PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29698850-1 2018 Stromal interaction molecule (STIM)-1 and -2 are multi-domain, single-pass transmembrane proteins involved in sensing changes in compartmentalized calcium (Ca2+) levels and transducing this cellular signal to Orai1 channel proteins. Calcium 147-154 stromal interaction molecule 1 Homo sapiens 0-44 29954946-0 2018 Pore properties of Orai1 calcium channel dimers and their activation by the STIM1 ER calcium sensor. Calcium 25-32 stromal interaction molecule 1 Homo sapiens 76-81 30159190-1 2018 York Platelet Syndrome (YPS) is a calcium channelopathy caused by gain of function in STIM1, a gene which acts as a calcium sensor. Calcium 34-41 stromal interaction molecule 1 Homo sapiens 86-91 29709426-2 2018 Recent study indicated that stromal interaction molecule 1 (STIM1) is the endoplasmic reticulum calcium sensor. Calcium 96-103 stromal interaction molecule 1 Homo sapiens 28-58 29709426-2 2018 Recent study indicated that stromal interaction molecule 1 (STIM1) is the endoplasmic reticulum calcium sensor. Calcium 96-103 stromal interaction molecule 1 Homo sapiens 60-65 29709426-5 2018 Our data demonstrated that PQ (500 muM, 24 h) induced intracellular ROS production and enhanced store-operated calcium entry (SOCE) activity which is correlated to STIM1 activation. Calcium 111-118 stromal interaction molecule 1 Homo sapiens 164-169 29780159-2 2018 Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE). Calcium 13-20 stromal interaction molecule 1 Homo sapiens 228-233 29978901-4 2018 STIM1 is an ER-resident, a single-pass transmembrane protein that serves as a calcium sensor within the ER lumen and a potent activator of ORAI1 calcium channels. Calcium 78-85 stromal interaction molecule 1 Homo sapiens 0-5 29780159-2 2018 Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE). Calcium 287-294 stromal interaction molecule 1 Homo sapiens 196-226 29780159-2 2018 Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE). Calcium 13-20 stromal interaction molecule 1 Homo sapiens 196-226 30421677-1 2018 BACKGROUND: Store-operated calcium entry (SOCE), primarily mediated by Orai1 and stromal interaction molecule 1 (STIM1), is a major Ca2+ influx pathway that has been linked to human diseases including myopathy, epilepsy, immunodeficiency, and cancer. Calcium 27-34 stromal interaction molecule 1 Homo sapiens 81-111 29920471-5 2018 The STIM1/Orai1-mediated SOC entry is the main cause of a sustained intracellular calcium ([Ca2+]i) elevation, which is different from a transient rise of [Ca2+]i mediated by IP3R and RyR. Calcium 82-89 stromal interaction molecule 1 Homo sapiens 4-9 30114708-0 2018 Orai1 and Stim1 Mediate the Majority of Store-Operated Calcium Entry in Multiple Myeloma and Have Strong Implications for Adverse Prognosis. Calcium 55-62 stromal interaction molecule 1 Homo sapiens 10-15 29780159-2 2018 Depletion of calcium in the lumen of the endoplasmic reticulum using inositol triphosphate (IP3) or thapsigargin (TG) is known to induce oligomerization and cytoskeleton-mediated translocation of stromal interaction molecule 1 (STIM1) to the plasma membrane, where it interacts with the calcium release-activated calcium channel Orai1 to mediate calcium influx; this process is referred to as store-operated calcium entry (SOCE). Calcium 287-294 stromal interaction molecule 1 Homo sapiens 196-226 29780159-9 2018 Downregulation of PAK1 activity via chemical inhibitors or by PAK1 shDNA expression impaired STIM1-mediated calcium mobilization via SOCE. Calcium 108-115 stromal interaction molecule 1 Homo sapiens 93-98 29780159-10 2018 Based on these findings, we propose that PAK1 interacts with STIM1 to regulate calcium mobilization and the formation of cellular adhesions. Calcium 79-86 stromal interaction molecule 1 Homo sapiens 61-66 29604963-0 2018 STIM1 and TRPV4 regulate fluid flow-induced calcium oscillation at early and late stages of osteoclast differentiation. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 0-5 29054597-0 2018 STIM1, but not STIM2, Is the Calcium Sensor Critical for Sweat Secretion. Calcium 29-36 stromal interaction molecule 1 Homo sapiens 0-5 29463029-5 2018 HEK293 cells that stably express human STIM1 and Orai1, components of the store-operated calcium entry (SOCE) machinery, gave a much higher RLA by stimulation with thapsigargin, an inhibitor of sarcoplasmic/endoplamic reticulum Ca2+-ATPase (SERCA). Calcium 89-96 stromal interaction molecule 1 Homo sapiens 39-44 29284605-3 2018 On store depletion, the endoplasmic reticulum calcium sensor STIM1 (stromal interaction molecule 1) redistributes into puncta at endoplasmic reticulum/plasma membrane junctions, a process supported by the cytoskeleton, where it interacts with the calcium channels; however, the mechanism for fine-tuning SOCE is not completely understood. Calcium 46-53 stromal interaction molecule 1 Homo sapiens 61-66 29284605-3 2018 On store depletion, the endoplasmic reticulum calcium sensor STIM1 (stromal interaction molecule 1) redistributes into puncta at endoplasmic reticulum/plasma membrane junctions, a process supported by the cytoskeleton, where it interacts with the calcium channels; however, the mechanism for fine-tuning SOCE is not completely understood. Calcium 46-53 stromal interaction molecule 1 Homo sapiens 68-98 29284605-4 2018 Our results demonstrate that STIM1 interacts with FLNA on calcium store depletion in human platelets. Calcium 58-65 stromal interaction molecule 1 Homo sapiens 29-34 30421677-1 2018 BACKGROUND: Store-operated calcium entry (SOCE), primarily mediated by Orai1 and stromal interaction molecule 1 (STIM1), is a major Ca2+ influx pathway that has been linked to human diseases including myopathy, epilepsy, immunodeficiency, and cancer. Calcium 27-34 stromal interaction molecule 1 Homo sapiens 113-118 28145580-8 2017 Orai1 and Stim1, two N-glycosylated proteins, are involved in Store-Operated Calcium Entry (SOCE), and are essential for breast tumor cell migration. Calcium 77-84 stromal interaction molecule 1 Homo sapiens 10-15 29438745-10 2018 Using our developed assay we identified the calcium homeostasis regulating proteins TPRV6, STIM1 and TRPC1 as modulators of pAKT levels in HCC-1569 cells. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 91-96 28919480-2 2017 Two main proteins sustain SOCE: STIM1 that acts as the calcium sensor in the endoplasmic reticulum (ER) and Orai1 responsible for calcium influx upon depletion of ER. Calcium 55-62 stromal interaction molecule 1 Homo sapiens 32-37 28919480-2 2017 Two main proteins sustain SOCE: STIM1 that acts as the calcium sensor in the endoplasmic reticulum (ER) and Orai1 responsible for calcium influx upon depletion of ER. Calcium 130-137 stromal interaction molecule 1 Homo sapiens 32-37 28105751-3 2017 Ang-II elevates intracellular Ca2+ through activation of the store-operated calcium entry (SOCE) involving an inositol-3-phosphate receptor (IP3R)-coupled depletion of endoplasmic reticular Ca2+ and a subsequent activation of the stromal interaction molecule 1 (STIM-1)/Orai-1 complex. Calcium 76-83 stromal interaction molecule 1 Homo sapiens 230-260 28105751-3 2017 Ang-II elevates intracellular Ca2+ through activation of the store-operated calcium entry (SOCE) involving an inositol-3-phosphate receptor (IP3R)-coupled depletion of endoplasmic reticular Ca2+ and a subsequent activation of the stromal interaction molecule 1 (STIM-1)/Orai-1 complex. Calcium 76-83 stromal interaction molecule 1 Homo sapiens 262-268 28930597-2 2018 SOCE is mediated by the endoplasmic reticulum calcium sensor STIMs (STIM1 and 2) and plasma membrane channel forming unit Orais (Orai 1-3). Calcium 46-53 stromal interaction molecule 1 Homo sapiens 68-79 29051492-2 2017 Here we demonstrate that calcium-bound calmodulin (Ca2+-CaM) binds to the core region of activated STIM1. Calcium 25-32 stromal interaction molecule 1 Homo sapiens 99-104 29166726-0 2017 [Interaction between TRPC1 and STIM1 in calcium sensing receptor mediated calcium influx and nitric oxide production in human umbilical vein endothelial cells]. Calcium 40-47 stromal interaction molecule 1 Homo sapiens 31-36 29109429-7 2017 Consistent with these results, translocation of the endogenous ER calcium sensor STIM1 to its target channel Orai1 was delayed following ER calcium store depletion. Calcium 66-73 stromal interaction molecule 1 Homo sapiens 81-86 29109429-7 2017 Consistent with these results, translocation of the endogenous ER calcium sensor STIM1 to its target channel Orai1 was delayed following ER calcium store depletion. Calcium 140-147 stromal interaction molecule 1 Homo sapiens 81-86 28815533-8 2017 Chlamydia also recruits STIM1, an ER calcium sensor involved in store-operated calcium entry (SOCE) at ER-PM MCS, and elucidating the role of STIM1 at ER-Chlamydia inclusion MCS may uncover additional role for these contacts. Calcium 37-44 stromal interaction molecule 1 Homo sapiens 24-29 29053695-2 2017 ER-resident STIM1 regulates the activity of PM Orai1 channels in a process known as store operated calcium (Ca2+) entry which is the principal Ca2+ signaling process that drives the immune response. Calcium 99-106 stromal interaction molecule 1 Homo sapiens 12-17 28479254-1 2017 The Ca2+ sensor proteins STIM1 and STIM2 are crucial elements of store-operated calcium entry (SOCE) in breast cancer cells. Calcium 80-87 stromal interaction molecule 1 Homo sapiens 25-30 27865927-0 2017 Structural perturbations induced by Asn131 and Asn171 glycosylation converge within the EFSAM core and enhance stromal interaction molecule-1 mediated store operated calcium entry. Calcium 166-173 stromal interaction molecule 1 Homo sapiens 111-141 28151650-0 2017 Molecular Dynamics Simulations of Membrane-Bound STIM1 to Investigate Conformational Changes during STIM1 Activation upon Calcium Release. Calcium 122-129 stromal interaction molecule 1 Homo sapiens 49-54 28151650-0 2017 Molecular Dynamics Simulations of Membrane-Bound STIM1 to Investigate Conformational Changes during STIM1 Activation upon Calcium Release. Calcium 122-129 stromal interaction molecule 1 Homo sapiens 100-105 28151650-3 2017 Stromal interacting molecule 1 (STIM1) plays a critical role in early sensing of changes in the ER"s calcium level, especially when there is a sudden release of stored calcium from the ER. Calcium 101-108 stromal interaction molecule 1 Homo sapiens 0-30 28151650-3 2017 Stromal interacting molecule 1 (STIM1) plays a critical role in early sensing of changes in the ER"s calcium level, especially when there is a sudden release of stored calcium from the ER. Calcium 101-108 stromal interaction molecule 1 Homo sapiens 32-37 28151650-3 2017 Stromal interacting molecule 1 (STIM1) plays a critical role in early sensing of changes in the ER"s calcium level, especially when there is a sudden release of stored calcium from the ER. Calcium 168-175 stromal interaction molecule 1 Homo sapiens 0-30 28151650-3 2017 Stromal interacting molecule 1 (STIM1) plays a critical role in early sensing of changes in the ER"s calcium level, especially when there is a sudden release of stored calcium from the ER. Calcium 168-175 stromal interaction molecule 1 Homo sapiens 32-37 28151650-4 2017 Inactive STIM1, which has a bound calcium ion, is activated upon ion release. Calcium 34-41 stromal interaction molecule 1 Homo sapiens 9-14 28151650-5 2017 Following activation of STIM1, there is STIM1-assisted initiation of extracellular calcium entry through channels in the cell membrane. Calcium 83-90 stromal interaction molecule 1 Homo sapiens 24-29 28151650-5 2017 Following activation of STIM1, there is STIM1-assisted initiation of extracellular calcium entry through channels in the cell membrane. Calcium 83-90 stromal interaction molecule 1 Homo sapiens 40-45 28151650-9 2017 For this purpose, the ER luminal portion of STIM1 (residues 58-236), which includes the sterile alpha motif (SAM) domain plus the calcium-binding EF-hand domains 1 and 2 attached to the STIM1 transmembrane region (TM), was modeled and embedded in a virtual membrane. Calcium 130-137 stromal interaction molecule 1 Homo sapiens 44-49 28151650-12 2017 Altogether, understanding conformational changes in STIM1 can help in drug discovery when targeting this key protein in intracellular calcium functions. Calcium 134-141 stromal interaction molecule 1 Homo sapiens 52-57 28624623-6 2017 We further found that mitochondrial fission-mediated calcium signaling was dependent on ROS-activated NF-kappaB pathways, which facilitated the expression of STIM1 and subsequent store-operated calciumentry. Calcium 53-60 stromal interaction molecule 1 Homo sapiens 158-163 28624464-4 2017 STIM1 mutations were investigated by fibroblast calcium imaging and 3D modelling. Calcium 48-55 stromal interaction molecule 1 Homo sapiens 0-5 29179526-5 2017 Store-operated Ca2+ entry, acts as the principal force of calcium influx, is composed of STIM1 and Orai1 on the plasma membrane. Calcium 58-65 stromal interaction molecule 1 Homo sapiens 89-94 28694529-2 2017 It stimulates store-operated calcium entry (SOCE) through the calcium release-activated calcium (CRAC) channel Orai1/Stim1 in endometrial Ishikawa cells. Calcium 29-36 stromal interaction molecule 1 Homo sapiens 117-122 28744649-2 2017 In stable STIM1 knockdown HEK S4 cells, single channels activated by depletion of intracellular calcium stores were detected by cell-attached patch-clamp technique and their electrophysiological parameters were described. Calcium 96-103 stromal interaction molecule 1 Homo sapiens 10-15 28744649-4 2017 We can conclude that electrophysiological peculiarities of store-regulated calcium entry observed in different cells can be explained by differences in STIM1 expression. Calcium 75-82 stromal interaction molecule 1 Homo sapiens 152-157 28326487-3 2017 The store-operated calcium (Ca2+) entry (SOCE) and its major mediator Stim1 have been shown to be implicated in a number of pathological processes typical for cancer. Calcium 19-26 stromal interaction molecule 1 Homo sapiens 70-75 28564609-1 2017 Interaction between the endoplasmic reticulum protein STIM1 and the plasma membrane channel ORAI1 generates calcium signals that are central for diverse cellular functions. Calcium 108-115 stromal interaction molecule 1 Homo sapiens 54-59 26277896-7 2017 Our data suggest that an influx of extracellular calcium, mediated by STIM1-operated calcium channels, may transmit the information about the intensity of extracellular TLR stimuli to initiate innate responses at an appropriate level. Calcium 49-56 stromal interaction molecule 1 Homo sapiens 70-75 28815533-8 2017 Chlamydia also recruits STIM1, an ER calcium sensor involved in store-operated calcium entry (SOCE) at ER-PM MCS, and elucidating the role of STIM1 at ER-Chlamydia inclusion MCS may uncover additional role for these contacts. Calcium 79-86 stromal interaction molecule 1 Homo sapiens 24-29 27041216-1 2016 STIM1 and ORAI1 constitute the core machinery of the ubiquitous store-operated calcium entry pathway and loss of function in these proteins is associated with severe immune and muscular disorders. Calcium 79-86 stromal interaction molecule 1 Homo sapiens 0-5 28625263-1 2017 OBJECTIVE: To explore the effect of toll-like receptor 4 (TLR4), myeloid differentiation protein-2 (MD2), and stromal interaction molecular 1 (STIM1) for regulating human vascular endothelial calcium overload injury and inflammatory reaction induced by bacterial endotoxin (LPS). Calcium 192-199 stromal interaction molecule 1 Homo sapiens 143-148 28625263-18 2017 CONCLUSIONS: TLR4, MD2, NF-kappaB signal and SOC calcium channel STIM1 mediate LPS induced-calcium influx and inflammatory mediators level in HUVEC cells. Calcium 49-56 stromal interaction molecule 1 Homo sapiens 65-70 28625263-19 2017 Extracellular calcium overload and inflammatory response by endotoxin induction can be effectively inhibited by down-regulation of TLR4, NF-kappaB and/or STIM1. Calcium 14-21 stromal interaction molecule 1 Homo sapiens 154-159 27459950-1 2016 STIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). Calcium 62-69 stromal interaction molecule 1 Homo sapiens 0-5 27459950-1 2016 STIM1 and Orai1 are the main components of a widely conserved Calcium influx pathway known as store-operated calcium entry (SOCE). Calcium 109-116 stromal interaction molecule 1 Homo sapiens 0-5 27459950-2 2016 STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER). Calcium 11-18 stromal interaction molecule 1 Homo sapiens 0-5 27459950-2 2016 STIM1 is a calcium sensor, which oligomerizes and activates Orai channels when calcium levels drop inside the endoplasmic reticulum (ER). Calcium 79-86 stromal interaction molecule 1 Homo sapiens 0-5 26738614-0 2016 Role of STIM1-Orai1 system in intra-cellular calcium elevation induced by ATP in cultured human keratinocytes. Calcium 45-52 stromal interaction molecule 1 Homo sapiens 8-13 27199756-9 2016 Furthermore, Phemindole mediated Store Operated Calcium Entry (SOCE) retardation favored inactivation of STIM1 and henceforth activated ER stress to induce apoptosis in TNBC cells. Calcium 48-55 stromal interaction molecule 1 Homo sapiens 105-110 27063589-2 2016 We report here a patient with severe combined immunodeficiency and absent store-operated calcium entry due to a novel mutation in ORAI1 that results in the expression of a C-terminally truncated protein that abolishes ORAI1 binding to STIM1. Calcium 89-96 stromal interaction molecule 1 Homo sapiens 235-240 26826124-0 2016 T Cell Receptor-induced Nuclear Factor kappaB (NF-kappaB) Signaling and Transcriptional Activation Are Regulated by STIM1- and Orai1-mediated Calcium Entry. Calcium 142-149 stromal interaction molecule 1 Homo sapiens 116-121 26546674-2 2016 The two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel pore-forming protein Orai1. Calcium 45-52 stromal interaction molecule 1 Homo sapiens 118-148 26560041-0 2016 A homozygous STIM1 mutation impairs store-operated calcium entry and natural killer cell effector function without clinical immunodeficiency. Calcium 51-58 stromal interaction molecule 1 Homo sapiens 13-18 26712003-2 2016 When bound and activated by stromal interacting molecule 1 (STIM1), an endoplasmic reticulum (ER)-resident calcium sensor, Orai1 channels possess high selectivity for calcium but extremely small conductance that has precluded direct recording of single-channel currents. Calcium 107-114 stromal interaction molecule 1 Homo sapiens 28-58 26712003-2 2016 When bound and activated by stromal interacting molecule 1 (STIM1), an endoplasmic reticulum (ER)-resident calcium sensor, Orai1 channels possess high selectivity for calcium but extremely small conductance that has precluded direct recording of single-channel currents. Calcium 107-114 stromal interaction molecule 1 Homo sapiens 60-65 26712003-2 2016 When bound and activated by stromal interacting molecule 1 (STIM1), an endoplasmic reticulum (ER)-resident calcium sensor, Orai1 channels possess high selectivity for calcium but extremely small conductance that has precluded direct recording of single-channel currents. Calcium 167-174 stromal interaction molecule 1 Homo sapiens 28-58 26712003-2 2016 When bound and activated by stromal interacting molecule 1 (STIM1), an endoplasmic reticulum (ER)-resident calcium sensor, Orai1 channels possess high selectivity for calcium but extremely small conductance that has precluded direct recording of single-channel currents. Calcium 167-174 stromal interaction molecule 1 Homo sapiens 60-65 26546674-2 2016 The two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel pore-forming protein Orai1. Calcium 45-52 stromal interaction molecule 1 Homo sapiens 150-155 26546674-3 2016 During store-operated calcium entry activation, calcium depletion from the endoplasmic reticulum triggers a series of conformational changes in STIM1 that unmask a minimal Orai1-activating domain (CRAC activation region (CAD)). Calcium 22-29 stromal interaction molecule 1 Homo sapiens 144-149 26546674-3 2016 During store-operated calcium entry activation, calcium depletion from the endoplasmic reticulum triggers a series of conformational changes in STIM1 that unmask a minimal Orai1-activating domain (CRAC activation region (CAD)). Calcium 48-55 stromal interaction molecule 1 Homo sapiens 144-149 26644574-3 2015 Research on calcium signaling has centered on STIM1, ORAI1, and a few proteins that directly modulate STIM-ORAI function. Calcium 12-19 stromal interaction molecule 1 Homo sapiens 46-51 26454179-1 2015 Store-operated calcium entry (SOCE) is a pathway that moves Ca(2+) across the plasma membrane and is mediated by two major proteins, STIM1 and Orai1. Calcium 15-22 stromal interaction molecule 1 Homo sapiens 133-138 26078003-8 2015 One of the individual proteins studied further was stromal interaction molecule (STIM1), a calcium sensor residing in the endoplasmic reticulum (ER) that is important in store-operated calcium entry. Calcium 91-98 stromal interaction molecule 1 Homo sapiens 81-86 26078003-8 2015 One of the individual proteins studied further was stromal interaction molecule (STIM1), a calcium sensor residing in the endoplasmic reticulum (ER) that is important in store-operated calcium entry. Calcium 185-192 stromal interaction molecule 1 Homo sapiens 81-86 25922260-1 2015 Store-operated calcium entry (SOCE) is activated within the endoplasmic reticulum (ER)-plasma membrane (PM) junctions in the plasma membrane and involves assembly of the channels, Orai1 and TRPC1, with the regulatory protein, STIM1, in response to depletion of Ca(2+) in the ER. Calcium 15-22 stromal interaction molecule 1 Homo sapiens 226-231 25953320-2 2015 Recently mutations in the gene encoding the main calcium sensor in the sarcoplasmic reticulum, stromal interaction molecule 1 (STIM1), have been identified as a cause of autosomal dominant tubular aggregate myopathy. Calcium 49-56 stromal interaction molecule 1 Homo sapiens 95-125 26138675-2 2015 Two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel pore-forming protein Orai1. Calcium 41-48 stromal interaction molecule 1 Homo sapiens 114-144 26138675-2 2015 Two key components of the store-operated calcium release-activated calcium channel are the Ca(2+)-sensing protein stromal interaction molecule 1 (STIM1) and the channel pore-forming protein Orai1. Calcium 41-48 stromal interaction molecule 1 Homo sapiens 146-151 26138675-3 2015 Following calcium depletion from the endoplasmic reticulum, STIM1 undergoes conformational changes that unmask an Orai1-activating domain called CAD. Calcium 10-17 stromal interaction molecule 1 Homo sapiens 60-65 25953320-2 2015 Recently mutations in the gene encoding the main calcium sensor in the sarcoplasmic reticulum, stromal interaction molecule 1 (STIM1), have been identified as a cause of autosomal dominant tubular aggregate myopathy. Calcium 49-56 stromal interaction molecule 1 Homo sapiens 127-132 25953320-6 2015 Sequencing of the STIM1 gene revealed a previously unreported missense mutation (c.242G>A; p.Gly81Asp) located in the first calcium binding EF domain. Calcium 127-134 stromal interaction molecule 1 Homo sapiens 18-23 25953320-7 2015 Functional characterization of the new STIM1 mutation by calcium imaging revealed that calcium influx was significantly increased in primary myoblasts of the index patient compared to controls pointing at a severe alteration of intracellular calcium homeostasis. Calcium 57-64 stromal interaction molecule 1 Homo sapiens 39-44 25953320-7 2015 Functional characterization of the new STIM1 mutation by calcium imaging revealed that calcium influx was significantly increased in primary myoblasts of the index patient compared to controls pointing at a severe alteration of intracellular calcium homeostasis. Calcium 87-94 stromal interaction molecule 1 Homo sapiens 39-44 25953320-7 2015 Functional characterization of the new STIM1 mutation by calcium imaging revealed that calcium influx was significantly increased in primary myoblasts of the index patient compared to controls pointing at a severe alteration of intracellular calcium homeostasis. Calcium 87-94 stromal interaction molecule 1 Homo sapiens 39-44 24957221-11 2015 CONCLUSION: These findings suggest that STIM1 is involved in several ways in the reaction of muscle fibres to denervation, probably reflecting alterations in calcium homeostasis in denervated muscle fibres. Calcium 158-165 stromal interaction molecule 1 Homo sapiens 40-45 26191202-1 2015 Orai1 and STIM1 mediate calcium release-activated calcium current (CRAC) which is the best characterized store-operated calcium current involving in a wide range of cell progresses, such as cell proliferation, metastasis, apoptosis. Calcium 24-31 stromal interaction molecule 1 Homo sapiens 10-15 26191202-1 2015 Orai1 and STIM1 mediate calcium release-activated calcium current (CRAC) which is the best characterized store-operated calcium current involving in a wide range of cell progresses, such as cell proliferation, metastasis, apoptosis. Calcium 50-57 stromal interaction molecule 1 Homo sapiens 10-15 26191202-1 2015 Orai1 and STIM1 mediate calcium release-activated calcium current (CRAC) which is the best characterized store-operated calcium current involving in a wide range of cell progresses, such as cell proliferation, metastasis, apoptosis. Calcium 50-57 stromal interaction molecule 1 Homo sapiens 10-15 25645930-2 2015 In immune cells, calcium entry occurs through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels, comprised of STIM1 and Orai1 proteins. Calcium 17-24 stromal interaction molecule 1 Homo sapiens 123-128 25533457-1 2015 The endoplasmic reticulum calcium sensors stromal interaction molecules 1 and 2 (STIM1 and STIM2) are key modulators of store-operated calcium entry. Calcium 26-33 stromal interaction molecule 1 Homo sapiens 42-79 25533457-1 2015 The endoplasmic reticulum calcium sensors stromal interaction molecules 1 and 2 (STIM1 and STIM2) are key modulators of store-operated calcium entry. Calcium 26-33 stromal interaction molecule 1 Homo sapiens 81-86 25533457-1 2015 The endoplasmic reticulum calcium sensors stromal interaction molecules 1 and 2 (STIM1 and STIM2) are key modulators of store-operated calcium entry. Calcium 135-142 stromal interaction molecule 1 Homo sapiens 42-79 25533457-1 2015 The endoplasmic reticulum calcium sensors stromal interaction molecules 1 and 2 (STIM1 and STIM2) are key modulators of store-operated calcium entry. Calcium 135-142 stromal interaction molecule 1 Homo sapiens 81-86 25533457-11 2015 These new data about cross-talk between STIM1 and STIM2 and their different roles in store-operated channel activation are indicative of an additional level in the regulation of store-operated calcium entry pathways. Calcium 193-200 stromal interaction molecule 1 Homo sapiens 40-45 25504574-1 2015 KEY POINTS: Although both the calcium store-dependent CRAC channels and the store-independent ARC channels are regulated by the protein STIM1, CRAC channels are regulated by STIM1 in the endoplasmic reticulum, whilst ARC channels are regulated by the STIM1 constitutively resident in the plasma membrane. Calcium 30-37 stromal interaction molecule 1 Homo sapiens 136-141 25447552-1 2015 STIM1 is a key regulator of store-operated calcium entry (SOCE), and therefore a mediator of Ca2+ entry-dependent cellular events. Calcium 43-50 stromal interaction molecule 1 Homo sapiens 0-5 26218135-1 2015 Stromal interaction molecules (STIM) 1 and 2 are sensors of the calcium concentration in the endoplasmic reticulum. Calcium 64-71 stromal interaction molecule 1 Homo sapiens 0-44 26218135-3 2015 The resulting store-operated calcium entry (SOCE), mostly controlled by the principal components STIM1 and ORAI1, has been particularly characterized in immune cells. Calcium 29-36 stromal interaction molecule 1 Homo sapiens 97-102 26218135-6 2015 STIM2 is required for SOCE in hippocampal synapses and cortical neurons, whereas STIM1 controls calcium store replenishment in cerebellar Purkinje neurons. Calcium 96-103 stromal interaction molecule 1 Homo sapiens 81-86 25190815-0 2014 Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells. Calcium 74-81 stromal interaction molecule 1 Homo sapiens 0-30 26584293-2 2015 Store-operated calcium entry (SOCE) and stromal interaction molecule 1 (STIM1) regulate platelet activity by modulating calcium influx. Calcium 120-127 stromal interaction molecule 1 Homo sapiens 40-70 26584293-2 2015 Store-operated calcium entry (SOCE) and stromal interaction molecule 1 (STIM1) regulate platelet activity by modulating calcium influx. Calcium 120-127 stromal interaction molecule 1 Homo sapiens 72-77 26584293-12 2015 CONCLUSION: Platelets from diabetic patients with PAD exhibited enhanced Store-operated calcium influx, which was associated with elevated STIM1/SERCA3 expression via a PLC-dependent pathway and was inhibited by menthol. Calcium 88-95 stromal interaction molecule 1 Homo sapiens 139-144 25326555-2 2014 Recently, STIM1, encoding a major calcium sensor of the endoplasmic reticulum, was identified as a TAM gene. Calcium 34-41 stromal interaction molecule 1 Homo sapiens 10-15 25326555-6 2014 We show that the mutations induce constitutive STIM1 clustering, strongly suggesting that calcium sensing and consequently calcium homoeostasis is impaired. Calcium 90-97 stromal interaction molecule 1 Homo sapiens 47-52 25326555-6 2014 We show that the mutations induce constitutive STIM1 clustering, strongly suggesting that calcium sensing and consequently calcium homoeostasis is impaired. Calcium 123-130 stromal interaction molecule 1 Homo sapiens 47-52 24246800-0 2014 Calcium signaling in B cells: regulation of cytosolic Ca2+ increase and its sensor molecules, STIM1 and STIM2. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 94-99 25190815-0 2014 Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells. Calcium 74-81 stromal interaction molecule 1 Homo sapiens 32-37 24845346-5 2014 The association of the TSPs with STIM1 is observed in both the presence and absence of calcium indicating that the calcium-dependent conformation of the signature domain of TSPs is not required for binding. Calcium 87-94 stromal interaction molecule 1 Homo sapiens 33-38 24681268-6 2014 A key protein involved in initiation of calcium flux is Stromal Interaction Molecule 1 (STIM1), which has recently been identified as a sensor of ER calcium levels. Calcium 40-47 stromal interaction molecule 1 Homo sapiens 56-86 24681268-6 2014 A key protein involved in initiation of calcium flux is Stromal Interaction Molecule 1 (STIM1), which has recently been identified as a sensor of ER calcium levels. Calcium 40-47 stromal interaction molecule 1 Homo sapiens 88-93 24681268-6 2014 A key protein involved in initiation of calcium flux is Stromal Interaction Molecule 1 (STIM1), which has recently been identified as a sensor of ER calcium levels. Calcium 149-156 stromal interaction molecule 1 Homo sapiens 56-86 24681268-6 2014 A key protein involved in initiation of calcium flux is Stromal Interaction Molecule 1 (STIM1), which has recently been identified as a sensor of ER calcium levels. Calcium 149-156 stromal interaction molecule 1 Homo sapiens 88-93 24681268-7 2014 STIM1 is an ER transmembrane protein that is activated by a drop in ER calcium levels. Calcium 71-78 stromal interaction molecule 1 Homo sapiens 0-5 24681268-10 2014 STIM1 is a promising target in drug discovery due to its key role early in calcium flux. Calcium 75-82 stromal interaction molecule 1 Homo sapiens 0-5 24583265-3 2014 Here we demonstrate that ORAI1 and STIM1 mediate store-operated calcium entry (SOCE) in pancreatic adenocarcinoma cell lines. Calcium 64-71 stromal interaction molecule 1 Homo sapiens 35-40 24845346-5 2014 The association of the TSPs with STIM1 is observed in both the presence and absence of calcium indicating that the calcium-dependent conformation of the signature domain of TSPs is not required for binding. Calcium 115-122 stromal interaction molecule 1 Homo sapiens 33-38 24845346-8 2014 These data indicate that the TSPs regulate STIM1 function and participate in the reciprocal regulation of two channels that mediate calcium entry into the cell. Calcium 132-139 stromal interaction molecule 1 Homo sapiens 43-48 24463213-4 2014 Indeed, we demonstrate that megakaryocytes express the major candidates to mediate Store-Operated Calcium Entry, stromal interaction molecule 1, Orai1 and canonical transient receptor potential 1, which are activated upon either pharmacological or physiological depletion of the intracellular calcium pool. Calcium 293-300 stromal interaction molecule 1 Homo sapiens 113-143 24834055-12 2014 This novel report of STIM1-2 and Orai1-3 mRNA expression in pregnant human myometrium and Orai1 regulation by IL-1beta indicates a potential role for these proteins in calcium signaling in human myometrium during pregnancy. Calcium 168-175 stromal interaction molecule 1 Homo sapiens 21-28 24501372-6 2014 We found that oxidant-induced increased S-glutathionylation and calcium-independent puncta formation of the ER calcium sensor STIM1 underlies the abnormal SOCE response in SOD1G93A astrocytes. Calcium 64-71 stromal interaction molecule 1 Homo sapiens 126-131 24501372-6 2014 We found that oxidant-induced increased S-glutathionylation and calcium-independent puncta formation of the ER calcium sensor STIM1 underlies the abnormal SOCE response in SOD1G93A astrocytes. Calcium 111-118 stromal interaction molecule 1 Homo sapiens 126-131 24109210-5 2013 We hypothesized that NSP4-mediated depletion of ER calcium activates store-operated calcium entry (SOCE) through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1). Calcium 51-58 stromal interaction molecule 1 Homo sapiens 149-179 24095720-0 2013 Inhibition of STIM1 phosphorylation underlies resveratrol-induced inhibition of store-operated calcium entry. Calcium 95-102 stromal interaction molecule 1 Homo sapiens 14-19 24109210-0 2013 Activation of the endoplasmic reticulum calcium sensor STIM1 and store-operated calcium entry by rotavirus requires NSP4 viroporin activity. Calcium 40-47 stromal interaction molecule 1 Homo sapiens 55-60 24109210-5 2013 We hypothesized that NSP4-mediated depletion of ER calcium activates store-operated calcium entry (SOCE) through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1). Calcium 51-58 stromal interaction molecule 1 Homo sapiens 181-186 24109210-5 2013 We hypothesized that NSP4-mediated depletion of ER calcium activates store-operated calcium entry (SOCE) through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1). Calcium 84-91 stromal interaction molecule 1 Homo sapiens 149-179 24109210-5 2013 We hypothesized that NSP4-mediated depletion of ER calcium activates store-operated calcium entry (SOCE) through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1). Calcium 84-91 stromal interaction molecule 1 Homo sapiens 181-186 24109210-5 2013 We hypothesized that NSP4-mediated depletion of ER calcium activates store-operated calcium entry (SOCE) through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1). Calcium 84-91 stromal interaction molecule 1 Homo sapiens 149-179 24109210-5 2013 We hypothesized that NSP4-mediated depletion of ER calcium activates store-operated calcium entry (SOCE) through activation of the ER calcium sensor stromal interaction molecule 1 (STIM1). Calcium 84-91 stromal interaction molecule 1 Homo sapiens 181-186 24331698-9 2013 Compared with the untreated control cells, the ethanol-treated cells showed significantly up-regulated mRNA and protein expression of both STIM1 and Orai1 at all times examined, suggesting that the ethanol-stimulated expression of STIM1 and Orai1 could persist for at least 72 h. The ethanol treatment induced increase in cytoplasmic calcium levels was significantly (and similarly) reduced by co-treatment with any of the three channel blockers. Calcium 334-341 stromal interaction molecule 1 Homo sapiens 139-144 24114840-0 2013 17beta-Estradiol inhibits phosphorylation of stromal interaction molecule 1 (STIM1) protein: implication for store-operated calcium entry and chronic lung diseases. Calcium 124-131 stromal interaction molecule 1 Homo sapiens 45-75 24114840-0 2013 17beta-Estradiol inhibits phosphorylation of stromal interaction molecule 1 (STIM1) protein: implication for store-operated calcium entry and chronic lung diseases. Calcium 124-131 stromal interaction molecule 1 Homo sapiens 77-82 24331698-9 2013 Compared with the untreated control cells, the ethanol-treated cells showed significantly up-regulated mRNA and protein expression of both STIM1 and Orai1 at all times examined, suggesting that the ethanol-stimulated expression of STIM1 and Orai1 could persist for at least 72 h. The ethanol treatment induced increase in cytoplasmic calcium levels was significantly (and similarly) reduced by co-treatment with any of the three channel blockers. Calcium 334-341 stromal interaction molecule 1 Homo sapiens 231-236 24331698-10 2013 CONCLUSION: Chronic ethanol exposure can increase the expression of STIM1 and Orai1 in primary liver cells, suggesting that ethanol may increase extracellular calcium influx by up-regulating expression of these SOCs protein molecules, ultimately aggravating liver cell damage. Calcium 159-166 stromal interaction molecule 1 Homo sapiens 68-73 24025406-1 2013 The discovery of the Orai proteins, and the identification of STIM1 as the molecule that regulates them, was based on their role in the agonist-activated store-operated entry of calcium via the CRAC channels. Calcium 178-185 stromal interaction molecule 1 Homo sapiens 62-67 23568369-1 2013 Stromal interaction molecules (STIM1 and STIM2) are critical components of store-operated calcium entry. Calcium 90-97 stromal interaction molecule 1 Homo sapiens 31-36 23711249-1 2013 In non-excitatory cells, stromal interaction molecule 1 (STIM1) and STIM2 mediate store-operated calcium entry via an interaction with ORAI1 calcium channels. Calcium 97-104 stromal interaction molecule 1 Homo sapiens 25-55 23711249-1 2013 In non-excitatory cells, stromal interaction molecule 1 (STIM1) and STIM2 mediate store-operated calcium entry via an interaction with ORAI1 calcium channels. Calcium 97-104 stromal interaction molecule 1 Homo sapiens 57-62 23951072-8 2013 Thapsigargin followed by extracellular Ca2+ exposure induced Ca2+-influx in H295R, and the cells expressed mRNA/protein of the component molecules for store-operated calcium entry (SOCE): transient receptor C (TRPC) channels, calcium release-activated calcium channel protein 1 (Orai-1), and the stromal interaction molecule 1 (STIM1). Calcium 166-173 stromal interaction molecule 1 Homo sapiens 296-326 23951072-8 2013 Thapsigargin followed by extracellular Ca2+ exposure induced Ca2+-influx in H295R, and the cells expressed mRNA/protein of the component molecules for store-operated calcium entry (SOCE): transient receptor C (TRPC) channels, calcium release-activated calcium channel protein 1 (Orai-1), and the stromal interaction molecule 1 (STIM1). Calcium 166-173 stromal interaction molecule 1 Homo sapiens 328-333 23698468-0 2013 Microtubule-associated histone deacetylase 6 supports the calcium store sensor STIM1 in mediating malignant cell behaviors. Calcium 58-65 stromal interaction molecule 1 Homo sapiens 79-84 23687376-1 2013 STIM1 (stromal interaction molecule 1) is a key regulator of store-operated calcium entry (SOCE). Calcium 76-83 stromal interaction molecule 1 Homo sapiens 0-5 23687376-1 2013 STIM1 (stromal interaction molecule 1) is a key regulator of store-operated calcium entry (SOCE). Calcium 76-83 stromal interaction molecule 1 Homo sapiens 7-37 23512989-3 2013 We showed that the thrombin-induced decrease in transendothelial electric resistance of cultured human endothelial cells required the endoplasmic reticulum-localized, calcium-sensing protein stromal interacting molecule 1 (STIM1), but was independent of Ca2+ entry across the plasma membrane and the Ca2+ release-activated Ca2+ channel protein Orai1, which is the target of STIM1 in the store-operated calcium entry pathway. Calcium 167-174 stromal interaction molecule 1 Homo sapiens 223-228 23613525-1 2013 Ca(2+) release-activated Ca(2+) (CRAC) channels are activated through a mechanism wherein depletion of intracellular calcium stores results in the aggregation of stromal interaction molecule 1 (STIM1), the endoplasmic reticulum (ER) Ca(2+) sensor, and Orai1, the CRAC channel protein, at overlapping sites in the ER and plasma membranes (PMs). Calcium 117-124 stromal interaction molecule 1 Homo sapiens 162-192 23613525-1 2013 Ca(2+) release-activated Ca(2+) (CRAC) channels are activated through a mechanism wherein depletion of intracellular calcium stores results in the aggregation of stromal interaction molecule 1 (STIM1), the endoplasmic reticulum (ER) Ca(2+) sensor, and Orai1, the CRAC channel protein, at overlapping sites in the ER and plasma membranes (PMs). Calcium 117-124 stromal interaction molecule 1 Homo sapiens 194-199 23395841-0 2013 The polybasic lysine-rich domain of plasma membrane-resident STIM1 is essential for the modulation of store-operated divalent cation entry by extracellular calcium. Calcium 156-163 stromal interaction molecule 1 Homo sapiens 61-66 23690558-3 2013 However, whilst STIM1 in the endoplasmic reticulum membrane is the critical sensor for the depletion of this calcium store that triggers CRAC channel activation, it is the pool of STIM1 constitutively resident in the plasma membrane that is essential for activation of the ARC channels. Calcium 109-116 stromal interaction molecule 1 Homo sapiens 16-21 23690558-6 2013 Specifically, loss of calcium from the EF-hand of STIM1 that forms the key initiation point for activation of the CRAC channels has no effect on ARC channel activity. Calcium 22-29 stromal interaction molecule 1 Homo sapiens 50-55 23512987-4 2013 The endoplasmic reticulum-resident calcium (Ca2+) sensor stromal interacton molecule 1 (STIM1) is intimately involved in the cellular response to thrombin. Calcium 35-42 stromal interaction molecule 1 Homo sapiens 57-86 23512987-4 2013 The endoplasmic reticulum-resident calcium (Ca2+) sensor stromal interacton molecule 1 (STIM1) is intimately involved in the cellular response to thrombin. Calcium 35-42 stromal interaction molecule 1 Homo sapiens 88-93 23332920-0 2013 Constitutive activation of the calcium sensor STIM1 causes tubular-aggregate myopathy. Calcium 31-38 stromal interaction molecule 1 Homo sapiens 46-51 23434597-3 2013 identify STIM1, an ER calcium sensor, as a key link between LPS-induced ROS, calcium oscillations, and endothelial cell (EC) dysfunction. Calcium 22-29 stromal interaction molecule 1 Homo sapiens 9-14 23434597-3 2013 identify STIM1, an ER calcium sensor, as a key link between LPS-induced ROS, calcium oscillations, and endothelial cell (EC) dysfunction. Calcium 77-84 stromal interaction molecule 1 Homo sapiens 9-14 22992728-0 2012 Modification of STIM1 by O-linked N-acetylglucosamine (O-GlcNAc) attenuates store-operated calcium entry in neonatal cardiomyocytes. Calcium 91-98 stromal interaction molecule 1 Homo sapiens 16-21 23546586-6 2013 Stromal interaction molecules (STIM), which consist of STIM1 and its homolog, STIM2, serve as ER calcium sensors and are essential for SOC influx after antigen stimulation. Calcium 97-104 stromal interaction molecule 1 Homo sapiens 55-60 23022228-0 2012 Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells. Calcium 78-85 stromal interaction molecule 1 Homo sapiens 13-43 23022228-0 2012 Knockdown of stromal interaction molecule 1 (STIM1) suppresses store-operated calcium entry, cell proliferation and tumorigenicity in human epidermoid carcinoma A431 cells. Calcium 78-85 stromal interaction molecule 1 Homo sapiens 45-50 23109337-1 2012 Orai1 is a plasma membrane protein that in its tetrameric form is responsible for calcium influx from the extracellular environment into the cytosol in response to interaction with the Ca(2+)-depletion sensor STIM1. Calcium 82-89 stromal interaction molecule 1 Homo sapiens 209-214 22938798-9 2012 All these results demonstrate an involvement in dystrophin-deficient myotubes of a specific calcium/PKC/PLC pathway in elevation of store-operated cation influx supported by the STIM1/Orai1/TRPC1 proteins, which is normally regulated by the alpha1-syntrophin/dystrophin scaffold. Calcium 92-99 stromal interaction molecule 1 Homo sapiens 178-183 23520759-4 2012 Sequentially, store-operated calcium channels (SOCC) are responsible for most of calcium influx from extracellular compartment, which is regulated by the cooperation of stromal interaction molecule 1 (STIM1), a Ca2+ sensor molecule in intracellular stores, and ORAI calcium release-activated calcium modulator 1 (Orail), a plasma membrane protein. Calcium 29-36 stromal interaction molecule 1 Homo sapiens 169-199 23520759-4 2012 Sequentially, store-operated calcium channels (SOCC) are responsible for most of calcium influx from extracellular compartment, which is regulated by the cooperation of stromal interaction molecule 1 (STIM1), a Ca2+ sensor molecule in intracellular stores, and ORAI calcium release-activated calcium modulator 1 (Orail), a plasma membrane protein. Calcium 29-36 stromal interaction molecule 1 Homo sapiens 201-206 23890114-1 2013 Although Orai channels and their regulator stromal interacting molecule 1 (STIM1) were originally identified and described as the key components of the store-operated highly calcium-selective CRAC channels, it is now clear that these proteins are equally essential components of the agonist-activated, store-independent calcium entry pathway mediated by the arachidonic acid-regulated calcium-selective (ARC) channel. Calcium 174-181 stromal interaction molecule 1 Homo sapiens 75-80 23890114-3 2013 Moreover, while STIM1 in the membrane of the endoplasmic reticulum is the critical sensor of intracellular calcium store depletion that results in the activation of the CRAC channels, it is the pool of STIM1 resident in the plasma membrane that regulates the activity of the store-independent ARC channels. Calcium 107-114 stromal interaction molecule 1 Homo sapiens 16-21 24351972-0 2013 STIM1/Orai1 coiled-coil interplay in the regulation of store-operated calcium entry. Calcium 70-77 stromal interaction molecule 1 Homo sapiens 0-5 24351972-1 2013 Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). Calcium 6-13 stromal interaction molecule 1 Homo sapiens 63-93 24351972-1 2013 Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). Calcium 6-13 stromal interaction molecule 1 Homo sapiens 95-100 24351972-1 2013 Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). Calcium 128-135 stromal interaction molecule 1 Homo sapiens 63-93 24351972-1 2013 Orai1 calcium channels in the plasma membrane are activated by stromal interaction molecule-1 (STIM1), an endoplasmic reticulum calcium sensor, to mediate store-operated calcium entry (SOCE). Calcium 128-135 stromal interaction molecule 1 Homo sapiens 95-100 23184982-6 2012 Further investigation revealed a unique receptor-mediated mechanism of calcium release from SGs that involves SG store-operated Orai channels activated by their regulator stromal interaction molecule 1 (STIM1) on the ER. Calcium 71-78 stromal interaction molecule 1 Homo sapiens 171-201 23184982-6 2012 Further investigation revealed a unique receptor-mediated mechanism of calcium release from SGs that involves SG store-operated Orai channels activated by their regulator stromal interaction molecule 1 (STIM1) on the ER. Calcium 71-78 stromal interaction molecule 1 Homo sapiens 203-208 22959994-4 2012 We have visualized the cytoskeletons formed by actin and tubulin, the chaperone PDI that catalyses native disulfide bond formation of proteins in the endoplasmic reticulum (ER) and the calcium sensor STIM1 that is integrated in ER membranes, using established cell lines. Calcium 185-192 stromal interaction molecule 1 Homo sapiens 200-205 22506990-0 2012 Homers regulate calcium entry and aggregation in human platelets: a role for Homers in the association between STIM1 and Orai1. Calcium 16-23 stromal interaction molecule 1 Homo sapiens 111-116 22712562-0 2012 STIM1 is necessary for store-operated calcium entry in turning growth cones. Calcium 38-45 stromal interaction molecule 1 Homo sapiens 0-5 22712562-3 2012 Stromal Interaction Molecule 1 (STIM1) is a calcium-sensing protein localized in the endoplasmic reticulum membrane that interacts with Orai proteins in the plasma membrane to initiate SOCE and refilling of intracellular calcium stores. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 0-30 22712562-3 2012 Stromal Interaction Molecule 1 (STIM1) is a calcium-sensing protein localized in the endoplasmic reticulum membrane that interacts with Orai proteins in the plasma membrane to initiate SOCE and refilling of intracellular calcium stores. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 32-37 22712562-3 2012 Stromal Interaction Molecule 1 (STIM1) is a calcium-sensing protein localized in the endoplasmic reticulum membrane that interacts with Orai proteins in the plasma membrane to initiate SOCE and refilling of intracellular calcium stores. Calcium 221-228 stromal interaction molecule 1 Homo sapiens 0-30 22712562-3 2012 Stromal Interaction Molecule 1 (STIM1) is a calcium-sensing protein localized in the endoplasmic reticulum membrane that interacts with Orai proteins in the plasma membrane to initiate SOCE and refilling of intracellular calcium stores. Calcium 221-228 stromal interaction molecule 1 Homo sapiens 32-37 22712562-5 2012 We show that STIM1 and Orai reorganize into puncta upon store depletion and during growth cone turning with STIM1 localization biased towards the turning side (high calcium side) of the growth cone. Calcium 165-172 stromal interaction molecule 1 Homo sapiens 13-18 22712562-5 2012 We show that STIM1 and Orai reorganize into puncta upon store depletion and during growth cone turning with STIM1 localization biased towards the turning side (high calcium side) of the growth cone. Calcium 165-172 stromal interaction molecule 1 Homo sapiens 108-113 22288713-9 2012 Inhibition of TLR4 effectively reverses LPS induction of inflammatory mediator generation and extracellular calcium influx mediated by STIM1. Calcium 108-115 stromal interaction molecule 1 Homo sapiens 135-140 22364775-2 2012 When these luminal stores become depleted, the transmembrane ER protein Stim1 oligomerizes and translocates within the ER membrane to puncta junctions to couple with Orai1 channels, activating store-operated calcium entry (SOCE). Calcium 208-215 stromal interaction molecule 1 Homo sapiens 72-77 22288713-5 2012 TLR4 protein levels increased significantly at 1 h and peaked at 12 h. NF-kappaB protein levels markedly increased at 1 h and peaked at 6 h. Knockdown of STIM1 alone, TLR4 alone or both STIM1 and TLR4 together, markedly abolished LPS-induced increase in calcium influx into cells (P<0.05, P<0.01 and P<0.01 respectively). Calcium 254-261 stromal interaction molecule 1 Homo sapiens 154-159 22451904-2 2012 Upon store depletion, the calcium sensor in the endoplasmic reticulum, STIM1, activates Orai1, a CRAC channel in the plasma membrane. Calcium 26-33 stromal interaction molecule 1 Homo sapiens 71-76 22298426-3 2012 Stromal interaction molecule 1 (Stim1), an internal calcium sensor of the endoplasmic reticulum store, promotes myogenesis via activation of NFATc3. Calcium 52-59 stromal interaction molecule 1 Homo sapiens 0-30 22298426-3 2012 Stromal interaction molecule 1 (Stim1), an internal calcium sensor of the endoplasmic reticulum store, promotes myogenesis via activation of NFATc3. Calcium 52-59 stromal interaction molecule 1 Homo sapiens 32-37 21876174-0 2011 Calcium store sensor stromal-interaction molecule 1-dependent signaling plays an important role in cervical cancer growth, migration, and angiogenesis. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 21-51 22260675-0 2012 Morphological and functional aspects of STIM1-dependent assembly and disassembly of store-operated calcium entry complexes. Calcium 99-106 stromal interaction molecule 1 Homo sapiens 40-45 22190180-1 2012 Stromal interaction molecule 1 (STIM1) deficiency is a rare genetic disorder of store-operated calcium entry, associated with a complex syndrome including immunodeficiency and immune dysregulation. Calcium 95-102 stromal interaction molecule 1 Homo sapiens 0-30 22190180-3 2012 We report two patients with a homozygous R429C point mutation in STIM1 completely abolishing store-operated calcium entry in T cells. Calcium 108-115 stromal interaction molecule 1 Homo sapiens 65-70 22201775-4 2012 Importantly, the ER calcium-sensor STIM1 has been shown to initiate SOCE via gating of SOCC. Calcium 20-27 stromal interaction molecule 1 Homo sapiens 35-40 21432868-0 2011 The calcium sensor STIM1 is regulated by androgens in prostate stromal cells. Calcium 4-11 stromal interaction molecule 1 Homo sapiens 19-24 21432868-12 2011 Androgens directly regulated STIM1 expression and STIM1 effects on store-operated calcium entry were inhibited by STIM1 knock-down. Calcium 82-89 stromal interaction molecule 1 Homo sapiens 50-55 21432868-12 2011 Androgens directly regulated STIM1 expression and STIM1 effects on store-operated calcium entry were inhibited by STIM1 knock-down. Calcium 82-89 stromal interaction molecule 1 Homo sapiens 50-55 21906591-3 2011 We confirmed the presence of SOCE and the expression of the calcium sensors STIM1 and STIM2, which convey information about the calcium load of the stores to channel proteins at the plasma membrane, in neurons and astrocytes. Calcium 60-67 stromal interaction molecule 1 Homo sapiens 76-81 21906591-3 2011 We confirmed the presence of SOCE and the expression of the calcium sensors STIM1 and STIM2, which convey information about the calcium load of the stores to channel proteins at the plasma membrane, in neurons and astrocytes. Calcium 128-135 stromal interaction molecule 1 Homo sapiens 76-81 22084111-3 2011 An ER calcium sensor, stromal interaction molecule 1 (STIM1), translocates within the ER membrane upon store depletion to the juxtaplasma membrane domain, where it interacts with intracellular domains of a highly calcium-selective plasma membrane ion channel, Orai1. Calcium 6-13 stromal interaction molecule 1 Homo sapiens 22-52 22084111-3 2011 An ER calcium sensor, stromal interaction molecule 1 (STIM1), translocates within the ER membrane upon store depletion to the juxtaplasma membrane domain, where it interacts with intracellular domains of a highly calcium-selective plasma membrane ion channel, Orai1. Calcium 6-13 stromal interaction molecule 1 Homo sapiens 54-59 22084111-4 2011 STIM1 gates Orai1, allowing calcium to enter the cytoplasm, where it repletes the ER store via calcium-ATPases pumps. Calcium 28-35 stromal interaction molecule 1 Homo sapiens 0-5 22065776-4 2011 We show that cells exposed to CD95L undergo a reorganization of the plasma membrane in which the Ca(2+) release-activated Ca(2+) channel Orai1 and the endoplasmic reticulum-resident activator stromal interaction molecule 1 colocalize with CD95 into a micrometer-sized cluster in which the channel elicits a polarized entry of calcium. Calcium 326-333 stromal interaction molecule 1 Homo sapiens 192-222 21786201-1 2011 The past five years have witnessed the discovery of the endoplasmic reticulum calcium (Ca(2+)) sensor STIM1 and the plasma membrane Ca(2+) channel Orai1 as the bona fide molecular components of the store-operated Ca(2+) entry (SOCE) and the Ca(2+) release-activated Ca(2+) current (I (CRAC)). Calcium 78-85 stromal interaction molecule 1 Homo sapiens 102-107 21670147-8 2011 Knockdown of STIM1 by short interfering RNA (siRNA) attenuates the calcium responses to hypoxia and subsequent AMPK phosphorylation, while inhibition of L-type calcium channels has no effect. Calcium 67-74 stromal interaction molecule 1 Homo sapiens 13-18 21565997-0 2011 TRPC1, STIM1, and ORAI influence signal-regulated intracellular and endoplasmic reticulum calcium dynamics in human myometrial cells. Calcium 90-97 stromal interaction molecule 1 Homo sapiens 7-12 21538465-8 2011 By triggering release of ER calcium with 3,5-dihydroxyphenylglycine (DHPG) or carbachol (Cch), agonists of type I metabotropic glutamate receptors (mGluR) and muscarinic acetylcholine receptors (mAChR), respectively, STIM1 was activated, and calcium entry (likely to represent SOCE) occurred in dendrites. Calcium 28-35 stromal interaction molecule 1 Homo sapiens 217-222 21880262-2 2011 Since then, STIM1 and ORAI1 have developed an ever increasing social network and to date are now linked to nine families of proteins involved in calcium signalling. Calcium 145-152 stromal interaction molecule 1 Homo sapiens 12-17 21880262-3 2011 As a result of this, STIM1 and ORAI1 are now involved in three separate calcium entry pathways, Icrac, Iarc (arachidonic regulated calcium current) and voltage-dependent channels. Calcium 72-79 stromal interaction molecule 1 Homo sapiens 21-26 21880262-4 2011 Physiopathological roles of STIM1 and ORAI1 were first described in the immunological system but, as main actors at the central node in the calcium signalling network, there are now clear evidences that mutations in genes coding STIM1 or ORAI1 interfere with several other diseases. Calcium 140-147 stromal interaction molecule 1 Homo sapiens 229-234 21053360-2 2011 However, recent works have accumulated evidences that STIM1 and STIM2 reside in endoplasmic reticulum (ER) and that both mainly sense ER Ca(2+) depletion, which plays an essential role in store operated calcium entry. Calcium 203-210 stromal interaction molecule 1 Homo sapiens 54-59 21713652-3 2011 Depletion of these stores activates influx of extracellular Ca(2+), usually referred to as store-operated calcium entry (SOCE), through the interaction of the Ca(2+)-sensor, stromal interacting molecule-1 (STIM1 ), in ER with Orai1(CRACM1) and transient receptor potential canonical (TRPC) channel proteins in the plasma membrane (PM). Calcium 106-113 stromal interaction molecule 1 Homo sapiens 174-204 21713652-3 2011 Depletion of these stores activates influx of extracellular Ca(2+), usually referred to as store-operated calcium entry (SOCE), through the interaction of the Ca(2+)-sensor, stromal interacting molecule-1 (STIM1 ), in ER with Orai1(CRACM1) and transient receptor potential canonical (TRPC) channel proteins in the plasma membrane (PM). Calcium 106-113 stromal interaction molecule 1 Homo sapiens 206-211 21176846-5 2011 The importance of store-operated calcium influx in muscle is confirmed in mice lacking STIM1 which die perinatally and in patients with mutations on STIM1 or Orai1 who exhibit a myopathy exhibited by hypotonia. Calcium 33-40 stromal interaction molecule 1 Homo sapiens 149-154 21353305-7 2011 STIM1 knock-down inhibited ER Ca(2+) uptake in intact but not in permeabilized cells, suggesting a privileged calcium entry-calcium refilling (CECR) coupling between plasma membrane SOC and ER calcium pump in the intact cell. Calcium 110-117 stromal interaction molecule 1 Homo sapiens 0-5 21353305-7 2011 STIM1 knock-down inhibited ER Ca(2+) uptake in intact but not in permeabilized cells, suggesting a privileged calcium entry-calcium refilling (CECR) coupling between plasma membrane SOC and ER calcium pump in the intact cell. Calcium 124-131 stromal interaction molecule 1 Homo sapiens 0-5 21901608-10 2011 Translocation of STIM1 and STIM2 from the endoplasmic reticulum to the plasma membrane is a key step in store operated calcium entry in the cell. Calcium 119-126 stromal interaction molecule 1 Homo sapiens 17-22 20729487-3 2010 STIM1 and STIM2 function as calcium sensors in the endoplasmic reticulum and can interact with and activate plasma membrane channels comprised of Orai1, Orai2, or Orai3 subunits. Calcium 28-35 stromal interaction molecule 1 Homo sapiens 0-5 21081754-1 2010 Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca(2+)) entry through plasma membrane Orai1 channels in response to decreased Ca(2+) concentrations in the endoplasmic reticulum lumen. Calcium 50-57 stromal interaction molecule 1 Homo sapiens 0-30 21081754-1 2010 Stromal interaction molecule 1 (STIM1) stimulates calcium ion (Ca(2+)) entry through plasma membrane Orai1 channels in response to decreased Ca(2+) concentrations in the endoplasmic reticulum lumen. Calcium 50-57 stromal interaction molecule 1 Homo sapiens 32-37 20952058-7 2010 Rapid access to single-cell calcium signals in large populations allowed us to precisely determine the relationship between SOCE activity and STIM1 levels, a key component of SOCE. Calcium 28-35 stromal interaction molecule 1 Homo sapiens 142-147 20929813-0 2010 The calcium store sensor, STIM1, reciprocally controls Orai and CaV1.2 channels. Calcium 4-11 stromal interaction molecule 1 Homo sapiens 26-31 20629634-0 2010 Evidence for an interaction between Golli and STIM1 in store-operated calcium entry. Calcium 70-77 stromal interaction molecule 1 Homo sapiens 46-51 20976103-5 2010 STIM1 is as an endoplasmic reticulum (ER) calcium sensor that has been shown to regulate store-operated Ca(2+) entry (SOCE). Calcium 42-49 stromal interaction molecule 1 Homo sapiens 0-5 20736304-0 2010 Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry. Calcium 73-80 stromal interaction molecule 1 Homo sapiens 19-24 20546784-2 2010 Calcium enters via ORAI1 as a mechanism to refill the sarcoplasmic/endoplasmic reticulum calcium stores, the depletion of which can be detected by the sensor protein STIM1. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 166-171 20546784-2 2010 Calcium enters via ORAI1 as a mechanism to refill the sarcoplasmic/endoplasmic reticulum calcium stores, the depletion of which can be detected by the sensor protein STIM1. Calcium 89-96 stromal interaction molecule 1 Homo sapiens 166-171 20149454-4 2010 Upon depletion of intracellular calcium stores, STIM1 (at the ER) and Orai (at the plasma membrane) aggregate into macromolecular complexes. Calcium 32-39 stromal interaction molecule 1 Homo sapiens 48-53 20392259-7 2010 Orai, through regulation by endoplasmic reticular store-sensing proteins, including Stim-1, may also mediate calcium influx and act as a signal amplifier for calcium release by other calcium channels. Calcium 109-116 stromal interaction molecule 1 Homo sapiens 84-90 20392259-7 2010 Orai, through regulation by endoplasmic reticular store-sensing proteins, including Stim-1, may also mediate calcium influx and act as a signal amplifier for calcium release by other calcium channels. Calcium 158-165 stromal interaction molecule 1 Homo sapiens 84-90 20347143-1 2010 STIM1 and Orai1 are the main players in capacitative calcium entry (CCE). Calcium 53-60 stromal interaction molecule 1 Homo sapiens 0-5 19327826-3 2009 The stromal interacting molecule (STIM1) has been recently identified as the calcium sensor located at the endoplasmic reticulum (ER), and responsible for communicating the deplete state of calcium stores to Orai at the plasma membrane (PM). Calcium 77-84 stromal interaction molecule 1 Homo sapiens 34-39 19754895-1 2009 In the last few years, great progress has been made in understanding how stromal interacting molecule 1 (STIM1), a protein containing a calcium sensor that is located in the endoplasmic reticulum, and Orai1, a protein that forms a calcium channel in the plasma membrane, interact and give rise to store-operated calcium entry. Calcium 136-143 stromal interaction molecule 1 Homo sapiens 73-103 19754895-1 2009 In the last few years, great progress has been made in understanding how stromal interacting molecule 1 (STIM1), a protein containing a calcium sensor that is located in the endoplasmic reticulum, and Orai1, a protein that forms a calcium channel in the plasma membrane, interact and give rise to store-operated calcium entry. Calcium 136-143 stromal interaction molecule 1 Homo sapiens 105-110 19754895-1 2009 In the last few years, great progress has been made in understanding how stromal interacting molecule 1 (STIM1), a protein containing a calcium sensor that is located in the endoplasmic reticulum, and Orai1, a protein that forms a calcium channel in the plasma membrane, interact and give rise to store-operated calcium entry. Calcium 231-238 stromal interaction molecule 1 Homo sapiens 105-110 19754897-0 2009 Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells. Calcium 61-68 stromal interaction molecule 1 Homo sapiens 46-51 19754903-2 2009 During the past few years, important details have been revealed about the mechanism of store-operated calcium entry in lymphocytes, including the molecular identity of calcium release-activated calcium (CRAC) channels and the endoplasmic reticulum (ER) calcium sensor (STIM1) responsible for CRAC channel activation following calcium depletion of stores. Calcium 102-109 stromal interaction molecule 1 Homo sapiens 269-274 19696927-8 2009 The spatial pattern of store-operated calcium entry in cones matched immunolocalization of the store-operated sensor STIM1. Calcium 38-45 stromal interaction molecule 1 Homo sapiens 117-122 20149454-2 2010 The recent identification of STIM1 as the putative sensing molecule responsible for communicating the depleted state of intracellular calcium stores to the plasma membrane channel highlights the relevance of protein complexes in calcium signaling. Calcium 134-141 stromal interaction molecule 1 Homo sapiens 29-34 20149454-2 2010 The recent identification of STIM1 as the putative sensing molecule responsible for communicating the depleted state of intracellular calcium stores to the plasma membrane channel highlights the relevance of protein complexes in calcium signaling. Calcium 229-236 stromal interaction molecule 1 Homo sapiens 29-34 19622395-0 2009 Plasma membrane associated membranes (PAM) from Jurkat cells contain STIM1 protein is PAM involved in the capacitative calcium entry? Calcium 119-126 stromal interaction molecule 1 Homo sapiens 69-74 19881501-0 2009 Phosphorylation of STIM1 underlies suppression of store-operated calcium entry during mitosis. Calcium 65-72 stromal interaction molecule 1 Homo sapiens 19-24 19765994-0 2009 STIM1 is a calcium sensor specialized for digital signaling. Calcium 11-18 stromal interaction molecule 1 Homo sapiens 0-5 19765994-4 2009 This influx occurs through a process known as store-operated calcium entry, which is initiated by calcium sensor proteins, STIM1 and STIM2, in the endoplasmic reticulum [3]. Calcium 61-68 stromal interaction molecule 1 Homo sapiens 123-128 19765994-4 2009 This influx occurs through a process known as store-operated calcium entry, which is initiated by calcium sensor proteins, STIM1 and STIM2, in the endoplasmic reticulum [3]. Calcium 98-105 stromal interaction molecule 1 Homo sapiens 123-128 19765994-5 2009 STIM2 is activated by changes in endoplasmic reticulum calcium near the resting level, whereas a threshold of calcium depletion is required for STIM1 activation [4]. Calcium 110-117 stromal interaction molecule 1 Homo sapiens 144-149 19765994-6 2009 Here we show that, surprisingly, it is STIM1 and not STIM2 that is exclusively involved in calcium entry during calcium oscillations. Calcium 91-98 stromal interaction molecule 1 Homo sapiens 39-44 19765994-6 2009 Here we show that, surprisingly, it is STIM1 and not STIM2 that is exclusively involved in calcium entry during calcium oscillations. Calcium 112-119 stromal interaction molecule 1 Homo sapiens 39-44 19483082-0 2009 Dependence of STIM1/Orai1-mediated calcium entry on plasma membrane phosphoinositides. Calcium 35-42 stromal interaction molecule 1 Homo sapiens 14-19 19483082-1 2009 Recent studies identified two main components of store-operated calcium entry (SOCE): the endoplasmic reticulum-localized Ca2+ sensor protein, STIM1, and the plasma membrane (PM)-localized Ca2+ channel, Orai1/CRACM1. Calcium 64-71 stromal interaction molecule 1 Homo sapiens 143-148 19630797-4 2009 Furthermore, we summarize work that lead to the discovery of STIM1 and Orai1 as key regulators of store-operated calcium entry (SOCE) in platelets. Calcium 113-120 stromal interaction molecule 1 Homo sapiens 61-66 19327826-3 2009 The stromal interacting molecule (STIM1) has been recently identified as the calcium sensor located at the endoplasmic reticulum (ER), and responsible for communicating the deplete state of calcium stores to Orai at the plasma membrane (PM). Calcium 190-197 stromal interaction molecule 1 Homo sapiens 34-39 19327826-4 2009 However, recent experimental findings suggest that Orai and STIM1 are only part of a larger molecular complex required to modulate store-operated calcium entry (SOCE). Calcium 146-153 stromal interaction molecule 1 Homo sapiens 60-65 19327826-6 2009 Using FRET imaging we show that under resting conditions (with calcium stores replenished) STIM1 travels continuously through the ER associated to the microtubule tracking protein, EB1. Calcium 63-70 stromal interaction molecule 1 Homo sapiens 91-96 19327826-12 2009 Replenishing intracellular calcium stores induces STIM1-Orai complex dissociation and shuts down inward currents. Calcium 27-34 stromal interaction molecule 1 Homo sapiens 50-55 19019825-1 2009 Stromal interaction molecules (STIM) 1 and STIM2 are regulators of store-operated calcium (Ca(2+)) entry as well as basal cytoplasmic Ca(2+) levels in human cells. Calcium 82-89 stromal interaction molecule 1 Homo sapiens 0-38 19338771-6 2009 Although the latter observation is correlative and needs additional confirmation it may suggest that deglycosylation of STIM1 protein deprives store-operated calcium entry system of an important regulatory mechanism. Calcium 158-165 stromal interaction molecule 1 Homo sapiens 120-125 18941110-3 2009 Here we show that macrophages lacking the endoplasmic reticulum-resident calcium sensor, STIM1, cannot activate FcgammaR-induced Ca(2+) entry and phagocytosis. Calcium 73-80 stromal interaction molecule 1 Homo sapiens 89-94 19088073-0 2009 STIM1- and Orai1-dependent store-operated calcium entry regulates human myoblast differentiation. Calcium 42-49 stromal interaction molecule 1 Homo sapiens 0-5 19088738-5 2009 The identification of two important molecular components of SOC channels, CRACM1 (the pore-forming subunit) and STIM1 (the sensor of stored calcium), has allowed genetic and molecular manipulation of the SOC entry pathway. Calcium 140-147 stromal interaction molecule 1 Homo sapiens 112-117 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 79-86 stromal interaction molecule 1 Homo sapiens 0-5 18854159-0 2008 Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry. Calcium 85-92 stromal interaction molecule 1 Homo sapiens 41-46 18448669-0 2008 Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps. Calcium 24-31 stromal interaction molecule 1 Homo sapiens 39-44 18484746-1 2008 Translocation of STIM1 and STIM2 from the endoplasmic reticulum to the plasma membrane is a key step in store-operated calcium entry in the cell. Calcium 119-126 stromal interaction molecule 1 Homo sapiens 17-22 18484746-2 2008 We show by isothermal titration calorimetry that calmodulin binds in a calcium-dependent manner to the polybasic C-termini of STIM1 and STIM2, a region critical for their translocation to the plasma membrane ( K D < or = 1 microM in calcium). Calcium 71-78 stromal interaction molecule 1 Homo sapiens 126-131 18484746-2 2008 We show by isothermal titration calorimetry that calmodulin binds in a calcium-dependent manner to the polybasic C-termini of STIM1 and STIM2, a region critical for their translocation to the plasma membrane ( K D < or = 1 microM in calcium). Calcium 236-243 stromal interaction molecule 1 Homo sapiens 126-131 18337241-0 2008 Novel role for STIM1 as a trigger for calcium influx factor production. Calcium 38-45 stromal interaction molecule 1 Homo sapiens 15-20 18337241-2 2008 Here we focus on the early ER-delimited steps of the SOCE pathway and demonstrate that STIM1 is critically involved in initiating of production of calcium influx factor (CIF), a diffusible messenger that can deliver the signal from the stores to plasma membrane and activate SOCE. Calcium 147-154 stromal interaction molecule 1 Homo sapiens 87-92 19172794-0 2008 [Regulation of store-operated calcium entry by STIM1]. Calcium 30-37 stromal interaction molecule 1 Homo sapiens 47-52 18542992-1 2008 Depletion of the endoplasmic reticulum (ER) calcium store triggers translocation of stromal interacting molecule one (STIM1) to the sub-plasmalemmal region and formation of puncta-structures in which STIM1 interacts and activates calcium channels. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 118-123 18542992-1 2008 Depletion of the endoplasmic reticulum (ER) calcium store triggers translocation of stromal interacting molecule one (STIM1) to the sub-plasmalemmal region and formation of puncta-structures in which STIM1 interacts and activates calcium channels. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 200-205 18802022-1 2008 Stromal interaction molecule 1 (STIM1) is a predicted single membrane-spanning protein involved in store-operated calcium entry and interacting with ion channels including TRPC1. Calcium 114-121 stromal interaction molecule 1 Homo sapiens 0-30 18802022-1 2008 Stromal interaction molecule 1 (STIM1) is a predicted single membrane-spanning protein involved in store-operated calcium entry and interacting with ion channels including TRPC1. Calcium 114-121 stromal interaction molecule 1 Homo sapiens 32-37 18802022-2 2008 Here, we focus on endogenous STIM1 of modulated vascular smooth muscle cells, which exhibited a nonselective cationic current in response to store depletion despite strong buffering of intracellular calcium at the physiological concentration. Calcium 199-206 stromal interaction molecule 1 Homo sapiens 29-34 18802022-4 2008 Calcium entry evoked by store depletion was partially inhibited by STIM1 short interfering RNA, whereas calcium release was unaffected. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 67-72 18802022-8 2008 STIM1 interacted with TRPC1, and TRPC1 contributed partially to calcium entry and cationic current. Calcium 64-71 stromal interaction molecule 1 Homo sapiens 0-5 18596693-0 2008 Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation. Calcium 36-43 stromal interaction molecule 1 Homo sapiens 19-24 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 79-86 stromal interaction molecule 1 Homo sapiens 183-188 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 105-112 stromal interaction molecule 1 Homo sapiens 0-5 18187424-1 2008 STIM1 and ORAI1 (also termed CRACM1) are essential components of the classical calcium release-activated calcium current; however, the mechanism of the transmission of information of STIM1 to the calcium release-activated calcium/ORAI1 channel is as yet unknown. Calcium 105-112 stromal interaction molecule 1 Homo sapiens 183-188 17299780-0 2007 Agonist-induced calcium entry correlates with STIM1 translocation. Calcium 16-23 stromal interaction molecule 1 Homo sapiens 46-51 17702753-5 2007 Amino acids 425-671 of STIM1, which contain a serine-proline-rich region, are important for the correct targeting of the STIM1 cluster to the cell periphery after calcium store depletion. Calcium 163-170 stromal interaction molecule 1 Homo sapiens 23-28 17702753-5 2007 Amino acids 425-671 of STIM1, which contain a serine-proline-rich region, are important for the correct targeting of the STIM1 cluster to the cell periphery after calcium store depletion. Calcium 163-170 stromal interaction molecule 1 Homo sapiens 121-126 18059272-0 2008 Essential function for the calcium sensor STIM1 in mast cell activation and anaphylactic responses. Calcium 27-34 stromal interaction molecule 1 Homo sapiens 42-47 17382385-6 2007 However, the functional significance of the cellular localisation of STIM1 and its domain structure only became evident after recent breakthrough research identified STIM1 as a key regulator of store-operated calcium (SOC) entry into cells. Calcium 209-216 stromal interaction molecule 1 Homo sapiens 69-74 17382385-6 2007 However, the functional significance of the cellular localisation of STIM1 and its domain structure only became evident after recent breakthrough research identified STIM1 as a key regulator of store-operated calcium (SOC) entry into cells. Calcium 209-216 stromal interaction molecule 1 Homo sapiens 166-171 34564947-1 2021 Store-operated Ca2+ entry (SOCE) machinery, including Orai channels, TRPCs, and STIM1, is key to cellular calcium homeostasis. Calcium 106-113 stromal interaction molecule 1 Homo sapiens 80-85 17224452-0 2007 Dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in store-operated calcium influx. Calcium 84-91 stromal interaction molecule 1 Homo sapiens 26-31 25558393-4 2014 Calcium sensor, STIM1, is required for activation of store-operated calcium entry in these cells. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 16-21 25558393-4 2014 Calcium sensor, STIM1, is required for activation of store-operated calcium entry in these cells. Calcium 68-75 stromal interaction molecule 1 Homo sapiens 16-21 23662438-2 2012 Discovery of STIM1 and STIM2 proteins located in the endoplasmic reticulum (ER) and playing a role of sensors of calcium, led to our understanding how the calcium signal from ER is propagated to calcium release-activated calcium channels (CRAC) located in the plasma membrane, resulting in their activation, flow of calcium into a cytoplasm and activation of calcium-dependent signaling. Calcium 113-120 stromal interaction molecule 1 Homo sapiens 13-18 23662438-2 2012 Discovery of STIM1 and STIM2 proteins located in the endoplasmic reticulum (ER) and playing a role of sensors of calcium, led to our understanding how the calcium signal from ER is propagated to calcium release-activated calcium channels (CRAC) located in the plasma membrane, resulting in their activation, flow of calcium into a cytoplasm and activation of calcium-dependent signaling. Calcium 155-162 stromal interaction molecule 1 Homo sapiens 13-18 23662438-2 2012 Discovery of STIM1 and STIM2 proteins located in the endoplasmic reticulum (ER) and playing a role of sensors of calcium, led to our understanding how the calcium signal from ER is propagated to calcium release-activated calcium channels (CRAC) located in the plasma membrane, resulting in their activation, flow of calcium into a cytoplasm and activation of calcium-dependent signaling. Calcium 155-162 stromal interaction molecule 1 Homo sapiens 13-18 23662438-2 2012 Discovery of STIM1 and STIM2 proteins located in the endoplasmic reticulum (ER) and playing a role of sensors of calcium, led to our understanding how the calcium signal from ER is propagated to calcium release-activated calcium channels (CRAC) located in the plasma membrane, resulting in their activation, flow of calcium into a cytoplasm and activation of calcium-dependent signaling. Calcium 155-162 stromal interaction molecule 1 Homo sapiens 13-18 34757454-4 2022 Intracellular calcium (Ca2+) homeostasis is regulated, among other mechanisms, by the calcium sensor stromal interaction molecule 1 (STIM1) and calcium release-activated calcium modulator (ORAI) members, which mediate the store-operated Ca2+ entry (SOCE). Calcium 14-21 stromal interaction molecule 1 Homo sapiens 101-131 34757454-4 2022 Intracellular calcium (Ca2+) homeostasis is regulated, among other mechanisms, by the calcium sensor stromal interaction molecule 1 (STIM1) and calcium release-activated calcium modulator (ORAI) members, which mediate the store-operated Ca2+ entry (SOCE). Calcium 14-21 stromal interaction molecule 1 Homo sapiens 133-138 34757454-4 2022 Intracellular calcium (Ca2+) homeostasis is regulated, among other mechanisms, by the calcium sensor stromal interaction molecule 1 (STIM1) and calcium release-activated calcium modulator (ORAI) members, which mediate the store-operated Ca2+ entry (SOCE). Calcium 86-93 stromal interaction molecule 1 Homo sapiens 101-131 34757454-4 2022 Intracellular calcium (Ca2+) homeostasis is regulated, among other mechanisms, by the calcium sensor stromal interaction molecule 1 (STIM1) and calcium release-activated calcium modulator (ORAI) members, which mediate the store-operated Ca2+ entry (SOCE). Calcium 86-93 stromal interaction molecule 1 Homo sapiens 133-138 34363007-5 2021 Further study revealed that PIM suppressed STIM1 puncta formation to inhibit store-operated calcium entry (SOCE) and subsequent NFAT activity. Calcium 92-99 stromal interaction molecule 1 Homo sapiens 43-48 34592581-1 2021 Stromal interaction molecule 1 (STIM1), as a dynamic calcium signal transducer and key regulator of cardiomyocyte Ca2+ homeostasis, has been implicated in various pathological processes related to sudden cardiac death originated from coronary artery disease (SCD-CAD). Calcium 53-60 stromal interaction molecule 1 Homo sapiens 0-30 34592581-1 2021 Stromal interaction molecule 1 (STIM1), as a dynamic calcium signal transducer and key regulator of cardiomyocyte Ca2+ homeostasis, has been implicated in various pathological processes related to sudden cardiac death originated from coronary artery disease (SCD-CAD). Calcium 53-60 stromal interaction molecule 1 Homo sapiens 32-37 34685684-0 2021 Apoptotic Cells Trigger Calcium Entry in Phagocytes by Inducing the Orai1-STIM1 Association. Calcium 24-31 stromal interaction molecule 1 Homo sapiens 74-79 34685684-3 2021 Here, using biophysical, biochemical, pharmaceutical, and genetic approaches, we show that apoptotic cells induced the Orai1-STIM1 interaction, leading to store-operated calcium entry (SOCE) in phagocytes through the Mertk-phospholipase C (PLC) gamma1-inositol 1,4,5-triphosphate receptor (IP3R) axis. Calcium 170-177 stromal interaction molecule 1 Homo sapiens 125-130 34685684-4 2021 Apoptotic cells induced calcium release from the endoplasmic reticulum, which led to the Orai1-STIM1 association and, consequently, SOCE in phagocytes. Calcium 24-31 stromal interaction molecule 1 Homo sapiens 95-100 34498097-1 2021 The calcium release-activated calcium (CRAC) channel consists of STIM1, a Ca2+ sensor in the endoplasmic reticulum (ER), and Orai1, the Ca2+ ion channel in the plasma membrane. Calcium 4-11 stromal interaction molecule 1 Homo sapiens 65-70 34498097-1 2021 The calcium release-activated calcium (CRAC) channel consists of STIM1, a Ca2+ sensor in the endoplasmic reticulum (ER), and Orai1, the Ca2+ ion channel in the plasma membrane. Calcium 30-37 stromal interaction molecule 1 Homo sapiens 65-70 17343823-2 2007 Recently, human Orai1 (the channel-forming subunit) and STIM1 (the calcium sensor) were identified as essential molecules for SOCE. Calcium 67-74 stromal interaction molecule 1 Homo sapiens 56-61 17218358-0 2007 Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. Calcium 27-34 stromal interaction molecule 1 Homo sapiens 50-55 17218358-0 2007 Role of the store-operated calcium entry proteins Stim1 and Orai1 in muscarinic cholinergic receptor-stimulated calcium oscillations in human embryonic kidney cells. Calcium 112-119 stromal interaction molecule 1 Homo sapiens 50-55 16807233-0 2006 Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. Calcium 21-28 stromal interaction molecule 1 Homo sapiens 126-131 16807233-0 2006 Large store-operated calcium selective currents due to co-expression of Orai1 or Orai2 with the intracellular calcium sensor, Stim1. Calcium 110-117 stromal interaction molecule 1 Homo sapiens 126-131 34979330-7 2022 The findings provide insight into the pathophysiology of muscle diseases linked to disturbances in STIM1-dependent calcium handling. Calcium 115-122 stromal interaction molecule 1 Homo sapiens 99-104 34730514-0 2021 Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1. Calcium 53-60 stromal interaction molecule 1 Homo sapiens 68-73 34417953-1 2021 The protein stromal interaction molecule 1 (STIM1) plays a pivotal role in mediating store-operated calcium entry (SOCE) into cells, which is essential for adaptive immunity. Calcium 100-107 stromal interaction molecule 1 Homo sapiens 12-42 34417953-1 2021 The protein stromal interaction molecule 1 (STIM1) plays a pivotal role in mediating store-operated calcium entry (SOCE) into cells, which is essential for adaptive immunity. Calcium 100-107 stromal interaction molecule 1 Homo sapiens 44-49 34417953-7 2021 This domain is crucial for the stabilisation of the tight quiescent form of STIM1 as well as for activating the ORAI calcium channel by direct contact, in the extended active form. Calcium 117-124 stromal interaction molecule 1 Homo sapiens 76-81 34939697-0 2022 ORAI1 regulates sustained cytosolic free calcium fluctuations during breast cancer cell apoptosis and apoptotic resistance via a STIM1 independent pathway. Calcium 41-48 stromal interaction molecule 1 Homo sapiens 129-134 34685498-0 2021 Plasma Membrane and Organellar Targets of STIM1 for Intracellular Calcium Handling in Health and Neurodegenerative Diseases. Calcium 66-73 stromal interaction molecule 1 Homo sapiens 42-47 34155535-1 2021 Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. Calcium 53-60 stromal interaction molecule 1 Homo sapiens 32-37 34155535-1 2021 Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. Calcium 92-99 stromal interaction molecule 1 Homo sapiens 0-30 34155535-1 2021 Stromal interaction molecule 1 (STIM1) and the ORAI1 calcium channel mediate store-operated calcium entry (SOCE) and regulate a multitude of cellular functions. Calcium 92-99 stromal interaction molecule 1 Homo sapiens 32-37 35395520-1 2022 The family of stromal interaction molecules (STIMs), comprising the homologs STIM1 and STIM2 with their different isoforms, has an intricate role in cellular calcium (Ca2+) homeostasis and signal transduction. Calcium 158-165 stromal interaction molecule 1 Homo sapiens 77-82 35151050-1 2022 Store-operated calcium entry (SOCE) is mediated by the endoplasmic reticulum (ER) Ca2+ sensors stromal interaction molecules (STIM1 and STIM2) and the plasma membrane Orai (Orai1, Orai2, Orai3) Ca2+ channels. Calcium 15-22 stromal interaction molecule 1 Homo sapiens 126-131 35151051-1 2022 Loss of function mutations in one of the core components of the calcium release-activated calcium (CRAC) channel complex, STIM1 and ORAI1, lead to severe immunodeficiency. Calcium 64-71 stromal interaction molecule 1 Homo sapiens 122-127 35151051-1 2022 Loss of function mutations in one of the core components of the calcium release-activated calcium (CRAC) channel complex, STIM1 and ORAI1, lead to severe immunodeficiency. Calcium 90-97 stromal interaction molecule 1 Homo sapiens 122-127 35254656-3 2022 Orai1 is a major calcium channel in the cell membrane of non-excitable cells, and its activity depends on the stromal interaction molecule 1 (Stim1). Calcium 17-24 stromal interaction molecule 1 Homo sapiens 110-140 35254656-3 2022 Orai1 is a major calcium channel in the cell membrane of non-excitable cells, and its activity depends on the stromal interaction molecule 1 (Stim1). Calcium 17-24 stromal interaction molecule 1 Homo sapiens 142-147 35254656-4 2022 Several groups reported that the store-operated calcium entry (SOCE) can be modulated through phosphorylation of Stim1 by protein kinases such as extracellular signal-regulated kinase (ERK), protein kinase A (PKA), and p21-activated kinase (PAK). Calcium 48-55 stromal interaction molecule 1 Homo sapiens 113-118 35254656-6 2022 OBJECTIVES: Here, we investigated whether PKC-beta controls intracellular calcium dynamics through Stim1. Calcium 74-81 stromal interaction molecule 1 Homo sapiens 99-104 35254656-8 2022 Intracellular calcium mobilization, via Stim1 mediated SOCE channel, were studied using in the presence of PKC activator or inhibitor under a confocal microscope. Calcium 14-21 stromal interaction molecule 1 Homo sapiens 40-45 35439114-7 2022 The phosphorylation of STIM1 by DYRK2 substantially increased the interaction of STIM1 with the ORAI1 channel, and C17 impeded the store-operated calcium entry process. Calcium 146-153 stromal interaction molecule 1 Homo sapiens 23-28 35439114-7 2022 The phosphorylation of STIM1 by DYRK2 substantially increased the interaction of STIM1 with the ORAI1 channel, and C17 impeded the store-operated calcium entry process. Calcium 146-153 stromal interaction molecule 1 Homo sapiens 81-86 35418597-6 2022 siRNA mediated knockdown (KD) of obligate calcium sensors STIM1 and STIM2 decreased the magnitude of muscarinic agonist induced oscillatory calcium release and attenuated SOCE in hOPCs. Calcium 42-49 stromal interaction molecule 1 Homo sapiens 58-63 35418597-6 2022 siRNA mediated knockdown (KD) of obligate calcium sensors STIM1 and STIM2 decreased the magnitude of muscarinic agonist induced oscillatory calcium release and attenuated SOCE in hOPCs. Calcium 140-147 stromal interaction molecule 1 Homo sapiens 58-63 35076181-1 2022 Deregulated store-operated calcium entry (SOCE) mediated by aberrant STIM1-ORAI1 signaling is closely implicated in cancer initiation and progression. Calcium 27-34 stromal interaction molecule 1 Homo sapiens 69-74 35571434-12 2022 The abnormal polarization of the neutrophils from the COPD patients was altered by the influence of store-operated calcium entry (SOCE) component matrix interaction molecules 1 and 2 and calcium release-activated calcium channel protein 1 (stromal interaction molecule 1 (STIM1), Stromal interaction molecule 2 (STIM2), and calcium release-activated calcium modulator 1 (ORAI1)). Calcium 115-122 stromal interaction molecule 1 Homo sapiens 272-277 35392575-2 2022 We further confirmed that melatonin promotes an increase in intracellular calcium concentrations through the STIM1/ORAI1 pathway, thereby inducing the proliferation of osteoblasts. Calcium 74-81 stromal interaction molecule 1 Homo sapiens 109-114 35392575-12 2022 Melatonin promotes an increase in intracellular calcium ion concentrations through the STIM1/ORAI1 pathway to induce osteoblast proliferation. Calcium 48-55 stromal interaction molecule 1 Homo sapiens 87-92 35636153-1 2022 Gain-of-function mutations on STIM1 and ORAI1 genes are responsible for an increased store-operated calcium entry, and underlie the characteristic symptoms of three overlapping ultra-rare genetic disorders (i.e tubular aggregate myopathy, Stormorken syndrome, York platelet syndrome) that can be grouped as tubular aggregate myopathies. Calcium 100-107 stromal interaction molecule 1 Homo sapiens 30-35 33850559-0 2021 Resveratrol sensitizes A549 cells to irradiation damage via suppression of store-operated calcium entry with Orai1 and STIM1 downregulation. Calcium 90-97 stromal interaction molecule 1 Homo sapiens 119-124 33713955-0 2021 STIM1 Regulates Endothelial Calcium Overload and Cytokine Upregulation During Sepsis. Calcium 28-35 stromal interaction molecule 1 Homo sapiens 0-5 33713955-1 2021 BACKGROUND: Stromal interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) is now recognized as the main mechanism of the majority of nonexcitable cell calcium influx. Calcium 170-177 stromal interaction molecule 1 Homo sapiens 12-42 33713955-1 2021 BACKGROUND: Stromal interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) is now recognized as the main mechanism of the majority of nonexcitable cell calcium influx. Calcium 170-177 stromal interaction molecule 1 Homo sapiens 44-49 33713955-3 2021 Whether STIM1-mediated SOCE plays a role in calcium overload in vascular endothelial cell injury remains unclear. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 8-13 33713955-7 2021 Meanwhile, similar to the blocking effect of the specific SOC inhibitors Gd3+ and La3+ on LPS-induced calcium influx, RNAi-mediated depletion of STIM1 or the SOC proteins TRPC1 and ORAI1 could significantly inhibit serum or LPS-induced extracellular calcium influx, as well as the expression of the inflammatory cytokines tumor necrosis factor, intercellular cell adhesion molecule-1, and endothelin-1. Calcium 250-257 stromal interaction molecule 1 Homo sapiens 145-150 33436389-10 2021 It further reveals the potential benefit of targeting STIM1-controlled calcium signaling and its downstream effectors in PDAC. Calcium 71-78 stromal interaction molecule 1 Homo sapiens 54-59 34015095-3 2021 Upon store depletion, stromal interaction molecule 1 (STIM1), an ER calcium sensor relocates into discrete puncta at the ER-plasma membrane junction region, which results in the coupling of Ca2+ channels to initiate SOCE. Calcium 68-75 stromal interaction molecule 1 Homo sapiens 22-52 34015095-3 2021 Upon store depletion, stromal interaction molecule 1 (STIM1), an ER calcium sensor relocates into discrete puncta at the ER-plasma membrane junction region, which results in the coupling of Ca2+ channels to initiate SOCE. Calcium 68-75 stromal interaction molecule 1 Homo sapiens 54-59 33733462-1 2021 STIM1, the stromal interaction molecule 1, is the key protein for maintaining calcium concentration in the endoplasmic reticulum by triggering the Store Operated Calcium Entry (SOCE). Calcium 78-85 stromal interaction molecule 1 Homo sapiens 0-5 33733462-1 2021 STIM1, the stromal interaction molecule 1, is the key protein for maintaining calcium concentration in the endoplasmic reticulum by triggering the Store Operated Calcium Entry (SOCE). Calcium 78-85 stromal interaction molecule 1 Homo sapiens 11-41 33733462-1 2021 STIM1, the stromal interaction molecule 1, is the key protein for maintaining calcium concentration in the endoplasmic reticulum by triggering the Store Operated Calcium Entry (SOCE). Calcium 162-169 stromal interaction molecule 1 Homo sapiens 0-5 33733462-1 2021 STIM1, the stromal interaction molecule 1, is the key protein for maintaining calcium concentration in the endoplasmic reticulum by triggering the Store Operated Calcium Entry (SOCE). Calcium 162-169 stromal interaction molecule 1 Homo sapiens 11-41 33718371-3 2021 TAM is caused by gain-of-function mutations in STIM1 or ORAI1, proteins responsible for Store-Operated-Calcium-Entry (SOCE), a pivotal mechanism in Ca2+ signaling. Calcium 103-110 stromal interaction molecule 1 Homo sapiens 47-52 33644073-1 2021 STIM1-mediated activation of calcium selective Orai channels is fundamental for life. Calcium 29-36 stromal interaction molecule 1 Homo sapiens 0-5 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 62-69 stromal interaction molecule 1 Homo sapiens 223-253 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 62-69 stromal interaction molecule 1 Homo sapiens 255-260 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 120-127 stromal interaction molecule 1 Homo sapiens 223-253 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 120-127 stromal interaction molecule 1 Homo sapiens 255-260 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 120-127 stromal interaction molecule 1 Homo sapiens 223-253 33937254-3 2021 A key effector downstream of PDGF receptors is store-operated calcium entry (SOCE) mediated through the plasma membrane calcium ion channel, ORAI1, which is activated by the endoplasmic reticulum (ER) calcium store sensor, stromal interaction molecule-1 (STIM1). Calcium 120-127 stromal interaction molecule 1 Homo sapiens 255-260 33867841-0 2021 3,3"-Diindolylmethane induces gastric cancer cells death via STIM1 mediated store-operated calcium entry. Calcium 91-98 stromal interaction molecule 1 Homo sapiens 61-66 33730587-6 2021 In conjunction with altered STIM1 splicing in human Alzheimer disease, our findings highlight STIM1 splicing as an important regulator of neuronal calcium homeostasis and of synaptic plasticity. Calcium 147-154 stromal interaction molecule 1 Homo sapiens 94-99 33468626-4 2021 This event was mediated by altered STIM1-sarco/endoplasmic reticulum calcium transport ATPase (SERCA) conformational change and enhanced SERCA pump activity leading to increased Store Operated Calcium Entry (SOCE). Calcium 69-76 stromal interaction molecule 1 Homo sapiens 35-40 33468626-4 2021 This event was mediated by altered STIM1-sarco/endoplasmic reticulum calcium transport ATPase (SERCA) conformational change and enhanced SERCA pump activity leading to increased Store Operated Calcium Entry (SOCE). Calcium 193-200 stromal interaction molecule 1 Homo sapiens 35-40 33106661-1 2021 The calcium release activated calcium channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. Calcium 4-11 stromal interaction molecule 1 Homo sapiens 120-125 33106661-1 2021 The calcium release activated calcium channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. Calcium 30-37 stromal interaction molecule 1 Homo sapiens 120-125 33106661-1 2021 The calcium release activated calcium channel is activated by the endoplasmic reticulum-resident calcium sensor protein STIM1. Calcium 30-37 stromal interaction molecule 1 Homo sapiens 120-125 33436389-0 2021 STIM1 Mediates Calcium-dependent Epigenetic Reprogramming in Pancreatic Cancer. Calcium 15-22 stromal interaction molecule 1 Homo sapiens 0-5 33436389-6 2021 Interestingly, RRM1, but not STIM1, was required for gemcitabine resistance, while high STIM1 levels caused an increase in cytosolic calcium concentration. Calcium 133-140 stromal interaction molecule 1 Homo sapiens 88-93 33436389-7 2021 Higher STIM1-dependent calcium influx led to an impaired ER stress response and a heightened NFAT activity. Calcium 23-30 stromal interaction molecule 1 Homo sapiens 7-12 33436389-9 2021 Taken together, our study uncovers previously unknown biologically relevant molecular properties of gemcitabine-resistant tumors, revealing an undescribed function of STIM1 as a rheostat directing the effects of calcium signaling and controlling epigenetic cell fate determination. Calcium 212-219 stromal interaction molecule 1 Homo sapiens 167-172 33469426-0 2020 Calcium Sensors STIM1 and STIM2 Regulate Different Calcium Functions in Cultured Hippocampal Neurons. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 16-21 33469426-0 2020 Calcium Sensors STIM1 and STIM2 Regulate Different Calcium Functions in Cultured Hippocampal Neurons. Calcium 51-58 stromal interaction molecule 1 Homo sapiens 16-21 33469426-5 2020 STIM1 mobility is associated with spontaneous calcium sparks, local transient rise in cytosolic [Ca2+]i, and in the formation and elongation of dendritic filopodia/spines. Calcium 46-53 stromal interaction molecule 1 Homo sapiens 0-5 33127334-5 2021 Our previous work had proved that LPS-induced cell injury was associated with store-operated calcium (SOC) entry mediated by stromal interaction molecule-1 (STIM 1) in Human umbilical vein endothelial cells (HUVEC), but the underlying molecular mechanism has not been adequately defined. Calcium 93-100 stromal interaction molecule 1 Homo sapiens 125-155 33127334-5 2021 Our previous work had proved that LPS-induced cell injury was associated with store-operated calcium (SOC) entry mediated by stromal interaction molecule-1 (STIM 1) in Human umbilical vein endothelial cells (HUVEC), but the underlying molecular mechanism has not been adequately defined. Calcium 93-100 stromal interaction molecule 1 Homo sapiens 157-163 32882268-5 2020 SOCC are regulated by Orai-1, Orai-2 and Orai-3 located on plasma membrane and two calcium-sensing ER membrane proteins known as stromal interaction molecules (STIM-1 and STIM-2). Calcium 83-90 stromal interaction molecule 1 Homo sapiens 160-166 33348924-4 2020 Stromal interaction molecule 1 (STIM1) is a calcium sensor in the endoplasmic reticulum, triggering the activation of store-operated calcium signaling. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 0-30 33348924-4 2020 Stromal interaction molecule 1 (STIM1) is a calcium sensor in the endoplasmic reticulum, triggering the activation of store-operated calcium signaling. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 32-37 33348924-4 2020 Stromal interaction molecule 1 (STIM1) is a calcium sensor in the endoplasmic reticulum, triggering the activation of store-operated calcium signaling. Calcium 133-140 stromal interaction molecule 1 Homo sapiens 0-30 33348924-4 2020 Stromal interaction molecule 1 (STIM1) is a calcium sensor in the endoplasmic reticulum, triggering the activation of store-operated calcium signaling. Calcium 133-140 stromal interaction molecule 1 Homo sapiens 32-37 33361160-1 2021 The initial activation step in the gating of ubiquitously expressed Orai1 calcium (Ca2+) ion channels represents the activation of the Ca2+-sensor protein STIM1 upon Ca2+ store-depletion of the endoplasmic reticulum. Calcium 74-81 stromal interaction molecule 1 Homo sapiens 155-160 33023909-0 2020 Fluctuation in O-GlcNAcylation inactivates STIM1 to reduce store-operated calcium ion entry via downregulation of Ser621 phosphorylation. Calcium 74-81 stromal interaction molecule 1 Homo sapiens 43-48 33023909-1 2020 Stromal interaction molecule 1 (STIM1) plays a pivotal role in store-operated Ca2+ entry (SOCE), an essential mechanism in cellular calcium signaling and in maintaining cellular calcium balance. Calcium 132-139 stromal interaction molecule 1 Homo sapiens 0-30 33023909-1 2020 Stromal interaction molecule 1 (STIM1) plays a pivotal role in store-operated Ca2+ entry (SOCE), an essential mechanism in cellular calcium signaling and in maintaining cellular calcium balance. Calcium 132-139 stromal interaction molecule 1 Homo sapiens 32-37 33023909-1 2020 Stromal interaction molecule 1 (STIM1) plays a pivotal role in store-operated Ca2+ entry (SOCE), an essential mechanism in cellular calcium signaling and in maintaining cellular calcium balance. Calcium 178-185 stromal interaction molecule 1 Homo sapiens 0-30 33023909-1 2020 Stromal interaction molecule 1 (STIM1) plays a pivotal role in store-operated Ca2+ entry (SOCE), an essential mechanism in cellular calcium signaling and in maintaining cellular calcium balance. Calcium 178-185 stromal interaction molecule 1 Homo sapiens 32-37 33250786-0 2020 STIM1/ORAI1 Loss-of-Function and Gain-of-Function Mutations Inversely Impact on SOCE and Calcium Homeostasis and Cause Multi-Systemic Mirror Diseases. Calcium 89-96 stromal interaction molecule 1 Homo sapiens 0-5 33182378-0 2020 Evaluation for the Genetic Association between Store-Operated Calcium Influx Pathway (STIM1 and ORAI1) and Human Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Infection. Calcium 62-69 stromal interaction molecule 1 Homo sapiens 86-91 32488451-9 2021 Additional evidence indicates that CASQ1 contributes to regulate the mechanism of store operated calcium entry in skeletal muscle via a direct interaction with the Stromal Interaction Molecule 1 (STIM1). Calcium 97-104 stromal interaction molecule 1 Homo sapiens 164-194 32576932-1 2020 Stromal interaction molecule-1 and -2 (STIM1/2) are endoplasmic reticulum (ER) membrane-inserted calcium (Ca2+) sensing proteins that, together with Orai1-composed Ca2+ channels on the plasma membrane (PM), regulate intracellular Ca2+ levels. Calcium 97-104 stromal interaction molecule 1 Homo sapiens 0-37 32576932-1 2020 Stromal interaction molecule-1 and -2 (STIM1/2) are endoplasmic reticulum (ER) membrane-inserted calcium (Ca2+) sensing proteins that, together with Orai1-composed Ca2+ channels on the plasma membrane (PM), regulate intracellular Ca2+ levels. Calcium 97-104 stromal interaction molecule 1 Homo sapiens 39-46 32488451-9 2021 Additional evidence indicates that CASQ1 contributes to regulate the mechanism of store operated calcium entry in skeletal muscle via a direct interaction with the Stromal Interaction Molecule 1 (STIM1). Calcium 97-104 stromal interaction molecule 1 Homo sapiens 196-201 32146159-1 2020 Calcium (Ca2+) release-activated Ca2+ (CRAC) channels mediated by STIM1/2 and ORAI (ORAI1-3) proteins form the dominant store-operated Ca2+ entry (SOCE) pathway in a wide variety of cells. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 66-73 31228261-2 2020 Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 0-30 31228261-2 2020 Stromal interaction molecule 1 (STIM1) is a calcium sensor and regulatory protein localized to the ER. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 32-37 31228261-4 2020 In outline, STIM1 senses an ER-luminal calcium decrease, relocalizes to ER-PM junctions, and recruits and gates ORAI1 channels. Calcium 39-46 stromal interaction molecule 1 Homo sapiens 12-17 31228261-5 2020 Recent work, reviewed here, has offered detailed insight into the process of sensing and communicating ER calcium-store depletion, and particularly into the STIM1 conformational change that is the basis for communication between the ER and the PM. Calcium 106-113 stromal interaction molecule 1 Homo sapiens 157-162 31936855-3 2020 Archetypal SOCs called calcium release-activated channels (CRACs) are composed of Orai1 proteins and are stimulated by the endo/sarcoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1) following store depletion. Calcium 23-30 stromal interaction molecule 1 Homo sapiens 163-193 32088216-0 2020 Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. Calcium 91-98 stromal interaction molecule 1 Homo sapiens 75-80 32088216-10 2020 Additional studies showed that melatonin elevated cytosolic calcium levels by upregulation of STIM1, leading to osteoblast apoptosis via the mitochondrial pathway. Calcium 60-67 stromal interaction molecule 1 Homo sapiens 94-99 32088216-11 2020 Finally, we demonstrated that the STIM1-mediated increase in cytosolic calcium levels induced apoptosis through the ERK pathway. Calcium 71-78 stromal interaction molecule 1 Homo sapiens 34-39 32088216-12 2020 SIGNIFICANCE: Melatonin induces mitochondrial apoptosis in osteoblasts by regulating the STIM1/cytosolic calcium elevation/ERK pathway. Calcium 105-112 stromal interaction molecule 1 Homo sapiens 89-94 32350310-10 2020 In the present study, SLC10A7 was established as a novel negative regulator of intracellular calcium signaling that most likely acts via STIM1, Orai1 and/or SERCA2 inhibition. Calcium 93-100 stromal interaction molecule 1 Homo sapiens 137-142 31831178-4 2020 Most recent observations revealed that the effect of beta-glycerophosphate on osteogenic signaling requires ORAI1, a Ca2+-channel accomplishing store-operated Ca2+-entry (SOCE), which is stimulated by Ca2+-sensor STIM1. Calcium 117-121 stromal interaction molecule 1 Homo sapiens 213-218 31831178-4 2020 Most recent observations revealed that the effect of beta-glycerophosphate on osteogenic signaling requires ORAI1, a Ca2+-channel accomplishing store-operated Ca2+-entry (SOCE), which is stimulated by Ca2+-sensor STIM1. Calcium 159-163 stromal interaction molecule 1 Homo sapiens 213-218 31831178-4 2020 Most recent observations revealed that the effect of beta-glycerophosphate on osteogenic signaling requires ORAI1, a Ca2+-channel accomplishing store-operated Ca2+-entry (SOCE), which is stimulated by Ca2+-sensor STIM1. Calcium 159-163 stromal interaction molecule 1 Homo sapiens 213-218 31838437-0 2020 STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry. Calcium 66-73 stromal interaction molecule 1 Homo sapiens 0-5 31838437-0 2020 STIM1 long and STIM1 gate differently TRPC1 during store-operated calcium entry. Calcium 66-73 stromal interaction molecule 1 Homo sapiens 15-20 31838437-10 2020 The role of endogenous TRPC1 in STIM1- and STIM1L-induced SOCE was confirmed by Ca2+ imaging experiments. Calcium 80-84 stromal interaction molecule 1 Homo sapiens 32-37 31952901-3 2020 While mutations in genes encoding key components of Ca2+ handling (ORAI1 and STIM1) underlie tubular aggregate myopathy, no causative genes have been associated with cylindrical spirals. Calcium 52-56 stromal interaction molecule 1 Homo sapiens 77-82 31936855-3 2020 Archetypal SOCs called calcium release-activated channels (CRACs) are composed of Orai1 proteins and are stimulated by the endo/sarcoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1) following store depletion. Calcium 23-30 stromal interaction molecule 1 Homo sapiens 195-200 31936855-3 2020 Archetypal SOCs called calcium release-activated channels (CRACs) are composed of Orai1 proteins and are stimulated by the endo/sarcoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1) following store depletion. Calcium 151-155 stromal interaction molecule 1 Homo sapiens 163-193 31936855-3 2020 Archetypal SOCs called calcium release-activated channels (CRACs) are composed of Orai1 proteins and are stimulated by the endo/sarcoplasmic reticulum Ca2+ sensor stromal interaction molecule 1 (STIM1) following store depletion. Calcium 151-155 stromal interaction molecule 1 Homo sapiens 195-200 31831524-1 2020 Store-operated calcium entry (SOCE) is a major Ca2+ influx pathway that is controlled by the ER Ca2+ sensor STIM1. Calcium 15-22 stromal interaction molecule 1 Homo sapiens 108-113 31831524-1 2020 Store-operated calcium entry (SOCE) is a major Ca2+ influx pathway that is controlled by the ER Ca2+ sensor STIM1. Calcium 47-51 stromal interaction molecule 1 Homo sapiens 108-113 31831524-1 2020 Store-operated calcium entry (SOCE) is a major Ca2+ influx pathway that is controlled by the ER Ca2+ sensor STIM1. Calcium 96-100 stromal interaction molecule 1 Homo sapiens 108-113 31831524-2 2020 Abnormal activation of STIM1 directly influences Ca2+ influx, resulting in severe diseases such as Stormorken syndrome. Calcium 49-53 stromal interaction molecule 1 Homo sapiens 23-28 31831524-3 2020 The inactivation domain of STIM1 (IDstim) has been identified as essential for Ca2+ dependent inactivation of STIM1 (CDI) after SOCE occurs. Calcium 79-83 stromal interaction molecule 1 Homo sapiens 27-32 31831524-3 2020 The inactivation domain of STIM1 (IDstim) has been identified as essential for Ca2+ dependent inactivation of STIM1 (CDI) after SOCE occurs. Calcium 79-83 stromal interaction molecule 1 Homo sapiens 110-115 31818466-0 2020 Increased Confinement and Polydispersity of STIM1 and Orai1 after Ca2+ Store Depletion. Calcium 66-70 stromal interaction molecule 1 Homo sapiens 44-49 31818466-1 2020 STIM1 (a Ca2+ sensor in the endoplasmic reticulum (ER) membrane) and Orai1 (a pore-forming subunit of the Ca2+-release-activated calcium channel in the plasma membrane) diffuse in the ER membrane and plasma membrane, respectively. Calcium 9-13 stromal interaction molecule 1 Homo sapiens 0-5 31818466-1 2020 STIM1 (a Ca2+ sensor in the endoplasmic reticulum (ER) membrane) and Orai1 (a pore-forming subunit of the Ca2+-release-activated calcium channel in the plasma membrane) diffuse in the ER membrane and plasma membrane, respectively. Calcium 129-136 stromal interaction molecule 1 Homo sapiens 0-5 31818466-2 2020 Upon depletion of Ca2+ stores in the ER, STIM1 translocates to the ER-plasma membrane junction and binds Orai1 to trigger store-operated Ca2+ entry. Calcium 18-22 stromal interaction molecule 1 Homo sapiens 41-46 31818466-2 2020 Upon depletion of Ca2+ stores in the ER, STIM1 translocates to the ER-plasma membrane junction and binds Orai1 to trigger store-operated Ca2+ entry. Calcium 137-141 stromal interaction molecule 1 Homo sapiens 41-46 31818466-3 2020 However, the motion of STIM1 and Orai1 during this process and its roles to Ca2+ entry is poorly understood. Calcium 76-80 stromal interaction molecule 1 Homo sapiens 23-28 31818466-4 2020 Here, we report real-time tracking of single STIM1 and Orai1 particles in the ER membrane and plasma membrane in living cells before and after Ca2+ store depletion. Calcium 143-147 stromal interaction molecule 1 Homo sapiens 45-50 31556856-4 2020 Following Ca2+ depletion in the Endoplasmic reticulum (ER) store, STIM1 interacts with ORAI1 and leads to the opening of the CRAC channel gate and consequently allows the influx of Ca2+ ions. Calcium 10-14 stromal interaction molecule 1 Homo sapiens 66-71 31556856-4 2020 Following Ca2+ depletion in the Endoplasmic reticulum (ER) store, STIM1 interacts with ORAI1 and leads to the opening of the CRAC channel gate and consequently allows the influx of Ca2+ ions. Calcium 181-185 stromal interaction molecule 1 Homo sapiens 66-71 31556856-5 2020 A plethora of studies report that aberrant CRAC channel activity due to Loss- or gain-of-function mutations in ORAI1 and STIM1 disturbs this Ca2+ homeostasis and cause several autoimmune disorders. Calcium 141-145 stromal interaction molecule 1 Homo sapiens 121-126 31844136-0 2019 A muscular hypotonia-associated STIM1 mutant at R429 induces abnormalities in intracellular Ca2+ movement and extracellular Ca2+ entry in skeletal muscle. Calcium 92-96 stromal interaction molecule 1 Homo sapiens 32-37 32038646-0 2019 Store-Operated Calcium Entry via STIM1 Contributes to MRGPRX2 Induced Mast Cell Functions. Calcium 15-22 stromal interaction molecule 1 Homo sapiens 33-38 32038646-5 2019 Previous reports showed that store-operated Ca2+ entry (SOCE) via the calcium sensor, stromal interaction molecule 1 (STIM1), regulates mast cell response induced by the high-affinity IgE receptor (FcepsilonRI). Calcium 70-77 stromal interaction molecule 1 Homo sapiens 86-116 32038646-5 2019 Previous reports showed that store-operated Ca2+ entry (SOCE) via the calcium sensor, stromal interaction molecule 1 (STIM1), regulates mast cell response induced by the high-affinity IgE receptor (FcepsilonRI). Calcium 70-77 stromal interaction molecule 1 Homo sapiens 118-123 31879743-5 2019 The expression levels of Orai1 and STIM1, key molecules in the process of store-operated calcium entry (SOCE) were detected by Western blot and RT-PCR. Calcium 89-96 stromal interaction molecule 1 Homo sapiens 35-40 31844136-0 2019 A muscular hypotonia-associated STIM1 mutant at R429 induces abnormalities in intracellular Ca2+ movement and extracellular Ca2+ entry in skeletal muscle. Calcium 124-128 stromal interaction molecule 1 Homo sapiens 32-37 31844136-1 2019 Stromal interaction molecule 1 (STIM1) mediates extracellular Ca2+ entry into the cytosol through a store-operated Ca2+ entry (SOCE) mechanism, which is involved in the physiological functions of various tissues, including skeletal muscle. Calcium 62-66 stromal interaction molecule 1 Homo sapiens 0-30 31844136-1 2019 Stromal interaction molecule 1 (STIM1) mediates extracellular Ca2+ entry into the cytosol through a store-operated Ca2+ entry (SOCE) mechanism, which is involved in the physiological functions of various tissues, including skeletal muscle. Calcium 62-66 stromal interaction molecule 1 Homo sapiens 32-37 31844136-1 2019 Stromal interaction molecule 1 (STIM1) mediates extracellular Ca2+ entry into the cytosol through a store-operated Ca2+ entry (SOCE) mechanism, which is involved in the physiological functions of various tissues, including skeletal muscle. Calcium 115-119 stromal interaction molecule 1 Homo sapiens 0-30 31844136-1 2019 Stromal interaction molecule 1 (STIM1) mediates extracellular Ca2+ entry into the cytosol through a store-operated Ca2+ entry (SOCE) mechanism, which is involved in the physiological functions of various tissues, including skeletal muscle. Calcium 115-119 stromal interaction molecule 1 Homo sapiens 32-37 31844136-8 2019 Moreover, R429C increased intracellular Ca2+ movement in response to membrane depolarization by eliminating the attenuation on dihydropyridine receptor-ryanodine receptor (DHPR-RyR1) coupling by endogenous STIM1. Calcium 40-44 stromal interaction molecule 1 Homo sapiens 206-211 31844136-12 2019 This study also suggests a novel clue that STIM1 in skeletal muscle could be related to mitochondria via regulating intra and extracellular Ca2+ movements. Calcium 140-144 stromal interaction molecule 1 Homo sapiens 43-48 31694111-0 2019 [Baicalin regulates STIM1-mediated calcium overload and reduces apoptosis of cardiomyocytes induced by lipopolysaccharide]. Calcium 35-42 stromal interaction molecule 1 Homo sapiens 20-25 31744929-0 2019 Sequential activation of STIM1 links Ca2+ with luminal domain unfolding. Calcium 37-41 stromal interaction molecule 1 Homo sapiens 25-30 31744929-1 2019 The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. Calcium 72-76 stromal interaction molecule 1 Homo sapiens 4-34 31744929-1 2019 The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. Calcium 72-76 stromal interaction molecule 1 Homo sapiens 36-41 31744929-1 2019 The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. Calcium 155-159 stromal interaction molecule 1 Homo sapiens 4-34 31744929-1 2019 The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. Calcium 155-159 stromal interaction molecule 1 Homo sapiens 36-41 31744929-1 2019 The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. Calcium 155-159 stromal interaction molecule 1 Homo sapiens 4-34 31744929-1 2019 The stromal interaction molecule 1 (STIM1) has two important functions, Ca2+ sensing within the endoplasmic reticulum and activation of the store-operated Ca2+ channel Orai1, enabling plasma-membrane Ca2+ influx. Calcium 155-159 stromal interaction molecule 1 Homo sapiens 36-41 31744929-2 2019 We combined molecular dynamics (MD) simulations with live-cell recordings and determined the sequential Ca2+-dependent conformations of the luminal STIM1 domain upon activation. Calcium 104-108 stromal interaction molecule 1 Homo sapiens 148-153 31744929-4 2019 In MD simulations, a single Ca2+ ion was sufficient to stabilize the luminal STIM1 complex. Calcium 28-32 stromal interaction molecule 1 Homo sapiens 77-82 31744929-6 2019 Point mutations associated with tubular aggregate myopathy or cancer that targeted the canonical EF hand, and the hydrophobic cleft yielded constitutively clustered STIM1, which was associated with activation of Ca2+ entry through Orai1 channels. Calcium 212-216 stromal interaction molecule 1 Homo sapiens 165-170 31744929-7 2019 On the basis of our results, we present a model of STIM1 Ca2+ binding and refine the currently known initial steps of STIM1 activation on a molecular level. Calcium 57-61 stromal interaction molecule 1 Homo sapiens 51-56 31728019-0 2019 Author Correction: STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion. Calcium 35-39 stromal interaction molecule 1 Homo sapiens 19-24 31018906-0 2019 Tmem178 negatively regulates store-operated calcium entry in myeloid cells via association with STIM1. Calcium 44-51 stromal interaction molecule 1 Homo sapiens 96-101 31489123-0 2019 Retraction: Deficient for endoplasmic reticulum calcium sensors Stim1 and Stim2 affects aberrant antibody affinity maturation in B cells. Calcium 48-55 stromal interaction molecule 1 Homo sapiens 64-69 30951783-2 2019 To better understand this calcium handling process in cardiomyocytes, we sought to identify unknown protein partners of stromal interaction molecule 1 (STIM1), a main regulatory protein of SOCE. Calcium 26-33 stromal interaction molecule 1 Homo sapiens 120-150 30951783-2 2019 To better understand this calcium handling process in cardiomyocytes, we sought to identify unknown protein partners of stromal interaction molecule 1 (STIM1), a main regulatory protein of SOCE. Calcium 26-33 stromal interaction molecule 1 Homo sapiens 152-157 30552899-6 2019 Reducing the expression of stromal interaction molecule 1 (STIM1) protein, a key protein in ROCE and SOCE, in cells exposure to nsEP resulted in a reduction in induced intracellular calcium rise. Calcium 182-189 stromal interaction molecule 1 Homo sapiens 27-57 31346209-0 2019 Septins organize endoplasmic reticulum-plasma membrane junctions for STIM1-ORAI1 calcium signalling. Calcium 81-88 stromal interaction molecule 1 Homo sapiens 69-74 30917547-5 2019 In this study, we showed that siRNA-mediated depletion of stromal interaction molecule 1 (STIM1) and transient receptor potential channel 1 (TRPC1), two players of the store-operated calcium entry, dramatically reduced CDDP cytotoxicity in NSCLC cells. Calcium 183-190 stromal interaction molecule 1 Homo sapiens 58-88 30917547-5 2019 In this study, we showed that siRNA-mediated depletion of stromal interaction molecule 1 (STIM1) and transient receptor potential channel 1 (TRPC1), two players of the store-operated calcium entry, dramatically reduced CDDP cytotoxicity in NSCLC cells. Calcium 183-190 stromal interaction molecule 1 Homo sapiens 90-95 30552899-6 2019 Reducing the expression of stromal interaction molecule 1 (STIM1) protein, a key protein in ROCE and SOCE, in cells exposure to nsEP resulted in a reduction in induced intracellular calcium rise. Calcium 182-189 stromal interaction molecule 1 Homo sapiens 59-64 30552899-7 2019 Additionally, after exposure to 1 and 20 nsEPs (16.2 kV/cm, 5 Hz), intracellular calcium rises were significantly reduced by the addition of GD3+ and SKF-96365 (1-[2-(4-methoxyphenyl)-2-[3-(4-methoxyphenyl) propoxy] ethyl-1H-imidazole hydrochloride, 100 muM), a blocker of STIM1 interaction. Calcium 81-88 stromal interaction molecule 1 Homo sapiens 273-278 30355649-2 2018 Previous studies indicated that early activation of osteoclasts relies on calcium entry through store-operated calcium (SOC) entry, and several genes, including STIM1, ORAI1, and ITPKC, are known as key regulators of SOC entry. Calcium 111-118 stromal interaction molecule 1 Homo sapiens 161-166 30528613-1 2019 A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels. Calcium 9-16 stromal interaction molecule 1 Homo sapiens 97-127 30528613-1 2019 A single calcium (Ca2+) binding site within the canonical EF-hand loop was thought to govern the stromal interaction molecule-1 (STIM1) structural changes that lead to activation of Orai1 Ca2+ channels. Calcium 9-16 stromal interaction molecule 1 Homo sapiens 129-134 30589833-15 2018 CONCLUSIONS When exposed to high tidal volume or large-magnitude CS, Stim1 and Orai1 expression are upregulated, which further activates calcium-sensitive PKCalpha and results in calcium overload, endothelial hyperpermeability, and, finally, lung injury. Calcium 137-144 stromal interaction molecule 1 Homo sapiens 69-74 30589833-15 2018 CONCLUSIONS When exposed to high tidal volume or large-magnitude CS, Stim1 and Orai1 expression are upregulated, which further activates calcium-sensitive PKCalpha and results in calcium overload, endothelial hyperpermeability, and, finally, lung injury. Calcium 179-186 stromal interaction molecule 1 Homo sapiens 69-74 30544747-8 2018 In addition, we found a reduction of calcium influx through a decrease in STIM1 protein after HSP27 was abolished. Calcium 37-44 stromal interaction molecule 1 Homo sapiens 74-79 30444880-4 2018 This allowed us to determine the calcium affinities of STIM1 and STIM2 both in cellulo and in situ, explaining the current discrepancies in the literature. Calcium 33-40 stromal interaction molecule 1 Homo sapiens 55-60 30382093-0 2018 Calcium sensing by the STIM1 ER-luminal domain. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 23-28 30185837-8 2018 A STIM1-GCaMP fusion protein indicates that STIM1 detects lower calcium concentrations near its EF-hand domain when IP3R is overexpressed when compared with the fluorescence reported by a GCaMP homogenously distributed in the ER lumen (ER-GCaMP). Calcium 64-71 stromal interaction molecule 1 Homo sapiens 2-7 30366379-1 2018 Stromal interaction molecule (STIM)-1 and -2 regulate agonist-induced and basal cytosolic calcium (Ca2+) levels after oligomerization and translocation to endoplasmic reticulum (ER)-plasma membrane (PM) junctions. Calcium 90-97 stromal interaction molecule 1 Homo sapiens 0-44 30373149-0 2018 Calcium Independent Effect of Orai1 and STIM1 in Non-Hodgkin B Cell Lymphoma Dissemination. Calcium 0-7 stromal interaction molecule 1 Homo sapiens 40-45 30185837-8 2018 A STIM1-GCaMP fusion protein indicates that STIM1 detects lower calcium concentrations near its EF-hand domain when IP3R is overexpressed when compared with the fluorescence reported by a GCaMP homogenously distributed in the ER lumen (ER-GCaMP). Calcium 64-71 stromal interaction molecule 1 Homo sapiens 44-49 30185837-10 2018 The activated IP3R provides a reduced intraluminal calcium microenvironment near STIM1, resulting in enhanced activation of Orai currents and SOCE. Calcium 51-58 stromal interaction molecule 1 Homo sapiens 81-86 30185837-0 2018 Association of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry. Calcium 65-72 stromal interaction molecule 1 Homo sapiens 27-32 30185837-0 2018 Association of the IP3R to STIM1 provides a reduced intraluminal calcium microenvironment, resulting in enhanced store-operated calcium entry. Calcium 128-135 stromal interaction molecule 1 Homo sapiens 27-32 30185837-4 2018 IP3R-STIM1 association results in enhanced STIM1 puncta formation and larger Orai-mediated whole-cell currents as well as increased calcium influx. Calcium 132-139 stromal interaction molecule 1 Homo sapiens 5-10