PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
23753526-7	2013	AC6 appeared to be an important isoform because protein kinase A (PKA), PKC and calcium all inhibited VIP-induced cAMP formation, whereas calcineurin or calmodulin did not modify the response to VIP.	Calcium	80-87	adenylate cyclase 6	Mus musculus	0-3	
28750036-1	2017	It has been proposed that a reduction in intracellular calcium causes an increase in intracellular cAMP and PKA activity through stimulation of calcium inhibitable adenylyl cyclase 6 and inhibition of phosphodiesterase 1 (PDE1), the main enzymes generating and degrading cAMP in the distal nephron and collecting duct, thus contributing to the development and progression of autosomal dominant polycystic kidney disease (ADPKD).	Calcium	55-62	adenylate cyclase 6	Mus musculus	164-182	
26932446-1	2016	The calcium-sensitive type VI adenylyl cyclase (AC6) is a membrane-bound adenylyl cyclase (AC) that converts ATP to cAMP under stimulation.	Calcium	4-11	adenylate cyclase 6	Mus musculus	48-51	
26932446-5	2016	Consequently, GluN2B-dependent calcium signaling and excitatory postsynaptic current, long-term depression, and spatial reversal learning are enhanced in the hippocampus of AC6(-/-) mice without altering the gross anatomy of the brain.	Calcium	31-38	adenylate cyclase 6	Mus musculus	173-176	
34411897-4	2021	To date, AC6, a calcium-inhibited AC, is the primary isoform studied in bone.	Calcium	16-23	adenylate cyclase 6	Mus musculus	9-12	
28750036-1	2017	It has been proposed that a reduction in intracellular calcium causes an increase in intracellular cAMP and PKA activity through stimulation of calcium inhibitable adenylyl cyclase 6 and inhibition of phosphodiesterase 1 (PDE1), the main enzymes generating and degrading cAMP in the distal nephron and collecting duct, thus contributing to the development and progression of autosomal dominant polycystic kidney disease (ADPKD).	Calcium	144-151	adenylate cyclase 6	Mus musculus	164-182	
20466003-1	2010	Adenylyl cyclase (AC) type VI (AC6) is a calcium-inhibitable enzyme which produces cAMP upon stimulation.	Calcium	41-48	adenylate cyclase 6	Mus musculus	31-34	
21527160-0	2011	Adenylyl cyclase 6 improves calcium uptake and left ventricular function in aged hearts.	Calcium	28-35	adenylate cyclase 6	Mus musculus	0-18	
21527160-1	2011	OBJECTIVES: This study tested the hypothesis that activation of adenylyl cyclase 6 (AC6) expression in cardiac myocytes improves calcium uptake and left ventricular (LV) function in aging mice.	Calcium	129-136	adenylate cyclase 6	Mus musculus	64-82	
21527160-1	2011	OBJECTIVES: This study tested the hypothesis that activation of adenylyl cyclase 6 (AC6) expression in cardiac myocytes improves calcium uptake and left ventricular (LV) function in aging mice.	Calcium	129-136	adenylate cyclase 6	Mus musculus	84-87	
21527160-10	2011	CONCLUSIONS: These results indicate that activation of cardiac AC6 expression improves impaired function of aged hearts through improved calcium uptake.	Calcium	137-144	adenylate cyclase 6	Mus musculus	63-66	
18071070-8	2008	CONCLUSIONS: The combination of impaired cardiac cAMP generation and calcium handling that result from AC6 deletion underlies abnormalities in left ventricular function.	Calcium	69-76	adenylate cyclase 6	Mus musculus	103-106	
17068292-0	2006	The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.	Calcium	4-11	adenylate cyclase 6	Mus musculus	138-141	
17068292-0	2006	The calcium paradoxon of renin release: calcium suppresses renin exocytosis by inhibition of calcium-dependent adenylate cyclases AC5 and AC6.	Calcium	40-47	adenylate cyclase 6	Mus musculus	138-141	
17068292-4	2006	Because cAMP is the main intracellular stimulator of renin release, we hypothesized that calcium might exert its suppressive effects on renin secretion via the inhibition of the calcium-regulated adenylate cyclases AC5 and AC6.	Calcium	89-96	adenylate cyclase 6	Mus musculus	223-226	
17068292-8	2006	The calcium-dependent inhibition of intracellular cAMP levels and renin release was prevented by small interfering RNA-mediated knockdown of AC5 and/or AC6 expression, underlining the functional significance of these AC isoforms in renin-producing cells.	Calcium	4-11	adenylate cyclase 6	Mus musculus	152-155