PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33859065-2 2021 Although several studies have reported the effects of FM on store-operated calcium entry (SOCE) via the ORAI1 channel, which is essential during intracellular calcium signaling cascade generation for T cell activation and mast cell degranulation, the effects of its isolated constituents on SOCE remain unidentified. Calcium 75-82 ORAI calcium release-activated calcium modulator 1 Homo sapiens 104-109 33713955-7 2021 Meanwhile, similar to the blocking effect of the specific SOC inhibitors Gd3+ and La3+ on LPS-induced calcium influx, RNAi-mediated depletion of STIM1 or the SOC proteins TRPC1 and ORAI1 could significantly inhibit serum or LPS-induced extracellular calcium influx, as well as the expression of the inflammatory cytokines tumor necrosis factor, intercellular cell adhesion molecule-1, and endothelin-1. Calcium 250-257 ORAI calcium release-activated calcium modulator 1 Homo sapiens 181-186 33713955-8 2021 Simultaneous downregulation of the SOCE core units TRPC1 and ORAI1 inhibited LPS-induced calcium influx and cytokine expression, which could not be restored by inducing STIM1. Calcium 89-96 ORAI calcium release-activated calcium modulator 1 Homo sapiens 61-66 34054913-0 2021 Association of CASR, CALCR, and ORAI1 Genes Polymorphisms With the Calcium Urolithiasis Development in Russian Population. Calcium 67-74 ORAI calcium release-activated calcium modulator 1 Homo sapiens 32-37 34054913-9 2021 We found statistically significant (unadjusted p-value < 0.05) associations between calcium urolithiasis and the polymorphisms in the following genes: CASR rs1042636 (OR = 3.18 for allele A), CALCR rs1801197 (OR = 6.84 for allele A), and ORAI1 rs6486795 (OR = 2.25 for allele C). Calcium 84-91 ORAI calcium release-activated calcium modulator 1 Homo sapiens 238-243 34055617-1 2021 Accumulating evidence suggested that calcium release-activated calcium modulator 1(ORAI1), a key calcium channel pore-forming protein-mediated store-operated Ca2+ entry (SOCE), is associated with human cancer. Calcium 37-44 ORAI calcium release-activated calcium modulator 1 Homo sapiens 83-88 33859065-2 2021 Although several studies have reported the effects of FM on store-operated calcium entry (SOCE) via the ORAI1 channel, which is essential during intracellular calcium signaling cascade generation for T cell activation and mast cell degranulation, the effects of its isolated constituents on SOCE remain unidentified. Calcium 159-166 ORAI calcium release-activated calcium modulator 1 Homo sapiens 104-109 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 62-69 ORAI calcium release-activated calcium modulator 1 Homo sapiens 141-146 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 120-127 ORAI calcium release-activated calcium modulator 1 Homo sapiens 141-146 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 120-127 ORAI calcium release-activated calcium modulator 1 Homo sapiens 141-146 33717700-0 2021 Inhibitory effects of alpha-Mangostin on T cell cytokine secretion via ORAI1 calcium channel and K+ channels inhibition. Calcium 77-84 ORAI calcium release-activated calcium modulator 1 Homo sapiens 71-76 33748129-4 2021 However, little is known regarding the role of SARAF, SOCE-associated regulatory factor, and Orai1, the pore-forming subunit of the store-operated calcium channel (SOCC), in angiogenesis. Calcium 147-154 ORAI calcium release-activated calcium modulator 1 Homo sapiens 93-98 33717700-4 2021 This signaling is mediated not only by the ORAI1 calcium channel, but also by potassium ion channels, which provide the electrical driving forces for generating sufficient calcium ion influx. Calcium 49-56 ORAI calcium release-activated calcium modulator 1 Homo sapiens 43-48 33717700-4 2021 This signaling is mediated not only by the ORAI1 calcium channel, but also by potassium ion channels, which provide the electrical driving forces for generating sufficient calcium ion influx. Calcium 172-179 ORAI calcium release-activated calcium modulator 1 Homo sapiens 43-48 33718371-3 2021 TAM is caused by gain-of-function mutations in STIM1 or ORAI1, proteins responsible for Store-Operated-Calcium-Entry (SOCE), a pivotal mechanism in Ca2+ signaling. Calcium 103-110 ORAI calcium release-activated calcium modulator 1 Homo sapiens 56-61 33127334-0 2021 LPS-induced vein endothelial cell injury and acute lung injury have Btk and Orai 1 to regulate SOC-mediated calcium influx. Calcium 108-115 ORAI calcium release-activated calcium modulator 1 Homo sapiens 76-82 33473127-4 2021 The STIM-Orai1 pathway regulates this rapid and restricted increase of calcium in the expanding blebs. Calcium 71-78 ORAI calcium release-activated calcium modulator 1 Homo sapiens 9-14 33473127-5 2021 Conversely, activated ERM protein binds to Orai1 to inhibit the store-operated calcium entry in retracting blebs, which results in decreased in cytoplasmic calcium, rapid reassembly of the actin cortex. Calcium 79-86 ORAI calcium release-activated calcium modulator 1 Homo sapiens 43-48 33473127-5 2021 Conversely, activated ERM protein binds to Orai1 to inhibit the store-operated calcium entry in retracting blebs, which results in decreased in cytoplasmic calcium, rapid reassembly of the actin cortex. Calcium 156-163 ORAI calcium release-activated calcium modulator 1 Homo sapiens 43-48 33316586-1 2021 The store-operated calcium channels Orai1-3 form extraordinary long and funnel like pores, in stark contrast to a classical pore loop architecture. Calcium 19-26 ORAI calcium release-activated calcium modulator 1 Homo sapiens 36-43 33127334-7 2021 SOC entry mediated by calcium release-activated calcium modulator (Orai) 1 and transient receptor potential canonical (TRPC) 1 was associated with LPS-induced calcium overload and cell apoptosis. Calcium 22-29 ORAI calcium release-activated calcium modulator 1 Homo sapiens 48-74 33361160-1 2021 The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca2+) ion channels represents the activation of the Ca2+-sensor protein STIM1 upon Ca2+ store-depletion of the endoplasmic reticulum. Calcium 74-81 ORAI calcium release-activated calcium modulator 1 Homo sapiens 68-73 33361541-11 2021 Intracellular calcium signaling was significantly inhibited by nootkatol in response to ORAI1 activation in human primary melanocytes (51.6% +- 0.98% at 100 muM). Calcium 14-21 ORAI calcium release-activated calcium modulator 1 Homo sapiens 88-93 32531836-3 2020 Bond tension on LFA-1 within the area of adhesive contact with endothelium elicits calcium entry through calcium release-activated calcium channel protein 1 (Orai-1) membrane channels that in turn activate neutrophil shape change and migration. Calcium 83-90 ORAI calcium release-activated calcium modulator 1 Homo sapiens 105-156 32844545-0 2020 17beta-Estradiol via Orai1 activates calcium mobilization to induce cell proliferation in epithelial ovarian cancer. Calcium 37-44 ORAI calcium release-activated calcium modulator 1 Homo sapiens 21-26 32844545-3 2020 We found that estrogen increased the calcium release-activated calcium channel modulator 1 (Orai1) protein expression levels in SK-OV-3 cells. Calcium 37-44 ORAI calcium release-activated calcium modulator 1 Homo sapiens 92-97 32844545-3 2020 We found that estrogen increased the calcium release-activated calcium channel modulator 1 (Orai1) protein expression levels in SK-OV-3 cells. Calcium 63-70 ORAI calcium release-activated calcium modulator 1 Homo sapiens 92-97 32844545-12 2020 Our results suggest that estrogen, by regulating Orai1, induced calcium influx to determine cell fate. Calcium 64-71 ORAI calcium release-activated calcium modulator 1 Homo sapiens 49-54 32531836-3 2020 Bond tension on LFA-1 within the area of adhesive contact with endothelium elicits calcium entry through calcium release-activated calcium channel protein 1 (Orai-1) membrane channels that in turn activate neutrophil shape change and migration. Calcium 83-90 ORAI calcium release-activated calcium modulator 1 Homo sapiens 158-164 32933717-5 2020 Then, we showed, by calcium imaging that BKCa overexpression enhanced endogenous and exogenous store-operated calcium entry (SOCE) and this enhancement could be blocked by Orai1 knockdown. Calcium 110-117 ORAI calcium release-activated calcium modulator 1 Homo sapiens 172-177 32882268-8 2020 In addition, silencing of Orai-1 and Orai-2 via chemical SOCE inhibitors and siRNAs inhibited calcium uptake and suppressed oral cancer cell proliferation, colony formation and migration. Calcium 94-101 ORAI calcium release-activated calcium modulator 1 Homo sapiens 26-32 33182378-0 2020 Evaluation for the Genetic Association between Store-Operated Calcium Influx Pathway (STIM1 and ORAI1) and Human Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection. Calcium 62-69 ORAI calcium release-activated calcium modulator 1 Homo sapiens 96-101 33250786-0 2020 STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases. Calcium 89-96 ORAI calcium release-activated calcium modulator 1 Homo sapiens 6-11 33127885-3 2020 Here, we report that Orai1, a Crbn substrate, is upregulated via its attenuated interaction with Crbn during efferocytosis, which increases calcium influx into phagocytes and thereby promotes efferocytosis. Calcium 140-147 ORAI calcium release-activated calcium modulator 1 Homo sapiens 21-26 33127885-5 2020 In addition, Orai1 associated with Crbn, resulting in ubiquitination and proteasomal degradation of Orai1 and alteration of SOCE-mediated calcium influx. Calcium 138-145 ORAI calcium release-activated calcium modulator 1 Homo sapiens 13-18 33127885-6 2020 The association of Orai1 with Crbn was attenuated during efferocytosis, leading to reduced ubiquitination of Orai1 and consequently upregulation of Orai1 and calcium influx. Calcium 158-165 ORAI calcium release-activated calcium modulator 1 Homo sapiens 19-24 33127885-6 2020 The association of Orai1 with Crbn was attenuated during efferocytosis, leading to reduced ubiquitination of Orai1 and consequently upregulation of Orai1 and calcium influx. Calcium 158-165 ORAI calcium release-activated calcium modulator 1 Homo sapiens 109-114 33127885-6 2020 The association of Orai1 with Crbn was attenuated during efferocytosis, leading to reduced ubiquitination of Orai1 and consequently upregulation of Orai1 and calcium influx. Calcium 158-165 ORAI calcium release-activated calcium modulator 1 Homo sapiens 109-114 33127885-7 2020 Collectively, our study reveals a regulatory mechanism by which calcium influx is modulated by a Crbn-Orai1 axis to facilitate efferocytosis. Calcium 64-71 ORAI calcium release-activated calcium modulator 1 Homo sapiens 102-107 33086068-6 2020 Oxidative stress suppresses SOCE and calcium currents in cells overexpressing STIM2 and ORAI1, an effect that is abolished by mutation of cysteine 313. Calcium 37-44 ORAI calcium release-activated calcium modulator 1 Homo sapiens 88-93 31600783-0 2020 Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression. Calcium 110-117 ORAI calcium release-activated calcium modulator 1 Homo sapiens 35-40 32854244-6 2020 Through the functional interaction with ORAI1 (calcium release-activated calcium channel protein 1), it modulates cytosolic calcium oscillations, thereby changing microtubule behavior. Calcium 47-54 ORAI calcium release-activated calcium modulator 1 Homo sapiens 40-45 31600783-0 2020 Single nucleotide polymorphisms in Orai1 associated with atopic dermatitis inhibit protein turnover, decrease calcium entry and disrupt calcium-dependent gene expression. Calcium 136-143 ORAI calcium release-activated calcium modulator 1 Homo sapiens 35-40 31600783-1 2020 Loss-of function mutations in Orai1 Ca2+ channels lead to a form of severe combined immunodeficiency, auto-immunity, muscle hypotonia and defects in dental enamel production and sweat gland function. Calcium 36-40 ORAI calcium release-activated calcium modulator 1 Homo sapiens 30-35 31600783-9 2020 The increase in membrane Orai1-SNP leads to a mis-match in Orai1:STIM stoichiometry, resulting in inhibition of Ca2+ entry and Ca2+-dependent gene expression. Calcium 112-116 ORAI calcium release-activated calcium modulator 1 Homo sapiens 25-30 31600783-9 2020 The increase in membrane Orai1-SNP leads to a mis-match in Orai1:STIM stoichiometry, resulting in inhibition of Ca2+ entry and Ca2+-dependent gene expression. Calcium 112-116 ORAI calcium release-activated calcium modulator 1 Homo sapiens 59-64 31600783-9 2020 The increase in membrane Orai1-SNP leads to a mis-match in Orai1:STIM stoichiometry, resulting in inhibition of Ca2+ entry and Ca2+-dependent gene expression. Calcium 127-131 ORAI calcium release-activated calcium modulator 1 Homo sapiens 25-30 31600783-9 2020 The increase in membrane Orai1-SNP leads to a mis-match in Orai1:STIM stoichiometry, resulting in inhibition of Ca2+ entry and Ca2+-dependent gene expression. Calcium 127-131 ORAI calcium release-activated calcium modulator 1 Homo sapiens 59-64 32821879-1 2020 ORAI1 constitutes the pore-forming subunit of the calcium release-activated calcium (CRAC) channel, which is responsible for store-operated calcium entry into lymphocytes. Calcium 50-57 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 32821879-1 2020 ORAI1 constitutes the pore-forming subunit of the calcium release-activated calcium (CRAC) channel, which is responsible for store-operated calcium entry into lymphocytes. Calcium 76-83 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 32821879-1 2020 ORAI1 constitutes the pore-forming subunit of the calcium release-activated calcium (CRAC) channel, which is responsible for store-operated calcium entry into lymphocytes. Calcium 76-83 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 32240745-8 2020 In addition to proximal FcepsilonRI signaling, we similarly show that MS4A4A regulates Orai1-mediated calcium entry downstream of calcium release from stores. Calcium 102-109 ORAI calcium release-activated calcium modulator 1 Homo sapiens 87-92 32240745-8 2020 In addition to proximal FcepsilonRI signaling, we similarly show that MS4A4A regulates Orai1-mediated calcium entry downstream of calcium release from stores. Calcium 130-137 ORAI calcium release-activated calcium modulator 1 Homo sapiens 87-92 32012922-0 2020 Transgenic Mice Overexpressing Human STIM2 and ORAI1 in Neurons Exhibit Changes in Behavior and Calcium Homeostasis but Show No Signs of Neurodegeneration. Calcium 96-103 ORAI calcium release-activated calcium modulator 1 Homo sapiens 47-52 32587130-1 2020 Gardenia jasminoides (GJ) is a widely used herbal medicine with antiinflammatory properties, but its effects on the ORAI1 channel, which is important in generating intracellular calcium signaling for T cell activation, remain unknown. Calcium 178-185 ORAI calcium release-activated calcium modulator 1 Homo sapiens 116-121 32146159-1 2020 Calcium (Ca2+) release-activated Ca2+ (CRAC) channels mediated by STIM1/2 and ORAI (ORAI1-3) proteins form the dominant store-operated Ca2+ entry (SOCE) pathway in a wide variety of cells. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 84-91 31228261-4 2020 In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Calcium 39-46 ORAI calcium release-activated calcium modulator 1 Homo sapiens 112-117 31846645-4 2020 We here show that rapid cytosolic CPP import depends upon an increase in intracellular calcium, likely caused by modulation of the Orai1 calcium channel. Calcium 87-94 ORAI calcium release-activated calcium modulator 1 Homo sapiens 131-136 31846645-4 2020 We here show that rapid cytosolic CPP import depends upon an increase in intracellular calcium, likely caused by modulation of the Orai1 calcium channel. Calcium 137-144 ORAI calcium release-activated calcium modulator 1 Homo sapiens 131-136 31831178-4 2020 Most recent observations revealed that the effect of beta-glycerophosphate on osteogenic signaling requires ORAI1, a Ca2+-channel accomplishing store-operated Ca2+-entry (SOCE), which is stimulated by Ca2+-sensor STIM1. Calcium 117-121 ORAI calcium release-activated calcium modulator 1 Homo sapiens 108-113 31831178-4 2020 Most recent observations revealed that the effect of beta-glycerophosphate on osteogenic signaling requires ORAI1, a Ca2+-channel accomplishing store-operated Ca2+-entry (SOCE), which is stimulated by Ca2+-sensor STIM1. Calcium 159-163 ORAI calcium release-activated calcium modulator 1 Homo sapiens 108-113 31831178-4 2020 Most recent observations revealed that the effect of beta-glycerophosphate on osteogenic signaling requires ORAI1, a Ca2+-channel accomplishing store-operated Ca2+-entry (SOCE), which is stimulated by Ca2+-sensor STIM1. Calcium 159-163 ORAI calcium release-activated calcium modulator 1 Homo sapiens 108-113 32350310-10 2020 In the present study, SLC10A7 was established as a novel negative regulator of intracellular calcium signaling that most likely acts via STIM1, Orai1 and/or SERCA2 inhibition. Calcium 93-100 ORAI calcium release-activated calcium modulator 1 Homo sapiens 144-149 32011316-0 2020 Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 16-21 31736242-7 2020 In addition, decreased expression of stromal interacting molecule 1-Orai1-mediated store-operated Ca2+ entry following an declined intracellular calcium level after 2 mM calcium treatment together with H2 O2 addition, implying impairment of calcium influx in senescent MRC-5 during H2 O2 -induced injury. Calcium 145-152 ORAI calcium release-activated calcium modulator 1 Homo sapiens 68-73 31736242-7 2020 In addition, decreased expression of stromal interacting molecule 1-Orai1-mediated store-operated Ca2+ entry following an declined intracellular calcium level after 2 mM calcium treatment together with H2 O2 addition, implying impairment of calcium influx in senescent MRC-5 during H2 O2 -induced injury. Calcium 170-177 ORAI calcium release-activated calcium modulator 1 Homo sapiens 68-73 31736242-7 2020 In addition, decreased expression of stromal interacting molecule 1-Orai1-mediated store-operated Ca2+ entry following an declined intracellular calcium level after 2 mM calcium treatment together with H2 O2 addition, implying impairment of calcium influx in senescent MRC-5 during H2 O2 -induced injury. Calcium 170-177 ORAI calcium release-activated calcium modulator 1 Homo sapiens 68-73 31952901-3 2020 While mutations in genes encoding key components of Ca2+ handling (ORAI1 and STIM1) underlie tubular aggregate myopathy, no causative genes have been associated with cylindrical spirals. Calcium 52-56 ORAI calcium release-activated calcium modulator 1 Homo sapiens 67-72 31936855-3 2020 Archetypal SOCs called calcium release-activated channels (CRACs) are composed of Orai1 proteins and are stimulated by the endo/sarcoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1) following store depletion. Calcium 23-30 ORAI calcium release-activated calcium modulator 1 Homo sapiens 82-87 31626806-1 2020 Store operated calcium (Ca2+) entry (SOCE) is the process whereby endoplasmic reticulum (ER) Ca2+ store depletion causes Orai1-composed Ca2+ channels on the plasma membrane (PM) to open, mediating a rise in cytosolic Ca2+ levels. Calcium 15-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 121-126 31936855-3 2020 Archetypal SOCs called calcium release-activated channels (CRACs) are composed of Orai1 proteins and are stimulated by the endo/sarcoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1) following store depletion. Calcium 151-155 ORAI calcium release-activated calcium modulator 1 Homo sapiens 82-87 31822631-1 2020 ORAI1 proteins form highly selective Ca2+ channels in the plasma membrane. Calcium 37-41 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 31818466-0 2020 Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion. Calcium 66-70 ORAI calcium release-activated calcium modulator 1 Homo sapiens 54-59 31818466-1 2020 STIM1 (a Ca2+ sensor in the endoplasmic reticulum (ER) membrane) and Orai1 (a pore-forming subunit of the Ca2+-release-activated calcium channel in the plasma membrane) diffuse in the ER membrane and plasma membrane, respectively. Calcium 106-110 ORAI calcium release-activated calcium modulator 1 Homo sapiens 69-74 31818466-1 2020 STIM1 (a Ca2+ sensor in the endoplasmic reticulum (ER) membrane) and Orai1 (a pore-forming subunit of the Ca2+-release-activated calcium channel in the plasma membrane) diffuse in the ER membrane and plasma membrane, respectively. Calcium 129-136 ORAI calcium release-activated calcium modulator 1 Homo sapiens 69-74 31818466-2 2020 Upon depletion of Ca2+ stores in the ER, STIM1 translocates to the ER-plasma membrane junction and binds Orai1 to trigger store-operated Ca2+ entry. Calcium 18-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 105-110 31818466-2 2020 Upon depletion of Ca2+ stores in the ER, STIM1 translocates to the ER-plasma membrane junction and binds Orai1 to trigger store-operated Ca2+ entry. Calcium 137-141 ORAI calcium release-activated calcium modulator 1 Homo sapiens 105-110 31818466-3 2020 However, the motion of STIM1 and Orai1 during this process and its roles to Ca2+ entry is poorly understood. Calcium 76-80 ORAI calcium release-activated calcium modulator 1 Homo sapiens 33-38 31818466-4 2020 Here, we report real-time tracking of single STIM1 and Orai1 particles in the ER membrane and plasma membrane in living cells before and after Ca2+ store depletion. Calcium 143-147 ORAI calcium release-activated calcium modulator 1 Homo sapiens 55-60 31676354-2 2020 The secretory pathway Ca2+ATPase 2 (SPCA2) interacts with Orai1, which is involved in SOCE and store independent Ca2+ entry (SICE). Calcium 22-26 ORAI calcium release-activated calcium modulator 1 Homo sapiens 58-63 31755615-14 2020 Taken together, our data suggested that EP4 activated PI3K and then induced Ca2+ influx from the extracellular space via Orai1, resulting in ERK phosphorylation and promoting cell migration. Calcium 76-80 ORAI calcium release-activated calcium modulator 1 Homo sapiens 121-126 31879743-5 2019 The expression levels of Orai1 and STIM1, key molecules in the process of store-operated calcium entry (SOCE) were detected by Western blot and RT-PCR. Calcium 89-96 ORAI calcium release-activated calcium modulator 1 Homo sapiens 25-30 31556856-4 2020 Following Ca2+ depletion in the Endoplasmic reticulum (ER) store, STIM1 interacts with ORAI1 and leads to the opening of the CRAC channel gate and consequently allows the influx of Ca2+ ions. Calcium 10-14 ORAI calcium release-activated calcium modulator 1 Homo sapiens 87-92 31556856-4 2020 Following Ca2+ depletion in the Endoplasmic reticulum (ER) store, STIM1 interacts with ORAI1 and leads to the opening of the CRAC channel gate and consequently allows the influx of Ca2+ ions. Calcium 181-185 ORAI calcium release-activated calcium modulator 1 Homo sapiens 87-92 31556856-5 2020 A plethora of studies report that aberrant CRAC channel activity due to Loss- or gain-of-function mutations in ORAI1 and STIM1 disturbs this Ca2+ homeostasis and cause several autoimmune disorders. Calcium 141-145 ORAI calcium release-activated calcium modulator 1 Homo sapiens 111-116 31744929-1 2019 The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. Calcium 155-159 ORAI calcium release-activated calcium modulator 1 Homo sapiens 168-173 31744929-1 2019 The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. Calcium 155-159 ORAI calcium release-activated calcium modulator 1 Homo sapiens 168-173 31744929-6 2019 Point mutations associated with tubular aggregate myopathy or cancer that targeted the canonical EF hand, and the hydrophobic cleft yielded constitutively clustered STIM1, which was associated with activation of Ca2+ entry through Orai1 channels. Calcium 212-216 ORAI calcium release-activated calcium modulator 1 Homo sapiens 231-236 31346185-6 2019 RV-induced [Ca2+]cyt spikes were primarily from ER calcium release and were attenuated by inhibiting the store-operated calcium entry (SOCE) channel Orai1. Calcium 120-127 ORAI calcium release-activated calcium modulator 1 Homo sapiens 149-154 31415242-0 2019 Calcium channel Orai1 promotes lymphocyte IL-17 expression and progressive kidney injury. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 16-21 31415242-1 2019 We hypothesized that the store-operated calcium entry (SOCE) channel, Orai1, participates in the activation of Th17 cells and influences renal injury. Calcium 40-47 ORAI calcium release-activated calcium modulator 1 Homo sapiens 70-75 31652779-1 2019 Orai1 plays a major role in store-operated Ca2+ entry (SOCE) in triple-negative breast cancer (TNBC) cells. Calcium 43-47 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 31652779-3 2019 The Ca2+ calmodulin-activated adenylyl cyclase type 8 (AC8) was reported to interact directly with Orai1, thus mediating a dynamic interplay between the Ca2+- and cyclic adenosine monophosphate (cAMP)-dependent signaling pathways. Calcium 4-8 ORAI calcium release-activated calcium modulator 1 Homo sapiens 99-104 31569936-2 2019 Of these proteins the ORAI1 one received major attention as plasma membrane constituent of store-operated calcium entry (SOCE) in non-excitable cells. Calcium 106-113 ORAI calcium release-activated calcium modulator 1 Homo sapiens 22-27 31346209-0 2019 Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling. Calcium 81-88 ORAI calcium release-activated calcium modulator 1 Homo sapiens 75-80 31036819-0 2019 A calcium/cAMP signaling loop at the ORAI1 mouth drives channel inactivation to shape NFAT induction. Calcium 2-9 ORAI calcium release-activated calcium modulator 1 Homo sapiens 37-42 30853710-1 2019 ORAI1 encodes a calcium channel essential in the store-operated calcium entry mechanism. Calcium 16-23 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 31281748-0 2019 Association of ORAI1 Genetic Polymorphism with Serum Calcium and Phosphorus Levels in Non-dialysis Chronic Kidney Disease Patients: A Case-control Study. Calcium 53-60 ORAI calcium release-activated calcium modulator 1 Homo sapiens 15-20 31281748-3 2019 This study aimed to examine the serum calcium and phosphorus levels in non-dialysis CKD patients and healthy controls to find out their association with ORAI1 genetic polymorphism. Calcium 38-45 ORAI calcium release-activated calcium modulator 1 Homo sapiens 153-158 30854480-0 2019 Heterologous calcium-dependent inactivation of Orai1 by neighboring TRPV1 channels modulates cell migration and wound healing. Calcium 13-20 ORAI calcium release-activated calcium modulator 1 Homo sapiens 47-52 31014395-5 2019 The molecular characterization of the calcium channels Orai1 and TRPC1 and to their partner STIM1 was performed by flow cytometry and/or Western blotting. Calcium 38-45 ORAI calcium release-activated calcium modulator 1 Homo sapiens 55-60 30854480-4 2019 Here we show that calcium entering through freely diffusing TRPV1 channels induce strong CDI on Orai1 while calcium entering through P2X4 channel does not. Calcium 18-25 ORAI calcium release-activated calcium modulator 1 Homo sapiens 96-101 30854480-7 2019 To our knowledge, this is the first study demonstrating that calcium arising from different channels may contribute to the modulation of Orai1 through CDI in freely diffusing single channels of living cells. Calcium 61-68 ORAI calcium release-activated calcium modulator 1 Homo sapiens 137-142 30754719-2 2019 ORAI1 is a protein that forms a calcium-permeable ion channel responsible for store-operated calcium entry (SOCE) in a variety of cell types. Calcium 32-39 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 30754719-2 2019 ORAI1 is a protein that forms a calcium-permeable ion channel responsible for store-operated calcium entry (SOCE) in a variety of cell types. Calcium 93-100 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 30589833-15 2018 CONCLUSIONS When exposed to high tidal volume or large-magnitude CS, Stim1 and Orai1 expression are upregulated, which further activates calcium-sensitive PKCalpha and results in calcium overload, endothelial hyperpermeability, and, finally, lung injury. Calcium 137-144 ORAI calcium release-activated calcium modulator 1 Homo sapiens 79-84 31659911-2 2019 It is initiated by antigen-mediated receptor stimulation that triggers store-operated calcium entry (SOCE) via ORAI1 calcium channel. Calcium 86-93 ORAI calcium release-activated calcium modulator 1 Homo sapiens 111-116 31659911-2 2019 It is initiated by antigen-mediated receptor stimulation that triggers store-operated calcium entry (SOCE) via ORAI1 calcium channel. Calcium 117-124 ORAI calcium release-activated calcium modulator 1 Homo sapiens 111-116 30528613-1 2019 A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels. Calcium 9-16 ORAI calcium release-activated calcium modulator 1 Homo sapiens 182-187 30589833-15 2018 CONCLUSIONS When exposed to high tidal volume or large-magnitude CS, Stim1 and Orai1 expression are upregulated, which further activates calcium-sensitive PKCalpha and results in calcium overload, endothelial hyperpermeability, and, finally, lung injury. Calcium 179-186 ORAI calcium release-activated calcium modulator 1 Homo sapiens 79-84 29908962-0 2018 Targeting Orai1-mediated store-operated calcium entry by RP4010 for anti-tumor activity in esophagus squamous cell carcinoma. Calcium 40-47 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 30373149-0 2018 Calcium Independent Effect of Orai1 and STIM1 in Non-Hodgkin B Cell Lymphoma Dissemination. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 30-35 29698850-1 2018 Stromal interaction molecule (STIM)-1 and -2 are multi-domain, single-pass transmembrane proteins involved in sensing changes in compartmentalized calcium (Ca2+) levels and transducing this cellular signal to Orai1 channel proteins. Calcium 147-154 ORAI calcium release-activated calcium modulator 1 Homo sapiens 209-214 29954946-0 2018 Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor. Calcium 25-32 ORAI calcium release-activated calcium modulator 1 Homo sapiens 19-24 29926068-0 2018 [Involvement of interaction between TRPC1 and Orai1 in calcium sensing receptor-mediated calcium influx and nitric oxide generation in human umbilical vein endothelial cells]. Calcium 55-62 ORAI calcium release-activated calcium modulator 1 Homo sapiens 46-51 29920471-5 2018 The STIM1/Orai1-mediated SOC entry is the main cause of a sustained intracellular calcium ([Ca2+]i) elevation, which is different from a transient rise of [Ca2+]i mediated by IP3R and RyR. Calcium 82-89 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 29780159-2 2018 Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE). Calcium 13-20 ORAI calcium release-activated calcium modulator 1 Homo sapiens 329-334 29184031-0 2017 Transmembrane helix connectivity in Orai1 controls two gates for calcium-dependent transcription. Calcium 65-72 ORAI calcium release-activated calcium modulator 1 Homo sapiens 36-41 30114708-0 2018 Orai1 and Stim1 Mediate the Majority of Store-Operated Calcium Entry in Multiple Myeloma and Have Strong Implications for Adverse Prognosis. Calcium 55-62 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 30421677-1 2018 BACKGROUND: Store-operated calcium entry (SOCE), primarily mediated by Orai1 and stromal interaction molecule 1 (STIM1), is a major Ca2+ influx pathway that has been linked to human diseases including myopathy, epilepsy, immunodeficiency, and cancer. Calcium 27-34 ORAI calcium release-activated calcium modulator 1 Homo sapiens 71-76 29311831-0 2017 Orai1 and Orai3 Mediate Store-Operated Calcium Entry Contributing to Neuronal Excitability in Dorsal Root Ganglion Neurons. Calcium 39-46 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 28919480-2 2017 Two main proteins sustain SOCE: STIM1 that acts as the calcium sensor in the endoplasmic reticulum (ER) and Orai1 responsible for calcium influx upon depletion of ER. Calcium 130-137 ORAI calcium release-activated calcium modulator 1 Homo sapiens 108-113 28145580-8 2017 Orai1 and Stim1, two N-glycosylated proteins, are involved in Store-Operated Calcium Entry (SOCE), and are essential for breast tumor cell migration. Calcium 77-84 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 29463029-5 2018 HEK293 cells that stably express human STIM1 and Orai1, components of the store-operated calcium entry (SOCE) machinery, gave a much higher RLA by stimulation with thapsigargin, an inhibitor of sarcoplasmic/endoplamic reticulum Ca2+-ATPase (SERCA). Calcium 89-96 ORAI calcium release-activated calcium modulator 1 Homo sapiens 49-54 28105751-3 2017 Ang-II elevates intracellular Ca2+ through activation of the store-operated calcium entry (SOCE) involving an inositol-3-phosphate receptor (IP3R)-coupled depletion of endoplasmic reticular Ca2+ and a subsequent activation of the stromal interaction molecule 1 (STIM-1)/Orai-1 complex. Calcium 76-83 ORAI calcium release-activated calcium modulator 1 Homo sapiens 270-276 29179526-5 2017 Store-operated Ca2+ entry, acts as the principal force of calcium influx, is composed of STIM1 and Orai1 on the plasma membrane. Calcium 58-65 ORAI calcium release-activated calcium modulator 1 Homo sapiens 99-104 29109429-7 2017 Consistent with these results, translocation of the endogenous ER calcium sensor STIM1 to its target channel Orai1 was delayed following ER calcium store depletion. Calcium 66-73 ORAI calcium release-activated calcium modulator 1 Homo sapiens 109-114 29109429-7 2017 Consistent with these results, translocation of the endogenous ER calcium sensor STIM1 to its target channel Orai1 was delayed following ER calcium store depletion. Calcium 140-147 ORAI calcium release-activated calcium modulator 1 Homo sapiens 109-114 29053695-2 2017 ER-resident STIM1 regulates the activity of PM Orai1 channels in a process known as store operated calcium (Ca2+) entry which is the principal Ca2+ signaling process that drives the immune response. Calcium 99-106 ORAI calcium release-activated calcium modulator 1 Homo sapiens 47-52 27865925-0 2017 Orai1 and Orai2 mediate store-operated calcium entry that regulates HL60 cell migration and FAK phosphorylation. Calcium 39-46 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 29872495-9 2018 This calcium-dependent survival is accompanied by the activation of ERK1/2, and its pharmacological inhibition completely abolished the increase in Kv10.1 and Orai1 expressions, activities, and the cell survival induced by collagen 1. Calcium 5-12 ORAI calcium release-activated calcium modulator 1 Homo sapiens 159-164 28114279-2 2017 Here, we report that SigmaR1, a stress-activated chaperone, is required to increase calcium influx by triggering the coupling between SK3, a Ca2+-activated K+ channel (KCNN3) and the voltage-independent calcium channel Orai1. Calcium 84-91 ORAI calcium release-activated calcium modulator 1 Homo sapiens 219-224 28694529-2 2017 It stimulates store-operated calcium entry (SOCE) through the calcium release-activated calcium (CRAC) channel Orai1/Stim1 in endometrial Ishikawa cells. Calcium 29-36 ORAI calcium release-activated calcium modulator 1 Homo sapiens 111-116 28263185-5 2017 In response to flow, the plasma membrane calcium channel ORAI1 mediates calcium influx in LECs and activates calmodulin to facilitate a physical interaction between Kruppel-like factor 2 (KLF2), the major regulator of shear responses, and PROX1, the master regulator of lymphatic development. Calcium 41-48 ORAI calcium release-activated calcium modulator 1 Homo sapiens 57-62 28564609-1 2017 Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. Calcium 108-115 ORAI calcium release-activated calcium modulator 1 Homo sapiens 92-97 27390850-0 2016 Calcium Influx of Mast Cells Is Inhibited by Aptamers Targeting the First Extracellular Domain of Orai1. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 98-103 27736292-0 2017 Orai1 regulates calcium entry into dendritic spines. Calcium 16-23 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 27677589-4 2016 In addition, FGF4 increased store-operated calcium entry (SOCE) and expression of the calcium signal-associated protein Orai1. Calcium 86-93 ORAI calcium release-activated calcium modulator 1 Homo sapiens 120-125 27041216-1 2016 STIM1 and ORAI1 constitute the core machinery of the ubiquitous store-operated calcium entry pathway and loss of function in these proteins is associated with severe immune and muscular disorders. Calcium 79-86 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 28247721-9 2016 The results indicate the presence of the association between recurrence-free urolithiasis and calcium release-activatedcalcium modulator 1 gene polymorphism (ORAI1, rs7135617), both in genotypes and alleles. Calcium 94-101 ORAI calcium release-activated calcium modulator 1 Homo sapiens 158-163 27471592-2 2016 The regulation of transcellular calcium transport by 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3, the active form of vitamin D) has been confirmed in humans and rodents, and regulators, including vitamin D receptor (VDR), calcium binding protein D9k (calbindin-D9k), plasma membrane Ca(2+)-ATPase 1b (PMCA1b), PMAC2b and Orai1, are involved in this process. Calcium 32-39 ORAI calcium release-activated calcium modulator 1 Homo sapiens 316-321 27459950-1 2016 STIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). Calcium 62-69 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 27459950-1 2016 STIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). Calcium 109-116 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 28258822-2 2017 Thus, it is hypothesized that regulating calcium entry through CRACM1 (the pore-forming subunit of calcium release-activated calcium (CRAC) channels; also known as ORAI1) may be beneficial for the management of RA. Calcium 41-48 ORAI calcium release-activated calcium modulator 1 Homo sapiens 63-69 28258822-2 2017 Thus, it is hypothesized that regulating calcium entry through CRACM1 (the pore-forming subunit of calcium release-activated calcium (CRAC) channels; also known as ORAI1) may be beneficial for the management of RA. Calcium 41-48 ORAI calcium release-activated calcium modulator 1 Homo sapiens 164-169 28258822-4 2017 Consistent with CRACM1 knockdown, calcium influx in synovial cells and the histopathological features of CIA were reduced. Calcium 34-41 ORAI calcium release-activated calcium modulator 1 Homo sapiens 16-22 28258822-7 2017 In summary, inhibiting calcium entry by CRACM1 knockdown suppressed arthritis development and may be therapeutically beneficial for RA patients. Calcium 23-30 ORAI calcium release-activated calcium modulator 1 Homo sapiens 40-46 26793113-0 2015 STIM and Orai1 Variants in Store-Operated Calcium Entry. Calcium 42-49 ORAI calcium release-activated calcium modulator 1 Homo sapiens 9-14 26792278-1 2016 BACKGROUND: Orai1, which is involved in store-operated calcium entry, has recently been implicated in cancer progression. Calcium 55-62 ORAI calcium release-activated calcium modulator 1 Homo sapiens 12-17 26992221-4 2016 The activation of SOCE increased ER and plasma membrane (PM) connections, which was linked by ER- resident stromal interaction molecule-1 (STIM1) protein and PM-resident calcium release- activated calcium modulator 1 (Orai1). Calcium 170-177 ORAI calcium release-activated calcium modulator 1 Homo sapiens 218-223 26738614-0 2016 Role of STIM1-Orai1 system in intra-cellular calcium elevation induced by ATP in cultured human keratinocytes. Calcium 45-52 ORAI calcium release-activated calcium modulator 1 Homo sapiens 14-19 27063589-1 2016 ORAI1 is the pore-forming subunit of the calcium release-activated calcium channel responsible for calcium influx into cells triggered by endoplasmic reticulum store depletion. Calcium 41-48 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 27063589-2 2016 We report here a patient with severe combined immunodeficiency and absent store-operated calcium entry due to a novel mutation in ORAI1 that results in the expression of a C-terminally truncated protein that abolishes ORAI1 binding to STIM1. Calcium 89-96 ORAI calcium release-activated calcium modulator 1 Homo sapiens 130-135 27063589-2 2016 We report here a patient with severe combined immunodeficiency and absent store-operated calcium entry due to a novel mutation in ORAI1 that results in the expression of a C-terminally truncated protein that abolishes ORAI1 binding to STIM1. Calcium 89-96 ORAI calcium release-activated calcium modulator 1 Homo sapiens 218-223 26826124-0 2016 T Cell Receptor-induced Nuclear Factor kappaB (NF-kappaB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry. Calcium 142-149 ORAI calcium release-activated calcium modulator 1 Homo sapiens 127-132 26546674-2 2016 The two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel pore-forming protein Orai1. Calcium 45-52 ORAI calcium release-activated calcium modulator 1 Homo sapiens 194-199 26712003-2 2016 When bound and activated by stromal interacting molecule 1 (STIM1), an endoplasmic reticulum (ER)-resident calcium sensor, Orai1 channels possess high selectivity for calcium but extremely small conductance that has precluded direct recording of single-channel currents. Calcium 107-114 ORAI calcium release-activated calcium modulator 1 Homo sapiens 123-128 26712003-2 2016 When bound and activated by stromal interacting molecule 1 (STIM1), an endoplasmic reticulum (ER)-resident calcium sensor, Orai1 channels possess high selectivity for calcium but extremely small conductance that has precluded direct recording of single-channel currents. Calcium 167-174 ORAI calcium release-activated calcium modulator 1 Homo sapiens 123-128 26712003-3 2016 We have developed an approach to visualize Orai1 activity by fusing Orai1 to fluorescent, genetically encoded calcium indicators (GECIs). Calcium 110-117 ORAI calcium release-activated calcium modulator 1 Homo sapiens 43-48 26546674-3 2016 During store-operated calcium entry activation, calcium depletion from the endoplasmic reticulum triggers a series of conformational changes in STIM1 that unmask a minimal Orai1-activating domain (CRAC activation region (CAD)). Calcium 48-55 ORAI calcium release-activated calcium modulator 1 Homo sapiens 172-177 26696631-0 2015 A calcium-accumulating region, CAR, in the channel Orai1 enhances Ca(2+) permeation and SOCE-induced gene transcription. Calcium 2-9 ORAI calcium release-activated calcium modulator 1 Homo sapiens 51-56 26644574-3 2015 Research on calcium signaling has centered on STIM1, ORAI1, and a few proteins that directly modulate STIM-ORAI function. Calcium 12-19 ORAI calcium release-activated calcium modulator 1 Homo sapiens 53-58 25922260-1 2015 Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER. Calcium 15-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 180-185 26454179-1 2015 Store-operated calcium entry (SOCE) is a pathway that moves Ca(2+) across the plasma membrane and is mediated by two major proteins, STIM1 and Orai1. Calcium 15-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 143-148 26191202-1 2015 Orai1 and STIM1 mediate calcium release-activated calcium current (CRAC) which is the best characterized store-operated calcium current involving in a wide range of cell progresses, such as cell proliferation, metastasis, apoptosis. Calcium 24-31 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 26178077-11 2015 CONCLUSIONS: This study provides insights in the anhidrotic ectodermal dysplasia phenotype due to Orai1 mutation and highlights the importance of calcium signaling in controlling ameloblast differentiation and maturation during tooth development. Calcium 146-153 ORAI calcium release-activated calcium modulator 1 Homo sapiens 98-103 26138675-2 2015 Two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel pore-forming protein Orai1. Calcium 41-48 ORAI calcium release-activated calcium modulator 1 Homo sapiens 190-195 26138675-3 2015 Following calcium depletion from the endoplasmic reticulum, STIM1 undergoes conformational changes that unmask an Orai1-activating domain called CAD. Calcium 10-17 ORAI calcium release-activated calcium modulator 1 Homo sapiens 114-119 25917787-0 2015 Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Calcium 38-45 ORAI calcium release-activated calcium modulator 1 Homo sapiens 14-19 25769459-0 2015 Orai1-Orai2 complex is involved in store-operated calcium entry in chondrocyte cell lines. Calcium 50-57 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 25917787-12 2015 CONCLUSIONS: Cytosolic calcium overload, mediated via ORAI1, contributes to the pathogenesis of acute pancreatitis. Calcium 23-30 ORAI calcium release-activated calcium modulator 1 Homo sapiens 54-59 26191202-1 2015 Orai1 and STIM1 mediate calcium release-activated calcium current (CRAC) which is the best characterized store-operated calcium current involving in a wide range of cell progresses, such as cell proliferation, metastasis, apoptosis. Calcium 50-57 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 26191202-1 2015 Orai1 and STIM1 mediate calcium release-activated calcium current (CRAC) which is the best characterized store-operated calcium current involving in a wide range of cell progresses, such as cell proliferation, metastasis, apoptosis. Calcium 50-57 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 24307733-0 2014 Calcium signaling via Orai1 is essential for induction of the nuclear orphan receptor pathway to drive Th17 differentiation. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 22-27 25896806-2 2015 Stromal interaction molecule (STIM) proteins regulate store-operated calcium entry (SOCE) by sensing Ca(2+) concentration in the ER and forming oligomers to trigger Ca(2+) entry through plasma membrane-localized Orai1 channels. Calcium 69-76 ORAI calcium release-activated calcium modulator 1 Homo sapiens 212-217 25645930-2 2015 In immune cells, calcium entry occurs through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels, comprised of STIM1 and Orai1 proteins. Calcium 17-24 ORAI calcium release-activated calcium modulator 1 Homo sapiens 133-138 25428882-1 2015 Orai1 interacts with transient receptor potential protein of the canonical subfamily (TRPC4) and contributes to calcium selectivity of the endothelial cell store-operated calcium entry current (ISOC). Calcium 112-119 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 25428882-1 2015 Orai1 interacts with transient receptor potential protein of the canonical subfamily (TRPC4) and contributes to calcium selectivity of the endothelial cell store-operated calcium entry current (ISOC). Calcium 171-178 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 25428882-2 2015 Orai1 silencing increases sodium permeability and decreases membrane-associated calcium, although it is not known whether Orai1 is an important determinant of cytosolic sodium transitions. Calcium 80-87 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 25026203-2 2014 Prostate cancer cells can undergo an oncogenic switch from a calcium influx pathway capable of inducing apoptosis involving ORAI1 channels to a pro-proliferative calcium influx pathway involving ORAI1/3 heteromeric channels. Calcium 61-68 ORAI calcium release-activated calcium modulator 1 Homo sapiens 124-129 24834055-12 2014 This novel report of STIM1-2 and Orai1-3 mRNA expression in pregnant human myometrium and Orai1 regulation by IL-1beta indicates a potential role for these proteins in calcium signaling in human myometrium during pregnancy. Calcium 168-175 ORAI calcium release-activated calcium modulator 1 Homo sapiens 33-38 24834055-12 2014 This novel report of STIM1-2 and Orai1-3 mRNA expression in pregnant human myometrium and Orai1 regulation by IL-1beta indicates a potential role for these proteins in calcium signaling in human myometrium during pregnancy. Calcium 168-175 ORAI calcium release-activated calcium modulator 1 Homo sapiens 90-95 24472175-0 2014 Inverse regulation of melanoma growth and migration by Orai1/STIM2-dependent calcium entry. Calcium 77-84 ORAI calcium release-activated calcium modulator 1 Homo sapiens 55-60 26218135-2 2015 Depletion of endoplasmic reticulum calcium stores activates STIM proteins which, in turn, bind and open calcium channels in the plasma membrane formed by the proteins ORAI1, ORAI2, and ORAI3. Calcium 35-42 ORAI calcium release-activated calcium modulator 1 Homo sapiens 167-172 26218135-3 2015 The resulting store-operated calcium entry (SOCE), mostly controlled by the principal components STIM1 and ORAI1, has been particularly characterized in immune cells. Calcium 29-36 ORAI calcium release-activated calcium modulator 1 Homo sapiens 107-112 25308275-5 2014 Biophysical studies revealed that AnCoA4 binds to the C terminus of Orai1, directly inhibiting calcium influx through the channel and also reducing binding of STIM1. Calcium 95-102 ORAI calcium release-activated calcium modulator 1 Homo sapiens 68-73 25190815-0 2014 Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells. Calcium 74-81 ORAI calcium release-activated calcium modulator 1 Homo sapiens 43-48 24583265-3 2014 Here we demonstrate that ORAI1 and STIM1 mediate store-operated calcium entry (SOCE) in pancreatic adenocarcinoma cell lines. Calcium 64-71 ORAI calcium release-activated calcium modulator 1 Homo sapiens 25-30 25226517-5 2014 Recently, Orai1, a pore subunit of a store-operated calcium channel that favors calcium influx, was shown to play a critical role to control proliferation and migration of basal keratinocytes. Calcium 52-59 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 24745010-8 2014 To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future. Calcium 37-44 ORAI calcium release-activated calcium modulator 1 Homo sapiens 62-67 24745010-8 2014 To have a better management of serum calcium, we suggest that ORAI1 polymorphisms might be used as a potential biomarker for initiating non-calcium-based phosphate binder in CKD patients in the future. Calcium 140-147 ORAI calcium release-activated calcium modulator 1 Homo sapiens 62-67 24277812-6 2013 Exploring underlying mechanisms, we show that the activation of Orai1-mediated calcium entry leads to enhancing focal adhesion turnover via a PKCbeta-Calpain-focal adhesion kinase pathway. Calcium 79-86 ORAI calcium release-activated calcium modulator 1 Homo sapiens 64-69 24359162-0 2013 Assessment of ORAI1-mediated basal calcium influx in mammary epithelial cells. Calcium 35-42 ORAI calcium release-activated calcium modulator 1 Homo sapiens 14-19 24376610-3 2013 To investigate the potential of inhibiting ion channel function with an antibody, we focused on Orai1, the pore subunit of the calcium channel responsible for store-operated calcium entry (SOCE) in T cells. Calcium 127-134 ORAI calcium release-activated calcium modulator 1 Homo sapiens 96-101 24094650-5 2013 We identify the ORAI1/NFAT calcium signaling pathway as an essential regulator of TSLP release from keratinocytes, the primary epithelial cells of the skin. Calcium 27-34 ORAI calcium release-activated calcium modulator 1 Homo sapiens 16-21 24331698-9 2013 Compared with the untreated control cells, the ethanol-treated cells showed significantly up-regulated mRNA and protein expression of both STIM1 and Orai1 at all times examined, suggesting that the ethanol-stimulated expression of STIM1 and Orai1 could persist for at least 72 h. The ethanol treatment induced increase in cytoplasmic calcium levels was significantly (and similarly) reduced by co-treatment with any of the three channel blockers. Calcium 334-341 ORAI calcium release-activated calcium modulator 1 Homo sapiens 149-154 24331698-9 2013 Compared with the untreated control cells, the ethanol-treated cells showed significantly up-regulated mRNA and protein expression of both STIM1 and Orai1 at all times examined, suggesting that the ethanol-stimulated expression of STIM1 and Orai1 could persist for at least 72 h. The ethanol treatment induced increase in cytoplasmic calcium levels was significantly (and similarly) reduced by co-treatment with any of the three channel blockers. Calcium 334-341 ORAI calcium release-activated calcium modulator 1 Homo sapiens 241-246 24331698-10 2013 CONCLUSION: Chronic ethanol exposure can increase the expression of STIM1 and Orai1 in primary liver cells, suggesting that ethanol may increase extracellular calcium influx by up-regulating expression of these SOCs protein molecules, ultimately aggravating liver cell damage. Calcium 159-166 ORAI calcium release-activated calcium modulator 1 Homo sapiens 78-83 23613525-1 2013 Ca(2+) release-activated Ca(2+) (CRAC) channels are activated through a mechanism wherein depletion of intracellular calcium stores results in the aggregation of stromal interaction molecule 1 (STIM1), the endoplasmic reticulum (ER) Ca(2+) sensor, and Orai1, the CRAC channel protein, at overlapping sites in the ER and plasma membranes (PMs). Calcium 117-124 ORAI calcium release-activated calcium modulator 1 Homo sapiens 252-257 23711249-0 2013 Native STIM2 and ORAI1 proteins form a calcium-sensitive and thapsigargin-insensitive complex in cortical neurons. Calcium 39-46 ORAI calcium release-activated calcium modulator 1 Homo sapiens 17-22 23711249-1 2013 In non-excitatory cells, stromal interaction molecule 1 (STIM1) and STIM2 mediate store-operated calcium entry via an interaction with ORAI1 calcium channels. Calcium 97-104 ORAI calcium release-activated calcium modulator 1 Homo sapiens 135-140 23711249-4 2013 Co-immunoprecipitation experiments revealed that the interaction between endogenous STIM2 and ORAI1 was greater in a low-calcium medium than in a high-calcium medium. Calcium 121-128 ORAI calcium release-activated calcium modulator 1 Homo sapiens 94-99 23711249-4 2013 Co-immunoprecipitation experiments revealed that the interaction between endogenous STIM2 and ORAI1 was greater in a low-calcium medium than in a high-calcium medium. Calcium 151-158 ORAI calcium release-activated calcium modulator 1 Homo sapiens 94-99 23711249-7 2013 However, the number of apparent STIM2-ORAI1 complexes increased when intracellular and subsequently ER calcium concentrations were decreased by BAPTA-AM or a low-calcium medium. Calcium 103-110 ORAI calcium release-activated calcium modulator 1 Homo sapiens 38-43 23711249-7 2013 However, the number of apparent STIM2-ORAI1 complexes increased when intracellular and subsequently ER calcium concentrations were decreased by BAPTA-AM or a low-calcium medium. Calcium 162-169 ORAI calcium release-activated calcium modulator 1 Homo sapiens 38-43 23711249-8 2013 Both Fura-2 acetoxymethyl ester calcium imaging and PLA in the same neuronal cell indicated that the calcium responses correlated strongly with the number of endogenous STIM2-ORAI1 complexes. Calcium 32-39 ORAI calcium release-activated calcium modulator 1 Homo sapiens 175-180 23711249-8 2013 Both Fura-2 acetoxymethyl ester calcium imaging and PLA in the same neuronal cell indicated that the calcium responses correlated strongly with the number of endogenous STIM2-ORAI1 complexes. Calcium 101-108 ORAI calcium release-activated calcium modulator 1 Homo sapiens 175-180 23711249-9 2013 The small drop in calcium levels in the ER caused by decreased intracellular calcium levels appeared to initiate the calcium-sensitive and thapsigargin-insensitive interaction between STIM2 and ORAI1. Calcium 18-25 ORAI calcium release-activated calcium modulator 1 Homo sapiens 194-199 23711249-9 2013 The small drop in calcium levels in the ER caused by decreased intracellular calcium levels appeared to initiate the calcium-sensitive and thapsigargin-insensitive interaction between STIM2 and ORAI1. Calcium 77-84 ORAI calcium release-activated calcium modulator 1 Homo sapiens 194-199 23711249-9 2013 The small drop in calcium levels in the ER caused by decreased intracellular calcium levels appeared to initiate the calcium-sensitive and thapsigargin-insensitive interaction between STIM2 and ORAI1. Calcium 77-84 ORAI calcium release-activated calcium modulator 1 Homo sapiens 194-199 23951072-8 2013 Thapsigargin followed by extracellular Ca2+ exposure induced Ca2+-influx in H295R, and the cells expressed mRNA/protein of the component molecules for store-operated calcium entry (SOCE): transient receptor C (TRPC) channels, calcium release-activated calcium channel protein 1 (Orai-1), and the stromal interaction molecule 1 (STIM1). Calcium 166-173 ORAI calcium release-activated calcium modulator 1 Homo sapiens 226-277 23951072-8 2013 Thapsigargin followed by extracellular Ca2+ exposure induced Ca2+-influx in H295R, and the cells expressed mRNA/protein of the component molecules for store-operated calcium entry (SOCE): transient receptor C (TRPC) channels, calcium release-activated calcium channel protein 1 (Orai-1), and the stromal interaction molecule 1 (STIM1). Calcium 166-173 ORAI calcium release-activated calcium modulator 1 Homo sapiens 279-285 23307288-0 2013 Ubiquilin 1 interacts with Orai1 to regulate calcium mobilization. Calcium 45-52 ORAI calcium release-activated calcium modulator 1 Homo sapiens 27-32 23890113-0 2013 Alternative forms of the store-operated calcium entry mediators, STIM1 and Orai1. Calcium 40-47 ORAI calcium release-activated calcium modulator 1 Homo sapiens 75-80 24351972-0 2013 STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Calcium 70-77 ORAI calcium release-activated calcium modulator 1 Homo sapiens 6-11 24351972-1 2013 Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). Calcium 6-13 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 24351972-1 2013 Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). Calcium 128-135 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 22547681-6 2012 The other subset of miR-519 target mRNAs encoded proteins that control intracellular calcium levels (notably, ATP2C1 and ORAI1); their downregulation by miR-519 aberrantly elevated levels of cytosolic [Ca(2+)] storage in HeLa cells, similarly increasing p21 levels in a manner dependent on the Ca(2+)-activated kinases CaMKII and GSK3beta. Calcium 85-92 ORAI calcium release-activated calcium modulator 1 Homo sapiens 121-126 23109337-1 2012 Orai1 is a plasma membrane protein that in its tetrameric form is responsible for calcium influx from the extracellular environment into the cytosol in response to interaction with the Ca(2+)-depletion sensor STIM1. Calcium 82-89 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 22938798-9 2012 All these results demonstrate an involvement in dystrophin-deficient myotubes of a specific calcium/PKC/PLC pathway in elevation of store-operated cation influx supported by the STIM1/Orai1/TRPC1 proteins, which is normally regulated by the alpha1-syntrophin/dystrophin scaffold. Calcium 92-99 ORAI calcium release-activated calcium modulator 1 Homo sapiens 184-189 22495877-0 2012 Human ether a-gogo K(+) channel 1 (hEag1) regulates MDA-MB-231 breast cancer cell migration through Orai1-dependent calcium entry. Calcium 117-124 ORAI calcium release-activated calcium modulator 1 Homo sapiens 101-106 23520759-4 2012 Sequentially, store-operated calcium channels (SOCC) are responsible for most of calcium influx from extracellular compartment, which is regulated by the cooperation of stromal interaction molecule 1 (STIM1), a Ca2+ sensor molecule in intracellular stores, and ORAI calcium release-activated calcium modulator 1 (Orail), a plasma membrane protein. Calcium 29-36 ORAI calcium release-activated calcium modulator 1 Homo sapiens 261-311 23785292-13 2013 In situ hybridization confirmed transcription of genes coding for the calcium sensor hippocalcin, the calcium transporter ORAI-1, and the calcium-binding protein calmodulin-4 in the reproductive system pointing to a role of calcium in parasite reproduction. Calcium 102-109 ORAI calcium release-activated calcium modulator 1 Homo sapiens 122-128 22506990-0 2012 Homers regulate calcium entry and aggregation in human platelets: a role for Homers in the association between STIM1 and Orai1. Calcium 16-23 ORAI calcium release-activated calcium modulator 1 Homo sapiens 121-126 21782006-0 2011 Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells. Calcium 96-103 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 22556336-1 2012 RATIONALE: Calcium entry through Orai1 channels drives vascular smooth muscle cell migration and neointimal hyperplasia. Calcium 11-18 ORAI calcium release-activated calcium modulator 1 Homo sapiens 33-38 22556336-9 2012 PDGF did not evoke redistribution, even though it caused calcium release and Orai1-mediated calcium entry in the same time period. Calcium 92-99 ORAI calcium release-activated calcium modulator 1 Homo sapiens 77-82 22556336-10 2012 After chemical blockade of Orai1-mediated calcium entry, however, PDGF caused redistribution. Calcium 42-49 ORAI calcium release-activated calcium modulator 1 Homo sapiens 27-32 22556336-11 2012 Similarly, mutagenic disruption of calcium flux through Orai1 caused PDGF to evoke redistribution, showing that calcium flux through the wild-type channels had been filling the stores. Calcium 35-42 ORAI calcium release-activated calcium modulator 1 Homo sapiens 56-61 22556336-11 2012 Similarly, mutagenic disruption of calcium flux through Orai1 caused PDGF to evoke redistribution, showing that calcium flux through the wild-type channels had been filling the stores. Calcium 112-119 ORAI calcium release-activated calcium modulator 1 Homo sapiens 56-61 22556336-12 2012 Acidification of the extracellular medium to pH 6.4 caused inhibition of Orai1-mediated calcium entry and conferred capability for PDGF to evoke complete redistribution and coclustering. Calcium 88-95 ORAI calcium release-activated calcium modulator 1 Homo sapiens 73-78 22364775-2 2012 When these luminal stores become depleted, the transmembrane ER protein Stim1 oligomerizes and translocates within the ER membrane to puncta junctions to couple with Orai1 channels, activating store-operated calcium entry (SOCE). Calcium 208-215 ORAI calcium release-activated calcium modulator 1 Homo sapiens 166-171 22144678-0 2012 Control of type I interferon-induced cell death by Orai1-mediated calcium entry in T cells. Calcium 66-73 ORAI calcium release-activated calcium modulator 1 Homo sapiens 51-56 22534489-0 2012 Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel. Calcium 17-24 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 22534489-1 2012 RATIONALE: Canonical transient receptor potential 4 (TRPC4) contributes to the molecular composition of a channel encoding for a calcium selective store-operated current, I(SOC), whereas Orai1 critically comprises a channel encoding for the highly selective calcium release activated calcium current, I(CRAC). Calcium 258-265 ORAI calcium release-activated calcium modulator 1 Homo sapiens 187-192 22534489-4 2012 OBJECTIVE: We tested the hypothesis that Orai1 interacts with TRPC4 and contributes to the channel"s selective calcium permeation important for endothelial barrier function. Calcium 111-118 ORAI calcium release-activated calcium modulator 1 Homo sapiens 41-46 22534489-10 2012 Conditional Orai1 knockdown reduced the probability for TRPC1/4 channel activation and converted it from a calcium-selective to a nonselective channel, an effect that was rescued on Orai1 reexpression. Calcium 107-114 ORAI calcium release-activated calcium modulator 1 Homo sapiens 12-17 22534489-12 2012 CONCLUSION: Orai1 interacts with TRPC4 in the endogenous channel complex, where it controls TRPC1/4 activation and channel permeation characteristics, including calcium selectivity, important for control of endothelial cell barrier function. Calcium 161-168 ORAI calcium release-activated calcium modulator 1 Homo sapiens 12-17 22451904-2 2012 Upon store depletion, the calcium sensor in the endoplasmic reticulum, STIM1, activates Orai1, a CRAC channel in the plasma membrane. Calcium 26-33 ORAI calcium release-activated calcium modulator 1 Homo sapiens 88-93 22031864-0 2012 The serum- and glucocorticoid-inducible kinase 1 (SGK1) influences platelet calcium signaling and function by regulation of Orai1 expression in megakaryocytes. Calcium 76-83 ORAI calcium release-activated calcium modulator 1 Homo sapiens 124-129 21782006-0 2011 Orai1/CRACM1 overexpression suppresses cell proliferation via attenuation of the store-operated calcium influx-mediated signalling pathway in A549 lung cancer cells. Calcium 96-103 ORAI calcium release-activated calcium modulator 1 Homo sapiens 6-12 21782006-12 2011 Importantly, Orai1/CRACM1 overexpression significantly attenuated EGF-mediated store-operated calcium influx. Calcium 94-101 ORAI calcium release-activated calcium modulator 1 Homo sapiens 13-18 21782006-12 2011 Importantly, Orai1/CRACM1 overexpression significantly attenuated EGF-mediated store-operated calcium influx. Calcium 94-101 ORAI calcium release-activated calcium modulator 1 Homo sapiens 19-25 21545575-6 2011 KEY RESULTS: Molecular disruption and rescue experiments indicated the importance of Orai1 in calcium entry caused by store depletion evoked passively or by platelet-derived growth factor (PDGF), suggesting the presence of Ca(2+) release-activated Ca(2+) (CRAC) channels like those of the immune system. Calcium 94-101 ORAI calcium release-activated calcium modulator 1 Homo sapiens 85-90 21945734-0 2011 Calcium entry via ORAI1 regulates glioblastoma cell proliferation and apoptosis. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 18-23 21945734-13 2011 CONCLUSION: Calcium entry via ORAI1 and CRAC channels are important for GBM proliferation and survival. Calcium 12-19 ORAI calcium release-activated calcium modulator 1 Homo sapiens 30-35 22084111-3 2011 An ER calcium sensor, stromal interaction molecule 1 (STIM1), translocates within the ER membrane upon store depletion to the juxtaplasma membrane domain, where it interacts with intracellular domains of a highly calcium-selective plasma membrane ion channel, Orai1. Calcium 6-13 ORAI calcium release-activated calcium modulator 1 Homo sapiens 260-265 22084111-4 2011 STIM1 gates Orai1, allowing calcium to enter the cytoplasm, where it repletes the ER store via calcium-ATPases pumps. Calcium 28-35 ORAI calcium release-activated calcium modulator 1 Homo sapiens 12-17 21545575-10 2011 CONCLUSIONS AND IMPLICATIONS: The data suggest that Orai1 has a role in human VSMC migration, and that a CRAC channel inhibitor has high potency and selectivity for the associated calcium entry, suggesting a distinct characteristic of vascular CRAC channels and the potential for selective chemical suppression of vascular remodelling. Calcium 180-187 ORAI calcium release-activated calcium modulator 1 Homo sapiens 52-57 21873556-4 2011 This study examined the novel hypothesis that store-operated calcium entry (SOCE) through Orai1 is abnormal in CF. Calcium 61-68 ORAI calcium release-activated calcium modulator 1 Homo sapiens 90-95 21441136-4 2011 METHODS AND RESULTS: In human umbilical vein endothelial cells, Orai1 disruption by short-interfering RNA or dominant-negative mutant Orai1 inhibited calcium release-activated (store-operated) calcium entry, VEGF-evoked calcium entry, cell migration, and in vitro tube formation. Calcium 193-200 ORAI calcium release-activated calcium modulator 1 Homo sapiens 64-69 21880262-4 2011 Physiopathological roles of STIM1 and ORAI1 were first described in the immunological system but, as main actors at the central node in the calcium signalling network, there are now clear evidences that mutations in genes coding STIM1 or ORAI1 interfere with several other diseases. Calcium 140-147 ORAI calcium release-activated calcium modulator 1 Homo sapiens 238-243 21441136-4 2011 METHODS AND RESULTS: In human umbilical vein endothelial cells, Orai1 disruption by short-interfering RNA or dominant-negative mutant Orai1 inhibited calcium release-activated (store-operated) calcium entry, VEGF-evoked calcium entry, cell migration, and in vitro tube formation. Calcium 150-157 ORAI calcium release-activated calcium modulator 1 Homo sapiens 64-69 21880262-2 2011 Since then, STIM1 and ORAI1 have developed an ever increasing social network and to date are now linked to nine families of proteins involved in calcium signalling. Calcium 145-152 ORAI calcium release-activated calcium modulator 1 Homo sapiens 22-27 21880262-3 2011 As a result of this, STIM1 and ORAI1 are now involved in three separate calcium entry pathways, Icrac, Iarc (arachidonic regulated calcium current) and voltage-dependent channels. Calcium 72-79 ORAI calcium release-activated calcium modulator 1 Homo sapiens 31-36 21880262-4 2011 Physiopathological roles of STIM1 and ORAI1 were first described in the immunological system but, as main actors at the central node in the calcium signalling network, there are now clear evidences that mutations in genes coding STIM1 or ORAI1 interfere with several other diseases. Calcium 140-147 ORAI calcium release-activated calcium modulator 1 Homo sapiens 38-43 21441136-4 2011 METHODS AND RESULTS: In human umbilical vein endothelial cells, Orai1 disruption by short-interfering RNA or dominant-negative mutant Orai1 inhibited calcium release-activated (store-operated) calcium entry, VEGF-evoked calcium entry, cell migration, and in vitro tube formation. Calcium 150-157 ORAI calcium release-activated calcium modulator 1 Homo sapiens 134-139 21441136-4 2011 METHODS AND RESULTS: In human umbilical vein endothelial cells, Orai1 disruption by short-interfering RNA or dominant-negative mutant Orai1 inhibited calcium release-activated (store-operated) calcium entry, VEGF-evoked calcium entry, cell migration, and in vitro tube formation. Calcium 193-200 ORAI calcium release-activated calcium modulator 1 Homo sapiens 64-69 21441136-4 2011 METHODS AND RESULTS: In human umbilical vein endothelial cells, Orai1 disruption by short-interfering RNA or dominant-negative mutant Orai1 inhibited calcium release-activated (store-operated) calcium entry, VEGF-evoked calcium entry, cell migration, and in vitro tube formation. Calcium 193-200 ORAI calcium release-activated calcium modulator 1 Homo sapiens 134-139 21441136-4 2011 METHODS AND RESULTS: In human umbilical vein endothelial cells, Orai1 disruption by short-interfering RNA or dominant-negative mutant Orai1 inhibited calcium release-activated (store-operated) calcium entry, VEGF-evoked calcium entry, cell migration, and in vitro tube formation. Calcium 193-200 ORAI calcium release-activated calcium modulator 1 Homo sapiens 134-139 21441136-7 2011 Orai1 disruption also inhibited calcium entry and tube formation in endothelial progenitor cells from human blood. Calcium 32-39 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 21441136-12 2011 CONCLUSIONS: The data suggest positive roles for Orai1 and CRAC channels in VEGF-evoked calcium entry and new opportunity for chemical modulation of angiogenesis. Calcium 88-95 ORAI calcium release-activated calcium modulator 1 Homo sapiens 49-54 21383014-1 2011 Calcium (Ca(2+)) influx through the plasma membrane store-operated Ca(2+) channel ORAI1 is controlled by Ca(2+) sensors of the stromal interaction molecule (STIM) family. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 82-87 21420116-0 2011 A polymorphism of the ORAI1 gene is associated with the risk and recurrence of calcium nephrolithiasis. Calcium 79-86 ORAI calcium release-activated calcium modulator 1 Homo sapiens 22-27 21176846-5 2011 The importance of store-operated calcium influx in muscle is confirmed in mice lacking STIM1 which die perinatally and in patients with mutations on STIM1 or Orai1 who exhibit a myopathy exhibited by hypotonia. Calcium 33-40 ORAI calcium release-activated calcium modulator 1 Homo sapiens 158-163 21420116-3 2011 We investigated the association between calcium containing nephrolithiasis and genetic variants of ORAI1 gene in Taiwanese patients. Calcium 40-47 ORAI calcium release-activated calcium modulator 1 Homo sapiens 99-104 21420116-12 2011 CONCLUSIONS: To our knowledge this is the first study identifying the novel polymorphisms of the ORAI1 gene, which may predispose to the risk of calcium nephrolithiasis and disease recurrence. Calcium 145-152 ORAI calcium release-activated calcium modulator 1 Homo sapiens 97-102 21224390-0 2011 ORAI1-mediated calcium influx in lactation and in breast cancer. Calcium 15-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 21224390-3 2011 We show that the store-operated calcium influx protein, Orai1, is increased during lactation whereas the Orai1 activator Stim1, but not Stim2, is downregulated. Calcium 32-39 ORAI calcium release-activated calcium modulator 1 Homo sapiens 56-61 21224390-5 2011 Our results suggest that calcium influx is remodeled in mammary epithelial cells during lactation, with calcium influx increased through Orai1, activated by Stim2. Calcium 25-32 ORAI calcium release-activated calcium modulator 1 Homo sapiens 137-142 21224390-5 2011 Our results suggest that calcium influx is remodeled in mammary epithelial cells during lactation, with calcium influx increased through Orai1, activated by Stim2. Calcium 104-111 ORAI calcium release-activated calcium modulator 1 Homo sapiens 137-142 21224390-7 2011 ORAI1 siRNA in breast cancer cells reduced store-operated calcium entry and remodeled the calcium influx associated with invasive stimuli. Calcium 58-65 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 21224390-7 2011 ORAI1 siRNA in breast cancer cells reduced store-operated calcium entry and remodeled the calcium influx associated with invasive stimuli. Calcium 90-97 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 20729487-3 2010 STIM1 and STIM2 function as calcium sensors in the endoplasmic reticulum and can interact with and activate plasma membrane channels comprised of Orai1, Orai2, or Orai3 subunits. Calcium 28-35 ORAI calcium release-activated calcium modulator 1 Homo sapiens 146-151 21300876-0 2011 ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis. Calcium 15-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 21300876-2 2011 Here, we have studied the role of the calcium release-activated calcium channel ORAI1 in human lymphocyte cytotoxicity. Calcium 38-45 ORAI calcium release-activated calcium modulator 1 Homo sapiens 80-85 21081754-1 2010 Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca(2+)) entry through plasma membrane Orai1 channels in response to decreased Ca(2+) concentrations in the endoplasmic reticulum lumen. Calcium 50-57 ORAI calcium release-activated calcium modulator 1 Homo sapiens 101-106 21713652-3 2011 Depletion of these stores activates influx of extracellular Ca(2+), usually referred to as store-operated calcium entry (SOCE), through the interaction of the Ca(2+)-sensor, stromal interacting molecule-1 (STIM1 ), in ER with Orai1(CRACM1) and transient receptor potential canonical (TRPC) channel proteins in the plasma membrane (PM). Calcium 106-113 ORAI calcium release-activated calcium modulator 1 Homo sapiens 226-231 21713652-3 2011 Depletion of these stores activates influx of extracellular Ca(2+), usually referred to as store-operated calcium entry (SOCE), through the interaction of the Ca(2+)-sensor, stromal interacting molecule-1 (STIM1 ), in ER with Orai1(CRACM1) and transient receptor potential canonical (TRPC) channel proteins in the plasma membrane (PM). Calcium 106-113 ORAI calcium release-activated calcium modulator 1 Homo sapiens 232-238 20961852-2 2010 The best studied store-operated calcium current is the calcium release-activated calcium (CRAC) current in T-cells and mast cells, with Orai1 representing the essential pore forming subunit. Calcium 32-39 ORAI calcium release-activated calcium modulator 1 Homo sapiens 136-141 20961852-2 2010 The best studied store-operated calcium current is the calcium release-activated calcium (CRAC) current in T-cells and mast cells, with Orai1 representing the essential pore forming subunit. Calcium 55-62 ORAI calcium release-activated calcium modulator 1 Homo sapiens 136-141 20961852-2 2010 The best studied store-operated calcium current is the calcium release-activated calcium (CRAC) current in T-cells and mast cells, with Orai1 representing the essential pore forming subunit. Calcium 55-62 ORAI calcium release-activated calcium modulator 1 Homo sapiens 136-141 20546784-2 2010 Calcium enters via ORAI1 as a mechanism to refill the sarcoplasmic/endoplasmic reticulum calcium stores, the depletion of which can be detected by the sensor protein STIM1. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 19-24 20546784-2 2010 Calcium enters via ORAI1 as a mechanism to refill the sarcoplasmic/endoplasmic reticulum calcium stores, the depletion of which can be detected by the sensor protein STIM1. Calcium 89-96 ORAI calcium release-activated calcium modulator 1 Homo sapiens 19-24 20172609-1 2010 Orai1, together with STIM1 and STIM2, constitutes the molecular basis for store-operated calcium entry (SOCE) and we have investigated their role in cell proliferation and cell cycle progression in HEK293 cells. Calcium 89-96 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 20103768-7 2010 The reduced ability to mobilize calcium was associated with reduced expression of ORAI1, the CRAC channel subunit. Calcium 32-39 ORAI calcium release-activated calcium modulator 1 Homo sapiens 82-87 20347143-1 2010 STIM1 and Orai1 are the main players in capacitative calcium entry (CCE). Calcium 53-60 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 20172609-8 2010 These observations reveal a tight relation between cell proliferation, calcium entry and Orai1 expression in HEK293 cells. Calcium 71-78 ORAI calcium release-activated calcium modulator 1 Homo sapiens 89-94 19965684-0 2010 Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow. Calcium 30-37 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 19965684-1 2010 Orai1 was reported to function as a calcium channel subunit that facilitates store operated calcium entry (SOCE) in T cells and is necessary for formation of the immune synapse. Calcium 36-43 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 19965684-3 2010 Orai1 function was assessed by real-time imaging of calcium transients as PMNs were stimulated to roll, arrest, and migrate on E-selectin and ICAM-1 in shear flow. Calcium 52-59 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 19965684-7 2010 These results suggest that calcium entry via Orai1 is the predominant SOCE that cooperates with cytoplasmic calcium store release in coordinating integrin-dependent PMN arrest and migration in the acute response to inflammation. Calcium 27-34 ORAI calcium release-activated calcium modulator 1 Homo sapiens 45-50 19483082-0 2009 Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. Calcium 35-42 ORAI calcium release-activated calcium modulator 1 Homo sapiens 20-25 19483082-1 2009 Recent studies identified two main components of store-operated calcium entry (SOCE): the endoplasmic reticulum-localized Ca2+ sensor protein, STIM1, and the plasma membrane (PM)-localized Ca2+ channel, Orai1/CRACM1. Calcium 64-71 ORAI calcium release-activated calcium modulator 1 Homo sapiens 203-208 19483082-1 2009 Recent studies identified two main components of store-operated calcium entry (SOCE): the endoplasmic reticulum-localized Ca2+ sensor protein, STIM1, and the plasma membrane (PM)-localized Ca2+ channel, Orai1/CRACM1. Calcium 64-71 ORAI calcium release-activated calcium modulator 1 Homo sapiens 209-215 19754895-1 2009 In the last few years, great progress has been made in understanding how stromal interacting molecule 1 (STIM1), a protein containing a calcium sensor that is located in the endoplasmic reticulum, and Orai1, a protein that forms a calcium channel in the plasma membrane, interact and give rise to store-operated calcium entry. Calcium 231-238 ORAI calcium release-activated calcium modulator 1 Homo sapiens 201-206 19088073-0 2009 STIM1- and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation. Calcium 42-49 ORAI calcium release-activated calcium modulator 1 Homo sapiens 11-16 19630797-4 2009 Furthermore, we summarize work that lead to the discovery of STIM1 and Orai1 as key regulators of store-operated calcium entry (SOCE) in platelets. Calcium 113-120 ORAI calcium release-activated calcium modulator 1 Homo sapiens 71-76 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 79-86 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 19088738-5 2009 The identification of two important molecular components of SOC channels, CRACM1 (the pore-forming subunit) and STIM1 (the sensor of stored calcium), has allowed genetic and molecular manipulation of the SOC entry pathway. Calcium 140-147 ORAI calcium release-activated calcium modulator 1 Homo sapiens 74-80 18326500-1 2008 Orai1 and TRPC1 have been proposed as core components of store-operated calcium release-activated calcium (CRAC) and store-operated calcium (SOC) channels, respectively. Calcium 72-79 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 79-86 ORAI calcium release-activated calcium modulator 1 Homo sapiens 29-35 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 79-86 ORAI calcium release-activated calcium modulator 1 Homo sapiens 230-235 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 105-112 ORAI calcium release-activated calcium modulator 1 Homo sapiens 10-15 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 105-112 ORAI calcium release-activated calcium modulator 1 Homo sapiens 29-35 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 105-112 ORAI calcium release-activated calcium modulator 1 Homo sapiens 230-235 17293345-8 2007 Together, these data establish Orai1 as a predominant mediator of store-operated calcium entry, proliferation, and cytokine production in T cells. Calcium 81-88 ORAI calcium release-activated calcium modulator 1 Homo sapiens 31-36 18059270-8 2008 In agreement with those findings, the store-operated calcium influx and development and proliferation of CRACM1-deficient T cells was unaffected. Calcium 53-60 ORAI calcium release-activated calcium modulator 1 Homo sapiens 105-111 17452328-0 2007 Calcium inhibition and calcium potentiation of Orai1, Orai2, and Orai3 calcium release-activated calcium channels. Calcium 23-30 ORAI calcium release-activated calcium modulator 1 Homo sapiens 47-52 17218358-0 2007 Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. Calcium 112-119 ORAI calcium release-activated calcium modulator 1 Homo sapiens 60-65 17343823-2 2007 Recently, human Orai1 (the channel-forming subunit) and STIM1 (the calcium sensor) were identified as essential molecules for SOCE. Calcium 67-74 ORAI calcium release-activated calcium modulator 1 Homo sapiens 16-21 17224452-0 2007 Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Calcium 84-91 ORAI calcium release-activated calcium modulator 1 Homo sapiens 32-37 16807233-0 2006 Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. Calcium 21-28 ORAI calcium release-activated calcium modulator 1 Homo sapiens 72-77 17360584-5 2007 Thus, Orai-1, -2, and -3 enhanced thapsigargin-induced calcium entry by 50-150% in cells stably overexpressing either TRPC3 or TRPC6. Calcium 55-62 ORAI calcium release-activated calcium modulator 1 Homo sapiens 6-24 16807233-0 2006 Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. Calcium 110-117 ORAI calcium release-activated calcium modulator 1 Homo sapiens 72-77 34800360-3 2021 We show that RHBDL2 prevents stochastic calcium signaling in unstimulated cells through conformational surveillance and cleavage of inappropriately activated Orai1. Calcium 40-47 ORAI calcium release-activated calcium modulator 1 Homo sapiens 158-163 33798603-2 2021 Many of these processes are known to be regulated by Store-Operated Calcium channels (SOCs), mong which ORAI1 is the most studied in cancer cells, leaving the role of other ORAI channels yet inadequately addressed. Calcium 68-75 ORAI calcium release-activated calcium modulator 1 Homo sapiens 104-109 34800360-1 2021 Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell-mediated immunity. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 122-127 16733527-2 2006 STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for controlling the store-operated CRAC current (I(CRAC)). Calcium 20-27 ORAI calcium release-activated calcium modulator 1 Homo sapiens 146-151 16733527-2 2006 STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for controlling the store-operated CRAC current (I(CRAC)). Calcium 73-80 ORAI calcium release-activated calcium modulator 1 Homo sapiens 124-130 16733527-2 2006 STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for controlling the store-operated CRAC current (I(CRAC)). Calcium 73-80 ORAI calcium release-activated calcium modulator 1 Homo sapiens 146-151 16733527-2 2006 STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for controlling the store-operated CRAC current (I(CRAC)). Calcium 73-80 ORAI calcium release-activated calcium modulator 1 Homo sapiens 124-130 16733527-2 2006 STIM1, the putative calcium sensor in the endoplasmic reticulum, and the calcium release-activated calcium (CRAC) modulator CRACM1 (also known as Orai1) in the plasma membrane have recently been shown to be essential for controlling the store-operated CRAC current (I(CRAC)). Calcium 73-80 ORAI calcium release-activated calcium modulator 1 Homo sapiens 146-151 34800360-1 2021 Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell-mediated immunity. Calcium 39-46 ORAI calcium release-activated calcium modulator 1 Homo sapiens 122-127 34800360-1 2021 Calcium influx through plasma membrane calcium release-activated calcium (CRAC) channels, which are formed of hexamers of Orai1, is a potent trigger for many important biological processes, most notably in T cell-mediated immunity. Calcium 65-72 ORAI calcium release-activated calcium modulator 1 Homo sapiens 122-127 34800360-4 2021 A conserved disease-linked proline residue is responsible for RHBDL2"s recognizing the active conformation of Orai1, which is required to sharpen switch-like signaling triggered by store-operated calcium entry. Calcium 196-203 ORAI calcium release-activated calcium modulator 1 Homo sapiens 110-115 34685684-0 2021 Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association. Calcium 24-31 ORAI calcium release-activated calcium modulator 1 Homo sapiens 68-73 34601312-1 2021 Store-operated calcium entry (SOCE) is triggered by assembly of Orai1 with STIM proteins in ER-PM junctions. Calcium 15-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 64-69 34685684-3 2021 Here, using biophysical, biochemical, pharmaceutical, and genetic approaches, we show that apoptotic cells induced the Orai1-STIM1 interaction, leading to store-operated calcium entry (SOCE) in phagocytes through the Mertk-phospholipase C (PLC) gamma1-inositol 1,4,5-triphosphate receptor (IP3R) axis. Calcium 170-177 ORAI calcium release-activated calcium modulator 1 Homo sapiens 119-124 34685684-4 2021 Apoptotic cells induced calcium release from the endoplasmic reticulum, which led to the Orai1-STIM1 association and, consequently, SOCE in phagocytes. Calcium 24-31 ORAI calcium release-activated calcium modulator 1 Homo sapiens 89-94 34639190-1 2021 Calcium signaling plays a vital role in the regulation of various cellular processes, including activation, proliferation, and differentiation of T-lymphocytes, which is mediated by ORAI1 and potassium (K+) channels. Calcium 0-7 ORAI calcium release-activated calcium modulator 1 Homo sapiens 182-187 35151050-1 2022 Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai (Orai1, Orai2, Orai3) Ca2+ channels. Calcium 15-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 167-171 34498097-1 2021 The calcium release-activated calcium (CRAC) channel consists of STIM1, a Ca2+ sensor in the endoplasmic reticulum (ER), and Orai1, the Ca2+ ion channel in the plasma membrane. Calcium 4-11 ORAI calcium release-activated calcium modulator 1 Homo sapiens 125-130 34498097-1 2021 The calcium release-activated calcium (CRAC) channel consists of STIM1, a Ca2+ sensor in the endoplasmic reticulum (ER), and Orai1, the Ca2+ ion channel in the plasma membrane. Calcium 30-37 ORAI calcium release-activated calcium modulator 1 Homo sapiens 125-130 34155535-1 2021 Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. Calcium 53-60 ORAI calcium release-activated calcium modulator 1 Homo sapiens 47-52 34155535-1 2021 Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. Calcium 92-99 ORAI calcium release-activated calcium modulator 1 Homo sapiens 47-52 35628366-6 2022 With this study, we show the involvement of the ORAI1 calcium channel in store-operated calcium entry (SOCE), the main calcium entry pathway in non-excitable cells, in two representative human AML cell lines (KG1 and U937) and in primary cells isolated from patients. Calcium 54-61 ORAI calcium release-activated calcium modulator 1 Homo sapiens 48-53 35628366-6 2022 With this study, we show the involvement of the ORAI1 calcium channel in store-operated calcium entry (SOCE), the main calcium entry pathway in non-excitable cells, in two representative human AML cell lines (KG1 and U937) and in primary cells isolated from patients. Calcium 88-95 ORAI calcium release-activated calcium modulator 1 Homo sapiens 48-53 35151050-1 2022 Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai (Orai1, Orai2, Orai3) Ca2+ channels. Calcium 15-22 ORAI calcium release-activated calcium modulator 1 Homo sapiens 173-178 35151051-1 2022 Loss of function mutations in one of the core components of the calcium release-activated calcium (CRAC) channel complex, STIM1 and ORAI1, lead to severe immunodeficiency. Calcium 64-71 ORAI calcium release-activated calcium modulator 1 Homo sapiens 132-137 35151051-1 2022 Loss of function mutations in one of the core components of the calcium release-activated calcium (CRAC) channel complex, STIM1 and ORAI1, lead to severe immunodeficiency. Calcium 90-97 ORAI calcium release-activated calcium modulator 1 Homo sapiens 132-137 35076181-1 2022 Deregulated store-operated calcium entry (SOCE) mediated by aberrant STIM1-ORAI1 signaling is closely implicated in cancer initiation and progression. Calcium 27-34 ORAI calcium release-activated calcium modulator 1 Homo sapiens 75-80 35254656-3 2022 Orai1 is a major calcium channel in the cell membrane of non-excitable cells, and its activity depends on the stromal interaction molecule 1 (Stim1). Calcium 17-24 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 35369318-0 2022 Parathyroid Hormone Promotes Human Umbilical Vein Endothelial Cell Migration and Proliferation Through Orai1-Mediated Calcium Signaling. Calcium 118-125 ORAI calcium release-activated calcium modulator 1 Homo sapiens 103-108 35571434-12 2022 The abnormal polarization of the neutrophils from the COPD patients was altered by the influence of store-operated calcium entry (SOCE) component matrix interaction molecules 1 and 2 and calcium release-activated calcium channel protein 1 (stromal interaction molecule 1 (STIM1), Stromal interaction molecule 2 (STIM2), and calcium release-activated calcium modulator 1 (ORAI1)). Calcium 115-122 ORAI calcium release-activated calcium modulator 1 Homo sapiens 324-369 35571434-12 2022 The abnormal polarization of the neutrophils from the COPD patients was altered by the influence of store-operated calcium entry (SOCE) component matrix interaction molecules 1 and 2 and calcium release-activated calcium channel protein 1 (stromal interaction molecule 1 (STIM1), Stromal interaction molecule 2 (STIM2), and calcium release-activated calcium modulator 1 (ORAI1)). Calcium 115-122 ORAI calcium release-activated calcium modulator 1 Homo sapiens 371-376 35392575-2 2022 We further confirmed that melatonin promotes an increase in intracellular calcium concentrations through the STIM1/ORAI1 pathway, thereby inducing the proliferation of osteoblasts. Calcium 74-81 ORAI calcium release-activated calcium modulator 1 Homo sapiens 115-120 35392575-12 2022 Melatonin promotes an increase in intracellular calcium ion concentrations through the STIM1/ORAI1 pathway to induce osteoblast proliferation. Calcium 48-55 ORAI calcium release-activated calcium modulator 1 Homo sapiens 93-98 35113933-1 2022 The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Calcium 4-11 ORAI calcium release-activated calcium modulator 1 Homo sapiens 24-29 35113933-1 2022 The calcium ion channel ORAI1 has emerged as a promising therapeutic target for the Coronavirus Disease 19 (COVID-19)-associated pneumonia, and a pharmacological inhibitor of ORAI1 has now reached clinical trials for severe COVID-19 pneumonia. Calcium 4-11 ORAI calcium release-activated calcium modulator 1 Homo sapiens 175-180 34939697-0 2022 ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway. Calcium 41-48 ORAI calcium release-activated calcium modulator 1 Homo sapiens 0-5 35636153-1 2022 Gain-of-function mutations on STIM1 and ORAI1 genes are responsible for an increased store-operated calcium entry, and underlie the characteristic symptoms of three overlapping ultra-rare genetic disorders (i.e tubular aggregate myopathy, Stormorken syndrome, York platelet syndrome) that can be grouped as tubular aggregate myopathies. Calcium 100-107 ORAI calcium release-activated calcium modulator 1 Homo sapiens 40-45