PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
12082084-5	2002	Present studies used an adenoviral construct that expresses the calcium-stimulated AC8 to convert normal calcium inhibition into stimulation of cAMP, within physiologically relevant concentration ranges.	Calcium	64-71	adenylate cyclase 8	Homo sapiens	83-86	
16750914-3	2006	For our studies, we chose the calcium-independent complex between calmodulin and a 25-amino acid peptide from the C-terminal region of adenylyl cyclase 8 containing an "IQ-like motif."	Calcium	30-37	adenylate cyclase 8	Homo sapiens	135-153	
16322659-2	2005	In the present study, we are mapping the interface of the calcium-dependent complex between calmodulin (CaM) and a peptide derived from the C-terminal region of adenylyl cyclase 8 (AC 8).	Calcium	58-65	adenylate cyclase 8	Homo sapiens	161-179	
16322659-2	2005	In the present study, we are mapping the interface of the calcium-dependent complex between calmodulin (CaM) and a peptide derived from the C-terminal region of adenylyl cyclase 8 (AC 8).	Calcium	58-65	adenylate cyclase 8	Homo sapiens	181-185	
19158400-0	2009	Insights into the residence in lipid rafts of adenylyl cyclase AC8 and its regulation by capacitative calcium entry.	Calcium	102-109	adenylate cyclase 8	Homo sapiens	63-66	
15574428-2	2005	This restrictive localization plays a key role in the regulation of the Ca(2+)-stimulable AC8 and the Ca(2+)-inhibitable AC6 by capacitative calcium entry.	Calcium	141-148	adenylate cyclase 8	Homo sapiens	90-93	
12082084-5	2002	Present studies used an adenoviral construct that expresses the calcium-stimulated AC8 to convert normal calcium inhibition into stimulation of cAMP, within physiologically relevant concentration ranges.	Calcium	105-112	adenylate cyclase 8	Homo sapiens	83-86	
12082084-7	2002	In PAECs, gap formation was progressive over 2 h, whereas in PMVECs, gap formation was rapid (within 10 min) and gaps resealed within 2 h. Expression of AC8 resulted in a modest calcium stimulation of cAMP, which virtually abolished thrombin-induced gap formation in PMVECs.	Calcium	178-185	adenylate cyclase 8	Homo sapiens	153-156	
10066258-2	1999	The type VIII AC (AC8) is one of three mammalian calcium-stimulated isoforms, each of which is expressed in a region-specific manner in the CNS.	Calcium	49-56	adenylate cyclase 8	Homo sapiens	18-21	
11264454-3	2001	The present review deals with various aspects of such regulations, emphasizing the role of calcium/calmodulin in activating AC1 and AC8 in the central nervous system, the potential inhibitory effect of calcium on AC5 and AC6, and the changes in the expression pattern of the isoforms during development.	Calcium	91-98	adenylate cyclase 8	Homo sapiens	132-135	
31652779-6	2019	AC8 knockdown in MDA-MB-231 cells, using two different small interfering RNAs (siRNAs), attenuates thapsigargin (TG)-induced Ca2+ entry and also Ca2+ influx mediated by co-expression of Orai1 and the Orai1-activating small fragment (OASF) of STIM1 (stromal interaction molecule-1).	Calcium	145-149	adenylate cyclase 8	Homo sapiens	0-3	
31652779-6	2019	AC8 knockdown in MDA-MB-231 cells, using two different small interfering RNAs (siRNAs), attenuates thapsigargin (TG)-induced Ca2+ entry and also Ca2+ influx mediated by co-expression of Orai1 and the Orai1-activating small fragment (OASF) of STIM1 (stromal interaction molecule-1).	Calcium	125-129	adenylate cyclase 8	Homo sapiens	0-3	
31652779-7	2019	Conversely, AC8 overexpression enhances SOCE, as well as Ca2+ entry, in cells co-expressing Orai1 and OASF.	Calcium	57-61	adenylate cyclase 8	Homo sapiens	12-15	
25859219-6	2015	Short (milliseconds or seconds) and long (minutes) term influences of calcium are discussed including direct regulation of ion channels and NCX, and control of the activity of calcium-dependent enzymes (including CaMKII, AC1, and AC8).	Calcium	70-77	adenylate cyclase 8	Homo sapiens	230-233	
27234425-6	2016	CONCLUSIONS: Our results suggest that calcium-stimulated AC8 is required to sustain the long-lasting anxiety caused by repeated EPM testing, and we can identify in AC8 a novel target for treating anxiety-related mood disorders.	Calcium	38-45	adenylate cyclase 8	Homo sapiens	57-60	
27234425-6	2016	CONCLUSIONS: Our results suggest that calcium-stimulated AC8 is required to sustain the long-lasting anxiety caused by repeated EPM testing, and we can identify in AC8 a novel target for treating anxiety-related mood disorders.	Calcium	38-45	adenylate cyclase 8	Homo sapiens	164-167	
25368329-3	2014	We demonstrate that an intracellular sodium channel variant, human macrophage SCN5A, initiates signaling and transcription through a calcium-dependent isoform of adenylate cyclase, ADCY8, and the transcription factor, ATF2.	Calcium	133-140	adenylate cyclase 8	Homo sapiens	181-186