PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 12568403-4 2003 IL-1 increased blood calcium and bone resorption in wild-type (wt), p50, and p52 single KO mice, but not in 3/4KO or dKO mice. Calcium 21-28 interleukin 1 complex Mus musculus 0-4 2165034-0 1990 Possible involvement of adenosine 3":5"-cyclic monophosphate and extracellular calcium ions in histamine stimulation of interleukin-1 release from macrophage-like P388D1 cells. Calcium 79-86 interleukin 1 complex Mus musculus 120-133 11125308-3 2000 Concanavalin A or phorbol myristate acetate/calcium ionophore/anti-CD3 stimulation of spleen cells from H2(b) congenic mice induced less IL-1, IL-2, IFN-gamma and MIF mRNA and/or protein than the equivalent cells from H2(d) mice. Calcium 44-51 interleukin 1 complex Mus musculus 137-141 7842348-2 1994 The results showed that calcium release from cultured calvariae was significantly increased after adding 20 ng/ml IL-1 (P < 0.01). Calcium 24-31 interleukin 1 complex Mus musculus 114-118 7842348-3 1994 The increase of calcium release stimulated by IL-1 was blocked by both calcitonin at the concentration of 10, 100, 1,000 ng/ml and indomethacin (10(-6), 10(-5) mol/L). Calcium 16-23 interleukin 1 complex Mus musculus 46-50 7842348-4 1994 The stimulation of calcium release by IL-1 was also blocked even adding 10 mol/L indomethacin 5 hours after adding IL-1 into the culture. Calcium 19-26 interleukin 1 complex Mus musculus 38-42 7842348-4 1994 The stimulation of calcium release by IL-1 was also blocked even adding 10 mol/L indomethacin 5 hours after adding IL-1 into the culture. Calcium 19-26 interleukin 1 complex Mus musculus 115-119 8399976-0 1993 Effect of alginate and calcium on secretion of IL-1 by immobilized Swiss peritoneal macrophages. Calcium 23-30 interleukin 1 complex Mus musculus 47-51 8399976-3 1993 Calcium and alginate individually enhance production of IL-1 by macrophages and act in synergy when macrophages are immobilized in calcium alginate matrix. Calcium 0-7 interleukin 1 complex Mus musculus 56-60 1830617-6 1991 Furthermore, anti-IL-1 serum partially suppressed the calcium release from Y4 LPS-stimulated BALB/c mouse calvaria. Calcium 54-61 interleukin 1 complex Mus musculus 18-22 2174106-3 1990 In the murine thymoma EL4.E1, IL-1 could synergize with the phosphoinositide pathway, because the cells made higher levels of IL-2 in the presence of IL-1 than could be induced by phorbol ester plus calcium ionophore alone. Calcium 199-206 interleukin 1 complex Mus musculus 30-34 7879702-3 1994 Human recombinant tumour necrosis factor-alpha (TNF-alpha) and the calcium ionophores A23187 and ionomycin induced a concentration-dependent increase of cell-associated IL-1 but failed to cause release of IL-1 at concentrations producing maximal stimulation of cell-associated IL-1. Calcium 67-74 interleukin 1 complex Mus musculus 169-173 7879702-7 1994 It appears that a calcium signal is sufficient for the transcription and translation of IL-1 mRNA but does not result in the secretion of biologically active forms of IL-1. Calcium 18-25 interleukin 1 complex Mus musculus 88-92 8511985-5 1993 The initial transient decrease in blood ionized calcium observed following an injection of IL-1 was also abrogated. Calcium 48-55 interleukin 1 complex Mus musculus 91-95 1792067-2 1991 The incubation of mouse hepatic sinusoidal endothelial cells with lipopolysaccharide (LPS) or calcium-ionophore (CaI) A23187 resulted in a concentration-dependent production of IL1 and PAF. Calcium 94-101 interleukin 1 complex Mus musculus 177-180 1902169-8 1991 IL-1 (60 pM) and PTH (2.4 nM) stimulation of PGE2 production showed a similar time course, with a lag phase of 0.75-1.5 h. Cortisol (1-100 nM) reduced basal PGE2 production and calcium release. Calcium 177-184 interleukin 1 complex Mus musculus 0-4 2104887-1 1990 Enhancement of IL-1 secretion and processing by calcium ionophores. Calcium 48-55 interleukin 1 complex Mus musculus 15-19 1692959-5 1990 That IL-1 and phorbol myristate acetate represent different stimuli was shown by their response to protein kinase C inhibitors, capacity to synergize with increased intracellular free calcium, and requirement for protein synthesis. Calcium 184-191 interleukin 1 complex Mus musculus 5-9 2104887-8 1990 The rapid release of IL-1 in response to a change in the intracellular level of calcium does not appear to be caused by release of a membrane-bound form of the protein, nor is there evidence that IL-1 is packaged and released from cytoskeletal associated secretory granules. Calcium 80-87 interleukin 1 complex Mus musculus 21-25 2788075-3 1989 Increased bone resorption inside the calvariae and elevated plasma calcium concentrations were present 24 h after the last IL-1 injection. Calcium 67-74 interleukin 1 complex Mus musculus 123-127 2789251-6 1989 Salmon calcitonin strongly suppressed the calcium release from mouse calvaria in the presence of membrane IL-1. Calcium 42-49 interleukin 1 complex Mus musculus 106-110 2848778-4 1988 An assay for the measurement of interleukin-1 (IL-1), based on its ability to induce interleukin-2 (IL-2) production by the EL-4 mouse thymoma line in the presence of the calcium ionophore A23187, was examined. Calcium 171-178 interleukin 1 complex Mus musculus 32-51 2462440-6 1988 Heparin, in combination with 0.1 mu/ml IL1, stimulated significant calcium release compared to heparin but not to IL1 tested alone. Calcium 67-74 interleukin 1 complex Mus musculus 39-42 2462440-8 1988 Two of the heparin fragments combined with 0.1 U/ml IL1 significantly inhibited calcium release compared to IL1 alone. Calcium 80-87 interleukin 1 complex Mus musculus 52-55 2462440-8 1988 Two of the heparin fragments combined with 0.1 U/ml IL1 significantly inhibited calcium release compared to IL1 alone. Calcium 80-87 interleukin 1 complex Mus musculus 108-111 2462440-9 1988 In combination with 1.0 U/ml of IL1, heparin and hyaluronic acid inhibited calcium release compared to IL1 alone but this inhibition was not significant. Calcium 75-82 interleukin 1 complex Mus musculus 32-35 3079793-0 1986 Activation of IL 1-dependent and IL 1-independent T cell lines by calcium ionophore and phorbol ester. Calcium 66-73 interleukin 1 complex Mus musculus 14-18 3084468-2 1986 An early intracellular event caused by exposure to IL-1 is an amiloride-sensitive progressive rise in the total concentration of intracellular sodium ([Na]i), caused by influx of Na+ from outside, and a transient fall in total intracellular calcium. Calcium 241-248 interleukin 1 complex Mus musculus 51-55 3079793-0 1986 Activation of IL 1-dependent and IL 1-independent T cell lines by calcium ionophore and phorbol ester. Calcium 66-73 interleukin 1 complex Mus musculus 33-37 3079793-8 1986 These observations suggest that the signal(s) provided by PHA and IL 1 involve at least in part a calcium flux, and activation of protein kinase C. Parallel experiments with the use of the IL 1-independent T cell lines showed a strong response to both agents when used simultaneously. Calcium 98-105 interleukin 1 complex Mus musculus 66-70 3079793-8 1986 These observations suggest that the signal(s) provided by PHA and IL 1 involve at least in part a calcium flux, and activation of protein kinase C. Parallel experiments with the use of the IL 1-independent T cell lines showed a strong response to both agents when used simultaneously. Calcium 98-105 interleukin 1 complex Mus musculus 189-193 3926280-1 1985 The effect of parathormone (PTH), lipopolysaccharide (LPS), or interleukin-1 (IL-1) on calcium release and collagen degradation in bone was examined in vitro using labeled neonatal calvaria of normal mice and also of osteopetrotic microphthalmic (mi/mi) mice that have defective osteoclasts. Calcium 87-94 interleukin 1 complex Mus musculus 63-82 3934287-1 1985 A simple and reliable biological assay for interleukin-1 (IL-1) was developed, based on the production of interleukin-2 (IL-2) from the EL-4 murine T-cell lymphoma cell line, in the presence of 2-5 X 10(-7) M calcium ionophore A23187. Calcium 209-216 interleukin 1 complex Mus musculus 43-62 33654394-9 2021 Also, IL-1-Exo reversed the LPS-induced effect on calcium signaling. Calcium 50-57 interleukin 1 complex Mus musculus 6-10 6432347-6 1984 In addition, the calcium ionophore also augmented release of IL-1 from the P388D1 murine macrophage cell line. Calcium 17-24 interleukin 1 complex Mus musculus 61-65