PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 24576174-12 2014 After treatment with calcium, the activity of AKT, PLCgamma-1, p38alpha and JNK was clearly enhanced and PTEN expression was almost completely abolished in bone metastasizing RCC cells. Calcium 21-28 mitogen-activated protein kinase 8 Homo sapiens 76-79 24407242-4 2014 P-JNK plus adenosine 5"-triphosphate (ATP) added to isolated liver mitochondria promoted superoxide production, which was amplified by addition of calcium and inhibited by a blocking peptide corresponding to the JNK binding site on Sab (KIM1). Calcium 147-154 mitogen-activated protein kinase 8 Homo sapiens 2-5 24123203-0 2013 Traumatic scratch injury in astrocytes triggers calcium influx to activate the JNK/c-Jun/AP-1 pathway and switch on GFAP expression. Calcium 48-55 mitogen-activated protein kinase 8 Homo sapiens 79-82 24123203-5 2013 Using the calcium blocker BAPTA-AM and the JNK inhibitor SP600125, we demonstrated that the calcium wave triggered the activation of JNK, which then phosphorylated the transcription factor c-Jun to facilitate the binding of AP-1 to the GFAP gene promoter to switch on GFAP upregulation. Calcium 10-17 mitogen-activated protein kinase 8 Homo sapiens 133-136 23683282-11 2013 CONCLUSIONS: This study showed that calcium ions released from MTA play an important role in odontoblastic differentiation of HDPCs via modulation of ERK and JNK activation. Calcium 36-43 mitogen-activated protein kinase 8 Homo sapiens 158-161 23774672-14 2013 Furthermore, evodiamine-mediated JNK activation was abolished by BAPTA-AM, an intracellular calcium scavenger, suggesting that evodiamine mediates autophagy via a calcium-JNK signaling pathway. Calcium 92-99 mitogen-activated protein kinase 8 Homo sapiens 33-36 19875701-0 2010 JNK mitogen-activated protein kinase limits calcium-dependent chloride secretion across colonic epithelial cells. Calcium 44-51 mitogen-activated protein kinase 8 Homo sapiens 0-3 23031789-2 2013 ASK1 activates c-jun N-terminal kinase (JNK) and p38 in response to various stimuli such as oxidative stress, endoplasmic reticulum stress, infection and calcium influx. Calcium 154-161 mitogen-activated protein kinase 8 Homo sapiens 15-38 23031789-2 2013 ASK1 activates c-jun N-terminal kinase (JNK) and p38 in response to various stimuli such as oxidative stress, endoplasmic reticulum stress, infection and calcium influx. Calcium 154-161 mitogen-activated protein kinase 8 Homo sapiens 40-43 23859041-7 2013 Within the JNK MAPK-signaling pathway, interactions between MAP3K7 and protein, vitamin C, iron, folic acid, carbohydrates, and cruciferous vegetables; MAP3K10 and folic acid; MAP3K9 and lutein/zeaxanthin; MAPK8 and calcium; MAP3K3 and calcium and lutein; MAP3K1 and cruciferous vegetables. Calcium 216-223 mitogen-activated protein kinase 8 Homo sapiens 11-14 23859041-7 2013 Within the JNK MAPK-signaling pathway, interactions between MAP3K7 and protein, vitamin C, iron, folic acid, carbohydrates, and cruciferous vegetables; MAP3K10 and folic acid; MAP3K9 and lutein/zeaxanthin; MAPK8 and calcium; MAP3K3 and calcium and lutein; MAP3K1 and cruciferous vegetables. Calcium 236-243 mitogen-activated protein kinase 8 Homo sapiens 11-14 22124122-6 2012 Wnt5a and calcium ionophore activate NFATc1, NFATc2, NF-kappaB, and B cell lymphoma 6 (BCL-6) promptly and upregulate CD40 expression in GC B and Ramos cells, whereas p53 and JNK are not upregulated or activated. Calcium 10-17 mitogen-activated protein kinase 8 Homo sapiens 175-178 22068233-0 2011 CpG protects human monocytic cells against HIV-Vpr-induced apoptosis by cellular inhibitor of apoptosis-2 through the calcium-activated JNK pathway in a TLR9-independent manner. Calcium 118-125 mitogen-activated protein kinase 8 Homo sapiens 136-139 22068233-10 2011 We also show that CpG induced JNK phosphorylation through activation of the calcium signaling pathway. Calcium 76-83 mitogen-activated protein kinase 8 Homo sapiens 30-33 22068233-11 2011 Taken together, our results suggest that CpG-induced protection may be mediated by c-IAP-2 through the calcium-activated JNK pathway via what appeared to be TLR9-independent signaling pathways. Calcium 103-110 mitogen-activated protein kinase 8 Homo sapiens 121-124 23711852-2 2013 Cross-linking of high-affinity receptors for IgE (FcepsilonRI) on mast cells results in rapid increases in intracellular free calcium concentration [Ca(2+)]i and consequent activation of many transcription factors, including NFAT, NF-kappaB, JNK and CREB. Calcium 126-133 mitogen-activated protein kinase 8 Homo sapiens 242-245 20122754-5 2011 Here we show that inhibition of GSK3 and JNK restores calcium oscillations in an hAPP expressing neuronal network, whereas inhibition of Cdk5 does not. Calcium 54-61 mitogen-activated protein kinase 8 Homo sapiens 41-44 20122754-7 2011 Altogether, these results indicate that the intracellular domain of APP is needed to inhibit neuronal calcium oscillations because GSK3/JNK phosphorylation of T668 controls APP trafficking at the plasma membrane. Calcium 102-109 mitogen-activated protein kinase 8 Homo sapiens 136-139 19700217-5 2010 The release of calcium triggered the production of ROS, which further enhances calcium overloading and subsequently activates p38, JNK and ERK1/2. Calcium 15-22 mitogen-activated protein kinase 8 Homo sapiens 131-134 20567760-0 2010 Chemical biology suggests a role for calcium signaling in mediating sustained JNK activation during apoptosis. Calcium 37-44 mitogen-activated protein kinase 8 Homo sapiens 78-81 20567760-5 2010 Recent evidence, using chemical biology, has raised the possibility that calcium signaling is involved in sustained JNK activation during late phases of apoptosis. Calcium 73-80 mitogen-activated protein kinase 8 Homo sapiens 116-119 20567760-6 2010 For at least some stimuli, calcium release leads to activation of calmodulin kinase II (CaMKII), apoptosis signaling kinase 1 (ASK1) and JNK. Calcium 27-34 mitogen-activated protein kinase 8 Homo sapiens 137-140 18673549-10 2008 CONCLUSION: Our study shows that calcium signaling is generally not an early event during the apoptosis process and suggests that a CaMKII/ASK1 signaling mechanism is important for sustained JNK activation and apoptosis by some types of stimuli. Calcium 33-40 mitogen-activated protein kinase 8 Homo sapiens 191-194 19486902-0 2009 Nobiletin, a dietary phytochemical, inhibits vascular smooth muscle cells proliferation via calcium-mediated c-Jun N-terminal kinases pathway. Calcium 92-99 mitogen-activated protein kinase 8 Homo sapiens 109-133 19502798-4 2009 We show that rapid AJ/TJ disassembly triggered by extracellular calcium depletion of T84 and SK-CO15 cell monolayers was accompanied by activation (phosphorylation) of JNK, and prevented by pharmacological inhibitors of JNK. Calcium 64-71 mitogen-activated protein kinase 8 Homo sapiens 168-171 19502798-4 2009 We show that rapid AJ/TJ disassembly triggered by extracellular calcium depletion of T84 and SK-CO15 cell monolayers was accompanied by activation (phosphorylation) of JNK, and prevented by pharmacological inhibitors of JNK. Calcium 64-71 mitogen-activated protein kinase 8 Homo sapiens 220-223 19502798-6 2009 JNK1 but not JNK2 was found to colocalize with intercellular junctions, and siRNA-mediated downregulation of JNK1 attenuated the TJ/AJ disruption caused by calcium depletion. Calcium 156-163 mitogen-activated protein kinase 8 Homo sapiens 0-4 19502798-6 2009 JNK1 but not JNK2 was found to colocalize with intercellular junctions, and siRNA-mediated downregulation of JNK1 attenuated the TJ/AJ disruption caused by calcium depletion. Calcium 156-163 mitogen-activated protein kinase 8 Homo sapiens 109-113 19502798-7 2009 JNK inhibition also blocked formation of characteristic contractile F-actin rings in calcium-depleted epithelial cells, suggesting that JNK regulates junctions by remodeling the actin cytoskeleton. Calcium 85-92 mitogen-activated protein kinase 8 Homo sapiens 0-3 19502798-7 2009 JNK inhibition also blocked formation of characteristic contractile F-actin rings in calcium-depleted epithelial cells, suggesting that JNK regulates junctions by remodeling the actin cytoskeleton. Calcium 85-92 mitogen-activated protein kinase 8 Homo sapiens 136-139 19502798-8 2009 In this role JNK acts downstream of the actin-reorganizing Rho-dependent kinase (ROCK), since ROCK inhibition abrogated JNK phosphorylation and TJ/AJ disassembly after calcium depletion. Calcium 168-175 mitogen-activated protein kinase 8 Homo sapiens 13-16 17964630-4 2008 In addition, multiple signaling pathways are involved cooperatively in the expression of COX-2 activated by the viral protein in a calcium-independent manner, which requires signaling components including JNK, ERK, and PKD2. Calcium 131-138 mitogen-activated protein kinase 8 Homo sapiens 205-208 15389694-10 2004 Cytoplasmic calcium increases may be causally related to the release of cytochrome c, and may also be a potential pathway for activation of JNK in hair cells. Calcium 12-19 mitogen-activated protein kinase 8 Homo sapiens 140-143 17514353-5 2007 Buffering of the calcium response attenuated mitochondrial impairment, recovered the cadmium-activated Akt, p53, JNK, ERK and p38, and subsequently blocked the apoptosis. Calcium 17-24 mitogen-activated protein kinase 8 Homo sapiens 113-116 17267381-5 2007 We also demonstrated that another unusual pathway, the calcium-independent PI3K/PKC epsilon/JNK/CREB pathway, functioned in cooperation with the calcium-dependent pathway to induce COX-2 expression upon stimulation by spike protein. Calcium 55-62 mitogen-activated protein kinase 8 Homo sapiens 92-95 17267381-5 2007 We also demonstrated that another unusual pathway, the calcium-independent PI3K/PKC epsilon/JNK/CREB pathway, functioned in cooperation with the calcium-dependent pathway to induce COX-2 expression upon stimulation by spike protein. Calcium 145-152 mitogen-activated protein kinase 8 Homo sapiens 92-95 14729602-3 2004 Calcium has also been shown to activate phosphatidylinositol triphosphate kinase and/or JNK. Calcium 0-7 mitogen-activated protein kinase 8 Homo sapiens 88-91 15226266-5 2004 We show here that the activation of JNK by this condition is initiated in the mitochondria and requires coupled electron transport, ROI generation, and calcium flux. Calcium 152-159 mitogen-activated protein kinase 8 Homo sapiens 36-39 15226266-7 2004 Interruption of these interactions with inactivated dominant negative mutant proteins, blocking calcium flux, or inhibiting electron transport through mitochondrial complexes II, III, or IV prevents JNK activation and results in a proapoptotic phenotype that is characteristic of JNK inhibition in this model of ischemia-reperfusion. Calcium 96-103 mitogen-activated protein kinase 8 Homo sapiens 199-202 14729602-4 2004 Here, we show that calcium signaling in ovarian surface epithelial cells not only induces telomerase activity via JNK but also activates Pyk2. Calcium 19-26 mitogen-activated protein kinase 8 Homo sapiens 114-117 14661261-4 2004 The immunohistochemical study demonstrated that the modulation of the calcium gradient by EDTA activated MAP kinases (ERK and JNK) in the rabbit vaginal mucosa. Calcium 70-77 mitogen-activated protein kinase 8 Homo sapiens 126-129 14507925-6 2003 The effect of calcium depends upon JNK activation, which primes the scaffold for ubiquitination-mediated degradation via the proteasome machinery. Calcium 14-21 mitogen-activated protein kinase 8 Homo sapiens 35-38 14507925-8 2003 These data indicate that calcium influx initiated by cytokines mediates ubiquitination and degradation of IB1/JIP1 and may, therefore, provide a link between calcium influx and JNK-mediated apoptosis in pancreatic beta-cells. Calcium 25-32 mitogen-activated protein kinase 8 Homo sapiens 177-180 14507925-8 2003 These data indicate that calcium influx initiated by cytokines mediates ubiquitination and degradation of IB1/JIP1 and may, therefore, provide a link between calcium influx and JNK-mediated apoptosis in pancreatic beta-cells. Calcium 158-165 mitogen-activated protein kinase 8 Homo sapiens 177-180 11018025-2 2000 To elucidate the role of MAPKs in keratinocyte differentiation, activation of ERK, JNK, and p38 in response to stimulation with extracellular calcium was analyzed. Calcium 142-149 mitogen-activated protein kinase 8 Homo sapiens 83-86 14507925-0 2003 Calcium- and proteasome-dependent degradation of the JNK scaffold protein islet-brain 1. Calcium 0-7 mitogen-activated protein kinase 8 Homo sapiens 53-56 12119061-7 2002 RESULTS: We found that a tyrosine phosphorylated Cas substrate domain acts as a dominant negative mutant by blocking Cas-mediated signaling events, including JNK activation by the oncogene v-crk in transient and stable lines and v-crk transformation. Calcium 49-52 mitogen-activated protein kinase 8 Homo sapiens 158-161 12119061-7 2002 RESULTS: We found that a tyrosine phosphorylated Cas substrate domain acts as a dominant negative mutant by blocking Cas-mediated signaling events, including JNK activation by the oncogene v-crk in transient and stable lines and v-crk transformation. Calcium 117-120 mitogen-activated protein kinase 8 Homo sapiens 158-161 10734116-5 2000 This JNK activation was associated with extracellular matrix synthesis and increased calcium deposition, the two hallmarks of bone formation. Calcium 85-92 mitogen-activated protein kinase 8 Homo sapiens 5-8 9573527-8 1998 Since an increase in intracellular calcium ([Ca2+]i) was shown to be necessary for ET-1-induced activation of JNK in mesangial cells, we measured [Ca2+]i using fura-2. Calcium 35-42 mitogen-activated protein kinase 8 Homo sapiens 110-113 9682214-7 1998 In contrast, the reduction in JNK activity in cells expressing bcl-2 can be restored by costimulation with a calcium ionophore. Calcium 109-116 mitogen-activated protein kinase 8 Homo sapiens 30-33 10064599-4 1999 Calcium-activated transcription mediated by c-Jun functions in the absence of stimulation of the c-Jun N-terminal protein kinase (JNK/SAPK1) signalling pathway and does not require c-Jun amino acid residues Ser63 and Ser73, the two major phosphorylation sites that regulate c-Jun activity in response to stress signals. Calcium 0-7 mitogen-activated protein kinase 8 Homo sapiens 130-139 9710210-4 1998 We have identified another putative SEK/ JNK pathway regulator, PKCtheta, which in contrast to CDC42, activates SEK and JNK maximally only in conjunction with a calcium signal delivered through calcineurin. Calcium 161-168 mitogen-activated protein kinase 8 Homo sapiens 41-44 9710210-4 1998 We have identified another putative SEK/ JNK pathway regulator, PKCtheta, which in contrast to CDC42, activates SEK and JNK maximally only in conjunction with a calcium signal delivered through calcineurin. Calcium 161-168 mitogen-activated protein kinase 8 Homo sapiens 120-123 9067893-12 1997 These results indicate that ET-1 is able to activate JNK in glomerular mesangial cells through PKC-independent and PTK-dependent pathways and intracellular calcium is necessary to the activation of JNK. Calcium 156-163 mitogen-activated protein kinase 8 Homo sapiens 198-201 9597145-5 1998 Recent findings in B lymphocytes have clearly illustrated that these external inputs affect the magnitude and duration of the intracellular calcium response, which in turn contributes to differential triggering of the transcriptional regulators NF kappa B, JNK, NFAT, and ERK. Calcium 140-147 mitogen-activated protein kinase 8 Homo sapiens 257-260 9207756-2 1997 Diacylglycerol (DAG) and calcium produce the activation of PKC, ERK and JNK kinases, implying a normal IL-2 response. Calcium 25-32 mitogen-activated protein kinase 8 Homo sapiens 72-75 9067893-8 1997 In contrast, ET-1-induced activation of JNK was significantly reduced by calcium chelation (with BAPTA/AM and EGTA). Calcium 73-80 mitogen-activated protein kinase 8 Homo sapiens 40-43 9067893-9 1997 In addition, ionomycin, a calcium ionophore, and thapsigargin, an intracellular calcium-rising agent, were able to induce the activation of JNK. Calcium 26-33 mitogen-activated protein kinase 8 Homo sapiens 140-143 9067893-9 1997 In addition, ionomycin, a calcium ionophore, and thapsigargin, an intracellular calcium-rising agent, were able to induce the activation of JNK. Calcium 80-87 mitogen-activated protein kinase 8 Homo sapiens 140-143 9126747-3 1997 We report here that the amplitude and duration of calcium signals in B lymphocytes controls differential activation of the pro-inflammatory transcriptional regulators NF-kappaB, c-Jun N-terminal kinase (JNK) and NFAT. Calcium 50-57 mitogen-activated protein kinase 8 Homo sapiens 178-201 9126747-3 1997 We report here that the amplitude and duration of calcium signals in B lymphocytes controls differential activation of the pro-inflammatory transcriptional regulators NF-kappaB, c-Jun N-terminal kinase (JNK) and NFAT. Calcium 50-57 mitogen-activated protein kinase 8 Homo sapiens 203-206 33610907-4 2021 Using a Piezo1-specific activator, Yoda1, we identified that calcium entry induced by Yoda1 resulted in phosphorylation of JNK, p38, and ERK, thereby activating the mitogen-activated protein kinase (MAPK) pathway, in a dose- and time-dependent manner. Calcium 61-68 mitogen-activated protein kinase 8 Homo sapiens 123-126 8939945-8 1996 Although maximal JNK activation by stress-dependent pathways (e.g. UV and anisomycin) was equivalent in the two cell lines, calcium-dependent JNK activation was 5-fold greater in GN4, correlating with CADTK activation. Calcium 124-131 mitogen-activated protein kinase 8 Homo sapiens 142-145 8939945-11 1996 In summary, cells expressing CADTK/PYK2 appear to have two alternative JNK activation pathways: one stress-activated and the other calcium-dependent. Calcium 131-138 mitogen-activated protein kinase 8 Homo sapiens 71-74 7565768-0 1995 Angiotensin II stimulates calcium-dependent activation of c-Jun N-terminal kinase. Calcium 26-33 mitogen-activated protein kinase 8 Homo sapiens 58-81 32065645-0 2020 Expression of Concern: "Cadmium Induces Intracellular Ca2+- and H2O2-Dependent Apoptosis through JNK- and p53-Mediated Pathways in Skin Epidermal Cell line". Calcium 54-58 mitogen-activated protein kinase 8 Homo sapiens 97-100 32787872-11 2020 Ethanol-increased NMDAR induced intracellular calcium overload and calmodulin-dependent protein kinase II (CaMKII) activation leading to phosphorylation of dynamin-related protein 1 (Drp1) and c-Jun N-terminal protein kinase 1 (JNK1). Calcium 46-53 mitogen-activated protein kinase 8 Homo sapiens 193-226 31649333-3 2020 Here we show that Emei is a novel ER Ca2+ regulator that synergizes with RasV12 to induce tumor growth via JNK-mediated Hippo signaling. Calcium 37-41 mitogen-activated protein kinase 8 Homo sapiens 107-110 31916113-4 2020 So far, inhibition of c-Jun N-terminal kinase (JNK) in high calcium medium has been supposed to be the only way to induce TJ formations in HaCaT cells; however, SP600125, a potent inhibitor of JNK showed cytostatic effects and clearly attenuated epidermal differentiation and stratification. Calcium 60-67 mitogen-activated protein kinase 8 Homo sapiens 22-45 31916113-4 2020 So far, inhibition of c-Jun N-terminal kinase (JNK) in high calcium medium has been supposed to be the only way to induce TJ formations in HaCaT cells; however, SP600125, a potent inhibitor of JNK showed cytostatic effects and clearly attenuated epidermal differentiation and stratification. Calcium 60-67 mitogen-activated protein kinase 8 Homo sapiens 47-50 31649333-4 2020 Emei disruption reduces ER Ca2+ level and subsequently leads to JNK activation and Hippo inactivation. Calcium 27-31 mitogen-activated protein kinase 8 Homo sapiens 64-67 31649333-7 2020 Together, our findings provide a novel mechanism of tumor growth that acts through intracellular Ca2+ levels to modulate JNK-mediated Hippo signaling. Calcium 97-101 mitogen-activated protein kinase 8 Homo sapiens 121-124 27001263-9 2016 The c-Jun N-terminal kinase (JNK) pathway was activated after treatment with IS, whereas inhibition of the JNK pathway partially attenuated the effect of IS on both the stimulation of Pit-1 expression and calcium deposition. Calcium 205-212 mitogen-activated protein kinase 8 Homo sapiens 107-110 28414098-0 2017 Cytosolic calcium mediates RIP1/RIP3 complex-dependent necroptosis through JNK activation and mitochondrial ROS production in human colon cancer cells. Calcium 10-17 mitogen-activated protein kinase 8 Homo sapiens 75-78 30556404-7 2019 A positive feedback loop between calcium (Ca2+) and c-Jun N-terminal kinase (JNK) occurred following ROS generation, leading to lysosomal membrane permeabilization and mitochondrial dysfunction. Calcium 33-40 mitogen-activated protein kinase 8 Homo sapiens 52-75 30556404-7 2019 A positive feedback loop between calcium (Ca2+) and c-Jun N-terminal kinase (JNK) occurred following ROS generation, leading to lysosomal membrane permeabilization and mitochondrial dysfunction. Calcium 33-40 mitogen-activated protein kinase 8 Homo sapiens 77-80 29644008-8 2018 The activity of SHC, AKT, ERK, P90RSK and JNK were enhanced after calcium treatment of CaSR-transfected cells. Calcium 66-73 mitogen-activated protein kinase 8 Homo sapiens 42-45 28919046-8 2017 The resultant rise in intracellular calcium and production of mitochondrial reactive oxygen species induced expression of NFAT responsive-genes and enhanced TGF-beta1 autoinduction through non-canonical JNK-dependent pathways. Calcium 36-43 mitogen-activated protein kinase 8 Homo sapiens 203-206 28414098-13 2017 In summary, our study demonstrated that RIP1/RIP3 complex-triggered cytosolic calcium accumulation is a critical mediator in MAM-induced necroptosis through sustained JNK activation and mitochondrial ROS production. Calcium 78-85 mitogen-activated protein kinase 8 Homo sapiens 167-170 24906456-12 2014 In conclusion, O2-induced EGFR transactivation initiates p38/JNK-mediated increases in cytosolic calcium and contributes to DA contraction. Calcium 97-104 mitogen-activated protein kinase 8 Homo sapiens 61-64 27563337-3 2016 IRE1-JNK and eIF2alpha-CHOP signaling pathways are the two important players of ER stress, which is also modulated by ROS production, calcium disturbance, and inflammatory factors. Calcium 134-141 mitogen-activated protein kinase 8 Homo sapiens 5-8 26272544-5 2015 Inhibition of the JNK signaling pathway using SP600125 blocked osteogenic differentiation in a dose-dependent manner, which was revealed by an ALP activity assay, extracellular calcium deposition detection, and expression of osteogenesis-relative genes (Runx2, ALP, and OCN) via RT-PCR and real-time PCR. Calcium 177-184 mitogen-activated protein kinase 8 Homo sapiens 18-21 24961950-0 2014 Endoplasmic reticulum stress-induced hepatic stellate cell apoptosis through calcium-mediated JNK/P38 MAPK and Calpain/Caspase-12 pathways. Calcium 77-84 mitogen-activated protein kinase 8 Homo sapiens 94-97 24961950-5 2014 As expected, preventing an increase in intracellular calcium levels using intracellular calcium chelators, EGTA, and BAPTA/AM, could substantially inhibit the phosphorylation of JNK and p38 MAPK, abolish the activation of calpains, namely caspase-12, caspase-9, and caspase-3, and provide significant protection for TG-treated activated HSCs. Calcium 53-60 mitogen-activated protein kinase 8 Homo sapiens 178-181 24961950-5 2014 As expected, preventing an increase in intracellular calcium levels using intracellular calcium chelators, EGTA, and BAPTA/AM, could substantially inhibit the phosphorylation of JNK and p38 MAPK, abolish the activation of calpains, namely caspase-12, caspase-9, and caspase-3, and provide significant protection for TG-treated activated HSCs. Calcium 88-95 mitogen-activated protein kinase 8 Homo sapiens 178-181 24961950-10 2014 These findings showed that the Calpain/Caspase-12 activation induced by ER stress and the JNK/p38 MAPK phosphorylation induced by the increase of intracellular calcium concentration releasing from ER are the novel signaling pathway underlying the molecular mechanism of fibrosis recovery. Calcium 160-167 mitogen-activated protein kinase 8 Homo sapiens 90-93 24908484-6 2014 Activation of TrkB receptors triggers a signaling cascade involving JNK-mediated activation of cJun that regulates tlx3, a glutamate/GABA selector gene, accounting for calcium-spike BDNF-dependent transmitter switching. Calcium 168-175 mitogen-activated protein kinase 8 Homo sapiens 68-71