PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 25168305-0 2014 Calcium dependent interaction of calmodulin with the GlyT1 C-terminus. Calcium 0-7 calmodulin 2 Mus musculus 33-43 25437912-0 2015 Structure of myosin-1c tail bound to calmodulin provides insights into calcium-mediated conformational coupling. Calcium 71-78 calmodulin 2 Mus musculus 37-47 25389288-5 2015 In this study, we identify calmodulin (CaM), a known transducer of the calcium signal, as the first positive regulator of CAPN3 autolytic activity. Calcium 71-78 calmodulin 2 Mus musculus 27-37 25389288-5 2015 In this study, we identify calmodulin (CaM), a known transducer of the calcium signal, as the first positive regulator of CAPN3 autolytic activity. Calcium 71-78 calmodulin 2 Mus musculus 39-42 25168305-3 2014 In this work we found that the C-terminal region of the mouse glycine transporter GlyT1b is able to specifically interact with calmodulin in the presence of calcium. Calcium 157-164 calmodulin 2 Mus musculus 127-137 24849454-7 2014 Iqcg interacts with calmodulin in a calcium dependent manner in the testis, suggesting that Iqcg may play a role through calcium signaling. Calcium 36-43 calmodulin 2 Mus musculus 20-30 24849454-7 2014 Iqcg interacts with calmodulin in a calcium dependent manner in the testis, suggesting that Iqcg may play a role through calcium signaling. Calcium 121-128 calmodulin 2 Mus musculus 20-30 24491550-0 2014 Identification of an atypical calcium-dependent calmodulin binding site on the C-terminal domain of GluN2A. Calcium 30-37 calmodulin 2 Mus musculus 48-58 24491550-5 2014 Using mass spectrometry we identified calmodulin as a calcium-dependent GluN2A binding partner. Calcium 54-61 calmodulin 2 Mus musculus 38-48 19336226-0 2009 Aquaporin 6 binds calmodulin in a calcium-dependent manner. Calcium 34-41 calmodulin 2 Mus musculus 18-28 21436055-7 2011 The calcium sensor calmodulin (at a normal intracellular concentration) markedly reduced ethanol-induced calcium release and trypsinogen activation in permeabilized cells, effects prevented by the calmodulin inhibitor peptide. Calcium 4-11 calmodulin 2 Mus musculus 19-29 21436055-7 2011 The calcium sensor calmodulin (at a normal intracellular concentration) markedly reduced ethanol-induced calcium release and trypsinogen activation in permeabilized cells, effects prevented by the calmodulin inhibitor peptide. Calcium 4-11 calmodulin 2 Mus musculus 197-207 21436055-12 2011 Calmodulin protects by reducing calcium release sensitivity. Calcium 32-39 calmodulin 2 Mus musculus 0-10 21516261-0 2011 Calcium-Sensitive Translocation of Calmodulin and Neurogranin between Soma and Dendrites of Mouse Hippocampal CA1 Neurons. Calcium 0-7 calmodulin 2 Mus musculus 35-45 20007969-3 2010 The adjacent end of alpha-spectrin, called the EF-domain, is calmodulin-like, with calcium-dependent and calcium-independent EF-hands. Calcium 83-90 calmodulin 2 Mus musculus 61-71 20007969-3 2010 The adjacent end of alpha-spectrin, called the EF-domain, is calmodulin-like, with calcium-dependent and calcium-independent EF-hands. Calcium 105-112 calmodulin 2 Mus musculus 61-71 18493953-11 2008 These results suggest that a significant amount of calmodulin may be trapped in an inactive state, unable to bind free calcium, and activate downstream signaling pathways. Calcium 119-126 calmodulin 2 Mus musculus 51-61 18635666-7 2008 Pyk2 was shown to bind specifically to a Cam agarose affinity column in a calcium-dependent manner, suggesting Cam and Pyk2 are capable of forming a complex. Calcium 74-81 calmodulin 2 Mus musculus 41-44 18635666-7 2008 Pyk2 was shown to bind specifically to a Cam agarose affinity column in a calcium-dependent manner, suggesting Cam and Pyk2 are capable of forming a complex. Calcium 74-81 calmodulin 2 Mus musculus 111-114 18635666-10 2008 Furthermore, association of Pyk2 and Cam may be required to mediate the effects of calcium on Pyk2 phosphorylation and subsequent activation of ERKs by GnRH. Calcium 83-90 calmodulin 2 Mus musculus 37-40 18598570-5 2008 Furthermore, we found that the calcium/CaM/CaMKII pathway was important for regulating spindle rotation. Calcium 31-38 calmodulin 2 Mus musculus 39-42 18032798-4 2008 Notably, the effect of extracellular calcium on AVP-dependent aquaporin-2 expression was prevented by inhibition of calmodulin. Calcium 37-44 calmodulin 2 Mus musculus 116-126 18032798-5 2008 In summary, our results show that high concentrations of extracellular calcium attenuate AVP-induced aquaporin-2 expression by activating the CaSR and reducing coupling efficiency between V(2) receptor and adenylate cyclase via a calmodulin-dependent mechanism in cultured cortical collecting duct cells. Calcium 71-78 calmodulin 2 Mus musculus 230-240 16183639-10 2005 Thus the mTOR-S6K pathway in neurons, a critical component of the late phase of LTP, is activated by glutamatergic stimulation in a calcium/calmodulin-dependent fashion through a calcium pool controlled by postsynaptic voltage-dependent calcium channels, whereas sustained stimulation of extrasynaptic glutamate receptors is inhibitory. Calcium 132-139 calmodulin 2 Mus musculus 140-150 17965257-11 2007 Calmodulin is an intracellular receptor for calcium. Calcium 44-51 calmodulin 2 Mus musculus 0-10 17151196-1 2006 A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. Calcium 32-39 calmodulin 2 Mus musculus 45-55 17151196-1 2006 A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. Calcium 32-39 calmodulin 2 Mus musculus 57-60 17151196-1 2006 A 2.5-A resolution structure of calcium-free calmodulin (CaM) bound to the first two IQ motifs of the murine myosin V heavy chain reveals an unusual CaM conformation. Calcium 32-39 calmodulin 2 Mus musculus 149-152 16442703-1 2006 The sarcolemmal calcium pumps (PMCA for plasma membrane calcium/calmodulin dependent ATPase) are a family of 10 transmembrane domain proteins ejecting calcium from the cytosol. Calcium 16-23 calmodulin 2 Mus musculus 64-74 15611992-2 2005 Like calmodulin, NCS-1 is a member of a family of calcium binding proteins that contain EF-hand motifs, which bind calcium and induce conformational changes in the protein. Calcium 50-57 calmodulin 2 Mus musculus 5-15 15901640-7 2005 In vitro translation of the corresponding Pde1a_v7 cDNA produced a 52-kDa polypeptide having cyclic nucleotide hydrolytic activity, which was stimulated threefold by calcium-bound calmodulin. Calcium 166-173 calmodulin 2 Mus musculus 180-190 15611992-2 2005 Like calmodulin, NCS-1 is a member of a family of calcium binding proteins that contain EF-hand motifs, which bind calcium and induce conformational changes in the protein. Calcium 115-122 calmodulin 2 Mus musculus 5-15 15109989-11 2004 Taking the data from calcium chelation and CaM inhibition together, our results suggest that the dynamic distribution patterns of calcium and activated CaM are crucial for oocyte maturation. Calcium 21-28 calmodulin 2 Mus musculus 152-155 15632291-6 2005 When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling. Calcium 112-119 calmodulin 2 Mus musculus 51-61 15632291-6 2005 When lysates from NIH3T3 cells were incubated with calmodulin-agarose beads in the presence of CaCl(2) or EGTA, calcium ion drastically enhanced the interaction between Nef and calmodulin, suggesting that the binding is under the influence of Ca(2+) signaling. Calcium 112-119 calmodulin 2 Mus musculus 177-187 15109989-11 2004 Taking the data from calcium chelation and CaM inhibition together, our results suggest that the dynamic distribution patterns of calcium and activated CaM are crucial for oocyte maturation. Calcium 130-137 calmodulin 2 Mus musculus 43-46 12734700-2 2003 The calcium-sensitive global motion of either calmodulin domain can be independently monitored in domain-specific interactions of either apo- or Ca(4).calmodulin with IQ3 or IQ4 peptides. Calcium 4-11 calmodulin 2 Mus musculus 46-56 12865156-2 2003 A reduction in serum calcium levels decreases calcium/calmodulin-dependent-dopamine synthesis in the brain and subsequently increases susceptibility to epileptic convulsions and induces abnormal behavior in EL mice. Calcium 21-28 calmodulin 2 Mus musculus 54-64 12668727-2 2003 Our group recently used a pharmacological approach to demonstrate that calmodulin (CaM), a 17 kDa calcium sensor protein, has a role in sperm capacitation. Calcium 98-105 calmodulin 2 Mus musculus 71-81 12668727-2 2003 Our group recently used a pharmacological approach to demonstrate that calmodulin (CaM), a 17 kDa calcium sensor protein, has a role in sperm capacitation. Calcium 98-105 calmodulin 2 Mus musculus 83-86 12734700-0 2003 Time-resolved fluorescence anisotropy studies show domain-specific interactions of calmodulin with IQ target sequences of myosin V. Single cysteine mutants of calmodulin, Cam(S38C) and Cam(N111C), have been specifically labelled with Alexa488 maleimide to study the effects of calcium on the structural dynamics of calmodulin complexed with IQ3, IQ4 and IQ34 target peptide motifs of mouse unconventional myosin-V. Calcium 277-284 calmodulin 2 Mus musculus 83-93 12734700-5 2003 The results demonstrate novel dynamic aspects of calmodulin-IQ interactions relating to the calcium regulation of motility of unconventional myosin. Calcium 92-99 calmodulin 2 Mus musculus 49-59 10970765-1 2000 Calmodulin (CaM) is a ubiquitous, highly conserved calcium sensor protein involved in the regulation of a wide variety of cellular events. Calcium 51-58 calmodulin 2 Mus musculus 0-10 15346980-10 2002 Our results further confirmed that the resumption of meiosis maturation was promoted in a calcium/CaM depended pathway. Calcium 90-97 calmodulin 2 Mus musculus 98-101 10893236-4 2000 Bip, CalP, and CalM are calcium-binding proteins and implicated in calcium homeostasis, whereas SFRP-2 is a negative regulator of Wnt signaling. Calcium 24-31 calmodulin 2 Mus musculus 15-19 10893236-4 2000 Bip, CalP, and CalM are calcium-binding proteins and implicated in calcium homeostasis, whereas SFRP-2 is a negative regulator of Wnt signaling. Calcium 67-74 calmodulin 2 Mus musculus 15-19 10970765-1 2000 Calmodulin (CaM) is a ubiquitous, highly conserved calcium sensor protein involved in the regulation of a wide variety of cellular events. Calcium 51-58 calmodulin 2 Mus musculus 12-15 10482245-0 1999 Calmodulin mediates calcium-dependent inactivation of the cerebellar type 1 inositol 1,4,5-trisphosphate receptor. Calcium 20-27 calmodulin 2 Mus musculus 0-10 10673339-2 2000 Many of the effects of calcium are mediated via its interaction with calmodulin and the subsequent activation of Ca(2+)/calmodulin-dependent (CaM) kinases. Calcium 23-30 calmodulin 2 Mus musculus 69-79 10673339-2 2000 Many of the effects of calcium are mediated via its interaction with calmodulin and the subsequent activation of Ca(2+)/calmodulin-dependent (CaM) kinases. Calcium 23-30 calmodulin 2 Mus musculus 120-130 10673339-2 2000 Many of the effects of calcium are mediated via its interaction with calmodulin and the subsequent activation of Ca(2+)/calmodulin-dependent (CaM) kinases. Calcium 23-30 calmodulin 2 Mus musculus 142-145 10488077-3 1999 Calcium inhibited both of these activities, but the addition of calmodulin restored the values to approximately 70% of control, indicating that calmodulin dissociation caused inhibition. Calcium 0-7 calmodulin 2 Mus musculus 144-154 10200558-1 1999 ALG-2 is a EF hand calcium binding protein with sequence homologies to calmodulin. Calcium 19-26 calmodulin 2 Mus musculus 71-81 9115241-2 1997 Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells. Calcium 79-86 calmodulin 2 Mus musculus 38-48 9316022-1 1997 Calmodulin is a calcium-binding protein that is highly abundant in the brain, where it is involved in many essential functions. Calcium 16-23 calmodulin 2 Mus musculus 0-10 9115241-2 1997 Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells. Calcium 79-86 calmodulin 2 Mus musculus 50-53 9115241-2 1997 Here we show that Rad and Gem bind to calmodulin (CaM)-Sepharose in vitro in a calcium-dependent manner and that Rad can be co-immunoprecipitated with CaM in C2C12 cells. Calcium 79-86 calmodulin 2 Mus musculus 151-154 9115241-10 1997 Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades. Calcium 177-184 calmodulin 2 Mus musculus 87-90 9115241-10 1997 Thus, the Rad family of GTP-binding proteins possess unique characteristics of binding CaM and calmodulin-dependent protein kinase II, suggesting a role for Rad-like GTPases in calcium activation of serine/threonine kinase cascades. Calcium 177-184 calmodulin 2 Mus musculus 95-105 8951173-1 1996 Calmodulin (CaM), a Ca(2+)-binding protein, is a multifunctional modulator mediating the calcium regulation of a large number of intracellular enzyme systems. Calcium 89-96 calmodulin 2 Mus musculus 0-10 8951173-1 1996 Calmodulin (CaM), a Ca(2+)-binding protein, is a multifunctional modulator mediating the calcium regulation of a large number of intracellular enzyme systems. Calcium 89-96 calmodulin 2 Mus musculus 12-15 7561871-11 1995 Calmodulin may mediate neuronal responses depending on the route by which calcium enters the neuron, resulting in activation of different enzymes. Calcium 74-81 calmodulin 2 Mus musculus 0-10 9284569-3 1996 In these animals, the excess of calmodulin decreases the cytosolic calcium levels in beta cells, leading to morphological and functional alterations that produce a severe IDDM. Calcium 67-74 calmodulin 2 Mus musculus 32-42 8900147-3 1996 In cells expressing wild-type neuromodulin, a complex with calmodulin that is sensitive to intracellular calcium and phosphorylation is localized to the plasma membrane. Calcium 105-112 calmodulin 2 Mus musculus 59-69 8877815-9 1996 A common mediator of the inhibitory actions of calcium may be the calcium receptor protein calmodulin the de novo synthesis of which is rapidly stimulated by glucocorticoid hormones. Calcium 47-54 calmodulin 2 Mus musculus 91-101 1337998-5 1992 Many of the cellular responses to calcium are mediated through calmodulin. Calcium 34-41 calmodulin 2 Mus musculus 63-73 7887964-3 1995 We report here that CaM can interact in a calcium-dependent manner with the untransformed glucocorticoid receptor (GR) complex containing hsp90. Calcium 42-49 calmodulin 2 Mus musculus 20-23 7599959-7 1995 These results suggest that CaM kinase activity is specifically required downstream of calcium influx in the CAM and FGF signaling pathway leading to axonal growth. Calcium 86-93 calmodulin 2 Mus musculus 27-30 7599959-7 1995 These results suggest that CaM kinase activity is specifically required downstream of calcium influx in the CAM and FGF signaling pathway leading to axonal growth. Calcium 86-93 calmodulin 2 Mus musculus 108-111 8286225-1 1993 Signal transduction of many intracellular events is initiated by a minute influx of calcium ions into the cells, resulting in the formation of calcium-calmodulin complex and cAMP. Calcium 84-91 calmodulin 2 Mus musculus 151-161 8189230-8 1994 These results strongly suggest that the cation permeability opened by 5-HT and substance P in NG 108-15 cells involves a calcium/calmodulin-dependent process. Calcium 121-128 calmodulin 2 Mus musculus 129-139 8166638-9 1994 Addition of calmodulin to the baculovirus-expressed gamma stimulates its activity 1.5-2.0 fold at pH 6.8 in both the presence and absence of calcium. Calcium 141-148 calmodulin 2 Mus musculus 12-22 8166638-12 1994 This result is unlike that for most calmodulin-stimulated kinases which bind calmodulin only in the presence of calcium and exhibit a decrease in their Km upon binding calmodulin. Calcium 112-119 calmodulin 2 Mus musculus 36-46 8166638-12 1994 This result is unlike that for most calmodulin-stimulated kinases which bind calmodulin only in the presence of calcium and exhibit a decrease in their Km upon binding calmodulin. Calcium 112-119 calmodulin 2 Mus musculus 77-87 8166638-12 1994 This result is unlike that for most calmodulin-stimulated kinases which bind calmodulin only in the presence of calcium and exhibit a decrease in their Km upon binding calmodulin. Calcium 112-119 calmodulin 2 Mus musculus 77-87 8166638-14 1994 of gamma in the presence of calmodulin and in the absence of calcium presents a novel mechanism for the regulation of a calmodulin-stimulated kinase. Calcium 61-68 calmodulin 2 Mus musculus 120-130 1360291-9 1992 The results also suggest that abnormal brain serotonin synthesis in obese mouse regulated by calmodulin might interact with certain factors, such as calcium ions, to complete the activation of serotonin-synthesized enzymes in the development of obesity. Calcium 149-156 calmodulin 2 Mus musculus 93-103 2182648-1 1990 The liver cell adhesion molecule (L-CAM) and N-cadherin or adherens junction-specific CAM (A-CAM) are structurally related cell surface glycoproteins that mediate calcium-dependent adhesion in different tissues. Calcium 163-170 calmodulin 2 Mus musculus 36-39 1649984-0 1991 The naphthalenesulphonamide calmodulin antagonist W7 and its 5-iodo-1-C8 analogue inhibit potassium and calcium currents in NG108-15 neuroblastoma x glioma cells in a manner possibly unrelated to their antagonism of calmodulin. Calcium 104-111 calmodulin 2 Mus musculus 28-38 1905264-6 1991 Chlorpromazine, which has an antagonistic action towards calmodulin, also suppressed the increases of calcium and ALP in the tooth germ. Calcium 102-109 calmodulin 2 Mus musculus 57-67 2182648-1 1990 The liver cell adhesion molecule (L-CAM) and N-cadherin or adherens junction-specific CAM (A-CAM) are structurally related cell surface glycoproteins that mediate calcium-dependent adhesion in different tissues. Calcium 163-170 calmodulin 2 Mus musculus 86-89 2673540-1 1989 Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. Calcium 58-65 calmodulin 2 Mus musculus 0-10 34411733-9 2021 This phenotype was associated with impaired calcium-dependent vasoconstriction and altered expression of calcium-sensitive proteins including SERCA and calmodulin. Calcium 105-112 calmodulin 2 Mus musculus 152-162 2350237-0 1990 A mechanism of cadmium poisoning: the cross effect of calcium and cadmium in the calmodulin-dependent system. Calcium 54-61 calmodulin 2 Mus musculus 81-91 2747661-9 1989 In addition, the results suggest that calcium regulates progression through mitosis by both calmodulin-dependent (metaphase transition) and -independent (prophase) mechanisms. Calcium 38-45 calmodulin 2 Mus musculus 92-102 2956551-3 1987 When lens Ca2+-ATPase activity was inhibited by those calmodulin antagonists, an accumulation of calcium in the lens was observed. Calcium 97-104 calmodulin 2 Mus musculus 54-64 2460125-4 1988 Intracellular calmodulin was significantly higher in rapidly dividing keratinocytes in normal (1.15 mM) calcium medium than in slower dividing cells in low (0.15 mM) calcium. Calcium 104-111 calmodulin 2 Mus musculus 14-24 2839192-4 1988 Both subunits bound [125I]calmodulin in a calcium-dependent manner and demonstrated calmodulin-dependent autophosphorylation. Calcium 42-49 calmodulin 2 Mus musculus 26-36 2839192-4 1988 Both subunits bound [125I]calmodulin in a calcium-dependent manner and demonstrated calmodulin-dependent autophosphorylation. Calcium 42-49 calmodulin 2 Mus musculus 84-94 3277881-2 1988 Embryonic spectrin binds 125I-calmodulin in a calcium-dependent fashion in the blot overlay technique. Calcium 46-53 calmodulin 2 Mus musculus 30-40 3038506-2 1987 More recently, in vitro evidence suggests that a calcium-binding protein, calmodulin, is also involved in the release of many hormones. Calcium 49-56 calmodulin 2 Mus musculus 74-84 3553102-1 1987 Calmodulin (CaM) is a major calcium-binding protein in the brain, where its immunoreactivity is mainly localized in the neurons. Calcium 28-35 calmodulin 2 Mus musculus 0-10 3553102-1 1987 Calmodulin (CaM) is a major calcium-binding protein in the brain, where its immunoreactivity is mainly localized in the neurons. Calcium 28-35 calmodulin 2 Mus musculus 12-15 4070338-0 1985 Effect of calmodulin antagonists on calcium and ethanol-induced sleeping time in mice. Calcium 36-43 calmodulin 2 Mus musculus 10-20 4028171-6 1985 The data suggest that activation of macrophages to the tumoricidal state is a calcium-dependent process involving the participation of calcium-regulated biochemical reactions whose activities can be modulated by pharmacological agents that frustrate transmembrane calcium fluxes and/or inhibit calmodulin function. Calcium 78-85 calmodulin 2 Mus musculus 294-304 4028171-6 1985 The data suggest that activation of macrophages to the tumoricidal state is a calcium-dependent process involving the participation of calcium-regulated biochemical reactions whose activities can be modulated by pharmacological agents that frustrate transmembrane calcium fluxes and/or inhibit calmodulin function. Calcium 135-142 calmodulin 2 Mus musculus 294-304 4028171-6 1985 The data suggest that activation of macrophages to the tumoricidal state is a calcium-dependent process involving the participation of calcium-regulated biochemical reactions whose activities can be modulated by pharmacological agents that frustrate transmembrane calcium fluxes and/or inhibit calmodulin function. Calcium 135-142 calmodulin 2 Mus musculus 294-304 4044638-14 1985 The mobility of LRB-CM in the cytoplasm was sensitive to treatment of the cells with trifluoperazine, which suggests that at least some of the intracellular binding sites are specific for calmodulin in the calcium-bound form. Calcium 206-213 calmodulin 2 Mus musculus 188-198 4070338-1 1985 This investigation was carried out to determine if calcium prolongation of ethanol-induced sleep is mediated by calmodulin and a calmodulin-dependent protein kinase. Calcium 51-58 calmodulin 2 Mus musculus 112-122 4070338-1 1985 This investigation was carried out to determine if calcium prolongation of ethanol-induced sleep is mediated by calmodulin and a calmodulin-dependent protein kinase. Calcium 51-58 calmodulin 2 Mus musculus 129-139 6529754-1 1984 Calmodulin is a small, acidic, calcium-binding protein thought to regulate many cellular functions. Calcium 31-38 calmodulin 2 Mus musculus 0-10 2992708-10 1985 Calcium redistributed soluble striatal calmodulin into the particulate fraction and EGTA shifted calmodulin from the particulate into the soluble fraction. Calcium 0-7 calmodulin 2 Mus musculus 39-49 2578538-3 1985 However, tissue levels of calmodulin did not change during a 3-day culture, with or without prolactin, suggesting that the regulatory component of the calcium-calmodulin system was the intracellular calcium concentration. Calcium 151-158 calmodulin 2 Mus musculus 159-169 4015040-1 1985 Flunarizine, a calcium-antagonist drug that binds to calmodulin, was found to inhibit the migration of both B16 melanoma cells and M5076 macrophage-like cancer cells. Calcium 15-22 calmodulin 2 Mus musculus 53-63 2579165-2 1985 We became interested in the role of the calcium binding protein, calmodulin, in hyperproliferative, low calcium regulated keratinocytes in vitro and in the in vivo hyperproliferative state, psoriasis. Calcium 40-47 calmodulin 2 Mus musculus 65-75 2579165-3 1985 Calmodulin levels were measured by radioimmune assay in neonatal mouse keratinocytes grown in 0.02 mM calcium (hyperproliferative) and 1.2 mM calcium (normal) media, and in cells that had been grown in low calcium medium and then switched to normal calcium. Calcium 102-109 calmodulin 2 Mus musculus 0-10 2579165-5 1985 However, when low calcium monolayers were compared to the normal basal monolayer, the low calcium hyperproliferative cells had more calmodulin. Calcium 18-25 calmodulin 2 Mus musculus 132-142 2579165-6 1985 Cells that were switched from 0.02 mM calcium to 1.2 mM calcium showed increasing calmodulin levels over time. Calcium 38-45 calmodulin 2 Mus musculus 82-92 2579165-6 1985 Cells that were switched from 0.02 mM calcium to 1.2 mM calcium showed increasing calmodulin levels over time. Calcium 56-63 calmodulin 2 Mus musculus 82-92 2982510-5 1985 Calmodulin inhibition by methyl-CCNU was dependent on the concentration of calcium in the preincubation mixture. Calcium 75-82 calmodulin 2 Mus musculus 0-10 6097217-5 1984 The loss of calmodulin from particulate preparations was associated with a decrease in agonist responsiveness (74%) and a marked change in the Ca2+-sensitivity of the enzyme, low concentrations of calcium (approx. Calcium 197-204 calmodulin 2 Mus musculus 12-22 6139089-9 1983 Both calcium transport and the (Ca2+ + Mg2+)-ATPase were significantly stimulated by the calcium-dependent regulatory protein calmodulin, especially when endogenous activator was removed by treatment with the calcium chelator ethylene glycol bis(beta-aminoethyl ether) N,N"-tetraacetic acid. Calcium 5-12 calmodulin 2 Mus musculus 126-136 6541589-1 1984 A class of proteins from mouse mammary epithelial cells has been isolated which, like the calcium-binding protein calmodulin (CaM), binds to phenothiazine in a calcium-dependent manner. Calcium 90-97 calmodulin 2 Mus musculus 114-124 6541589-1 1984 A class of proteins from mouse mammary epithelial cells has been isolated which, like the calcium-binding protein calmodulin (CaM), binds to phenothiazine in a calcium-dependent manner. Calcium 90-97 calmodulin 2 Mus musculus 126-129 6605252-0 1983 Calcium control of actin-myosin based contraction in triton models of mouse 3T3 fibroblasts is mediated by the myosin light chain kinase (MLCK)-calmodulin complex. Calcium 0-7 calmodulin 2 Mus musculus 144-154 6605252-7 1983 The combined results indicate that contractility of non-muscle cellular models is controlled by calmodulin-dependent MLCK acting on the actin-myosin-containing microfilaments with a calcium control exerted in the phosphorylation step of myosin. Calcium 182-189 calmodulin 2 Mus musculus 96-106 6572895-3 1983 The protein has an apparent native Mr of 125,000-150,000 and binds calmodulin in a calcium-dependent manner with a Kd of 20 nM. Calcium 83-90 calmodulin 2 Mus musculus 67-77 6196336-1 1983 Calmodulin is a well-known calcium-binding protein which is ubiquitous in the plant and animal kingdoms and regulates many cellular processes. Calcium 27-34 calmodulin 2 Mus musculus 0-10 6294249-9 1983 Modulation of the intracellular distribution of calmodulin by opioid peptides and alkaloids may control the activity of various membrane-bound and cytosolic systems that are calmodulin- and/or calcium-dependent. Calcium 193-200 calmodulin 2 Mus musculus 48-58 6814940-2 1982 When the recompaction medium contained trifluoperazine (TFP)(0.05 mM), an inhibitor of the calcium-dependent protein calmodulin, the embryos failed to recompact. Calcium 91-98 calmodulin 2 Mus musculus 117-127 30890031-3 2019 The aim of the current study was to assess whether the calcium/calmodulin pathway is a principal target of environmentally relevant Pb during pro-inflammatory activation in a RAW 264.7 macrophage cell line. Calcium 55-62 calmodulin 2 Mus musculus 63-73 32522522-8 2020 Furthermore, the elevation of intracellular calcium levels was shown to activate the calmodulin (CaM)/calmodulin-dependent protein kinase (CaMK) pathway. Calcium 44-51 calmodulin 2 Mus musculus 85-95 32522522-8 2020 Furthermore, the elevation of intracellular calcium levels was shown to activate the calmodulin (CaM)/calmodulin-dependent protein kinase (CaMK) pathway. Calcium 44-51 calmodulin 2 Mus musculus 97-100 32522522-8 2020 Furthermore, the elevation of intracellular calcium levels was shown to activate the calmodulin (CaM)/calmodulin-dependent protein kinase (CaMK) pathway. Calcium 44-51 calmodulin 2 Mus musculus 102-112 31628181-7 2019 Inhibition of slow endocytosis in PKC or calmodulin 2 knock-out hippocampal synapses was rescued by overexpressing wild-type PKC or calmodulin, but not calcium-binding-deficient PKC or calmodulin mutant, respectively, suggesting that calcium stimulates endocytosis by binding with its calcium sensor PKC and calmodulin. Calcium 234-241 calmodulin 2 Mus musculus 41-53 31628181-7 2019 Inhibition of slow endocytosis in PKC or calmodulin 2 knock-out hippocampal synapses was rescued by overexpressing wild-type PKC or calmodulin, but not calcium-binding-deficient PKC or calmodulin mutant, respectively, suggesting that calcium stimulates endocytosis by binding with its calcium sensor PKC and calmodulin. Calcium 234-241 calmodulin 2 Mus musculus 41-53 31628181-8 2019 PKC and calmodulin 2 knock-out inhibited calcium-dependent vesicle mobilization to the readily releasable pool, suggesting that PKC and calmodulin may mediate calcium-dependent facilitation of vesicle mobilization. Calcium 41-48 calmodulin 2 Mus musculus 8-20 31628181-8 2019 PKC and calmodulin 2 knock-out inhibited calcium-dependent vesicle mobilization to the readily releasable pool, suggesting that PKC and calmodulin may mediate calcium-dependent facilitation of vesicle mobilization. Calcium 41-48 calmodulin 2 Mus musculus 8-18 31628181-8 2019 PKC and calmodulin 2 knock-out inhibited calcium-dependent vesicle mobilization to the readily releasable pool, suggesting that PKC and calmodulin may mediate calcium-dependent facilitation of vesicle mobilization. Calcium 159-166 calmodulin 2 Mus musculus 8-20 31628181-8 2019 PKC and calmodulin 2 knock-out inhibited calcium-dependent vesicle mobilization to the readily releasable pool, suggesting that PKC and calmodulin may mediate calcium-dependent facilitation of vesicle mobilization. Calcium 159-166 calmodulin 2 Mus musculus 8-18 31628181-13 2019 Using genetic tools together with capacitance measurements, optical imaging and electron microscopy, we identified two calcium sensors, including protein kinase C (alpha and beta isoforms) and calmodulin, for the most commonly observed forms of endocytosis: slow, rapid, and bulk. Calcium 119-126 calmodulin 2 Mus musculus 193-203 32970800-3 2021 Endothelial calmodulin (CaM), a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for TEM. Calcium 36-43 calmodulin 2 Mus musculus 12-22 32970800-3 2021 Endothelial calmodulin (CaM), a key calcium signaling protein, interacts with the IQ domain of IQGAP1, which is localized to endothelial junctions and is required for TEM. Calcium 36-43 calmodulin 2 Mus musculus 24-27 32970800-4 2021 In the presence of calcium, CaM binds endothelial calcium/calmodulin kinase IIdelta (CaMKIIdelta). Calcium 19-26 calmodulin 2 Mus musculus 28-31 32970800-4 2021 In the presence of calcium, CaM binds endothelial calcium/calmodulin kinase IIdelta (CaMKIIdelta). Calcium 19-26 calmodulin 2 Mus musculus 58-68 32970800-7 2021 These findings highlight novel roles for endothelial CaM and CaMKIIdelta in transducing the spatiotemporally restricted calcium signaling required for TEM. Calcium 120-127 calmodulin 2 Mus musculus 53-56 31635807-6 2020 In the presence of dantrolene, the occurrence of both Ca2+ sparks and spontaneous Ca2+ transients was inhibited, which was associated with enhanced calmodulin binding affinity to the RyR2. Calcium 54-58 calmodulin 2 Mus musculus 148-158 31635807-6 2020 In the presence of dantrolene, the occurrence of both Ca2+ sparks and spontaneous Ca2+ transients was inhibited, which was associated with enhanced calmodulin binding affinity to the RyR2. Calcium 82-86 calmodulin 2 Mus musculus 148-158 31628181-0 2019 Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. Calcium 41-48 calmodulin 2 Mus musculus 21-31 31628181-0 2019 Protein Kinase C and Calmodulin Serve As Calcium Sensors for Calcium-Stimulated Endocytosis at Synapses. Calcium 61-68 calmodulin 2 Mus musculus 21-31 31628181-3 2019 Here, we examined two calcium binding proteins, protein kinase C (PKC) and calmodulin. Calcium 22-29 calmodulin 2 Mus musculus 75-85 31628181-4 2019 Whether PKC is involved in endocytosis was unclear; whether calmodulin acts as a calcium sensor for endocytosis was neither clear, although calmodulin involvement in endocytosis had been suggested. Calcium 81-88 calmodulin 2 Mus musculus 60-70