PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16920718-0 2006 Calcium-dependent modulation of poly(ADP-ribose) polymerase-1 alters cellular metabolism and DNA repair. Calcium 0-7 poly(ADP-ribose) polymerase 1 Homo sapiens 32-61 30867423-4 2019 PARP1 deficiency blocks, whereas PARP1 overexpression exacerbates, the transdifferentiation of VSMCs from a contractile to an osteogenic phenotype, the expression of mineralization-regulating proteins, and calcium deposition. Calcium 206-213 poly(ADP-ribose) polymerase 1 Homo sapiens 0-5 30867423-4 2019 PARP1 deficiency blocks, whereas PARP1 overexpression exacerbates, the transdifferentiation of VSMCs from a contractile to an osteogenic phenotype, the expression of mineralization-regulating proteins, and calcium deposition. Calcium 206-213 poly(ADP-ribose) polymerase 1 Homo sapiens 33-38 28525621-2 2017 Under robust oxidative DNA damage, PARP-1 is hyperactivated, resulting in the depletion of NAD+ and ATP with accompanying elevations in intracellular calcium concentrations (iCa2+), and ultimately necrotic cell death. Calcium 150-157 poly(ADP-ribose) polymerase 1 Homo sapiens 35-41 20961042-5 2010 BAPTA/AM and calpeptin inhibited the cordycepin-induced cleavage of caspase 7 and poly (ADP-ribose) polymerase (PARP), implying an upstream role of calcium and calpain. Calcium 148-155 poly(ADP-ribose) polymerase 1 Homo sapiens 112-116 19490937-5 2009 The mechanism of cell death induced by simultaneous treatment of Alp and caffeine was associated with the calcium-mediated activation of mu-calpain, release of lysosomal protease cathepsin B, activation of PARP and cleavage of caspase 3. Calcium 106-113 poly(ADP-ribose) polymerase 1 Homo sapiens 206-210 27470189-5 2016 Cell death with DNA breaks in the nucleus was greater using combined regimens of PAM and HDAC inhibitors such as trichostatin A (TSA) and valproic acid (VPA) than a single PAM treatment and was accompanied by the activation of poly (ADP-ribose) polymerase-1 (PARP-1), depletion of ATP, and elevations in intracellular calcium levels. Calcium 318-325 poly(ADP-ribose) polymerase 1 Homo sapiens 227-257 21979311-7 2011 These calcium reactions were compared and analyzed with the results of cell viability test, Hoechst staining, intracellular reactive oxygen species level and expression of caspase-3, and poly-ADP-ribose polymerase (PARP). Calcium 6-13 poly(ADP-ribose) polymerase 1 Homo sapiens 187-213 21979311-7 2011 These calcium reactions were compared and analyzed with the results of cell viability test, Hoechst staining, intracellular reactive oxygen species level and expression of caspase-3, and poly-ADP-ribose polymerase (PARP). Calcium 6-13 poly(ADP-ribose) polymerase 1 Homo sapiens 215-219 14529457-7 2003 This review will present some of the latest mechanistic evidence documenting the potential involvement of PARP-1 inhibitors in protecting mitochondrial function and preventing necrosis, apoptosis and mitochondrial calcium cycling. Calcium 214-221 poly(ADP-ribose) polymerase 1 Homo sapiens 106-112 16630823-4 2006 When neurons are stimulated by membrane depolarization, calcium signaling mediated by CaMKII induces dissociation of KIF4 from PARP-1, resulting in upregulation of PARP-1 activity, which supports neuron survival. Calcium 56-63 poly(ADP-ribose) polymerase 1 Homo sapiens 127-133 16630823-4 2006 When neurons are stimulated by membrane depolarization, calcium signaling mediated by CaMKII induces dissociation of KIF4 from PARP-1, resulting in upregulation of PARP-1 activity, which supports neuron survival. Calcium 56-63 poly(ADP-ribose) polymerase 1 Homo sapiens 164-170 9759901-6 1998 Inhibition of PARS by 3-aminobenzamide or 5-iodo-6-amino-1,2-benzopyrone attenuated peroxynitrite-induced delta psi(m) reduction, secondary reactive oxygen intermediate generation, cardiolipin degradation, and intracellular calcium mobilization. Calcium 224-231 poly(ADP-ribose) polymerase 1 Homo sapiens 14-18 9920281-7 1999 The chelation of intracellular calcium by bis-(o-aminophenoxy)-ethane-N,N,N1,N1-tetraacidic acid/tetraacetoxymethyl) ester also prevented the dramatic loss of NAD+, demonstrating that Ca2+ is an activating factor in PARP-mediated cell killing. Calcium 31-38 poly(ADP-ribose) polymerase 1 Homo sapiens 216-220 9850147-1 1998 In the infant brain, ischemia-induced ionic and enzyme mechanisms may independently lead to cell death by energy depletion: resequestration of calcium mobilized from intracellular stores consumes ATP, and activated poly(ADP-ribose) polymerase (PARP) uses oxidized nicotinamide adenine dinucleotide to form polyADP-ribosyl nuclear proteins associated with DNA damage. Calcium 143-150 poly(ADP-ribose) polymerase 1 Homo sapiens 244-248 33811702-2 2021 However, little is known about how PARP1 hyperactivity is regulated during calcium overload. Calcium 75-82 poly(ADP-ribose) polymerase 1 Homo sapiens 35-40 9166714-8 1997 This may occur by ONOO- interfering with key enzymes of the tricarboxylic acid cycle, the mitochondrial respiratory chain, mitochondrial calcium metabolism, or DNA damage with subsequent activation of the energy-consuming pathway involving poly(ADP-ribose) synthetase. Calcium 137-144 poly(ADP-ribose) polymerase 1 Homo sapiens 240-267 32036619-5 2020 While best understood for its role in promoting DNA repair, our group has shown that PARP-1 activity can be stimulated via Ca2+ influx-dependent ERK1/2-mediated phosphorylation. Calcium 123-127 poly(ADP-ribose) polymerase 1 Homo sapiens 85-91 32036619-6 2020 However, to date, the route of Ca2+ entry responsible for stimulating PARP-1 has not been identified. Calcium 31-35 poly(ADP-ribose) polymerase 1 Homo sapiens 70-76 32036619-7 2020 A likely candidate is via Ca2+ -permeable transient receptor potential melastatin 2 (TRPM2) channels activated downstream of PARP-1 in a cascade that involves ADP-ribose (ADPR) production by poly(ADP-ribose) glycohydrolase (PARG). Calcium 26-30 poly(ADP-ribose) polymerase 1 Homo sapiens 125-131 32036619-10 2020 Furthermore, we show that Ca2+ influx is necessary to activate PARP-1/TRPM2 signaling, in an ERK1/2-dependent, but DNA damage independent, manner. Calcium 26-30 poly(ADP-ribose) polymerase 1 Homo sapiens 63-69