhanced phosphorylation of Erk is, at least in part, mediated through EP1 receptors and EGFR phosphorylation induced by increases in the intracellular concentration of calcium. Calcium 235-242 mitogen-activated protein kinase 1 Homo sapiens 94-97 19039081-7 2008 We found the cell had a calcium-dependent adenylate cyclase, and MeHg could inhibit the phosphorylation of extracellular-signal regulated kinase (ERK). Calcium 24-31 mitogen-activated protein kinase 1 Homo sapiens 107-144 19039081-7 2008 We found the cell had a calcium-dependent adenylate cyclase, and MeHg could inhibit the phosphorylation of extracellular-signal regulated kinase (ERK). Calcium 24-31 mitogen-activated protein kinase 1 Homo sapiens 146-149 18268018-3 2008 Varying calcium concentrations significantly modified the repertoire of ERK2-interacting proteins, of which many were identified. Calcium 8-15 mitogen-activated protein kinase 1 Homo sapiens 72-76 18268018-4 2008 The effect of calcium on ERK interactions also influenced the localization of ERKs, as calcium chelators enhanced nuclear translocation, whereas elevated calcium levels prevented it. Calcium 14-21 mitogen-activated protein kinase 1 Homo sapiens 25-28 18268018-4 2008 The effect of calcium on ERK interactions also influenced the localization of ERKs, as calcium chelators enhanced nuclear translocation, whereas elevated calcium levels prevented it. Calcium 14-21 mitogen-activated protein kinase 1 Homo sapiens 78-82 18268018-4 2008 The effect of calcium on ERK interactions also influenced the localization of ERKs, as calcium chelators enhanced nuclear translocation, whereas elevated calcium levels prevented it. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 25-28 18268018-4 2008 The effect of calcium on ERK interactions also influenced the localization of ERKs, as calcium chelators enhanced nuclear translocation, whereas elevated calcium levels prevented it. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 78-82 18268018-4 2008 The effect of calcium on ERK interactions also influenced the localization of ERKs, as calcium chelators enhanced nuclear translocation, whereas elevated calcium levels prevented it. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 25-28 18268018-4 2008 The effect of calcium on ERK interactions also influenced the localization of ERKs, as calcium chelators enhanced nuclear translocation, whereas elevated calcium levels prevented it. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 78-82 18268018-5 2008 This effect of calcium was apparent upon lysophosphatidic acid stimulation, where ERKs translocation was delayed compared with that induced by EGF in a calcium-dependent manner. Calcium 15-22 mitogen-activated protein kinase 1 Homo sapiens 82-86 18268018-6 2008 In vitro translocation assay revealed that high calcium concentrations affect ERK translocation by preventing the shuttling machinery through the nuclear envelope, probably due to higher binding to nuclear pore proteins. Calcium 48-55 mitogen-activated protein kinase 1 Homo sapiens 78-81 18268018-9 2008 This translocation is delayed when calcium levels are increased, and this modifies the localization of ERKs and, therefore, also their spatiotemporal regulation. Calcium 35-42 mitogen-activated protein kinase 1 Homo sapiens 103-107 18268018-10 2008 Thus, calcium regulates ERK localization, which is important for the compartmentalization of ERKs with their proper substrates and thereby their signaling specificity. Calcium 6-13 mitogen-activated protein kinase 1 Homo sapiens 24-27 18268018-10 2008 Thus, calcium regulates ERK localization, which is important for the compartmentalization of ERKs with their proper substrates and thereby their signaling specificity. Calcium 6-13 mitogen-activated protein kinase 1 Homo sapiens 93-97 17964630-4 2008 In addition, multiple signaling pathways are involved cooperatively in the expression of COX-2 activated by the viral protein in a calcium-independent manner, which requires signaling components including JNK, ERK, and PKD2. Calcium 131-138 mitogen-activated protein kinase 1 Homo sapiens 210-213 19704446-0 2008 Calcium regulates ERK signaling by modulating its protein-protein interactions. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 18-21 19704446-2 2008 Two important signaling components in the network are the extracellular signal-regulated kinase (ERK) signaling cascade and elevation of calcium concentrations, which transmit signals of hormones, growth factors and other ligands. Calcium 137-144 mitogen-activated protein kinase 1 Homo sapiens 58-95 19704446-2 2008 Two important signaling components in the network are the extracellular signal-regulated kinase (ERK) signaling cascade and elevation of calcium concentrations, which transmit signals of hormones, growth factors and other ligands. Calcium 137-144 mitogen-activated protein kinase 1 Homo sapiens 97-100 19704446-5 2008 We have recently shown that calcium modulates the protein interaction properties of ERKs, which further affect the subcellular localization of the latter and as a consequence also the distribution of their targets. Calcium 28-35 mitogen-activated protein kinase 1 Homo sapiens 84-88 19704446-6 2008 These effects of calcium are important in determining the specificity of the ERK cascade, and thereby, play important roles in the regulation of ERK-dependent cellular processes. Calcium 17-24 mitogen-activated protein kinase 1 Homo sapiens 77-80 19704446-6 2008 These effects of calcium are important in determining the specificity of the ERK cascade, and thereby, play important roles in the regulation of ERK-dependent cellular processes. Calcium 17-24 mitogen-activated protein kinase 1 Homo sapiens 145-148 17686966-8 2007 Removal of extracellular calcium or inhibition of capacitative calcium entry by 2-APB prevented ciglitazone-induced EGFR transactivation and Erk activation but did not affect upstream kinase signaling pathways. Calcium 63-70 mitogen-activated protein kinase 1 Homo sapiens 141-144 17641674-10 2007 CONCLUSIONS AND IMPLICATIONS: MAPKs, specifically ERK 2, link palytoxin cytotoxicity with its effects on calcium homeostasis after inhibition of the Na,K-ATPase. Calcium 105-112 mitogen-activated protein kinase 1 Homo sapiens 50-55 17327421-5 2007 Using dominant-negative point mutations and chemical inhibitors, we identified that calcium-dependent proline-rich tyrosine kinase 2 specifically acts as a scaffold for a focal adhesion/cytoskeleton-dependent complex comprised of c-Src, Grb2, and mSos that translocates an ERK-activating signal to the nucleus. Calcium 84-91 mitogen-activated protein kinase 1 Homo sapiens 273-276 17485079-4 2007 Therefore, a common pathway initiated by a rapid rise in calcium and followed by calcium-mediated activation of ERK is involved in the transcriptional induction of functional MT1 and MT2 isoforms and in the progression of the cell cycle in thyroid cancer cells exposed to cadmium. Calcium 57-64 mitogen-activated protein kinase 1 Homo sapiens 112-115 17485079-4 2007 Therefore, a common pathway initiated by a rapid rise in calcium and followed by calcium-mediated activation of ERK is involved in the transcriptional induction of functional MT1 and MT2 isoforms and in the progression of the cell cycle in thyroid cancer cells exposed to cadmium. Calcium 81-88 mitogen-activated protein kinase 1 Homo sapiens 112-115 17267381-3 2007 We found that an upstream calcium-dependent PKC isozyme PKC alpha that modulates the downstream ERK/NF-kappaB pathway through an influx of extracellular Ca2+ is induced by the spike protein of SARS-CoV. Calcium 26-33 mitogen-activated protein kinase 1 Homo sapiens 96-99 17298299-7 2007 Finally ADP- or G(i)+G(z)-induced ERK phosphorylation was blocked in the presence of extracellular calcium. Calcium 99-106 mitogen-activated protein kinase 1 Homo sapiens 34-37 17298299-9 2007 We also conclude that extracellular calcium blocks ADP-induced thromboxane A2 generation through the inhibition of ERK activation. Calcium 36-43 mitogen-activated protein kinase 1 Homo sapiens 115-118 18034588-6 2007 Developments in describing the role of intracellular calcium ([Ca(2+)](i)) and its correlation with cellular signalling systems, Ras/Raf/mitogen extracellular kinase (MEK)/extracellular signal-regulated protein kinase (ERK), and interaction of these pathways with cyclic adenosine monophosphate (cAMP) levels, provide new insights on treatment strategies. Calcium 53-60 mitogen-activated protein kinase 1 Homo sapiens 219-222 17449939-0 2007 Autocrine extracellular signal-regulated kinase activation in normal human keratinocytes is not interrupted by calcium triggering and is involved in the control of cell cycle at the early stage of calcium-induced differentiation. Calcium 197-204 mitogen-activated protein kinase 1 Homo sapiens 10-47 17449939-2 2007 However, during the condition of calcium-induced differentiation, how the autocrine ERK signaling is regulated and affected is poorly understood. Calcium 33-40 mitogen-activated protein kinase 1 Homo sapiens 84-87 17449939-3 2007 The purpose of this study was to understand and to obtain clues to the possible function of the autocrine ERK activation during the calcium-induced differentiation of NHEK. Calcium 132-139 mitogen-activated protein kinase 1 Homo sapiens 106-109 17449939-4 2007 We demonstrated that the autocrine activated ERK was not interrupted by calcium triggering and that it was sustained for at least one day after changing the medium. Calcium 72-79 mitogen-activated protein kinase 1 Homo sapiens 45-48 17449939-5 2007 We also found that the autocrine ERK activation was associated with the expression of cyclin D1 and the cell cycle regulation at the early stage of calcium triggering by treating the cells with the mitogen-activated protein kinase inhibitor PD98059. Calcium 148-155 mitogen-activated protein kinase 1 Homo sapiens 33-36 17449939-8 2007 We suggest that the activation of autocrine ERK is not interrupted by calcium triggering and it might participate in cell growth during the early stage of calcium-induced differentiation in NHEK. Calcium 155-162 mitogen-activated protein kinase 1 Homo sapiens 44-47 17307136-5 2007 These results establish a calcium crystal induced, calcium/calmodulin independent, signaling pathway in which BCP crystals activate Ras/MAPK, which can directly target an SRF-containing transcription factor complex, to induce fibroblasts to secrete metalloproteinases. Calcium 26-33 mitogen-activated protein kinase 1 Homo sapiens 136-140 17085321-3 2006 Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p<0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK. Calcium 36-43 mitogen-activated protein kinase 1 Homo sapiens 139-142 17085321-3 2006 Phorbol myristate acetate (PMA) and calcium ionophore, A23187 further enhanced PGE(2) synthesis (p<0.001) and caused phosphorylation of ERK that was sustained for up to 16 h. COX-2 protein expression and PGE(2) synthesis were increased following exposure to combinations of stimuli that increased intracellular Ca(2+), and activated protein kinase C as well as ERK. Calcium 36-43 mitogen-activated protein kinase 1 Homo sapiens 364-367 17088408-9 2006 Similar to E2, genistein, glycitein and the isoflavonoid metabolite equol induced higher concentrations of intracellular free calcium, an event that could provide the upstream mechanism(s) induced by E2 and phytoestrogens that initiates the signaling cascade which results in the activation of extracellular signal-regulated kinase (ERK) signaling pathways and modulation of Sp-1 sites of the VDR gene, and culminates in enhanced VDR expression. Calcium 126-133 mitogen-activated protein kinase 1 Homo sapiens 294-331 17088408-9 2006 Similar to E2, genistein, glycitein and the isoflavonoid metabolite equol induced higher concentrations of intracellular free calcium, an event that could provide the upstream mechanism(s) induced by E2 and phytoestrogens that initiates the signaling cascade which results in the activation of extracellular signal-regulated kinase (ERK) signaling pathways and modulation of Sp-1 sites of the VDR gene, and culminates in enhanced VDR expression. Calcium 126-133 mitogen-activated protein kinase 1 Homo sapiens 333-336 16893669-9 2006 Altogether, these results represent the first evidence to date suggesting that P2Y(2) receptor stimulation by ATP in osteoblasts sensitizes mechanical stress activated calcium channels leading to calcium influx and a fast activation of the ERK 1/2 and p38 MAPK pathways. Calcium 168-175 mitogen-activated protein kinase 1 Homo sapiens 252-255 16467404-12 2006 These data indicate that in HAEC, CXCR3-mediated chemotaxis involves a G protein, which activates both the p38 MAPK and PI3K pathways in a calcium-independent fashion. Calcium 139-146 mitogen-activated protein kinase 1 Homo sapiens 107-110 16888186-7 2006 Intracellular calcium depletion modulated PACAP-associated ERK but not p38 phosphorylation; in contrast, extracellular calcium depletion modulated PACAP-associated p38 but not ERK phosphorylation. Calcium 14-21 mitogen-activated protein kinase 1 Homo sapiens 59-62 16601239-10 2006 Consistent with the known calcium dependence of PKCalpha signaling, blocking of the calcium signaling with the intracellular calcium-chelating agent BAPTA led to abrogation of PKCalpha nuclear translocation, ERK2 phosphorylation, and collagen production. Calcium 84-91 mitogen-activated protein kinase 1 Homo sapiens 208-212 16601239-10 2006 Consistent with the known calcium dependence of PKCalpha signaling, blocking of the calcium signaling with the intracellular calcium-chelating agent BAPTA led to abrogation of PKCalpha nuclear translocation, ERK2 phosphorylation, and collagen production. Calcium 84-91 mitogen-activated protein kinase 1 Homo sapiens 208-212 15713425-0 2005 Calcium and the replication of human vascular smooth muscle cells: studies on the activation and translocation of extracellular signal regulated kinase (ERK) and cyclin D1 expression. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 114-151 16554661-5 2006 ANG2-dependent ERK activation was mediated by both protein kinase C (PKC)- and calcium-dependent mechanisms and was associated with tyrosine phosphorylation of EGFR. Calcium 79-86 mitogen-activated protein kinase 1 Homo sapiens 15-18 16148159-7 2005 Intracellular calcium depletion modulated PACAP-associated ERK but not p38 phosphorylation; in contrast, extracellular calcium depletion modulated PACAP-associated p38 but not ERK phosphorylation. Calcium 14-21 mitogen-activated protein kinase 1 Homo sapiens 59-62 15931263-4 2005 Differentiation occurs via a calcium-dependent mechanism involving the CaMKII and MAPK/ERK pathways. Calcium 29-36 mitogen-activated protein kinase 1 Homo sapiens 87-90 15890781-0 2005 The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade. Calcium 19-26 mitogen-activated protein kinase 1 Homo sapiens 111-114 15890781-0 2005 The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade. Calcium 19-26 mitogen-activated protein kinase 1 Homo sapiens 115-119 15890781-0 2005 The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade. Calcium 68-75 mitogen-activated protein kinase 1 Homo sapiens 111-114 15890781-0 2005 The frequencies of calcium oscillations are optimized for efficient calcium-mediated activation of Ras and the ERK/MAPK cascade. Calcium 68-75 mitogen-activated protein kinase 1 Homo sapiens 115-119 15728661-4 2005 In untreated cells, IL-1 induced a prolonged increase of free intracellular calcium, which was required for ERK activation. Calcium 76-83 mitogen-activated protein kinase 1 Homo sapiens 108-111 15713425-0 2005 Calcium and the replication of human vascular smooth muscle cells: studies on the activation and translocation of extracellular signal regulated kinase (ERK) and cyclin D1 expression. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 153-156 15180997-0 2004 Calcium-induced matrix metalloproteinase 9 gene expression is differentially regulated by ERK1/2 and p38 MAPK in oral keratinocytes and oral squamous cell carcinoma. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 101-104 15263001-0 2004 Calcium restriction allows cAMP activation of the B-Raf/ERK pathway, switching cells to a cAMP-dependent growth-stimulated phenotype. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 56-59 15263001-6 2004 In M-1 cells, we showed that calcium restriction was associated with an elevation in B-Raf protein levels and cAMP-stimulated, Ras-dependent activation of B-Raf and ERK. Calcium 29-36 mitogen-activated protein kinase 1 Homo sapiens 165-168 15263001-11 2004 We conclude that disruption of calcium mobilization in cells that are normally growth-inhibited by cAMP can derepress the B-Raf/ERK pathway, thus converting these cells to a phenotype that is growth-stimulated by cAMP. Calcium 31-38 mitogen-activated protein kinase 1 Homo sapiens 128-131 15180997-8 2004 Together these data support a model wherein calcium-induced MMP-9 expression is differentially regulated by the ERK1/2 and p38 MAPK pathways in oral keratinocytes, and the data suggest that a loss of this regulatory mechanism accompanies malignant transformation of the oral epithelium. Calcium 44-51 mitogen-activated protein kinase 1 Homo sapiens 123-126 15917990-7 2005 PAF-induced ERK phosphorylation is mediated by PI3K, PKC, PLA2, PLC, and extracellular calcium, whereas fMLP-induced ERK phosphorylation does not involve the PKC-gamma isoform and extracellular calcium. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 12-15 15356166-8 2004 Using specific pharmalogical inhibitors of ERK (PD098059) and p38 MAPK (SB203580), we found that PACAP-mediated calcium increase was ERK and PLC dependent and p38 independent. Calcium 112-119 mitogen-activated protein kinase 1 Homo sapiens 43-46 15356166-8 2004 Using specific pharmalogical inhibitors of ERK (PD098059) and p38 MAPK (SB203580), we found that PACAP-mediated calcium increase was ERK and PLC dependent and p38 independent. Calcium 112-119 mitogen-activated protein kinase 1 Homo sapiens 133-136 15180997-6 2004 Pharmacologic inhibition of p38 MAPK activity or expression of a catalytically inactive mutant of the upstream kinase MAPK kinase 3 (MKK3) increased the calcium induced MMP-9 gene expression, demonstrating that p38 MAPK activity negatively regulated this process. Calcium 153-160 mitogen-activated protein kinase 1 Homo sapiens 211-214 15094063-3 2004 TG-stimulated ERK1/ERK2 phosphorylation was also diminished in buffer containing EGTA, a calcium chelator, further suggesting the implication of calcium influx in MAPK activation in these cells. Calcium 89-96 mitogen-activated protein kinase 1 Homo sapiens 19-23 15253728-18 2004 However, Hcy50 micromol/L induced a brief increase in intracellular mesangial cell calcium within 5 minutes, and the calcium ionophores A23187 and ionomycin increased Erk activity while chelation of intracellular calcium with BAPTA-AM abrogated the Erk response to Hcy. Calcium 117-124 mitogen-activated protein kinase 1 Homo sapiens 167-170 15253728-18 2004 However, Hcy50 micromol/L induced a brief increase in intracellular mesangial cell calcium within 5 minutes, and the calcium ionophores A23187 and ionomycin increased Erk activity while chelation of intracellular calcium with BAPTA-AM abrogated the Erk response to Hcy. Calcium 117-124 mitogen-activated protein kinase 1 Homo sapiens 249-252 15253728-18 2004 However, Hcy50 micromol/L induced a brief increase in intracellular mesangial cell calcium within 5 minutes, and the calcium ionophores A23187 and ionomycin increased Erk activity while chelation of intracellular calcium with BAPTA-AM abrogated the Erk response to Hcy. Calcium 117-124 mitogen-activated protein kinase 1 Homo sapiens 167-170 15253728-18 2004 However, Hcy50 micromol/L induced a brief increase in intracellular mesangial cell calcium within 5 minutes, and the calcium ionophores A23187 and ionomycin increased Erk activity while chelation of intracellular calcium with BAPTA-AM abrogated the Erk response to Hcy. Calcium 117-124 mitogen-activated protein kinase 1 Homo sapiens 249-252 15253728-22 2004 CONCLUSION: Hcy increases Erk activity in mesangial cells via a calcium-dependent mechanism, resulting in increased AP-1 nuclear protein binding, cell DNA synthesis and proliferation and induction of endoplasmic reticulum stress. Calcium 64-71 mitogen-activated protein kinase 1 Homo sapiens 26-29 15150258-0 2004 Calcium activation of ERK mediated by calmodulin kinase I. Elevated intracellular Ca(2+) triggers numerous signaling pathways including protein kinases such as the calmodulin-dependent kinases (CaMKs) and the extracellular signal-regulated kinases (ERKs). Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 22-25 15150258-0 2004 Calcium activation of ERK mediated by calmodulin kinase I. Elevated intracellular Ca(2+) triggers numerous signaling pathways including protein kinases such as the calmodulin-dependent kinases (CaMKs) and the extracellular signal-regulated kinases (ERKs). Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 249-253 15094063-3 2004 TG-stimulated ERK1/ERK2 phosphorylation was also diminished in buffer containing EGTA, a calcium chelator, further suggesting the implication of calcium influx in MAPK activation in these cells. Calcium 145-152 mitogen-activated protein kinase 1 Homo sapiens 19-23 14978732-3 2004 We report that: (1) removal of calcium from the culture medium of newly confluent Caco-2/15 cells (30 min, 4 mM EGTA) results in the disruption of both adherens and tight junctions and clearly decreases Akt phosphorylation while increasing MEK and ERK activities. Calcium 31-38 mitogen-activated protein kinase 1 Homo sapiens 248-251 14575691-9 2003 When a p38 inhibitor, SB 203580, was added to the culture medium in group C, AlPase activity, formation of bone nodules, and calcium deposits were completely inhibited. Calcium 125-132 mitogen-activated protein kinase 1 Homo sapiens 7-10 15030385-7 2004 Taken together the results imply that neuronal CCK gene transcription is regulated by the cumulative action of calcium and cAMP via stimulation of the PKA and ERK signalling pathways and that synergy is accomplished by the coordinate activation of CREB and CBP. Calcium 111-118 mitogen-activated protein kinase 1 Homo sapiens 159-162 12657694-6 2003 Activation of ERK was reduced when calcium influx was diminished. Calcium 35-42 mitogen-activated protein kinase 1 Homo sapiens 14-17 12925744-5 2003 Activation of extracellular receptor kinase (ERK) is required for estrogen-induced neuroprotection and calcium regulation. Calcium 103-110 mitogen-activated protein kinase 1 Homo sapiens 14-43 12925744-5 2003 Activation of extracellular receptor kinase (ERK) is required for estrogen-induced neuroprotection and calcium regulation. Calcium 103-110 mitogen-activated protein kinase 1 Homo sapiens 45-48 12842872-1 2003 The Tec family kinase Itk plays a critical role in signal transduction downstream of the T cell antigen receptor and has been implicated in the activation of phospholipase C-gamma1, a key regulator of calcium mobilization and extracellular signal-regulated kinase (ERK) activation. Calcium 201-208 mitogen-activated protein kinase 1 Homo sapiens 265-268 12807488-5 2003 Such Erk MAPkinase activation is downstream of calcium influx and targets LPS-induced IL-12 p40 transcription by suppressing the synthesis of the transcription factor, interferon regulatory factor-1 (IRF-1). Calcium 47-54 mitogen-activated protein kinase 1 Homo sapiens 5-8 12657694-9 2003 These findings demonstrate for the first time that ATP released by mechanical injury is one of the signals that triggers ERK activation and suggest a role for extracellular ATP, P2 purinergic receptors, and calcium-dependent ERK signaling in the astrocytic response to brain trauma. Calcium 207-214 mitogen-activated protein kinase 1 Homo sapiens 121-124 12657694-9 2003 These findings demonstrate for the first time that ATP released by mechanical injury is one of the signals that triggers ERK activation and suggest a role for extracellular ATP, P2 purinergic receptors, and calcium-dependent ERK signaling in the astrocytic response to brain trauma. Calcium 207-214 mitogen-activated protein kinase 1 Homo sapiens 225-228 12055097-4 2002 Expression of a dominant negative PI3K totally inhibited ERK activation in response to calcium. Calcium 87-94 mitogen-activated protein kinase 1 Homo sapiens 57-60 12379481-12 2002 We conclude that the calcium ionophore A23187 and the receptor agonist fMLP both act through common pathways to stimulate PAF synthesis, with p38 MAP kinase regulating acetyltransferase and supplementing ERK activation of cPLA(2). Calcium 21-28 mitogen-activated protein kinase 1 Homo sapiens 204-207 12423240-2 2002 The stimulation of astrocytes with micromolar concentrations of the dinucleotide elicited rapid increases in intracellular calcium concentration ([Ca2+]i), showing an EC50 value of 15.27 +/- 0.61 micro m. Moreover, the stimulation of cells with nanomolar concentrations of Ap5A, unable to induce calcium responses, increased the phosphorylated forms of extracellular-signal regulated kinase 1/2 (ERK) with an EC50 value of 9.8 +/- 2.4 nm. Calcium 123-130 mitogen-activated protein kinase 1 Homo sapiens 353-394 12423240-2 2002 The stimulation of astrocytes with micromolar concentrations of the dinucleotide elicited rapid increases in intracellular calcium concentration ([Ca2+]i), showing an EC50 value of 15.27 +/- 0.61 micro m. Moreover, the stimulation of cells with nanomolar concentrations of Ap5A, unable to induce calcium responses, increased the phosphorylated forms of extracellular-signal regulated kinase 1/2 (ERK) with an EC50 value of 9.8 +/- 2.4 nm. Calcium 123-130 mitogen-activated protein kinase 1 Homo sapiens 396-399 11454659-6 2001 The calcium channel blockers nifedipine and verapamil, or removal of extracellular calcium inhibited UK14304-induced contractions and phosphorylation of Erk, demonstrating the importance of an influx of extracellular calcium. Calcium 4-11 mitogen-activated protein kinase 1 Homo sapiens 153-156 11574537-9 2001 In summary, our results demonstrate that NT stimulates calcium-dependent NF-kappaB and Ras-dependent Erk pathways that mediate the release of IL-8 from non-transformed human colonocytes. Calcium 55-62 mitogen-activated protein kinase 1 Homo sapiens 101-104 12089357-3 2002 Calcium pathways depend on calmodulin kinase II (CAMKII) activity, and calcium-independent pathways are accounted for in part by MAPK activation (Rap1/B-Raf/MAPK-ERK kinase/ERK1/2), demonstrated by the use of molecular and pharmacological tools. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 162-165 12089357-3 2002 Calcium pathways depend on calmodulin kinase II (CAMKII) activity, and calcium-independent pathways are accounted for in part by MAPK activation (Rap1/B-Raf/MAPK-ERK kinase/ERK1/2), demonstrated by the use of molecular and pharmacological tools. Calcium 71-78 mitogen-activated protein kinase 1 Homo sapiens 162-165 12161078-0 2002 The ERK cascade, a new pathway involved in the activation of store-mediated calcium entry in human platelets. Calcium 76-83 mitogen-activated protein kinase 1 Homo sapiens 4-7 11590203-4 2001 Activation of both ERK and NF-kappaB was blocked by wortmannin and LY294002, specific inhibitors of PI 3-K. Wortmannin also inhibited the Fc receptor-mediated increase in the cytosolic calcium concentration, but it did not block immunoglobulin G (IgG)-mediated phagocytosis. Calcium 185-192 mitogen-activated protein kinase 1 Homo sapiens 19-22 11454659-6 2001 The calcium channel blockers nifedipine and verapamil, or removal of extracellular calcium inhibited UK14304-induced contractions and phosphorylation of Erk, demonstrating the importance of an influx of extracellular calcium. Calcium 83-90 mitogen-activated protein kinase 1 Homo sapiens 153-156 11454659-9 2001 These data demonstrate that alpha(2) adrenoceptor-mediated vasoconstriction in the porcine palmar lateral vein is dependent upon activation of the Erk signal transduction cascade, which is downstream of an influx of extracellular calcium, and activation of Src tyrosine kinases. Calcium 230-237 mitogen-activated protein kinase 1 Homo sapiens 147-150 11133526-0 2001 Urea signaling to ERK phosphorylation in renal medullary cells requires extracellular calcium but not calcium entry. Calcium 86-93 mitogen-activated protein kinase 1 Homo sapiens 18-21 11278479-0 2001 Role of the ERK pathway in the activation of store-mediated calcium entry in human platelets. Calcium 60-67 mitogen-activated protein kinase 1 Homo sapiens 12-15 11165042-9 2001 One mechanism requires GnRH-induced ERK and JNK activation, while a second MAPK-independent pathway requires a thapsigargin-sensitive calcium signal. Calcium 134-141 mitogen-activated protein kinase 1 Homo sapiens 75-79 11369935-0 2001 A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication. Calcium 2-9 mitogen-activated protein kinase 1 Homo sapiens 57-60 11139572-0 2001 cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons. Calcium 113-120 mitogen-activated protein kinase 1 Homo sapiens 129-132 11139572-3 2001 We have found that PKA-induced CREB phosphorylation and CREB-dependent transcription are mediated by calcium (Ca(2+)) release from intracellular stores and are blocked by inhibitors of the protein kinase C and ERK pathways. Calcium 101-108 mitogen-activated protein kinase 1 Homo sapiens 210-213 11062237-2 2001 Tetrodotoxin, NMDA receptor antagonists, or reduced extracellular calcium (0.1 mm) greatly decreased basal levels of phospho-ERK2, indicating that activity-dependent activation of NMDA receptors maintained a high level of basal ERK2 activation. Calcium 66-73 mitogen-activated protein kinase 1 Homo sapiens 125-129 11062237-2 2001 Tetrodotoxin, NMDA receptor antagonists, or reduced extracellular calcium (0.1 mm) greatly decreased basal levels of phospho-ERK2, indicating that activity-dependent activation of NMDA receptors maintained a high level of basal ERK2 activation. Calcium 66-73 mitogen-activated protein kinase 1 Homo sapiens 228-232 11062237-4 2001 Addition of a calcium ionophore or 100 microm NMDA decreased phospho-ERK2 in the presence of 1 mm extracellular calcium but enhanced phospho-ERK2 in 0.1 mm extracellular calcium. Calcium 14-21 mitogen-activated protein kinase 1 Homo sapiens 69-73 11062237-4 2001 Addition of a calcium ionophore or 100 microm NMDA decreased phospho-ERK2 in the presence of 1 mm extracellular calcium but enhanced phospho-ERK2 in 0.1 mm extracellular calcium. Calcium 14-21 mitogen-activated protein kinase 1 Homo sapiens 141-145 11062237-4 2001 Addition of a calcium ionophore or 100 microm NMDA decreased phospho-ERK2 in the presence of 1 mm extracellular calcium but enhanced phospho-ERK2 in 0.1 mm extracellular calcium. Calcium 112-119 mitogen-activated protein kinase 1 Homo sapiens 69-73 11062237-4 2001 Addition of a calcium ionophore or 100 microm NMDA decreased phospho-ERK2 in the presence of 1 mm extracellular calcium but enhanced phospho-ERK2 in 0.1 mm extracellular calcium. Calcium 112-119 mitogen-activated protein kinase 1 Homo sapiens 69-73 11133526-7 2001 Taken together, these data indicate that urea-inducible ERK activation requires calcium action but not calcium entry. Calcium 80-87 mitogen-activated protein kinase 1 Homo sapiens 56-59 11133526-3 2001 We now show that urea-inducible ERK activation requires extracellular calcium; unexpectedly, it occurs independently of activation of cPKC isoforms. Calcium 70-77 mitogen-activated protein kinase 1 Homo sapiens 32-35 11018025-8 2000 Despite the transient nature of ERK activation, calcium-induced expression of the cyclin-dependent kinase inhibitor p21/Cip1 and the differentiation marker involucrin was sensitive to MEK inhibition, which suggests a role for the Raf/MEK/ERK pathway in early stages of keratinocyte differentiation. Calcium 48-55 mitogen-activated protein kinase 1 Homo sapiens 238-241 10508738-3 1999 In particular, it has become evident that multiple second messengers, such as cyclic adenosine monophosphate, protein kinase A, calcium, and diacylglycerol, can control ERK signalling via the small G proteins Ras and Rap1. Calcium 128-135 mitogen-activated protein kinase 1 Homo sapiens 169-172 11018025-0 2000 Ras-independent activation of the Raf/MEK/ERK pathway upon calcium-induced differentiation of keratinocytes. Calcium 59-66 mitogen-activated protein kinase 1 Homo sapiens 42-45 11018025-2 2000 To elucidate the role of MAPKs in keratinocyte differentiation, activation of ERK, JNK, and p38 in response to stimulation with extracellular calcium was analyzed. Calcium 142-149 mitogen-activated protein kinase 1 Homo sapiens 78-81 11018025-3 2000 We provide evidence that calcium-induced differentiation of keratinocytes is associated with rapid and transient activation of the Raf/MEK/ERK pathway. Calcium 25-32 mitogen-activated protein kinase 1 Homo sapiens 139-142 11018025-4 2000 Stimulation of keratinocytes with extracellular calcium resulted in activation of Raf isozymes and their downstream effector ERK within 10-15 min, but did not increase JNK or p38 activity. Calcium 48-55 mitogen-activated protein kinase 1 Homo sapiens 125-128 11018025-5 2000 Calcium-induced ERK activation differed in kinetics from mitogenic ERK activation by epidermal growth factor and could be modulated by alterations of intracellular calcium levels. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 16-19 11018025-5 2000 Calcium-induced ERK activation differed in kinetics from mitogenic ERK activation by epidermal growth factor and could be modulated by alterations of intracellular calcium levels. Calcium 164-171 mitogen-activated protein kinase 1 Homo sapiens 16-19 11018025-6 2000 Interestingly, calcium stimulation led to down-regulation of Ras activity at the same time that ERK activation was initiated. Calcium 15-22 mitogen-activated protein kinase 1 Homo sapiens 96-99 11018025-7 2000 Expression of a dominant-negative mutant of Ras also did not significantly impair calcium-induced ERK activation, indicating that calcium-mediated ERK activation does not require active Ras. Calcium 130-137 mitogen-activated protein kinase 1 Homo sapiens 147-150 11018025-8 2000 Despite the transient nature of ERK activation, calcium-induced expression of the cyclin-dependent kinase inhibitor p21/Cip1 and the differentiation marker involucrin was sensitive to MEK inhibition, which suggests a role for the Raf/MEK/ERK pathway in early stages of keratinocyte differentiation. Calcium 48-55 mitogen-activated protein kinase 1 Homo sapiens 32-35 11089552-7 2000 PD98059 abolished the increase of intracellular calcium induced by PTH demonstrating that ERK2 activation is directly involved in the increase of intracellular calcium activated by PTH in the DCT. Calcium 48-55 mitogen-activated protein kinase 1 Homo sapiens 90-94 11089552-7 2000 PD98059 abolished the increase of intracellular calcium induced by PTH demonstrating that ERK2 activation is directly involved in the increase of intracellular calcium activated by PTH in the DCT. Calcium 160-167 mitogen-activated protein kinase 1 Homo sapiens 90-94 11089552-8 2000 Thus, PTH- stimulated ERK2 activation is PKC dependent and calcium independent. Calcium 59-66 mitogen-activated protein kinase 1 Homo sapiens 22-26 10980593-6 2000 A rise of the intracellular calcium concentration was necessary and sufficient to mediate galanin-induced ERK activation. Calcium 28-35 mitogen-activated protein kinase 1 Homo sapiens 106-109 11164895-0 2000 Calcium-induced ERK activation in human T lymphocytes occurs via p56(Lck) and CaM-kinase. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 16-19 11164895-1 2000 We previously demonstrated that stimulation of human T-lymphocytes with calcium ionophores induced the phosphorylation and enzymatic activation of ERK2. Calcium 72-79 mitogen-activated protein kinase 1 Homo sapiens 147-151 11164895-4 2000 To further elucidate the mechanism by which calcium-induced ERK activation occurs, we used the CaM-kinase inhibitor KN-93 and an inactive analog of KN-93 (KN-92). Calcium 44-51 mitogen-activated protein kinase 1 Homo sapiens 60-63 11164895-7 2000 To determine if p56(Lck) was involved in calcium-induced ERK activation, we stimulated the p56(Lck) negative Jurkat cell derivatives, J.CaM1.6 and J.CaM1/Rep3, with ionomycin. Calcium 41-48 mitogen-activated protein kinase 1 Homo sapiens 57-60 10869721-4 2000 The mitogenic signaling pathway from P2Y receptors to ERK involves phospholipase D and a calcium-independent PKC isoform, PKCdelta. Calcium 89-96 mitogen-activated protein kinase 1 Homo sapiens 54-57 10588362-0 1999 Glutamate-stimulated calcium activation of Ras/Erk pathway mediated by nitric oxide. Calcium 21-28 mitogen-activated protein kinase 1 Homo sapiens 47-50 10588362-2 1999 Calcium-dependent activation of Ras and extracellular signal-regulated kineses (Erks) may transmit the glutamate signal to the nucleus which is ultimately important for long-lasting neuronal responses. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 80-84 10588362-3 1999 The mechanism by which changes in cytoplasmic calcium mediate NMDA-induced activation of Ras and Erk is not known. Calcium 46-53 mitogen-activated protein kinase 1 Homo sapiens 97-100 10588362-4 1999 In cerebral cortical neurons, this calcium influx through NMDA receptors activates Ras and its downstream effector, Erk, via nitric oxide (NO) generation by calcium-dependent neuronal NO synthase. Calcium 35-42 mitogen-activated protein kinase 1 Homo sapiens 116-119 10588362-4 1999 In cerebral cortical neurons, this calcium influx through NMDA receptors activates Ras and its downstream effector, Erk, via nitric oxide (NO) generation by calcium-dependent neuronal NO synthase. Calcium 157-164 mitogen-activated protein kinase 1 Homo sapiens 116-119 9507015-0 1998 Requirements of focal adhesions and calcium fluxes for interleukin-1-induced ERK kinase activation and c-fos expression in fibroblasts. Calcium 36-43 mitogen-activated protein kinase 1 Homo sapiens 77-80 10349832-6 1999 Increasing extracellular calcium enhanced ERK activation but reversed SAPK activation, further distinguishing the calcium dependencies of these two NMDA receptor-mediated effects. Calcium 25-32 mitogen-activated protein kinase 1 Homo sapiens 42-45 10475609-0 1999 Calcium-induced ERK activation in human T lymphocytes. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 16-19 10475609-1 1999 We have previously shown that stimulation of B lymphocytes with calcium ionophores lead to the phosphorylation and enzymatic activation of ERK2. Calcium 64-71 mitogen-activated protein kinase 1 Homo sapiens 139-143 12671299-12 1998 The exact mechanisms by which MAPK and caspases are activated by these agents are currently unknown, but may involve oxidative modification of glutathione (GSH) and/or protein thiols, and/or generation of secondary messengers, ceramide and calcium, which further activate downstream events. Calcium 240-247 mitogen-activated protein kinase 1 Homo sapiens 30-34 10349832-0 1999 Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons. Calcium 12-19 mitogen-activated protein kinase 1 Homo sapiens 45-48 10349832-4 1999 In primary cultures of striatal neurons, glutamatergic activation of ERK and one of its transcription factor targets, CREB, showed a calcium dependence typical of NMDA receptor-mediated responses. Calcium 133-140 mitogen-activated protein kinase 1 Homo sapiens 69-72 9870922-0 1999 Endothelin-stimulated ERK activation in airway smooth-muscle cells requires calcium influx and Raf activation. Calcium 76-83 mitogen-activated protein kinase 1 Homo sapiens 22-25 9705309-0 1998 The Raf-MEK-ERK cascade represents a common pathway for alteration of intracellular calcium by Ras and protein kinase C in cardiac myocytes. Calcium 84-91 mitogen-activated protein kinase 1 Homo sapiens 12-15 9705309-1 1998 Ras and protein kinase C (PKC), which regulate the Raf-MEK-ERK cascade, may participate in the development of cardiac hypertrophy, a condition characterized by diminished and prolonged contractile calcium transients. Calcium 197-204 mitogen-activated protein kinase 1 Homo sapiens 59-62 9507015-9 1998 Calcium depletion abolished IL-1-induced calcium uptake, ERK activation, and c-fos expression. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 57-60 9507015-12 1998 This is consistent with a requirement for calcium in the activation of ERKs and their involvement in the induction of c-fos expression through the SRE site on the 5" promoter of the c-fos gene. Calcium 42-49 mitogen-activated protein kinase 1 Homo sapiens 71-75 9507015-13 1998 Our results demonstrate that in cells attached to substrates by focal adhesions, IL-1-mediated calcium flux is required for ERK activation and c-fos expression but not for JNK or p38 activation. Calcium 95-102 mitogen-activated protein kinase 1 Homo sapiens 124-127 9207756-2 1997 Diacylglycerol (DAG) and calcium produce the activation of PKC, ERK and JNK kinases, implying a normal IL-2 response. Calcium 25-32 mitogen-activated protein kinase 1 Homo sapiens 64-67 9597145-5 1998 Recent findings in B lymphocytes have clearly illustrated that these external inputs affect the magnitude and duration of the intracellular calcium response, which in turn contributes to differential triggering of the transcriptional regulators NF kappa B, JNK, NFAT, and ERK. Calcium 140-147 mitogen-activated protein kinase 1 Homo sapiens 272-275 8757255-0 1996 Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 96-99 8941662-9 1996 Phorbol 12-myristate 13-acetate, calcium ionophore, and cAMP analogues only increased ERK activity but had no significant effects on JNK or p38. Calcium 33-40 mitogen-activated protein kinase 1 Homo sapiens 86-89 34374340-5 2021 We show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Calcium 13-20 mitogen-activated protein kinase 1 Homo sapiens 63-66 8557975-7 1996 Expression of the MAP kinase-specific phosphatase, MKP-1, which blocks ERK activation, inhibited IL-2 promoter and NF-AT-driven transcription stimulated by a calcium ionophore and PMA, and in addition, MKP-1 neutralized the transcriptional enhancement caused by active Raf-1 and MEK1 expression. Calcium 158-165 mitogen-activated protein kinase 1 Homo sapiens 71-74 7935423-3 1994 In this study, we measured the effect of both EGF and calcium treatment on activation of p21ras and ERK2. Calcium 54-61 mitogen-activated protein kinase 1 Homo sapiens 100-104 7935423-7 1994 On the contrary, calcium treatment inhibited EGF-induced stimulation of ERK2 activity. Calcium 17-24 mitogen-activated protein kinase 1 Homo sapiens 72-76 7935423-8 1994 In order to determine the site at which calcium treatment interferes in EGF-induced signaling, we analyzed the effect of calcium on the various steps that are involved in EGF-induced, p21ras-dependent activation of ERK2. Calcium 40-47 mitogen-activated protein kinase 1 Homo sapiens 215-219 33771646-0 2021 Calcium channel blockers lercanidipine and amlodipine inhibit YY1/ERK/TGF-beta mediated transcription and sensitize the gastric cancer cells to doxorubicin. Calcium 0-7 mitogen-activated protein kinase 1 Homo sapiens 66-69 34374340-5 2021 We show that calcium and cAMP work synergistically to activate ERK and that stimuli given with large inter-trial intervals activate more ERK than shorter intervals. Calcium 13-20 mitogen-activated protein kinase 1 Homo sapiens 137-140 35173627-8 2021 TRPV1 activation causes calcium-dependent activation of a signaling cascade in the lens epithelium that involves PI3 kinase, ERK, Akt and WNK. Calcium 24-31 mitogen-activated protein kinase 1 Homo sapiens 125-128 35150734-7 2022 These effects may be related to the inhibition of RhoA or Rac1, as well as the activation of Wnt and Erk pathway, with a calcium homeostasis. Calcium 121-128 mitogen-activated protein kinase 1 Homo sapiens 101-104 35254656-4 2022 Several groups reported that the store-operated calcium entry (SOCE) can be modulated through phosphorylation of Stim1 by protein kinases such as extracellular signal-regulated kinase (ERK), protein kinase A (PKA), and p21-activated kinase (PAK). Calcium 48-55 mitogen-activated protein kinase 1 Homo sapiens 146-183 35254656-4 2022 Several groups reported that the store-operated calcium entry (SOCE) can be modulated through phosphorylation of Stim1 by protein kinases such as extracellular signal-regulated kinase (ERK), protein kinase A (PKA), and p21-activated kinase (PAK). Calcium 48-55 mitogen-activated protein kinase 1 Homo sapiens 185-188