PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 2170596-1 1990 The calcium permeability of the mouse muscle nicotinic ACh receptor (nAChR) was determined using patch-clamp techniques. Calcium 4-11 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 45-67 14762152-3 2004 The nicotine response was blocked by d-tubocurarine and mecamylamine but not alpha-bungarotoxin, indicating the presence of calcium permeable, non-alpha7 nicotinic acetylcholine receptor (nAChR) subtype. Calcium 124-131 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 188-193 14762152-4 2004 Agonist efficacy order for eliciting the axonal nAChR calcium response was cytisine approximately nicotine >> acetylcholine. Calcium 54-61 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 48-53 8987780-9 1997 With use of cadmium and nickel ions as selective blockers, it was found that in different sensory nuclei the presynaptic influx of calcium could result either from the activation of voltage-dependent calcium channels or from a direct influx through nAChR channels. Calcium 131-138 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 249-254 7542542-11 1995 These data provide additional in vivo evidence that altering calcium dynamics can modulate neuronal nAChR function. Calcium 61-68 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 100-105 2170596-6 1990 With pure 110-mM calcium as the external cation, the slope conductance of the nAChR channel at negative potentials is 12 pS. Calcium 17-24 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 78-83 2170596-8 1990 The ion-permeation model predicts that calcium contributes about 2% of the total inward current through a nAChR channel in physiologic solution. Calcium 39-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 106-111 2170596-1 1990 The calcium permeability of the mouse muscle nicotinic ACh receptor (nAChR) was determined using patch-clamp techniques. Calcium 4-11 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 69-74 2170596-5 1990 In pure external calcium, the conductance of the nAChR is similar to the conductance of the NMDA receptor or the L-type Ca channel. Calcium 17-24 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 49-54 27657497-9 2016 Furthermore, Vim KO resulted in significant reduction in neuronal injury and in alpha7 nAChR-mediated calcium signaling. Calcium 102-109 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 80-92 33739565-0 2021 Calcium activity in response to nAChR ligands in murine bone marrow granulocytes with different Gr-1 expression. Calcium 0-7 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 32-37 33739565-10 2021 Thus, calcium response to nAChR ligands in bone marrow PMNs depends on their maturity level. Calcium 6-13 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 26-31 33074245-4 2020 The authors identify two proteins, the voltage-dependent calcium channel auxiliary subunit BARP and the unfolded protein response sensor IRE1alpha, that are required for robust heterologous expression of alpha6beta4, an nAChR subtype in dorsal root ganglia (DRG). Calcium 57-64 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 220-225 30515567-3 2019 However, in developing neurons, poor calcium buffering may cause alpha7 nAChR activation to be neurotoxic. Calcium 37-44 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 65-77 29870540-12 2018 We also examined downstream targets of alpha7nAChR activation and found that calcium and PKC activation are involved down stream of NNK stimulation of alpha7nAChR. Calcium 77-84 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 39-50 29870540-12 2018 We also examined downstream targets of alpha7nAChR activation and found that calcium and PKC activation are involved down stream of NNK stimulation of alpha7nAChR. Calcium 77-84 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 151-162 29316656-3 2018 The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 muM (EC100) acetylcholine but was less potent (IC50 ~ 3 muM) at alpha7 nAChR activated by 10 muM (EC50) acetylcholine and had a low affinity to alpha4beta2 and alpha3-containing nAChR, as well as to GABAA or 5HT3 receptors. Calcium 49-56 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 76-81 29316656-3 2018 The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 muM (EC100) acetylcholine but was less potent (IC50 ~ 3 muM) at alpha7 nAChR activated by 10 muM (EC50) acetylcholine and had a low affinity to alpha4beta2 and alpha3-containing nAChR, as well as to GABAA or 5HT3 receptors. Calcium 49-56 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 166-171 29316656-3 2018 The peptide effectively inhibited (IC50 ~ 19 nM) calcium response of muscle nAChR evoked by 30 muM (EC100) acetylcholine but was less potent (IC50 ~ 3 muM) at alpha7 nAChR activated by 10 muM (EC50) acetylcholine and had a low affinity to alpha4beta2 and alpha3-containing nAChR, as well as to GABAA or 5HT3 receptors. Calcium 49-56 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 166-171 30896303-0 2019 Sinomenine regulates CD14/TLR4, JAK2/STAT3 pathway and calcium signal via alpha7nAChR to inhibit inflammation in LPS-stimulated macrophages. Calcium 55-62 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 74-85 29923678-7 2018 Conversely, the proportions of cells responding with calcium rises induced by nAChR stimulation did not change in either gender according to treatment. Calcium 53-60 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 78-83 28904864-4 2017 Interaction with Galphai mediates alpha7 nAChR signaling via enhanced intracellular calcium release and a decrease in cAMP, p38 phosphorylation, and TNF-alpha release. Calcium 84-91 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 34-46 20561218-7 2010 RESULTS: Murine periodontal ligament cells expressed several subunits of nAChR, which have functional calcium signals in response to nicotine. Calcium 102-109 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 73-78 23136348-5 2013 I show that most of these cells in the RMS exhibit large nAChR-mediated calcium transients upon application of acetylcholine (ACh). Calcium 72-79 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 57-62 22506481-4 2012 Acetylcholine-evoked [(3) H]-GABA release from SuSC crude synaptosomal preparations is calcium dependent, blocked by the voltage-sensitive calcium channel blocker, cadmium, and the nAChR antagonist mecamylamine, but is unaffected by muscarinic, glutamatergic, P2X and 5-HT3 receptor antagonists. Calcium 87-94 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 181-186 26970742-8 2016 nAChR ligands inhibited RANKL-induced calcium oscillation, a well-established phenomenon of osteoclastogenesis. Calcium 38-45 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 0-5 26170298-6 2015 PG-PG interactions are modulated by nicotinic acetylcholine receptors (nAChRs), and our data suggest that changes in intracellular calcium concentrations triggered by nAChR activation can be amplified by GABA release. Calcium 131-138 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 71-76 24312364-5 2013 We found that biologically-relevant concentrations of Abeta1-42 elicited alpha7nAChR-dependent calcium elevations in hippocampal CA1 astrocytes and induced NMDAR-mediated slow inward currents (SICs) in CA1 neurons. Calcium 95-102 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 73-84 21966399-10 2011 Furthermore, alpha7 nAChR is the major calcium channel for nicotine- and E. coli K1-increased intracellular calcium concentrations of mouse BMEC. Calcium 39-46 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 20-25 21966399-11 2011 Taken together, our data suggest that alpha7 nAChR plays a detrimental role in the host defense against meningitic infection by modulation of pathogen invasion, PMN recruitment, calcium signaling and neuronal inflammation. Calcium 178-185 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 38-50 18817758-9 2008 Inhibition of cholinergically induced intracellular calcium signalling by various omega-conotoxins indicated functional expression of alpha 3 beta 4 and alpha 7 nAChR subtypes in murine SPG cells, which could be supported by RT-PCR analysis of the neonatal mouse SPG. Calcium 52-59 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 153-166 18331729-3 2008 We have previously shown that functional nicotinic acetylcholine receptors (nAChRs) already expressed in embryonic cells mediate elevations in cytosolic free calcium concentration ([Ca2+]i) via calcium influx through nAChR channels whereas intracellular stores contribute to nAChR- and mAChR-mediated calcium fluxes in differentiated cells [Resende et al., Cell Calcium 43 (2008) 107-121]. Calcium 158-165 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 76-81 18331729-3 2008 We have previously shown that functional nicotinic acetylcholine receptors (nAChRs) already expressed in embryonic cells mediate elevations in cytosolic free calcium concentration ([Ca2+]i) via calcium influx through nAChR channels whereas intracellular stores contribute to nAChR- and mAChR-mediated calcium fluxes in differentiated cells [Resende et al., Cell Calcium 43 (2008) 107-121]. Calcium 158-165 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 217-222 18331729-3 2008 We have previously shown that functional nicotinic acetylcholine receptors (nAChRs) already expressed in embryonic cells mediate elevations in cytosolic free calcium concentration ([Ca2+]i) via calcium influx through nAChR channels whereas intracellular stores contribute to nAChR- and mAChR-mediated calcium fluxes in differentiated cells [Resende et al., Cell Calcium 43 (2008) 107-121]. Calcium 194-201 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 76-81 18331729-3 2008 We have previously shown that functional nicotinic acetylcholine receptors (nAChRs) already expressed in embryonic cells mediate elevations in cytosolic free calcium concentration ([Ca2+]i) via calcium influx through nAChR channels whereas intracellular stores contribute to nAChR- and mAChR-mediated calcium fluxes in differentiated cells [Resende et al., Cell Calcium 43 (2008) 107-121]. Calcium 194-201 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 217-222 18331729-3 2008 We have previously shown that functional nicotinic acetylcholine receptors (nAChRs) already expressed in embryonic cells mediate elevations in cytosolic free calcium concentration ([Ca2+]i) via calcium influx through nAChR channels whereas intracellular stores contribute to nAChR- and mAChR-mediated calcium fluxes in differentiated cells [Resende et al., Cell Calcium 43 (2008) 107-121]. Calcium 194-201 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 76-81 18331729-3 2008 We have previously shown that functional nicotinic acetylcholine receptors (nAChRs) already expressed in embryonic cells mediate elevations in cytosolic free calcium concentration ([Ca2+]i) via calcium influx through nAChR channels whereas intracellular stores contribute to nAChR- and mAChR-mediated calcium fluxes in differentiated cells [Resende et al., Cell Calcium 43 (2008) 107-121]. Calcium 194-201 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 217-222 18331729-3 2008 We have previously shown that functional nicotinic acetylcholine receptors (nAChRs) already expressed in embryonic cells mediate elevations in cytosolic free calcium concentration ([Ca2+]i) via calcium influx through nAChR channels whereas intracellular stores contribute to nAChR- and mAChR-mediated calcium fluxes in differentiated cells [Resende et al., Cell Calcium 43 (2008) 107-121]. Calcium 362-369 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 76-81 18331729-3 2008 We have previously shown that functional nicotinic acetylcholine receptors (nAChRs) already expressed in embryonic cells mediate elevations in cytosolic free calcium concentration ([Ca2+]i) via calcium influx through nAChR channels whereas intracellular stores contribute to nAChR- and mAChR-mediated calcium fluxes in differentiated cells [Resende et al., Cell Calcium 43 (2008) 107-121]. Calcium 362-369 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 217-222 17716785-8 2008 The pro-oxidative effect induced by AMPH and MDMA showed a strong dependence on calcium (extracellular and from internal stores) and also was inhibited by nicotinic receptor (nAChR) antagonists dihydro-beta-erythroidine, methyllycaconitine (MLA) and alpha-bungarotoxin. Calcium 80-87 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 175-180 17204496-3 2007 A major species of neuronal nAChRs contains the alpha7 gene product and has a high relative permeability to calcium. Calcium 108-115 cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus 48-54