PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 19723525-4 2010 Furthermore, the imbalance of calcium homeostasis increased the level of BAX, decreased the level of Bcl-2, induced cytochrome c release and activated caspase-3, leading to intranucleosomal DNA fragmentation and plasma membrane damage, eventually resulting in cell apoptosis. Calcium 30-37 caspase 3 Homo sapiens 151-160 20810541-5 2010 Multiple features of GW7845-induced cell death were suppressed by the calcium chelator BAPTA, including MAPK activation, loss of mitochondrial membrane potential, cytochrome c release, caspase-3 activation, and DNA fragmentation. Calcium 70-77 caspase 3 Homo sapiens 185-194 19626422-0 2010 Caspase-3 and -9 are activated in human myeloid HL-60 cells by calcium signal. Calcium 63-70 caspase 3 Homo sapiens 0-16 19490937-5 2009 The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3. Calcium 106-113 caspase 3 Homo sapiens 227-236 19734695-8 2009 In sum, our results suggest that spermatozoa treated with calcium mobilizing agents, such as H(2)O(2) and progesterone, seem to undergo an apoptosis process that is dependent on caspase-3 activation. Calcium 58-65 caspase 3 Homo sapiens 178-187 19103761-3 2009 In human neuroblastoma (SK-N-SH) cells, thioureylenes (thiopental, carbimazole) inhibited the calcium-dependent neuronal protein phosphatase (PP)-2B, the activation of the proapoptotic transcription factor nuclear factor of activated T-cells, BAD-induced initiation of caspase-3, and poly-(ADP-ribose)-polymerase cleavage. Calcium 94-101 caspase 3 Homo sapiens 269-278 18958330-3 2008 Of the various possible pathways for the induction of apoptosis, experiments demonstrate that calcium is released from the endoplasmic reticulum, cytochrome c is liberated from the mitochondria to the cytosol, pro-caspase-3 is activated, poly-(ADP-ribose) polymerase is cleaved, and the chromatin is condensed subsequent to photodynamic treatment of these cells. Calcium 94-101 caspase 3 Homo sapiens 210-223 15618541-10 2005 CONCLUSIONS: OxLDL-induced apoptosis involves 2 distinct calcium-dependent pathways, the first mediated by calpain/mPTP/cytochrome C/caspase-3 and the second mediated by apoptosis-inducing factor, which is cyclosporin-insensitive and caspase-independent. Calcium 57-64 caspase 3 Homo sapiens 133-142 18155705-10 2008 Pretreatment of spermatozoa with Ru360, to block the calcium uptake into mitochondria, also was able to decrease the activation of caspase-3 and phosphatidylserine exposure that was stimulated by either H2O2 or P. CONCLUSION(S): These findings suggest that H2O2- and P-induced mitochondrial apoptosis is dependent on calcium signaling. Calcium 317-324 caspase 3 Homo sapiens 131-140 18434534-0 2008 Isoflurane-induced caspase-3 activation is dependent on cytosolic calcium and can be attenuated by memantine. Calcium 66-73 caspase 3 Homo sapiens 19-28 18434534-4 2008 We therefore set out to assess effects of extracellular calcium concentration on isoflurane-induced caspase-3 activation in H4 human neuroglioma cells stably transfected to express human full-length APP (H4-APP cells). Calcium 56-63 caspase 3 Homo sapiens 100-109 15848173-1 2005 We have shown previously that calcium could trigger nuclear fragmentation, which was associated with a caspase 3 (C3)-like activity [Juin, P., Pelletier, M., Oliver, L., Tremblais, K., Gregoire, M., Meflah, K. and Vallette, F.M. Calcium 30-37 caspase 3 Homo sapiens 103-112 15848173-1 2005 We have shown previously that calcium could trigger nuclear fragmentation, which was associated with a caspase 3 (C3)-like activity [Juin, P., Pelletier, M., Oliver, L., Tremblais, K., Gregoire, M., Meflah, K. and Vallette, F.M. Calcium 30-37 caspase 3 Homo sapiens 114-116 15848173-2 2005 (1998) Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system. Calcium 49-56 caspase 3 Homo sapiens 22-31 15848173-7 2005 The cleavage of C3 via calcium-dependent proteolysis is independent of caspase 9; lysate exposure to calcium prevents further cleavage and activation by the cytochrome c and dATP pathway. Calcium 23-30 caspase 3 Homo sapiens 16-18 15848173-7 2005 The cleavage of C3 via calcium-dependent proteolysis is independent of caspase 9; lysate exposure to calcium prevents further cleavage and activation by the cytochrome c and dATP pathway. Calcium 101-108 caspase 3 Homo sapiens 16-18 15848173-8 2005 Altogether, our data suggest that calcium could favour a necrotic mechanism by inducing the generation of a form of C3 insensitive to mitochondrial activation. Calcium 34-41 caspase 3 Homo sapiens 116-118 18520043-4 2008 These studies indicate that the increase in potency for 3 may be related, in part, to an activation of caspase-3, increasing free calcium concentration and topoisomerase II inhibition. Calcium 130-137 caspase 3 Homo sapiens 103-112 16791842-5 2006 Activation of caspase-3 by physiological concentrations of cellular agonists, including thrombin or CCK-8, is independent of rises in cytosolic calcium concentration but requires PKC activation, and is necessary for agonist-induced activation of the tyrosine kinases Btk and pp60src and for several cellular functions, including store-operated calcium entry, platelet aggregation, or pancreatic secretion. Calcium 144-151 caspase 3 Homo sapiens 14-23 16791842-5 2006 Activation of caspase-3 by physiological concentrations of cellular agonists, including thrombin or CCK-8, is independent of rises in cytosolic calcium concentration but requires PKC activation, and is necessary for agonist-induced activation of the tyrosine kinases Btk and pp60src and for several cellular functions, including store-operated calcium entry, platelet aggregation, or pancreatic secretion. Calcium 344-351 caspase 3 Homo sapiens 14-23 16394273-0 2006 PS2 mutation increases neuronal cell vulnerability to neurotoxicants through activation of caspase-3 by enhancing of ryanodine receptor-mediated calcium release. Calcium 145-152 caspase 3 Homo sapiens 91-100 15302579-5 2004 APC attenuated calcium-induced cell death via prevention of cell apoptosis, as indicated by a decrease in both active caspase-3 and morphologically apoptotic cells. Calcium 15-22 caspase 3 Homo sapiens 118-127 15500948-6 2004 Cytochrome C (Cyto C) release from mitochondria into cytosol and Caspase-3 activation after HMME-PDT were inhibited by BAPTA/AM (an intracellular calcium chelator). Calcium 146-153 caspase 3 Homo sapiens 65-74 15474552-4 2004 The treatment of BAPTA-AM, permeable endogenous calcium chelator, inhibited GJBRH-induced caspase-3 and -9 activations, the release of cytochrome c and Smac/DIABLO into cytoplasm and the resultant cell death in HeLa human cervical carcinoma cells. Calcium 48-55 caspase 3 Homo sapiens 90-106 15284241-0 2004 Caspase-3-induced truncation of type 1 inositol trisphosphate receptor accelerates apoptotic cell death and induces inositol trisphosphate-independent calcium release during apoptosis. Calcium 151-158 caspase 3 Homo sapiens 0-9 14713297-5 2003 Our results showed that reduction of ER calcium release can partially attenuate Abeta peptide neurotoxicity evaluated by LDH release, caspase-3 activity and quantification of apoptotic cells. Calcium 40-47 caspase 3 Homo sapiens 134-143 14695652-0 2004 Intracellular calcium release is required for caspase-3 and -9 activation. Calcium 14-21 caspase 3 Homo sapiens 46-62 12975376-8 2003 Calcium release from the endoplasmic reticulum and activation of caspase-8 are the upstream signals modulating the caspase-3-mediated activation of PKR by Abeta peptide. Calcium 0-7 caspase 3 Homo sapiens 115-124 12809603-6 2003 Further analysis showed that lysophosphatidylcholine was released from apoptotic cells due to the caspase-3 mediated activation of the calcium-independent phospholipase A(2). Calcium 135-142 caspase 3 Homo sapiens 98-107 14646222-3 2003 Studies on the effects of the intracellular calcium chelator BAPTA-AM on the induction of apoptosis and the activation of SAPK/JNK and caspase-3 proved that the chelation of calcium merely delayed the onset of radiation-induced apoptosis and the activation of SAPK/JNK and caspase-3. Calcium 44-51 caspase 3 Homo sapiens 135-144 14646222-3 2003 Studies on the effects of the intracellular calcium chelator BAPTA-AM on the induction of apoptosis and the activation of SAPK/JNK and caspase-3 proved that the chelation of calcium merely delayed the onset of radiation-induced apoptosis and the activation of SAPK/JNK and caspase-3. Calcium 174-181 caspase 3 Homo sapiens 135-144 14646222-3 2003 Studies on the effects of the intracellular calcium chelator BAPTA-AM on the induction of apoptosis and the activation of SAPK/JNK and caspase-3 proved that the chelation of calcium merely delayed the onset of radiation-induced apoptosis and the activation of SAPK/JNK and caspase-3. Calcium 174-181 caspase 3 Homo sapiens 273-282 12176903-2 2002 The activity of calpains (calcium-dependent, neutral proteases, active in the cells responding to signals inducing a rise of cytoplasmic Ca(++)) is involved in the regulation of apoptosis of some cell types by interaction with caspase-3. Calcium 26-33 caspase 3 Homo sapiens 227-236 12509415-4 2003 Cisplatin-induced caspase-3 activation in cytoplasts required calcium and the activity of the calcium-dependent protease calpain. Calcium 62-69 caspase 3 Homo sapiens 18-27 12446691-10 2003 Interestingly, the cytosolic calcium chelator BAPTA-AM and K-201 protected RA-treated chondrocytes from undergoing apoptotic changes, as indicated by higher bcl-2 gene expression, reduced caspase-3 activity, and the percentage of TUNEL-positive cells. Calcium 29-36 caspase 3 Homo sapiens 188-197 11876554-15 2001 Digoxin induced alteration in intracellular calcium/magnesium ratios and low ubiquinone levels can lead to a mitochondrial dysfunction resulting in increased free radical generation and reduced scavenging & caspase-3 activation producing a P21 defect contributing to oncogenesis. Calcium 44-51 caspase 3 Homo sapiens 211-220 11032173-0 2000 Effect of Bcl-2 and caspase-3 on calcium distribution in apoptosis of HL-60 cells. Calcium 33-40 caspase 3 Homo sapiens 20-29 11832715-5 2002 The consequential decrease in mitochondrial calcium, cytochrome c release and Bax translocation to mitochondria, which resulted in the activation of caspase 3 leading to apoptotic cell death, was measured by biochemical and confocal microscopy. Calcium 44-51 caspase 3 Homo sapiens 149-158 11278424-20 2001 Finally, we have demonstrated that calsenilin is a substrate for caspase-3, and we have used site-directed mutagenesis to map the caspase-3 cleavage site to a region that is proximal to the calcium binding domain of calsenilin. Calcium 190-197 caspase 3 Homo sapiens 130-139 11032173-7 2000 The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi"s apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspase-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase-3. Calcium 88-95 caspase 3 Homo sapiens 36-45 11032173-7 2000 The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi"s apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspase-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase-3. Calcium 88-95 caspase 3 Homo sapiens 189-198 11032173-7 2000 The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi"s apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspase-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase-3. Calcium 88-95 caspase 3 Homo sapiens 189-198 10477693-5 1999 Calcium ionophore-stimulated platelets also recapitulated apoptotic events, including cell shrinkage, plasma membrane microvesiculation, phosphatidyl serine externalization, and proteolysis of procaspase-9, procaspase-3, gelsolin, and protein kinase C-delta. Calcium 0-7 caspase 3 Homo sapiens 207-219 11032173-7 2000 The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi"s apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspase-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase-3. Calcium 275-282 caspase 3 Homo sapiens 36-45 11032173-7 2000 The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi"s apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspase-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase-3. Calcium 275-282 caspase 3 Homo sapiens 189-198 11032173-7 2000 The results indicate that activated caspase-3 can promote the movement of intracellular calcium from Golgi"s apparatus to nucleus, and the process is inhibited by Ac-DEVD-CHO (inhibitor of caspase-3), and that Bcl-2 can inhibit the movement and accumulation of intracellular calcium in nucleus through its inhibition on caspase-3. Calcium 275-282 caspase 3 Homo sapiens 189-198 10828033-3 2000 Cleavage by caspase-3 generates an amino-terminal fragment of gelsolin that can sever actin filaments independently of calcium regulation. Calcium 119-126 caspase 3 Homo sapiens 12-21 32402583-9 2020 Additionally, an intracellular calcium rise and subsequent mitochondrial membrane potential collapse, P53 phosphorylation, reduced BcL-2/Bax ratio in the mitochondrial membrane, release cytochrome c from mitochondria, leading to the subsequent activation of caspase 3 activation by H2O2 were all markedly suppressed in the presence of luteolin. Calcium 31-38 caspase 3 Homo sapiens 258-267 8647264-0 1996 Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP. Calcium 61-68 caspase 3 Homo sapiens 177-181 34309093-2 2021 Circulating Caspase-3 has also been associated with diabetes and coronary calcium score. Calcium 74-81 caspase 3 Homo sapiens 12-21 34044258-6 2021 The mechanism of mechanical apoptosis (mechanoptosis) of transformed cells involves calcium influx through the mechanosensitive channel, Piezo1 that activates calpain 2 dependent apoptosis through the BAX molecule and subsequent mitochondrial activation of caspase 3 on both fibronetin and collagen matrices. Calcium 84-91 caspase 3 Homo sapiens 257-266 33171207-11 2021 By using calcium channel blocker Nimodipine, the increase of intracellular Ca2+ was attenuated, and the death rate of neurons, the ROS and opening of mPTP, decreased ATP production, the expressions of cytochrome c, cleaved caspase-9, cleaved caspase-3 and the ratio of Bax/Bcl-2 were alleviated. Calcium 9-16 caspase 3 Homo sapiens 242-251 10528917-0 1999 Effects of intracellular calcium chelator BAPTA-AM on radiation-induced apoptosis regulated by activation of SAPK/JNK and caspase-3 in MOLT-4 cells. Calcium 25-32 caspase 3 Homo sapiens 122-131 10528917-6 1999 CONCLUSION: These results revealed that chelation of calcium merely delayed the onset of the radiation-induced apoptosis regulated by the activation of SAPK/JNK and caspase-3, and calcium was not essential for the induction of apoptosis in X-irradiated MOLT-4 cells. Calcium 53-60 caspase 3 Homo sapiens 165-174 9651349-0 1998 Induction of a caspase-3-like activity by calcium in normal cytosolic extracts triggers nuclear apoptosis in a cell-free system. Calcium 42-49 caspase 3 Homo sapiens 15-24 9651349-10 1998 The enhanced caspase-3 activity induced by calcium was inhibited by protease inhibitors affecting morphological nuclear apoptosis except for those responsible for the degradation of lamin A. Calcium 43-50 caspase 3 Homo sapiens 13-22 8647264-0 1996 Ligation of CD40 rescues Ramos-Burkitt lymphoma B cells from calcium ionophore- and antigen receptor-triggered apoptosis by inhibiting activation of the cysteine protease CPP32/Yama and cleavage of its substrate PARP. Calcium 61-68 caspase 3 Homo sapiens 171-176 33022360-9 2020 Restoration of physiological apoptosis by increasing the release of intracellular calcium to generate ROS thereby reducing the mitochondrial membrane potential for the release of cytochrome c and activation of caspase-3 was also reported with Imatinib administration. Calcium 82-89 caspase 3 Homo sapiens 210-219 31918031-6 2020 This inhibition led to mitochondrial depolarisation in response to physiological and pathological calcium stimuli and made these cells vulnerable to calcium-induced caspase 3 activation and cell death. Calcium 98-105 caspase 3 Homo sapiens 165-174 31918031-6 2020 This inhibition led to mitochondrial depolarisation in response to physiological and pathological calcium stimuli and made these cells vulnerable to calcium-induced caspase 3 activation and cell death. Calcium 149-156 caspase 3 Homo sapiens 165-174 31438500-9 2019 Caspase 3 and 12 activation was induced by DA compared to vehicle at 24 h. These studies indicate that clinically relevant concentrations of DA impair HK-2 cells by dysregulating calcium, inducing mitochondrial turnover and oxidative stress, and activating apoptosis. Calcium 179-186 caspase 3 Homo sapiens 0-9 28730337-13 2017 In addition, the calcium chelators, EDTA and BAPTA, and RNAi disruption of the NMDA receptor reduced ethanol-induced caspase-3 activation in H4 cells. Calcium 17-24 caspase 3 Homo sapiens 117-126 29438593-3 2018 Betulinic acid, thapsigargin, and the calcium ionophore treatment resulted in an increased number of sperm cells with caspase 9 and caspase 3 activation, disrupted mitochondrial membrane potential, and a reacted acrosome. Calcium 38-45 caspase 3 Homo sapiens 132-141 29263678-5 2017 We found that during apoptosis, cleaved caspase 3 could activate cytosolic calcium-independent phospholipase A2, which stimulated the release of arachidonic acid (AA) and triggered the production of prostaglandin E2 (PGE2). Calcium 75-82 caspase 3 Homo sapiens 40-49 28730337-15 2017 Our results indicate that ethanol-induced caspase-3 activation and apoptosis are likely to be dependent on cytosolic calcium levels and that they can be reduced by memantine treatment. Calcium 117-124 caspase 3 Homo sapiens 42-51 24802256-10 2015 Blockade of intracellular calcium release decreased caspase-3 activation, but had no effect on AA-induced p38-MAPK activation. Calcium 26-33 caspase 3 Homo sapiens 52-61 27572620-6 2017 Moreover, a reduction in extracellular calcium reduced E-cadherin and enhanced caspase 3/7 activity (apoptosis), whereas calcium chelation by EGTA (ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid) resulted in enhanced lipogenesis. Calcium 39-46 caspase 3 Homo sapiens 79-88 24751678-8 2014 Furthermore, RCAN1.4 overexpression exacerbated calcium overloading-induced neuronal apoptosis, which was mediated by caspase-3 apoptotic pathway. Calcium 48-55 caspase 3 Homo sapiens 118-127 24961950-5 2014 As expected, preventing an increase in intracellular calcium levels using intracellular calcium chelators, EGTA, and BAPTA/AM, could substantially inhibit the phosphorylation of JNK and p38 MAPK, abolish the activation of calpains, namely caspase-12, caspase-9, and caspase-3, and provide significant protection for TG-treated activated HSCs. Calcium 53-60 caspase 3 Homo sapiens 266-275 24961950-5 2014 As expected, preventing an increase in intracellular calcium levels using intracellular calcium chelators, EGTA, and BAPTA/AM, could substantially inhibit the phosphorylation of JNK and p38 MAPK, abolish the activation of calpains, namely caspase-12, caspase-9, and caspase-3, and provide significant protection for TG-treated activated HSCs. Calcium 88-95 caspase 3 Homo sapiens 266-275 25549352-8 2014 Furthermore, we show that intense heat stress may induce apoptosis in HUVEC cells through the calcium-mediated mitochondrial apoptotic pathway, as indicated by elevation of cytoplasmic Ca2+, expression of Apaf-1, activation of caspase-9 and caspase-3, PARP cleavage, and ultimately nucleosomal DNA fragmentation; Reactive oxygen species (ROS) appear to act upstream in this process. Calcium 94-101 caspase 3 Homo sapiens 241-250 23122728-4 2013 We detected a robust increase in calcium levels in response to staurosporine treatment in primary human fibroblasts and HeLa cells in the presence of the caspase inhibitor Z-VAD, indicating that calcium release during the initiation of apoptosis occurs independently of caspase 3. Calcium 33-40 caspase 3 Homo sapiens 270-279 23122728-4 2013 We detected a robust increase in calcium levels in response to staurosporine treatment in primary human fibroblasts and HeLa cells in the presence of the caspase inhibitor Z-VAD, indicating that calcium release during the initiation of apoptosis occurs independently of caspase 3. Calcium 195-202 caspase 3 Homo sapiens 270-279 23103827-2 2012 The anti-beta(1)-AR IgG binds and activates atria beta(1)-AR, increasing the intracellular calcium concentration, which, in turn, activates caspases-3, -8, and -9. Calcium 91-98 caspase 3 Homo sapiens 140-162 21979311-7 2011 These calcium reactions were compared and analyzed with the results of cell viability test, Hoechst staining, intracellular reactive oxygen species level and expression of caspase-3, and poly-ADP-ribose polymerase (PARP). Calcium 6-13 caspase 3 Homo sapiens 172-181 22982862-0 2012 Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3. Calcium 29-36 caspase 3 Homo sapiens 86-95 23098449-10 2012 OD values of caspase-3 and caspase-9 were increased and expression of bcl-2 was increased and bax was decreased in protein levels in RL952 cells after 24 h of hyperin treatment, Moreover, intracellular calcium accumulation occurred in hyperin-treated cells. Calcium 202-209 caspase 3 Homo sapiens 13-22