PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24980112-4 2014 We found that the effect of LL-37 preconditioning was specific to clonogenic cells and was mediated specifically by increased calcium influx with the activation of downstream signaling through mammalian target of rapamycin complex 1 (mTORC1). Calcium 126-133 CREB regulated transcription coactivator 1 Mus musculus 234-240 25772363-4 2015 Co-imaging mTORC1 activity and calcium dynamics revealed that a growth-factor-induced calcium transient contributes to mTORC1 activity. Calcium 31-38 CREB regulated transcription coactivator 1 Mus musculus 119-125 25772363-4 2015 Co-imaging mTORC1 activity and calcium dynamics revealed that a growth-factor-induced calcium transient contributes to mTORC1 activity. Calcium 86-93 CREB regulated transcription coactivator 1 Mus musculus 11-17 25772363-4 2015 Co-imaging mTORC1 activity and calcium dynamics revealed that a growth-factor-induced calcium transient contributes to mTORC1 activity. Calcium 86-93 CREB regulated transcription coactivator 1 Mus musculus 119-125 25278019-0 2014 Orexin/hypocretin activates mTOR complex 1 (mTORC1) via an Erk/Akt-independent and calcium-stimulated lysosome v-ATPase pathway. Calcium 83-90 CREB regulated transcription coactivator 1 Mus musculus 44-50 25278019-5 2014 Rather, our studies indicate that orexin activates mTORC1 via extracellular calcium influx and the lysosome pathway involving v-ATPase and Rag GTPases. Calcium 76-83 CREB regulated transcription coactivator 1 Mus musculus 51-57 25278019-6 2014 Moreover, a cytoplasmic calcium transient is sufficient to mimic orexin/GPCR signaling to mTORC1 activation in a v-ATPase-dependent manner. Calcium 24-31 CREB regulated transcription coactivator 1 Mus musculus 90-96 22236576-6 2012 Activity-dependent CREB transcription induced by calcium/cAMP signals is disrupted through a mechanism involving deregulation of calcium/calcineurin-mediated dephosphorylation and activation of CRTC1. Calcium 49-56 CREB regulated transcription coactivator 1 Mus musculus 194-199 24855942-3 2014 Loss of TRPV1 inactivates a calcium-signaling cascade that ends in the nuclear exclusion of the CREB-regulated transcriptional coactivator CRTC1 within pain sensory neurons originating from the spinal cord. Calcium 28-35 CREB regulated transcription coactivator 1 Mus musculus 139-144 34824550-16 2021 These genes might act on KARS and mTORC1 pathways and participate in metabolic reprogramming and regulation of calcium homeostasis in platinum-resistant cells. Calcium 111-118 CREB regulated transcription coactivator 1 Mus musculus 34-40 34944044-4 2021 Importantly, calcium signaling produced by TRPML1 (transient receptor potential cation channel, mucolipin subfamily) has been shown to regulate autophagic progression through biogenesis of autophagic-lysosomal organelles, activation of mTORC1 (mechanistic target of rapamycin complex 1) and degradation of autophagic cargo. Calcium 13-20 CREB regulated transcription coactivator 1 Mus musculus 236-242 32062191-7 2020 Interestingly, PP242 (mTORC1/2 inhibitor) or Akt inhibitor X, like rapamycin (mTORC1 inhibitor), reduced the basal or hsBAFF-induced [Ca2+]i elevations. Calcium 134-138 CREB regulated transcription coactivator 1 Mus musculus 22-28 34499406-0 2021 Increased mitochondrial calcium uptake and concomitant mitochondrial activity by presenilin loss promotes mTORC1 signaling to drive neurodegeneration. Calcium 24-31 CREB regulated transcription coactivator 1 Mus musculus 106-112 33864571-9 2021 In the OOA model, upregulated extracellular regulated protein kinases 1/2 (ERK1/2), which can be regulated by SOCC and IP3R proteins transient receptor potential canonical 1 (TRPC1)/IP3R with elevated cytoplasmic calcium signaling, over-inhibited forkhead/winged helix O (FOXO) signaling and over-activated mammalian target of rapamycin complex 1 (mTORC1) signaling. Calcium 213-220 CREB regulated transcription coactivator 1 Mus musculus 348-354 33864571-12 2021 Our findings indicate that upregulated SOCC and IP3R channels and subsequent elevated cytoplasmic calcium signaling in hepatocyte fatty lesions inhibits hepatocyte autophagy through (TRPC1/IP3R)/ERK/(FOXO/mTORC1) signaling pathways, causes lipid accumulation and degeneration in hepatocytes, and promotes NAFLD occurrence and development. Calcium 98-105 CREB regulated transcription coactivator 1 Mus musculus 205-211 32690540-6 2020 BBOX1 depletion suppresses IP3R3 mediated endoplasmic reticulum calcium release, therefore impairing calcium-dependent energy-generating processes including mitochondrial respiration and mTORC1 mediated glycolysis, which leads to apoptosis and impaired cell cycle progression in TNBC cells. Calcium 101-108 CREB regulated transcription coactivator 1 Mus musculus 187-193 32062191-9 2020 The results indicate that rapamycin inhibits BAFF-stimulated B-cell proliferation and survival by blunting mTORC1/2-mediated [Ca2+]i elevations and suppressing Ca2+-CaMKII-dependent PTEN/Akt-Erk1/2 signaling pathway. Calcium 126-130 CREB regulated transcription coactivator 1 Mus musculus 107-113 32173353-11 2020 Collectively, these results reveal a novel link between sarcoplasmic reticulum calcium homeostasis and mTORC1 activation that is regulated by Saraf. Calcium 79-86 CREB regulated transcription coactivator 1 Mus musculus 103-109 28303961-5 2017 Release of calcium from the endoplasmic reticulum store triggers rapid mTORC2 activation, similar to ammonium-induced activation, the latter being conversely prevented by calcium chelation.Moreover, in analogy to growth factors, ammonium triggers the AKT-dependent phosphoinhibition of the TSC complex and of PRAS40, two negative regulators of mTORC1. Calcium 11-18 CREB regulated transcription coactivator 1 Mus musculus 344-350 30539788-9 2019 During the digestion of AHs, macrophage mTORC1 was activated and coupled with dynamin-related protein 1 to facilitate the latter"s phosphorylation, leading to mitochondrial fission-mediated calcium release. Calcium 190-197 CREB regulated transcription coactivator 1 Mus musculus 40-46 30338034-6 2018 It inhibited store-operated calcium entry (SOCE) and Mcl-1 translation through mTORC1 deactivation. Calcium 28-35 CREB regulated transcription coactivator 1 Mus musculus 79-85 31365870-5 2019 NOX1 co-localizes with mTORC1 in VPS41-/VPS39-positive lysosomes, where mTORC1 binds to S100A9, a member of S100 calcium binding proteins, in a NOX1-produced ROS-dependent manner. Calcium 113-120 CREB regulated transcription coactivator 1 Mus musculus 23-29 31365870-5 2019 NOX1 co-localizes with mTORC1 in VPS41-/VPS39-positive lysosomes, where mTORC1 binds to S100A9, a member of S100 calcium binding proteins, in a NOX1-produced ROS-dependent manner. Calcium 113-120 CREB regulated transcription coactivator 1 Mus musculus 72-78 30890691-7 2019 In contrast, chemical inhibition of mTORC1 accelerates calcium-induced keratinocyte differentiation, suggesting that activation of autophagy promotes the differentiation process. Calcium 55-62 CREB regulated transcription coactivator 1 Mus musculus 36-42 28611595-9 2017 In turn, reduced mTORC1 activity increases the protein expression of syntaxin-1A and promotes the surface expression of the ionotropic glutamate receptor N-methyl-D-aspartate (NMDA)-type subunit 1 (GluN1) that facilitates increased calcium entry to turn mTORC1 back on. Calcium 232-239 CREB regulated transcription coactivator 1 Mus musculus 17-23 28611595-9 2017 In turn, reduced mTORC1 activity increases the protein expression of syntaxin-1A and promotes the surface expression of the ionotropic glutamate receptor N-methyl-D-aspartate (NMDA)-type subunit 1 (GluN1) that facilitates increased calcium entry to turn mTORC1 back on. Calcium 232-239 CREB regulated transcription coactivator 1 Mus musculus 254-260 27787197-1 2016 Blockade of lysosomal calcium release due to lysosomal lipid accumulation has been shown to inhibit mTORC1 signaling. Calcium 22-29 CREB regulated transcription coactivator 1 Mus musculus 100-106 27787197-2 2016 However, the mechanism by which lysosomal calcium regulates mTORC1 has remained undefined. Calcium 42-49 CREB regulated transcription coactivator 1 Mus musculus 60-66 27787197-3 2016 Herein we report that proper lysosomal calcium release through the calcium channel TRPML1 is required for mTORC1 activation. Calcium 39-46 CREB regulated transcription coactivator 1 Mus musculus 106-112 27787197-5 2016 Lysosomal calcium activates mTORC1 by inducing association of calmodulin (CaM) with mTOR. Calcium 10-17 CREB regulated transcription coactivator 1 Mus musculus 28-34 27787197-7 2016 Moreover, CaM is capable of stimulating the kinase activity of mTORC1 in a calcium-dependent manner in vitro. Calcium 75-82 CREB regulated transcription coactivator 1 Mus musculus 63-69 27787197-8 2016 These results reveal that mTOR is a new type of CaM-dependent kinase, and TRPML1, lysosomal calcium and CaM play essential regulatory roles in the mTORC1 signaling pathway. Calcium 92-99 CREB regulated transcription coactivator 1 Mus musculus 147-153 26923592-4 2016 Normalization of Sestrin2 levels through overexpression or elevation of nuclear calcium rescued mTORC1 tethering and initiated clearance. Calcium 80-87 CREB regulated transcription coactivator 1 Mus musculus 96-102