PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
20059748-1	2010	Niemann-Pick disease type C is a complex lysosomal storage disorder caused by mutations in either the NPC1 or NPC2 genes that is characterized at the cellular level by the storage of multiple lipids, defective lysosomal calcium homeostasis and unique trafficking defects.	Calcium	220-227	NPC intracellular cholesterol transporter 1	Homo sapiens	102-106	
31601621-0	2019	Disease-associated mutations in Niemann-Pick type C1 alter ER calcium signaling and neuronal plasticity.	Calcium	62-69	NPC intracellular cholesterol transporter 1	Homo sapiens	32-52	
19566836-14	2010	Loss-of-function mutations in the NPC1 gene lead to a failure of the calcium-mediated fusion of endosomes with lysosomes, resulting in the accumulation of cholesterol and other lipids in late endosomes and lysosomes.	Calcium	69-76	NPC intracellular cholesterol transporter 1	Homo sapiens	34-38	
26014711-5	2015	Impaired cholesterol trafficking and unesterified cholesterol accumulation in the late endosomes and lysosomals, as a results of mutations in NPC1 or NPC2 genes, are initial for the disease, and defective cellular autophagy, defective lysosomal calcium homeostasis and oxidative stress may all play roles in the physiological processes.	Calcium	245-252	NPC intracellular cholesterol transporter 1	Homo sapiens	142-146	
25946402-6	2016	Niemann-Pick disease type C is a rare, devastating, inherited lysosomal storage disease with a unique cellular phenotype characterized by lysosomal accumulation of sphingosine, various glycosphingolipids and cholesterol and a reduction in lysosomal calcium.	Calcium	249-256	NPC intracellular cholesterol transporter 1	Homo sapiens	0-27	
24131821-19	2013	We were able to describe functional/structural sub-domain architecture related to key residues for starch cleavage, calcium, and chloride binding sites in the alpha-amylase, and sterol opening-defining modules and disease-related residues in the NPC1.	Calcium	116-123	NPC intracellular cholesterol transporter 1	Homo sapiens	246-250	
25637190-0	2015	Rescue of an in vitro neuron phenotype identified in Niemann-Pick disease, type C1 induced pluripotent stem cell-derived neurons by modulating the WNT pathway and calcium signaling.	Calcium	163-170	NPC intracellular cholesterol transporter 1	Homo sapiens	53-82	
24068806-3	2013	Since adenosine A2A receptors (A2ARs) control lysosome trafficking and pH, which closely regulates lysosomal calcium, we hypothesized a role for these receptors in NPC1.	Calcium	109-116	NPC intracellular cholesterol transporter 1	Homo sapiens	164-168	
22505584-5	2012	We demonstrate that targeting endoplasmic reticulum (ER) calcium levels using ryanodine receptor (RyR) antagonists increased steady-state levels of the NPC1 I1061T protein.	Calcium	57-64	NPC intracellular cholesterol transporter 1	Homo sapiens	152-156