PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 30899939-6 2018 Staining of ALP and the calcium nodule deposition were consistent with the activity of ALP, the levels of osteopontin and osteocalcin. Calcium 24-31 bone gamma-carboxyglutamate protein Homo sapiens 122-133 28616217-8 2017 In VDRA-untreated patients, OC+ PACs correlated positively with calcium levels, while in VDRA-treated patients, VDR+ PACs correlated positively with interleukin 6 levels, and OC+ PACs correlated positively 25-hydroxyvitamin D levels. Calcium 65-72 bone gamma-carboxyglutamate protein Homo sapiens 28-30 28849089-6 2017 Our results revealed significant correlations between classical biochemical bone and metabolic parameters, such as osteocalcin and parathyroid hormone with lipid and glucose biomarkers, sustaining the crosstalk between calcium and bone parameters and cardiovascular risk. Calcium 219-226 bone gamma-carboxyglutamate protein Homo sapiens 115-126 28686548-6 2017 Osteocalcin and matrix-Gla (glutamate-containing) protein (MGP) exemplify vitamin K-dependent proteins involved in building bone matrix and keeping calcium from accumulating in the arterial walls, respectively. Calcium 148-155 bone gamma-carboxyglutamate protein Homo sapiens 0-11 29749440-5 2018 For instance, carboxylated osteocalcin is beneficial for bone and aids the deposition of calcium into the bone matrix. Calcium 89-96 bone gamma-carboxyglutamate protein Homo sapiens 27-38 27689678-8 2016 Using 3 5 mEq/L dCa, an independent association of acute calcium buffer capacity with undercarboxylated osteocalcin (beta = 0 512, P = 0 002) was demonstrated. Calcium 57-64 bone gamma-carboxyglutamate protein Homo sapiens 104-115 30603469-11 2017 After 6 days of cultivation, the expression of RUNX2 was higher in the magnesium ion-implanted surface and the expression of osteocalcin was lower in the calcium ion-implanted surface. Calcium 154-161 bone gamma-carboxyglutamate protein Homo sapiens 125-136 26403401-3 2015 Cytosolic calcium activates the calmodulin pathway, thus resulting in an up-regulated expression of osteogenic genes, such as transforming growth factor-beta superfamily genes (TGF-beta1, -beta2 -beta3, bone morphogenetic protein-2 and -4), fibroblast growth factor (FGF)-2, osteocalcin (BGP) and alkaline phosphatase (ALP). Calcium 10-17 bone gamma-carboxyglutamate protein Homo sapiens 288-291 27965939-4 2016 RESULTS: Stepwise multiple regression analysis adjusted for age, sex, menopausal status, body mass index, serum alkaline phosphatase, serum calcium and phosphate showed that osteocalcin negatively correlated with serum glucose (beta=-0.145, P=0.001) and homeostasis model assessment of insulin resistance (HOMA-IR) index (beta=-1.794, P=0.027) independently. Calcium 140-147 bone gamma-carboxyglutamate protein Homo sapiens 174-185 26403401-3 2015 Cytosolic calcium activates the calmodulin pathway, thus resulting in an up-regulated expression of osteogenic genes, such as transforming growth factor-beta superfamily genes (TGF-beta1, -beta2 -beta3, bone morphogenetic protein-2 and -4), fibroblast growth factor (FGF)-2, osteocalcin (BGP) and alkaline phosphatase (ALP). Calcium 10-17 bone gamma-carboxyglutamate protein Homo sapiens 275-286 23362258-3 2013 In this study, a natural motif sequence consisting of 13 amino acids present in the first helix of osteocalcin was selected based on its calcium binding ability and used as substrate for nucleation of HA crystals. Calcium 137-144 bone gamma-carboxyglutamate protein Homo sapiens 99-110 25677815-5 2015 RESULTS: Serum osteocalcin level was independently associated with menopausal status, bone mineral density, calcium, phosphate, alkaline phosphatase, fasting blood glucose, triglyceride, low-density lipoprotein cholesterol, alanine aminotransferase, gamma-glutamyltransferase, and NAFLD. Calcium 108-115 bone gamma-carboxyglutamate protein Homo sapiens 15-26 25355142-4 2014 In addition, it has been also revealed that osteocalcin or fibroblast growth factor 23 (FGF23) , which is produced by osteoblasts, has an important role in glucose metabolism, fat metabolism, or calcium homeostasis. Calcium 195-202 bone gamma-carboxyglutamate protein Homo sapiens 44-55 24896339-2 2014 Human OCN contains up to three gamma-carboxyglutamic acid (Gla-OCN) residues at positions 17, 21 and 24 which are thought to increase calcium binding strength, improving mechanical properties of the bone matrix. Calcium 134-141 bone gamma-carboxyglutamate protein Homo sapiens 6-9 24896339-2 2014 Human OCN contains up to three gamma-carboxyglutamic acid (Gla-OCN) residues at positions 17, 21 and 24 which are thought to increase calcium binding strength, improving mechanical properties of the bone matrix. Calcium 134-141 bone gamma-carboxyglutamate protein Homo sapiens 63-66 23139068-2 2013 The presence of the three residues of gamma-carbossiglutamatic acid, specific of the active form of OC protein, allows the protein to bind calcium and consequently hydroxyapatite. Calcium 139-146 bone gamma-carboxyglutamate protein Homo sapiens 100-102 23791847-6 2013 Calcium appeared to promote osteoblast to osteocyte differentiation, as indicated by increased expression of osteocalcin (OCN), E11, dentin matrix protein 1 (DMP1) and SOST mRNA. Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 109-120 23791847-6 2013 Calcium appeared to promote osteoblast to osteocyte differentiation, as indicated by increased expression of osteocalcin (OCN), E11, dentin matrix protein 1 (DMP1) and SOST mRNA. Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 122-125 23522918-5 2013 Within both diabetes groups (group D and group DN), no significant change in BAP is observed, however group DN showed higher level of BGP, higher level of HOP and lower BMD than group D. Urine calcium was increased in both group D and DN with group D having higher levels than group DN. Calcium 193-200 bone gamma-carboxyglutamate protein Homo sapiens 134-137 19767102-8 2009 A significant negative correlation was observed between serum calcium and OC level. Calcium 62-69 bone gamma-carboxyglutamate protein Homo sapiens 74-76 21860562-0 2011 Vitamin K supplement along with vitamin D and calcium reduced serum concentration of undercarboxylated osteocalcin while increasing bone mineral density in Korean postmenopausal women over sixty-years-old. Calcium 46-53 bone gamma-carboxyglutamate protein Homo sapiens 103-114 21519236-10 2011 Osteocalcin is one of the clues in the interaction between calcium and glucose metabolism, and the discovery of the osteocalcin receptor will aid in the study of these relationships. Calcium 59-66 bone gamma-carboxyglutamate protein Homo sapiens 0-11 26746856-1 2011 Besides locomotion, organ protection, and calcium-phosphorus homeostasis, the three classical functions of the skeleton, bone remodeling affects energy metabolism through uncarboxylated osteocalcin, a recently discovered hormone secreted by osteoblasts. Calcium 42-49 bone gamma-carboxyglutamate protein Homo sapiens 186-197 20044757-9 2011 We found significant decreases in changes of urinary hydroxyproline, and significant increases in serum osteocalcin during the intervention period in the calcium/milk intervention groups than those in the control group (all p < 0.05). Calcium 154-161 bone gamma-carboxyglutamate protein Homo sapiens 104-115 20118484-8 2010 Univariate analysis showed that calcium balance correlated with calcium gradient, parathyroid hormone (PTH), osteocalcin and dialysis vintage. Calcium 32-39 bone gamma-carboxyglutamate protein Homo sapiens 109-120 20094707-2 2010 In animal models, serum OC levels are strongly correlated with vascular calcium content, however, the association of OC with vascular calcification in humans is uncertain. Calcium 72-79 bone gamma-carboxyglutamate protein Homo sapiens 24-26 22034088-0 2012 Extracellular calcium chronically induced human osteoblasts effects: specific modulation of osteocalcin and collagen type XV. Calcium 14-21 bone gamma-carboxyglutamate protein Homo sapiens 92-103 22006368-6 2012 At day 4, osteocalcin (OC) overexpression preceded the formation of calcium-containing nodule formation as assessed by X-ray analyses. Calcium 68-75 bone gamma-carboxyglutamate protein Homo sapiens 10-21 21346725-1 2011 Besides locomotion, organ protection, and calcium-phosphorus homeostasis, the three classical functions of the skeleton, bone remodeling affects energy metabolism through uncarboxylated osteocalcin, a recently discovered hormone secreted by osteoblasts. Calcium 42-49 bone gamma-carboxyglutamate protein Homo sapiens 186-197 22211018-4 2011 The aim of this study is (1) to measure the specific, sensitive bone formation marker such as osteocalcin and BMD in postmenopausal osteoporosis women and postmenopausal non-osteoporosis women; (2) the follow up study to evaluate the impact of specific antiresorptive therapy (alendronate + calcium + vitamin D) regimen in postmenopausal osteoporosis by assaying osteocalcin and BMD. Calcium 291-298 bone gamma-carboxyglutamate protein Homo sapiens 94-105 21263745-3 2010 During the differentiation process, DPSCs express specific bone proteins like Runx-2, Osx, OPN and OCN with a sequential expression, analogous to those occurring during osteoblast differentiation, and produce extracellular calcium deposits. Calcium 223-230 bone gamma-carboxyglutamate protein Homo sapiens 99-102 20378261-9 2010 Osteocalcin plays a role in calcium uptake and bone mineralization. Calcium 28-35 bone gamma-carboxyglutamate protein Homo sapiens 0-11 20118484-9 2010 Multivariate analysis revealed that calcium balance was dependent on calcium gradient, PTH and osteocalcin. Calcium 36-43 bone gamma-carboxyglutamate protein Homo sapiens 95-106 19718820-5 2009 There was a high direct correlation between the serum levels of OC, CTTP and those of calcium and an inverse correlation between the serum concentrations of alkaline phosphatase and PTH and those of calcium in the groups of geriatric patients with IHD and OP. Calcium 86-93 bone gamma-carboxyglutamate protein Homo sapiens 64-66 19087913-7 2008 Based on a multivariate regression analysis, in all females significant independent predictors of osteocalcin level were fasting blood glucose, whole and lean body mass glucose uptake, metabolic clearance rate, estradiol and LDL-cholesterol levels (determined 92% of its value), while in all men these were serum calcium, OGTT glucose area under the curve, free fatty acid levels, insulogenic index, HOMA-R and waist/hip ratio (determined 95% of its value). Calcium 313-320 bone gamma-carboxyglutamate protein Homo sapiens 98-109 17074112-13 2006 In the calcium preparation group and control group, the levels of BMD, E(2), ALP, BGP and insulin-like growth factor I decreased (P < 0.05), while those of IL-6, TNFalpha and NTX increased (P < 0.05). Calcium 7-14 bone gamma-carboxyglutamate protein Homo sapiens 82-85 19035501-8 2008 At followup, levels of 1,25-dihydroxyvitamin D3, PTH, OC, and urine phosphorus were lower in the group receiving calcium supplementation. Calcium 113-120 bone gamma-carboxyglutamate protein Homo sapiens 54-56 17701663-8 2007 Serum calcium levels strongly correlated with osteocalcin and crosslaps in mothers (r = 0.21, p = 0.001 and r = 0.25, p = 0.001, respectively). Calcium 6-13 bone gamma-carboxyglutamate protein Homo sapiens 46-57 17314699-2 2007 Osteocalcin contains glutamic acid (Gla) residues, which have a high affinity for calcium. Calcium 82-89 bone gamma-carboxyglutamate protein Homo sapiens 0-11 17357457-11 2007 The electron microscopy showed that there was a calcium element in the cytoplasm, the alkaline phosphatase result was positive, and the expression of osteocalcin was increased. Calcium 48-55 bone gamma-carboxyglutamate protein Homo sapiens 150-161 17287704-6 2007 The ability of SLLLT irradiation to stimulate bone production was evaluated by determining the expression of osteocalcin and alkaline phosphatase, proteins involved in calcium nodule formation. Calcium 168-175 bone gamma-carboxyglutamate protein Homo sapiens 109-120 16563471-3 2006 After transcription and translation the protein is formed, e.g. osteocalcin or calcium binding protein. Calcium 79-86 bone gamma-carboxyglutamate protein Homo sapiens 64-75 19035501-7 2008 Calcium-treated patients with < or =4 joints with active disease had lower levels of osteocalcin (OC). Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 88-99 19035501-7 2008 Calcium-treated patients with < or =4 joints with active disease had lower levels of osteocalcin (OC). Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 101-103 18096456-12 2008 High extracellular calcium increased the mineralization of hMSC and the expression of osteocalcin, but this effect was not mimicked by neomycin. Calcium 19-26 bone gamma-carboxyglutamate protein Homo sapiens 86-97 17631676-5 2008 The highest osteocalcin production obtained from the biomaterial 5SiHA after cell culture for 2 days demonstrated that the presence of silica in the biomaterials enhanced the cell differentiation by the rapid release of silicate and calcium ions. Calcium 233-240 bone gamma-carboxyglutamate protein Homo sapiens 12-23 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Calcium 248-255 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Calcium 248-255 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Calcium 248-255 bone gamma-carboxyglutamate protein Homo sapiens 120-122 16848114-7 2006 There was a positive correlation between serum phosphorus (P) and OC (r=0.394, p=0.031), alkaline phosphatase (ALP) and OC (r=0.520, p=0.003), and parathyroid hormone (PTH) and OC (r=0.441, p=0.017), whereas no correlation was found between OC and calcium (Ca) and OC and magnesium (Mg). Calcium 248-255 bone gamma-carboxyglutamate protein Homo sapiens 120-122 15779069-9 2005 Calcium and vitamin D supplementation resulted in an increase in 25-hydroxy-vitamin D (P < 0.001), 1,25-dihydroxy-vitamin D (P = 0.048) and osteocalcin (P = 0.045), whereas levels of parathyroid hormone were decreased (P = 0.007). Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 143-154 16869105-2 2005 The carboxylation makes immature osteocalcin or undercarboxylated osteocalcin (ucOC) into mature osteocalcin which enhances calcium binding in bone. Calcium 124-131 bone gamma-carboxyglutamate protein Homo sapiens 33-44 16869105-2 2005 The carboxylation makes immature osteocalcin or undercarboxylated osteocalcin (ucOC) into mature osteocalcin which enhances calcium binding in bone. Calcium 124-131 bone gamma-carboxyglutamate protein Homo sapiens 66-77 16869105-2 2005 The carboxylation makes immature osteocalcin or undercarboxylated osteocalcin (ucOC) into mature osteocalcin which enhances calcium binding in bone. Calcium 124-131 bone gamma-carboxyglutamate protein Homo sapiens 66-77 15648030-6 2005 The effects of elevated phosphate on HSMC were mediated by a sodium-dependent phosphate cotransporter (NPC) as indicated by the ability of the specific NPC inhibitor phosphonoformic acid to dose-dependently inhibit phosphate-induced calcium deposition as well as osteocalcin and Cbfa-1 gene expression. Calcium 233-240 bone gamma-carboxyglutamate protein Homo sapiens 263-274 15667217-1 2005 Osteocalcin is a small (45 amino acids) secreted protein found to accumulate in bone and dentin of many organisms by interacting with calcium and hydroxyapatite, through the presence of three gamma-carboxylated residues. Calcium 134-141 bone gamma-carboxyglutamate protein Homo sapiens 0-11 15667217-3 2005 The three-dimensional fit between the A. regius structure and that of the only other known X-ray structure, the porcine osteocalcin, revealed a superposition of the Calpha atoms of their metal chelating residues, Gla and Asp, showing that their spatial distribution is consistent with the interatomic distances of calcium cations in the hydroxyapatite crystals. Calcium 314-321 bone gamma-carboxyglutamate protein Homo sapiens 120-131 15667217-8 2005 This further suggests that the known high affinity of osteocalcin for bone mineral may be derived from the clustering of calcium binding sites on this surface of the molecules. Calcium 121-128 bone gamma-carboxyglutamate protein Homo sapiens 54-65 12818462-5 2003 RESULTS: In calcium-treated women serum plasma osteocalcin (BGP) and hydroxyproline/creatinine urinary excretion (OHP/Cr) remained stable during all the observation period. Calcium 12-19 bone gamma-carboxyglutamate protein Homo sapiens 47-58 15126218-6 2003 Three-dimensional structure predictions developed by modeling of conserved domains of osteocalcin supported a role for glutamic acid residues in the calcium mineralization process. Calcium 149-156 bone gamma-carboxyglutamate protein Homo sapiens 86-97 15240619-3 2004 Bone calcium deposition was associated with the availability of dietary calcium, total serum osteocalcin, and leptin concentrations. Calcium 5-12 bone gamma-carboxyglutamate protein Homo sapiens 93-104 15244341-4 2004 The OCN pellet slowly releases calcium and nitrate, together with ocher, into the sediment water interface, where all three components play an important role in reducing phosphate release from sediments. Calcium 31-38 bone gamma-carboxyglutamate protein Homo sapiens 4-7 14586470-4 2003 Here we present the X-ray crystal structure of porcine osteocalcin at 2.0 A resolution, which reveals a negatively charged protein surface that coordinates five calcium ions in a spatial orientation that is complementary to calcium ions in a hydroxyapatite crystal lattice. Calcium 161-168 bone gamma-carboxyglutamate protein Homo sapiens 55-66 14586470-4 2003 Here we present the X-ray crystal structure of porcine osteocalcin at 2.0 A resolution, which reveals a negatively charged protein surface that coordinates five calcium ions in a spatial orientation that is complementary to calcium ions in a hydroxyapatite crystal lattice. Calcium 224-231 bone gamma-carboxyglutamate protein Homo sapiens 55-66 12818462-5 2003 RESULTS: In calcium-treated women serum plasma osteocalcin (BGP) and hydroxyproline/creatinine urinary excretion (OHP/Cr) remained stable during all the observation period. Calcium 12-19 bone gamma-carboxyglutamate protein Homo sapiens 60-63 12565780-1 2003 OBJECTIVES: Osteocalcin is a vitamin-K dependent protein which is related to the metabolism of bone and calcium. Calcium 104-111 bone gamma-carboxyglutamate protein Homo sapiens 12-23 12215865-4 2002 Statistically significant improvement seemed to happen in the patients receiving calcitonin plus calcium therapy (P < 0.05) concerning levels of serum IL-6r at the 1st month (P < 0.05), IL-10, IL-2r, IL-6r, and osteocalcin at the 3rd month, and IL-6r and osteocalcin at the end of the 6th month. Calcium 97-104 bone gamma-carboxyglutamate protein Homo sapiens 217-228 12198018-1 2002 BACKGROUND: Our randomized, placebo-controlled supplementation study of 160 rural Gambian children aged 8.3-11.9 y showed that an increase in calcium intake of 714 mg/d for 12 mo resulted in a 5% increase in forearm bone mineral acquisition and a 22% decrease in plasma osteocalcin concentration, a bone formation marker, but had no effect on height or bone dimensions. Calcium 142-149 bone gamma-carboxyglutamate protein Homo sapiens 270-281 12215865-4 2002 Statistically significant improvement seemed to happen in the patients receiving calcitonin plus calcium therapy (P < 0.05) concerning levels of serum IL-6r at the 1st month (P < 0.05), IL-10, IL-2r, IL-6r, and osteocalcin at the 3rd month, and IL-6r and osteocalcin at the end of the 6th month. Calcium 97-104 bone gamma-carboxyglutamate protein Homo sapiens 261-272 11247890-4 2001 Vitamin K is a cofactor in the carboxylation of osteocalcin, a protein essential for calcium binding to bone. Calcium 85-92 bone gamma-carboxyglutamate protein Homo sapiens 48-59 12202187-2 2002 Analysis by SEM and AFM shows, that the addition of osteocalcin causes a nanosize microstructure of the calcium cement, which can be explained by inhibited growth of HAP crystals. Calcium 104-111 bone gamma-carboxyglutamate protein Homo sapiens 52-63 11683536-5 2001 Both calcium supplement use and alcohol intake were associated with lower mean serum osteocalcin (a marker of bone formation) and NTX z-scores. Calcium 5-12 bone gamma-carboxyglutamate protein Homo sapiens 85-96 12602117-8 2002 Low serum calcium was associated with elevated PTH- (r = -0.75, p = 0.001), serum cross laps- (r = -0.61, p = 0.01), osteocalcin levels (r = -0.49, p = 0.05), was an independent predictor of femoral neck bone mass (r = 0.57, p = 0.02) and accounted for 36% of this variance. Calcium 10-17 bone gamma-carboxyglutamate protein Homo sapiens 117-128 11853280-5 2001 The calcium treated group was switched to the vitamin K2 treated group at the end of six months and showed a decrease of the level of undercarboxylated osteocalcin the same as the former vitamin K2 treated group. Calcium 4-11 bone gamma-carboxyglutamate protein Homo sapiens 152-163 11514404-6 2001 Significant associations were present between changes of serum intact osteocalcin and 24-h calcium excretion (P <0.001), nitrogen balance and 24-h phosphorus excretion (P <0.001), nitrogen balance and renal N-telopeptide excretion (P <0.05), and between serum osteocalcin and nitrogen balance (P <0.025). Calcium 91-98 bone gamma-carboxyglutamate protein Homo sapiens 70-81 11374034-2 2001 BACKGROUND: Vitamin K has a key function in the synthesis of at least two proteins involved in calcium and bone metabolism, namely osteocalcin and matrix Gla-protein (MGP). Calcium 95-102 bone gamma-carboxyglutamate protein Homo sapiens 131-142 11009570-6 2000 The effects of elevated phosphate on HSMCs were mediated by a sodium-dependent phosphate cotransporter (NPC), as indicated by the ability of the specific NPC inhibitor phosphonoformic acid, to dose dependently inhibit phosphate-induced calcium deposition as well as osteocalcin and Cbfa-1 gene expression. Calcium 236-243 bone gamma-carboxyglutamate protein Homo sapiens 266-277 10648270-10 2000 At the end of the study, the calcium group had a significantly lower mean plasma osteocalcin concentration than the placebo group after adjustment for baseline concentration, sex, and pubertal status (-21.9 +/- 6.5%; P = 0.001). Calcium 29-36 bone gamma-carboxyglutamate protein Homo sapiens 81-92 9626637-7 1998 There was a statistical effect of calcium supplementation during weight loss to suppress pyridinium cross-links, osteocalcin, and PTH (p < 0.05, < 0.01, and < 0.05, respectively). Calcium 34-41 bone gamma-carboxyglutamate protein Homo sapiens 113-124 10486212-2 1999 Temporally, osteocalcin appears in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. Calcium 123-130 bone gamma-carboxyglutamate protein Homo sapiens 12-23 9626120-10 1998 Calcium depletion had contrasting effects on bone formation markers; whereas depletion significantly reduced the serum PICP level, it significantly increased serum osteocalcin level. Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 164-175 10446063-15 1999 The results of this study show that osteonectin, osteopontin, and osteocalcin colocalized with calcium deposits with apoB, fibrin, and MMP-3 in advanced, symptomatic carotid lesions. Calcium 95-102 bone gamma-carboxyglutamate protein Homo sapiens 66-77 10102913-8 1999 CONCLUSION: Decreases in Oc assay values are inhibited by calcium chelation, and slowed by reduced temperatures. Calcium 58-65 bone gamma-carboxyglutamate protein Homo sapiens 25-27 9846861-9 1998 Calcium supplementation lowered osteocalcin (P < 0.05) but not alkaline phosphatase, which remained elevated in the osteoporotic subjects at all stages. Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 32-43 9839845-7 1998 In all subjects increased vitamin K was associated with an increased calcium-binding capacity of osteocalcin. Calcium 69-76 bone gamma-carboxyglutamate protein Homo sapiens 97-108 9610372-6 1998 A sequence that the calcium influx activates PkA which, in turn, activates c-fos and COX-2 transcription resulting in the production of proteins such as IGF-I and osteocalcin. Calcium 20-27 bone gamma-carboxyglutamate protein Homo sapiens 163-174 9012695-14 1997 Thus, the serum levels of ICTP and osteocalcin seem related to bone turnover and calcium metabolism, and provide further information about myeloma activity, particularly in normocalcaemic patients. Calcium 81-88 bone gamma-carboxyglutamate protein Homo sapiens 35-46 9200002-5 1997 Elevated levels of calcium ion inhibit the plasmin-mediated lysis of osteocalcin. Calcium 19-26 bone gamma-carboxyglutamate protein Homo sapiens 69-80 9421231-11 1997 Reducing the extracellular calcium concentration with EGTA (microM range) totally inhibited the effect of Glipizide and Glybenclamide on osteocalcin secretion (p < 0.005), which remained at the same levels as controls. Calcium 27-34 bone gamma-carboxyglutamate protein Homo sapiens 137-148 7696837-4 1994 Circular dichroism measurement showed that the conformation of osteocalcin containing three Gla residues dramatically changed on addition of calcium ions, whereas the peptide containing glutamic acid at position 17 did not. Calcium 141-148 bone gamma-carboxyglutamate protein Homo sapiens 63-74 9350477-6 1997 Human carboxylated osteocalcin contains 3 gamma-carboxyglutamyl residues which confer a highly specific affinity to the calcium ion of the hydroxyapatite molecule. Calcium 120-127 bone gamma-carboxyglutamate protein Homo sapiens 19-30 8669416-7 1996 A multiple-regression model using a biochemical marker of bone turnover (serum osteocalcin) and postmenarcheal age (a measure of sexual maturation) described 75% of the variability in calcium retention. Calcium 184-191 bone gamma-carboxyglutamate protein Homo sapiens 79-90 7626415-2 1995 Calbindin-D9k, calbindin-D28k and osteocalcin are presented as the most-extensively investigated vitamin D-dependent calcium-binding proteins. Calcium 117-124 bone gamma-carboxyglutamate protein Homo sapiens 34-45 7985641-6 1994 After the calcium load there were decreases in the urinary hydroxyproline-creatinine ratio from 11 +/- 1.1 to 7.9 +/- 0.6 (P < 0.01), the urinary deoxypyridinoline-creatinine ratio from 14.0 +/- 1.8 to 10.1 +/- 0.9 (P < 0.05), and the urinary pyridinoline-creatinine ratio from 52 +/- 5 to 40 +/- 3 (P < 0.01) between baseline and 6 h. There was no change in plasma osteocalcin. Calcium 10-17 bone gamma-carboxyglutamate protein Homo sapiens 375-386 7699131-5 1994 Adequate calcium intake also protected against increased bone resorption, as evidenced in particular by the reduced serum osteocalcin, a parameter of bone turnover. Calcium 9-16 bone gamma-carboxyglutamate protein Homo sapiens 122-133 7962073-0 1994 Osteocalcin induces chemotaxis, secretion of matrix proteins, and calcium-mediated intracellular signaling in human osteoclast-like cells. Calcium 66-73 bone gamma-carboxyglutamate protein Homo sapiens 0-11 7962073-9 1994 The action of BGP on osteoclasts was mediated by an intracellular calcium increase due to release from thapsigargin-sensitive stores. Calcium 66-73 bone gamma-carboxyglutamate protein Homo sapiens 14-17 7817811-9 1994 These results demonstrate that TGF-beta 1 is a strong inhibitor of the synthesis of osteocalcin, a calcium binding protein participating in bone mineralization, by counteracting the stimulatory effects of other hormones on its synthesis. Calcium 99-106 bone gamma-carboxyglutamate protein Homo sapiens 84-95 9039155-4 1997 Compared with patients maintained at low calcium intake, essential hypertensive patients under oral calcium supplementation significantly reduced serum osteocalcin (from 22.2 +/- 1.9 to 17.9 +/- 2.0 micrograms/L; P = .0015), parathormone (from 4.20 +/- 0.38 to 3.30 +/- 0.36 pmol/L; P = .0003), and 1,25(OH)2-vitamin D3 (from 98.0 +/- 11.0 to 61.6 +/- 5.7 pmol/L; P = .0062). Calcium 100-107 bone gamma-carboxyglutamate protein Homo sapiens 152-163 9127475-3 1997 However, circulating immunoreactive osteocalcin (irOC) consists of several fractions, which may differ from each other with respect to size and calcium binding properties. Calcium 144-151 bone gamma-carboxyglutamate protein Homo sapiens 36-47 8939765-0 1996 Plasma osteocalcin in healthy Nigerian children and in children with calcium-deficiency rickets. Calcium 69-76 bone gamma-carboxyglutamate protein Homo sapiens 7-18 8939765-3 1996 The study was aimed at establishing a reference range for healthy Nigerian children determining any changes in plasma osteocalcin levels occurring in children with calcium-deficiency rickets. Calcium 164-171 bone gamma-carboxyglutamate protein Homo sapiens 118-129 8854076-0 1996 Osteocalcin response to calcium-restricted diet: a helpful tool for the workup of hypercalciuria. Calcium 24-31 bone gamma-carboxyglutamate protein Homo sapiens 0-11 8854076-2 1996 This study investigated whether the osteocalcin response (OCR) to a calcium-restricted diet is a potential tool for the differential therapy of hypercalciuria. Calcium 68-75 bone gamma-carboxyglutamate protein Homo sapiens 36-47 7696837-5 1994 These findings clearly show that the Gla residue at position 17 is essential for a calcium-dependent conformational transition of osteocalcin. Calcium 83-90 bone gamma-carboxyglutamate protein Homo sapiens 130-141 7816001-5 1994 In the calcium group the opposite was observed with small decreases in alakline phosphatase and osteocalcin by 8.2 and 11.0%, respectively, and no change in BBC. Calcium 7-14 bone gamma-carboxyglutamate protein Homo sapiens 96-107 7823258-8 1994 However, cord blood osteocalcin decreased between 27 and 36 weeks of gestation during which period calcium accumulation by the fetus increases. Calcium 99-106 bone gamma-carboxyglutamate protein Homo sapiens 20-31 8243426-6 1993 It was also found that an adequate intake of calcium protected against increased bone resorption, as evidenced in particular by the reduced levels of serum osteocalcin, a parameter of bone turnover. Calcium 45-52 bone gamma-carboxyglutamate protein Homo sapiens 156-167 8281940-9 1993 The low concentrations of IGF-I used in this study suggest that IGF-I is an important normal regulator of the synthesis of osteocalcin, a bone calcium-binding protein participating in bone mineralization, by modulating the effects of steroid hormones on its synthesis. Calcium 143-150 bone gamma-carboxyglutamate protein Homo sapiens 123-134 1394980-3 1992 Binding of the antibodies to osteocalcin was calcium-dependent. Calcium 45-52 bone gamma-carboxyglutamate protein Homo sapiens 29-40 8347293-8 1993 Calcium supplementation may be necessary in children with asthma treated with inhaled steroids since this treatment may cause reduction in osteocalcin, a marker of osteoblast activity and bone formation. Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 139-150 8323382-2 1993 The aim of this study was to examine the rate of bone formation measured by osteocalcin in 38 patients with ankylosing spondylitis (AS) and its dependence on various parameters of calcium and phosphate metabolism. Calcium 180-187 bone gamma-carboxyglutamate protein Homo sapiens 76-87 1774075-5 1991 It appears that BGLAP is the third calcium-binding protein that maps to human chromosome 1q and mouse Chromosome 3. Calcium 35-42 bone gamma-carboxyglutamate protein Homo sapiens 16-21 1398473-1 1992 Since osteocalcin has been suggested to play a role in calcium homeostasis, we investigated its serum levels in 6 healthy subjects during a rapid calcium infusion. Calcium 55-62 bone gamma-carboxyglutamate protein Homo sapiens 6-17 1398473-1 1992 Since osteocalcin has been suggested to play a role in calcium homeostasis, we investigated its serum levels in 6 healthy subjects during a rapid calcium infusion. Calcium 146-153 bone gamma-carboxyglutamate protein Homo sapiens 6-17 1456082-5 1992 In young men, there were unexpected but significant associations between lower femoral neck BMD and higher serum osteocalcin and urinary calcium/creatinine excretion after age adjustment. Calcium 137-144 bone gamma-carboxyglutamate protein Homo sapiens 113-124 1657256-13 1991 Increasing the extracellular calcium concentration of the incubation media resulted in a dose-dependent increase in osteocalcin secretion (P less than 0.01). Calcium 29-36 bone gamma-carboxyglutamate protein Homo sapiens 116-127 1657256-15 1991 In contrast, an increase in extracellular calcium stimulated osteocalcin release. Calcium 42-49 bone gamma-carboxyglutamate protein Homo sapiens 61-72 1991812-10 1991 These data indicate that osteocalcin concentrations in the circulation may be acutely regulated by calcium and/or PTH. Calcium 99-106 bone gamma-carboxyglutamate protein Homo sapiens 25-36 2040247-9 1991 For example, the 1,25-dihydroxyvitamin D3-stimulated synthesis of osteocalcin, a calcium-binding protein synthesized by osteoblastic bone cells, is inhibited by low levels of lead. Calcium 81-88 bone gamma-carboxyglutamate protein Homo sapiens 66-77 1752232-0 1991 Effect of dietary calcium on serum BGP (osteocalcin). Calcium 18-25 bone gamma-carboxyglutamate protein Homo sapiens 35-38 1752232-0 1991 Effect of dietary calcium on serum BGP (osteocalcin). Calcium 18-25 bone gamma-carboxyglutamate protein Homo sapiens 40-51 1752232-1 1991 The present study was designed to clarify the effects of dietary calcium (Ca) intake on serum BGP (osteocalcin) levels. Calcium 65-72 bone gamma-carboxyglutamate protein Homo sapiens 94-97 1752232-1 1991 The present study was designed to clarify the effects of dietary calcium (Ca) intake on serum BGP (osteocalcin) levels. Calcium 65-72 bone gamma-carboxyglutamate protein Homo sapiens 99-110 1742505-10 1991 We think that the low osteocalcin levels observed in cirrhotics may be a consequence of "hepatic osteodystrophy" due to low vitamin D and calcium plasma levels. Calcium 138-145 bone gamma-carboxyglutamate protein Homo sapiens 22-33 2612000-4 1989 The binding of the antibody to BGP was calcium-dependent. Calcium 39-46 bone gamma-carboxyglutamate protein Homo sapiens 31-34 2200239-10 1990 This transient dissociation results in a reduction in serum calcium, leading to a rise in serum 1,25-(OH)2D3, which in turn stimulates BGP production. Calcium 60-67 bone gamma-carboxyglutamate protein Homo sapiens 135-138 34456863-12 2021 After controlling for age, sex, disease duration, serum 25(OH)D, phosphorus, and calcium concentration, the positive correlation between OCN and PTH was still statistically significant (r = 0.323, p = 0.000). Calcium 81-88 bone gamma-carboxyglutamate protein Homo sapiens 137-140 2151224-10 1990 The biochemistry of bone metabolism showed a significantly increased fasting urinary excretion of calcium and hydroxyproline in patients with complications, but not in the group without complications, and there was a negative correlation between plasma BGP (osteocalcin) and hemoglobin A1C for all patients. Calcium 98-105 bone gamma-carboxyglutamate protein Homo sapiens 253-256 2380597-1 1990 Bone gamma-carboxyglutamic acid containing protein (BGP) has been considered to play an important role in mineralization of bone, because this protein is capable of binding to calcium ions. Calcium 176-183 bone gamma-carboxyglutamate protein Homo sapiens 52-55 2345632-1 1990 The measurement of serum osteocalcin is a new sensitive and specific method in the evaluation of calcium metabolism disorders. Calcium 97-104 bone gamma-carboxyglutamate protein Homo sapiens 25-36 2330270-2 1990 It has been established that there is an inverse correlation between osteocalcin content and the level of parathyroid hormone and a direct correlation between osteocalcin content and the concentration of total and ionized calcium and calcitonin in the blood. Calcium 222-229 bone gamma-carboxyglutamate protein Homo sapiens 159-170 34643227-6 2021 DMY treatment significantly attenuated calcium/phosphate-induced calcification of rat and human VSMCs in a dose-dependent manner, as shown by alizarin red S staining and calcium content assay, associated with down-regulation of osteogenic markers including type I collagen (COL I), RUNX2, BMP2 and osteocalcin (OCN). Calcium 39-46 bone gamma-carboxyglutamate protein Homo sapiens 298-309 34643227-6 2021 DMY treatment significantly attenuated calcium/phosphate-induced calcification of rat and human VSMCs in a dose-dependent manner, as shown by alizarin red S staining and calcium content assay, associated with down-regulation of osteogenic markers including type I collagen (COL I), RUNX2, BMP2 and osteocalcin (OCN). Calcium 39-46 bone gamma-carboxyglutamate protein Homo sapiens 311-314 35507859-8 2022 Calcium affected (P < 0.05) the plasmal contents of phosphorus (P), osteocalcin (OC), parathyroid hormone (PTH) and calcitonin (CT) and the contents of OC and PTH were also influenced by dietary NPP. Calcium 0-7 bone gamma-carboxyglutamate protein Homo sapiens 68-79 3264644-0 1988 [Serum osteocalcin level as a marker of the functional state of osteoblasts after oral calcium tolerance test]. Calcium 87-94 bone gamma-carboxyglutamate protein Homo sapiens 7-18 2785110-1 1989 The binding interaction of bone Gla protein (BGP), or osteocalcin, to phospholipid vesicles in the presence of calcium has been investigated. Calcium 111-118 bone gamma-carboxyglutamate protein Homo sapiens 27-43 2785110-1 1989 The binding interaction of bone Gla protein (BGP), or osteocalcin, to phospholipid vesicles in the presence of calcium has been investigated. Calcium 111-118 bone gamma-carboxyglutamate protein Homo sapiens 45-48 2785110-1 1989 The binding interaction of bone Gla protein (BGP), or osteocalcin, to phospholipid vesicles in the presence of calcium has been investigated. Calcium 111-118 bone gamma-carboxyglutamate protein Homo sapiens 54-65 3264644-5 1988 In 3 patients with renal hypercalciuria, often leading to general osteoporosis, an acute rise of serum osteocalcin level was found after the oral calcium tolerance test. Calcium 146-153 bone gamma-carboxyglutamate protein Homo sapiens 103-114 3501439-1 1987 The effect of calcium infusion on osteocalcin(Bone Gla Protein, BGP) serum levels were studied in a group of preterm newborns with bw appropriate for gestational age. Calcium 14-21 bone gamma-carboxyglutamate protein Homo sapiens 34-45 3501439-3 1987 Moreover, calcium infusion induced a significant decrease in BGP values, inversely correlated with serum calcium. Calcium 10-17 bone gamma-carboxyglutamate protein Homo sapiens 61-64 3501439-3 1987 Moreover, calcium infusion induced a significant decrease in BGP values, inversely correlated with serum calcium. Calcium 105-112 bone gamma-carboxyglutamate protein Homo sapiens 61-64 3501439-4 1987 Since calcium loading increases both Ca availability for bone formation and BGP affinity for mineral surfaces, reduction of osteocalcin serum levels might reflect a shift of the protein from bloodstream to bone, suggesting an intervention in regulating an effective calcium uptake. Calcium 6-13 bone gamma-carboxyglutamate protein Homo sapiens 76-79 3501439-4 1987 Since calcium loading increases both Ca availability for bone formation and BGP affinity for mineral surfaces, reduction of osteocalcin serum levels might reflect a shift of the protein from bloodstream to bone, suggesting an intervention in regulating an effective calcium uptake. Calcium 266-273 bone gamma-carboxyglutamate protein Homo sapiens 124-135 3498205-2 1987 Taking into account the involvement of the measurement of osteocalcin, a protein-containing gamma-carboxyglutamic acid (Gla), in investigating the physiopathology of bone and calcium metabolism, a radioimmunoassay (RIA) method useful in human clinics was developed. Calcium 175-182 bone gamma-carboxyglutamate protein Homo sapiens 58-69 3496351-5 1987 No significant correlations were found between maternal osteocalcin concentrations and serum phosphorus, alkaline phosphatase, or iPTH, but significant negative correlations were found between osteocalcin and total calcium or total protein. Calcium 215-222 bone gamma-carboxyglutamate protein Homo sapiens 193-204 3512259-3 1986 This results in reduced amounts of osteocalcin bone, probably because devoid of the calcium-binding Gla residues, the protein no longer accumulates in bone. Calcium 84-91 bone gamma-carboxyglutamate protein Homo sapiens 35-46 3492836-3 1986 The aim of this study was to examine the rate of bone formation measured by osteocalcin in patients (pts) with rheumatoid arthritis (RA) (n = 58) and osteoarthrosis (OA) (n = 14) and its dependence on various parameters of calcium and phosphate metabolism, especially vitamin D metabolites. Calcium 223-230 bone gamma-carboxyglutamate protein Homo sapiens 76-87 11537812-2 1986 In this paper we describe investigations in which we have checked whether the bone loss in astronauts as well as in osteoporotic patients may be related to abnormalities in a recently discovered calcium-binding protein, named osteocalcin. Calcium 195-202 bone gamma-carboxyglutamate protein Homo sapiens 226-237 3015628-3 1986 Therefore serum osteocalcin was measured in 88 controls and 112 patients with disorders of calcium and phosphate metabolism, isolated elevation of alkaline serum phosphatase in the absence of disease (isolated hyperphosphatasaemia) and children prone to osteopenia. Calcium 91-98 bone gamma-carboxyglutamate protein Homo sapiens 16-27 11537812-3 1986 It was observed that in all subjects of a limited number of osteoporotic patients, the amount of calcium-binding groups (Gla-residues) in the circulating osteocalcin was substantially reduced. Calcium 97-104 bone gamma-carboxyglutamate protein Homo sapiens 154-165 3878367-10 1985 Thus, in the studied disorders of calcium metabolism, individual serum levels of BGP depend on both mineralization rate and renal function. Calcium 34-41 bone gamma-carboxyglutamate protein Homo sapiens 81-84 33340588-3 2021 METHODS: Three forms of Ocn, differentially carboxylated at the Glu-17, 21 and 24 residues, along with a mutated form of Ocn carrying Glu/Ala mutations, are modeled and simulated using molecular dynamics (MD) simulation in the presence of calcium ions. Calcium 239-246 bone gamma-carboxyglutamate protein Homo sapiens 24-27 6311379-9 1983 The formation of organized extracellular pattern by X-ray diffraction allowed sufficient mineral accumulation for detection with calcium, Gla, and osteocalcin increasing allowed sufficient mineral accumulation for detection of an apatite-like pattern by X-ray diffraction with calcium, Gla, and osteocalcin increasing proportionately as mineral is deposited. Calcium 277-284 bone gamma-carboxyglutamate protein Homo sapiens 147-158 6601977-5 1983 BGP retains its chemotactic activity after conversion of the gamma-carboxyglutamic acid residues to glutamic acid, indicating that this biological effect requires neither gamma-carboxyglutamate nor the ability of BGP to bind calcium. Calcium 225-232 bone gamma-carboxyglutamate protein Homo sapiens 0-3 6441624-0 1984 Serum bone Gla protein variations during estrogen and calcium prophylaxis of postmenopausal women. Calcium 54-61 bone gamma-carboxyglutamate protein Homo sapiens 6-22 6441624-1 1984 We have evaluated serum bone Gla protein (BGP) changes in a double-blind study of early postmenopausal women during treatment with estrogen and calcium. Calcium 144-151 bone gamma-carboxyglutamate protein Homo sapiens 24-40 33340588-9 2021 CONCLUSIONS: The carboxylation status of Ocn as well and its calcium coordination appear to have a direct influence on Ocn structure and dynamics, possibly leading to the known differences in Ocn biological function. Calcium 61-68 bone gamma-carboxyglutamate protein Homo sapiens 41-44 33340588-9 2021 CONCLUSIONS: The carboxylation status of Ocn as well and its calcium coordination appear to have a direct influence on Ocn structure and dynamics, possibly leading to the known differences in Ocn biological function. Calcium 61-68 bone gamma-carboxyglutamate protein Homo sapiens 119-122 33340588-9 2021 CONCLUSIONS: The carboxylation status of Ocn as well and its calcium coordination appear to have a direct influence on Ocn structure and dynamics, possibly leading to the known differences in Ocn biological function. Calcium 61-68 bone gamma-carboxyglutamate protein Homo sapiens 119-122 31583921-3 2020 After intervention, compared with control, isoflavone and calcium groups, mean changes from their corresponding baseline values of BMD, calcium/phosphorus, vitamin D and glutathione peroxidase (GSH-pX) activity were significantly increased, however, those of phosphorus, osteocalcin, luteinizing hormone (LH) and follicle stimulating hormone (FSH) were significantly decreased in isoflavone combined with calcium group. Calcium 58-65 bone gamma-carboxyglutamate protein Homo sapiens 271-282 32712610-10 2020 Multivariate regression analysis revealed significant independent association of (1) iCaMB with the dialysate-to-blood calcium gradient at HD start and (2) intradialytic calcium buffer capacity with undercarboxylated osteocalcin. Calcium 170-177 bone gamma-carboxyglutamate protein Homo sapiens 217-228 31659413-12 2020 Patients with a high osteocalcin level may prone to have a higher demand for calcium supplementation. Calcium 77-84 bone gamma-carboxyglutamate protein Homo sapiens 21-32 31761176-7 2020 Furthermore, the SiNPs-CaP have good cytocompatibility and promote the osteogenic differentiation of human bone marrow mesenchymal stem cells (hBMSC), with alkaline phosphatase, osteopontin and osteocalcin production levels comparable to the ones obtained in standard osteogenic medium. Calcium 23-26 bone gamma-carboxyglutamate protein Homo sapiens 194-205 31726453-8 2020 Pre-dialytic, post-dialytic, average for treatment time and average weekly concentrations of ionized calcium in serum correlated positively with serum osteocalcin. Calcium 101-108 bone gamma-carboxyglutamate protein Homo sapiens 151-162 31726453-9 2020 Serum osteocalcin and osteopontin levels were associated with the masses of total and ionized calcium, respectively, removed during 3 hemodialysis sessions. Calcium 94-101 bone gamma-carboxyglutamate protein Homo sapiens 6-17 31726453-10 2020 CONCLUSIONS: During hemodialysis, phosphate removal was associated with serum PTH, whereas calcium kinetics was influenced by serum osteocalcin and osteopontin. Calcium 91-98 bone gamma-carboxyglutamate protein Homo sapiens 132-143 32712610-12 2020 CONCLUSIONS: In line with our proof-of-concept study, we provide clinical evidence for a rapidly accessible and exchangeable calcium pool involved in intradialytic calcium regulation and for the role of osteocalcin as a potential biomarker. Calcium 125-132 bone gamma-carboxyglutamate protein Homo sapiens 203-214 32712610-12 2020 CONCLUSIONS: In line with our proof-of-concept study, we provide clinical evidence for a rapidly accessible and exchangeable calcium pool involved in intradialytic calcium regulation and for the role of osteocalcin as a potential biomarker. Calcium 164-171 bone gamma-carboxyglutamate protein Homo sapiens 203-214 30362184-7 2019 On the other hand, OC enhanced the differentiation of hBM MSC into osteoblasts and demonstrated an increase in extracellular calcium levels and alkaline phosphatase activity, as well as higher messenger RNA levels of mature osteogenic markers osteopontin and osteocalcin. Calcium 125-132 bone gamma-carboxyglutamate protein Homo sapiens 19-21 31342138-0 2019 Effects of calcium supplementation on circulating osteocalcin and glycated haemoglobin in older women. Calcium 11-18 bone gamma-carboxyglutamate protein Homo sapiens 50-61 31342138-1 2019 One year of calcium supplementation in older women led to modest reductions in total osteocalcin and undercarboxylated osteocalcin (ucOC), with no changes in muscle or fat mass, or glycated haemoglobin. Calcium 12-19 bone gamma-carboxyglutamate protein Homo sapiens 85-96 31342138-1 2019 One year of calcium supplementation in older women led to modest reductions in total osteocalcin and undercarboxylated osteocalcin (ucOC), with no changes in muscle or fat mass, or glycated haemoglobin. Calcium 12-19 bone gamma-carboxyglutamate protein Homo sapiens 119-130 31342138-11 2019 In exploratory analyses, total calcium (dietary and supplemental) was inversely related to TOC and ucOC, indicating calcium intake is an important dietary determinant of osteocalcin levels. Calcium 31-38 bone gamma-carboxyglutamate protein Homo sapiens 170-181 31342138-11 2019 In exploratory analyses, total calcium (dietary and supplemental) was inversely related to TOC and ucOC, indicating calcium intake is an important dietary determinant of osteocalcin levels. Calcium 116-123 bone gamma-carboxyglutamate protein Homo sapiens 170-181