PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 20195498-2 2010 The induction of late-phase LTP (L-LTP) in the CA1 region of the hippocampus requires several kinases, including CaMKII and PKA, which are activated by calcium-dependent signaling processes and other intracellular signaling pathways. Calcium 152-159 carbonic anhydrase 1 Homo sapiens 47-50 16777351-13 2006 Further, estrogen preconditioning initiated a calcium-mediated signaling pathway leading to protection of CA1 neurons against ischemia. Calcium 46-53 carbonic anhydrase 1 Homo sapiens 106-109 19879359-0 2010 Differential NMDA receptor-dependent calcium loading and mitochondrial dysfunction in CA1 vs. CA3 hippocampal neurons. Calcium 37-44 carbonic anhydrase 1 Homo sapiens 86-89 19879359-4 2010 Consequently, CA1 mitochondria exhibit stronger calcium accumulation, more extensive swelling and damage, stronger depolarization of their membrane potential, and a significant increase in ROS generation. Calcium 48-55 carbonic anhydrase 1 Homo sapiens 14-17 18336307-5 2008 These two CAs are catalytically efficient with almost identical activity to that of the human isoform CA I for the CO(2) hydration reaction, and highly inhibited by many sulfonamides/sulfamates, including acetazolamide, ethoxzolamide, topiramate and sulpiride, all clinically used drugs. Calcium 10-13 carbonic anhydrase 1 Homo sapiens 102-106 17680671-7 2007 When Schaffer collateral synapses stained with calcium orange AM, a membrane-permeable calcium indicator, were regionally stimulated with 1 mM glutamate, calcium orange signal was increased in the CA1 pyramidal cell layer. Calcium 47-54 carbonic anhydrase 1 Homo sapiens 197-200 17272353-2 2007 We have used high-speed confocal and two-photon imaging to measure calcium and voltage signals associated with action potential propagation into oblique branches of CA1 pyramidal neurons in adult hippocampal slices. Calcium 67-74 carbonic anhydrase 1 Homo sapiens 165-168 19666491-4 2009 By measuring calcium-dependent fluorescence transients in dendritic spines, we show that CA2 neurons have smaller action potential-evoked intracellular Ca(2+) transients because of a higher endogenous Ca(2+)-buffering capacity and significantly higher rates of Ca(2+) extrusion when compared with CA1 and CA3 neurons. Calcium 13-20 carbonic anhydrase 1 Homo sapiens 297-300 19086158-13 2008 The serine headgroup in the second site binds through a Gla domain-bound calcium ion Ca1, Gla30, and Lys11. Calcium 73-80 carbonic anhydrase 1 Homo sapiens 85-88 18812492-0 2008 Chronic benzodiazepine administration potentiates high voltage-activated calcium currents in hippocampal CA1 neurons. Calcium 73-80 carbonic anhydrase 1 Homo sapiens 105-108 18812492-3 2008 High voltage-activated (HVA) calcium currents were measured in whole-cell recordings from acutely isolated hippocampal CA1 neurons after a 1-week flurazepam (FZP) treatment that results in withdrawal-anxiety. Calcium 29-36 carbonic anhydrase 1 Homo sapiens 119-122 18647831-4 2008 IA training is followed by an increase of the phosphorylation of calcium and calmodulin-dependent protein kinase II (CaMKII) and ERK2 in CA1 but only an increase of the phosphorylation of ERK2 in BLA. Calcium 65-72 carbonic anhydrase 1 Homo sapiens 137-140 16899258-1 2007 The triggering of both NMDA receptor-dependent long-term potentiation (LTP) and long-term depression (LTD) in the CA1 region of the hippocampus requires a rise in postsynaptic calcium. Calcium 176-183 carbonic anhydrase 1 Homo sapiens 114-117 16736206-2 2006 The apical dendrites of CA1 pyramidal neurons in hippocampus express a wide variety of sodium, calcium, potassium, and other voltage-gated channels. Calcium 95-102 carbonic anhydrase 1 Homo sapiens 24-27 16763032-0 2006 Muscarinic enhancement of R-type calcium currents in hippocampal CA1 pyramidal neurons. Calcium 33-40 carbonic anhydrase 1 Homo sapiens 65-68 16283763-4 2005 Upon the addition of calcium, particularly at Ca:beta-casein molar ratios above approximately 5:1, a stronger interfacial gel forms more quickly; for example, the interfacial shear moduli increase twice as rapidly. Calcium 21-28 carbonic anhydrase 1 Homo sapiens 46-53 16085109-9 2006 Simulations performed with a network of four zero-Ca2+ CA1 pyramidal neurons modeled in zero-calcium conditions also show that spontaneous sustained activity can propagate by potassium lateral diffusion alone with a velocity of approximately 0.93 mm/sec. Calcium 93-100 carbonic anhydrase 1 Homo sapiens 55-58 16582904-2 2006 Here, however, we demonstrate that long-term potentiation (LTP) in CA1 hippocampal pyramidal neurons causes rapid incorporation of GluR2-lacking calcium-permeable (CP)-AMPARs: CP-AMPARs are present transiently, being replaced by GluR2-containing AMPARs approximately 25 min after LTP induction. Calcium 145-152 carbonic anhydrase 1 Homo sapiens 67-70 16480690-1 2006 Hippocampal CA1 pyramidal neurons undergo delayed neurodegeneration after transient forebrain ischemia, and the phenomenon is dependent upon hyperactivation of l-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype of glutamate receptors, resulting in aberrant intracellular calcium influx. Calcium 290-297 carbonic anhydrase 1 Homo sapiens 12-15 16459200-2 2006 When zinc release from Schaffer collaterals was examined using ZnAF-2, a membrane-impermeable zinc indicator, ZnAF-2 signal in the stratum radiatum of the CA1 was increased by tetanic stimuli at 100 Hz for 1s, suggesting that zinc is released from Schaffer collaterals in a calcium- and impulse-dependent manner. Calcium 274-281 carbonic anhydrase 1 Homo sapiens 155-158 16459200-4 2006 When tetanic stimuli at 100 Hz for 5s were delivered to the dentate granule cells, the increase in calcium signal in the stratum radiatum of the CA1, as well as in the stratum lucidum of the CA3, was attenuated by addition of 10 microM zinc, while enhanced by addition of 1mM CaEDTA, a membrane-impermeable zinc chelator. Calcium 99-106 carbonic anhydrase 1 Homo sapiens 145-148 16459200-5 2006 The increase in calcium signal in the CA1, in which Schaffer collateral synapses exist, during delivery of tetanic stimuli at 100 Hz for 1s to the Schaffer collateral-commissural pathway was also significantly enhanced by addition of 1mM CaEDTA. Calcium 16-23 carbonic anhydrase 1 Homo sapiens 38-41 16459200-6 2006 These results suggest that zinc released from Schaffer collaterals suppressively modulates presynaptic and postsynaptic calcium signaling in the CA1, followed by the suppression of glutamate release. Calcium 120-127 carbonic anhydrase 1 Homo sapiens 145-148 12763626-0 2003 Effect of D-2 amino-5-phosphonopentanoate and nifedipine on postsynaptic calcium changes associated with long-term potentiation in hippocampal CA1 area. Calcium 73-80 carbonic anhydrase 1 Homo sapiens 143-146 15958743-3 2005 Using current-clamp recordings in hippocampal slices, we find that the ADP in CA1 pyramidal neurons is mediated by an Ni2+-sensitive calcium tail current. Calcium 133-140 carbonic anhydrase 1 Homo sapiens 78-81 15158018-1 2004 In normal gerbils, intracellular zinc ions ([Zn2+]i) and calcium ions ([Ca2+]i) accumulate in hippocampal CA1 neurons after global ischemia. Calcium 57-64 carbonic anhydrase 1 Homo sapiens 106-109 15147321-0 2004 Frequency-dependent requirement for calcium store-operated mechanisms in induction of homosynaptic long-term depression at hippocampus CA1 synapses. Calcium 36-43 carbonic anhydrase 1 Homo sapiens 135-138 14736852-2 2004 In this study, two-photon imaging was used to explore the basic properties of dendritic calcium signaling in CA1 stratum radiatum interneurons. Calcium 88-95 carbonic anhydrase 1 Homo sapiens 109-112 14736858-0 2004 Intracellular astrocyte calcium waves in situ increase the frequency of spontaneous AMPA receptor currents in CA1 pyramidal neurons. Calcium 24-31 carbonic anhydrase 1 Homo sapiens 110-113 14724233-0 2004 Differential calcium-dependent modulation of NMDA currents in CA1 and CA3 hippocampal pyramidal cells. Calcium 13-20 carbonic anhydrase 1 Homo sapiens 62-65 14517184-0 2003 Pentobarbitone modulates calcium transients in axons and synaptic boutons of hippocampal CA1 neurons. Calcium 25-32 carbonic anhydrase 1 Homo sapiens 89-92 15234260-9 2004 For calcium detection in the CA1 region, we also conducted alizarin red staining. Calcium 4-11 carbonic anhydrase 1 Homo sapiens 29-32 12763626-1 2003 The induction of long-term potentiation (LTP) in CA1 hippocampal area requires a rise in intracellular postsynaptic calcium. Calcium 116-123 carbonic anhydrase 1 Homo sapiens 49-52 12763626-3 2003 We have addressed the relative contribution of these routes of calcium entry before and during LTP expression, in synaptically evoked dendritic calcium transients from a population of CA1 pyramidal neurons. Calcium 63-70 carbonic anhydrase 1 Homo sapiens 184-187 12763626-3 2003 We have addressed the relative contribution of these routes of calcium entry before and during LTP expression, in synaptically evoked dendritic calcium transients from a population of CA1 pyramidal neurons. Calcium 144-151 carbonic anhydrase 1 Homo sapiens 184-187 12609911-8 2003 We show that the small persistent sodium current can play a key role in spontaneous CA1 activity in zero-calcium solutions. Calcium 105-112 carbonic anhydrase 1 Homo sapiens 84-87 12650963-1 2003 Long-term potentiation (LTP), in the hippocampal CA1 region is dependent on postsynaptic calcium influx. Calcium 89-96 carbonic anhydrase 1 Homo sapiens 49-52 11997681-0 2002 L-AP3 blocks rises in intracellular calcium associated with hippocampal CA1 LTP. Calcium 36-43 carbonic anhydrase 1 Homo sapiens 72-75 12499871-0 2002 Thapsigargin blocks STP and LTP related calcium enhancements in hippocampal CA1 area. Calcium 40-47 carbonic anhydrase 1 Homo sapiens 76-79 12499871-1 2002 Multiple calcium signaling pathways, including intracellular calcium release that is mediated by inositol triphosphate (IP3) or ryanodine calcium store receptors, seem to be involved in CA1 hippocampal synaptic plasticity. Calcium 9-16 carbonic anhydrase 1 Homo sapiens 186-189 12499871-1 2002 Multiple calcium signaling pathways, including intracellular calcium release that is mediated by inositol triphosphate (IP3) or ryanodine calcium store receptors, seem to be involved in CA1 hippocampal synaptic plasticity. Calcium 61-68 carbonic anhydrase 1 Homo sapiens 186-189 12351710-1 2002 ATP receptors participate in synaptic transmission and intracellular calcium signaling in the hippocampus by providing a component of the excitatory input to CA1 pyramidal neurons. Calcium 69-76 carbonic anhydrase 1 Homo sapiens 158-161 11978822-0 2002 Nuclear calcium signaling evoked by cholinergic stimulation in hippocampal CA1 pyramidal neurons. Calcium 8-15 carbonic anhydrase 1 Homo sapiens 75-78 11978822-4 2002 Activation of muscarinic acetylcholine receptors by synaptic stimulation of cholinergic afferents or application of muscarinic agonist in CA1 pyramidal neurons evoked a focal rise in free calcium in the apical dendrite that propagated as a wave into the soma and invaded the nucleus. Calcium 188-195 carbonic anhydrase 1 Homo sapiens 138-141 11739569-4 2001 Whole-cell, intracellular, and field-potential recordings from CA1 pyramidal cells showed that the presynaptic BK channels are activated by calcium influx and can contribute to repolarization of the presynaptic action potential (AP) and negative feedback control of Ca(2+) influx and transmitter release. Calcium 140-147 carbonic anhydrase 1 Homo sapiens 63-66 11247989-1 2001 We previously identified cholinergic-dependent plateau potentials (PPs) in CA1 pyramidal neurons that were intrinsically generated by interplay between voltage-gated calcium entry and a Ca(2+)-activated nonselective cation conductance. Calcium 166-173 carbonic anhydrase 1 Homo sapiens 75-78 11067971-1 2000 High-voltage-activated calcium currents (HVA) of CA1 neurons are prominently attenuated following a switch from HEPES-buffered solution to one buffered with CO(2)/HCO(3)(-). Calcium 23-30 carbonic anhydrase 1 Homo sapiens 49-52 11117745-4 2000 Here we show that, in the CA1 region of the hippocampus, reduction of postsynaptic calcium influx by partial blockade of NMDA (N-methyl-D-aspartate) receptors results in a conversion of LTP to LTD and a loss of input specificity normally associated with LTP, with LTD appearing at heterosynaptic inputs. Calcium 83-90 carbonic anhydrase 1 Homo sapiens 26-29 11160456-2 2001 The objective of the present study was to determine whether the pattern and intensity of synaptic activity could differentially regulate MAPK phosphorylation via selective activation of different modes of calcium influx into CA1 pyramidal neurons. Calcium 205-212 carbonic anhydrase 1 Homo sapiens 225-228 11077079-3 2001 Perfusion of hippocampal slices with 0-added calcium and high potassium induced field bursts in CA1 and the dentate gyrus. Calcium 45-52 carbonic anhydrase 1 Homo sapiens 96-99 11101200-7 2000 The second mechanism, suggested by us, directly acts on the vascular smooth muscle CA I isozyme, so that its inhibition should ensure an adequate pH for calcium ions transport through the channels, having as result vasodilation. Calcium 153-160 carbonic anhydrase 1 Homo sapiens 83-87 10844014-0 2000 In CA1 pyramidal neurons of the hippocampus protein kinase C regulates calcium-dependent inactivation of NMDA receptors. Calcium 71-78 carbonic anhydrase 1 Homo sapiens 3-6 9665618-0 1998 Reduced calcium elevation in hippocampal CA1 neurons of ischemia-tolerant gerbils. Calcium 8-15 carbonic anhydrase 1 Homo sapiens 41-44 11012086-8 2000 The Ca(o)-induced increase in Ca(i) in both lines was inhibited by the Ca2+ entry blocker SK&F 96365 or depolarization in high K+ bathing solution, demonstrating its dependence of calcium influx. Calcium 184-191 carbonic anhydrase 1 Homo sapiens 30-35 10516298-0 1999 Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons. Calcium 10-17 carbonic anhydrase 1 Homo sapiens 111-114 10516298-1 1999 In CA1 pyramidal neurons of the hippocampus, calcium-dependent spikes occur in vivo during specific behavioral states and may be enhanced during epileptiform activity. Calcium 45-52 carbonic anhydrase 1 Homo sapiens 3-6 10516298-3 1999 Using dendritic and somatic patch-pipette recordings, we show that calcium spikes are initiated in the apical dendrites of CA1 pyramidal neurons and drive bursts of sodium-dependent action potentials at the soma. Calcium 67-74 carbonic anhydrase 1 Homo sapiens 123-126 10341236-0 1999 Calcium-induced calcium release contributes to action potential-evoked calcium transients in hippocampal CA1 pyramidal neurons. Calcium 0-7 carbonic anhydrase 1 Homo sapiens 105-108 10341236-0 1999 Calcium-induced calcium release contributes to action potential-evoked calcium transients in hippocampal CA1 pyramidal neurons. Calcium 16-23 carbonic anhydrase 1 Homo sapiens 105-108 10341236-0 1999 Calcium-induced calcium release contributes to action potential-evoked calcium transients in hippocampal CA1 pyramidal neurons. Calcium 71-78 carbonic anhydrase 1 Homo sapiens 105-108 10036277-1 1999 Long-term potentiation (LTP) and long-term depression (LTD), two prominent forms of synaptic plasticity at glutamatergic afferents to CA1 hippocampal pyramidal cells, are both triggered by the elevation of postsynaptic intracellular calcium concentration ([Ca2+]i). Calcium 233-240 carbonic anhydrase 1 Homo sapiens 134-137 10036277-2 1999 To understand how one signaling molecule can be responsible for triggering two opposing forms of synaptic modulation, different postsynaptic [Ca2+]i elevation patterns were generated by a new caged calcium compound nitrophenyl-ethylene glycol-bis(beta-aminoethyl ether)-N,N,N",N"-tetraacetic acid in CA1 pyramidal cells. Calcium 198-205 carbonic anhydrase 1 Homo sapiens 300-303 11810440-0 1999 Detection of calcium and aluminum in pyramidal neurons in the gerbil hippocampal CA1 region following repeated brief cerebral ischemia: X-ray microanalysis. Calcium 13-20 carbonic anhydrase 1 Homo sapiens 81-84 10479156-4 1999 It is shown here that agents that increase intracellular calcium [Ca++]i (A23187 and thapsigargin) in human monocytic cells also induce IL-1beta expression. Calcium 57-64 carbonic anhydrase 1 Homo sapiens 66-72 10393102-5 1999 Calcium imaging with bis-fura-2 after loading CE into hippocampal CA1 pyramidal cells in hippocampal slices revealed slow, local calcium transients independent of membrane depolarization. Calcium 0-7 carbonic anhydrase 1 Homo sapiens 66-69 10393102-5 1999 Calcium imaging with bis-fura-2 after loading CE into hippocampal CA1 pyramidal cells in hippocampal slices revealed slow, local calcium transients independent of membrane depolarization. Calcium 129-136 carbonic anhydrase 1 Homo sapiens 66-69 9632393-1 1998 Long-term potentiation (LTP) at the Schaffer collateral-CA1 synapse involves interacting signaling components, including calcium (Ca2+)/calmodulin-dependent protein kinase II (CaMKII) and cyclic adenosine monophosphate (cAMP) pathways. Calcium 121-128 carbonic anhydrase 1 Homo sapiens 56-59 9665618-4 1998 Here we show, using Ca2+ imaging, that intracellular calcium ([Ca2+]i) elevation in CA1 neurons after an anoxic-aglycemic episode is markedly inhibited in the ischemia-tolerant gerbil. Calcium 53-60 carbonic anhydrase 1 Homo sapiens 84-87 9351447-12 1997 High intracellular calcium concentration, [Ca]i, lowered propagation safety and caused earlier block when intercellular coupling was reduced. Calcium 19-26 carbonic anhydrase 1 Homo sapiens 43-47 9500960-9 1998 The CA1-CA2 neurons express high amounts of calbindin-D28k under stress conditions because their activity may involve a high rate of calcium buffering. Calcium 133-140 carbonic anhydrase 1 Homo sapiens 4-7 9418702-2 1997 DESIGN: Study of oocyte development and intracellular calcium [Ca]i dynamics of activated oocytes. Calcium 54-61 carbonic anhydrase 1 Homo sapiens 63-67 9682189-5 1998 The co-operative, converging pre-synaptic activity can induce localized fast spikes and associated calcium influx in the apical dendrites of CA1 pyramidal cells, a necessary condition for the induction of synaptic plasticity. Calcium 99-106 carbonic anhydrase 1 Homo sapiens 141-144 9418702-9 1997 CONCLUSION(S): Human oocytes activated with calcium ionophore A23187 or ionomycin exhibited elevated [Ca]i but remained resistant to subsequent meiotic maturation and cleavage. Calcium 44-51 carbonic anhydrase 1 Homo sapiens 102-106 9351447-13 1997 [Ca]i affected conduction via calcium-dependent inactivation of ICa(L). Calcium 30-37 carbonic anhydrase 1 Homo sapiens 1-5 9204921-0 1997 A long-lasting calcium-activated nonselective cationic current is generated by synaptic stimulation or exogenous activation of group I metabotropic glutamate receptors in CA1 pyramidal neurons. Calcium 15-22 carbonic anhydrase 1 Homo sapiens 171-174 9141619-2 1997 Susceptible target cells (JY cells), but not unsusceptible target cells (K562 cells), increased the intracellular calcium concentration ([Ca]i) in almost all indo-1-loaded YTN cells with a lag time, although the kinetics of increase in [Ca]i differed in individual YTN cells. Calcium 114-121 carbonic anhydrase 1 Homo sapiens 138-142 9141619-3 1997 The increase in [Ca]i was completely blocked by 2 mM EGTA and partially (around 50%) blocked by 10 microM nicardipine, the extents of inhibition of calcium response correlating well with those of inhibition of cytotoxic activity. Calcium 148-155 carbonic anhydrase 1 Homo sapiens 17-21 8951712-0 1996 Intracellular inositol 1,3,4,5-tetrakisphosphate enhances the calcium current in hippocampal CA1 neurones of the gerbil after ischaemia. Calcium 62-69 carbonic anhydrase 1 Homo sapiens 93-96 8890451-1 1996 Long-term potentiation (LTP) and long-term depression (LTD) are calcium-dependent forms of synaptic plasticity observed in area CA1 of the hippocampus. Calcium 64-71 carbonic anhydrase 1 Homo sapiens 128-131 8913363-9 1996 These results indicate that serotonin inhibits the afterhyperpolarization in the CA1 region of hippocampus by reducing the ability of extracellular calcium to trigger calcium release from intracellular stores. Calcium 148-155 carbonic anhydrase 1 Homo sapiens 81-84 8913363-9 1996 These results indicate that serotonin inhibits the afterhyperpolarization in the CA1 region of hippocampus by reducing the ability of extracellular calcium to trigger calcium release from intracellular stores. Calcium 167-174 carbonic anhydrase 1 Homo sapiens 81-84 8964794-10 1996 The persistent expression of NGFI-A in the CA1 neurons destined to die could therefore be due to ischemia-induced transcriptional activation caused by, e.g., increased intracellular calcium levels plus a lack of negative feedback caused by the blockade of the translation of NGFI-A mRNA into protein. Calcium 182-189 carbonic anhydrase 1 Homo sapiens 43-46 8921284-8 1996 Calcium imaging data using hippocampal acute slices showed that hypoxia-hypoglycaemia in vitro provoked intense Ca2+ mobilization with increased PIP2 immunostaining specifically in CA-1 neurons. Calcium 0-7 carbonic anhydrase 1 Homo sapiens 181-185 8784235-0 1996 Calcium movement in ischemia-tolerant hippocampal CA1 neurons after transient forebrain ischemia in gerbils. Calcium 0-7 carbonic anhydrase 1 Homo sapiens 50-53 8756437-4 1996 Stimulation of the Schaffer collaterals (50 Hz, 2 sec) resulted in increases in the concentration of intracellular calcium ([Ca2+]i) in the astrocytes located in the stratum radiatum of CA1. Calcium 115-122 carbonic anhydrase 1 Homo sapiens 186-189 8755599-3 1996 Here we used a cytochemical method that allowed detection in CA1 hippocampus at the electron microscopy level of a stimulation-specific, D-AP5-sensitive accumulation of calcium in postsynaptic spines and presynaptic terminals following application of high-frequency trains. Calcium 169-176 carbonic anhydrase 1 Homo sapiens 61-64 8638124-1 1996 Voltage-activated calcium (Ca2+) influx is increased in mammalian CA1 hippocampal neurons during aging. Calcium 18-25 carbonic anhydrase 1 Homo sapiens 66-69 8731458-2 1996 In our studies, consistent with previous reports, patients with depression exhibited an exaggerated increase in 5-HT-stimulated intracellular calcium concentration ([Ca++]i). Calcium 142-149 carbonic anhydrase 1 Homo sapiens 166-172 7870309-0 1994 Impairment of GABAA receptor function by N-methyl-D-aspartate-mediated calcium influx in isolated CA1 pyramidal cells. Calcium 71-78 carbonic anhydrase 1 Homo sapiens 98-101 7472451-0 1995 Coupling potentials in CA1 neurons during calcium-free-induced field burst activity. Calcium 42-49 carbonic anhydrase 1 Homo sapiens 23-26 7552371-3 1995 Following either ischemic insult, the hippocampal CA1 region showed a loss of pyramidal neurons together with a diffuse calcium accumulation as shown by alizarin red S staining. Calcium 120-127 carbonic anhydrase 1 Homo sapiens 50-53 8717068-2 1996 A microfluorometry was carried out to investigate the effect of 3-isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine (ibudilast) on changes in levels of intracellular calcium concentration ([Ca2+]i) induced by in vitro ischaemia in the CA1 field of gerbil hippocampal slices. Calcium 162-169 carbonic anhydrase 1 Homo sapiens 231-234 8612769-0 1996 A calcium switch for the functional coupling between alpha (hslo) and beta subunits (KV,Ca beta) of maxi K channels. Calcium 2-9 carbonic anhydrase 1 Homo sapiens 88-95 8612769-1 1996 KV,Ca beta subunit dramatically increases the apparent calcium sensitivity of the alpha subunit of MaxiK channels when probed in the micromolar [Ca2+]i range. Calcium 55-62 carbonic anhydrase 1 Homo sapiens 3-10 8989380-2 1995 The propagation of antidromically activated action potentials in CA1 pyramidal neurons was examined with intrasomatic and intradendritic electrical recording and optical measurements using the fluorescent calcium indicator Calcium Green-1. Calcium 205-212 carbonic anhydrase 1 Homo sapiens 65-68 7583322-0 1995 Spermine increases paired-pulse facilitation in area CA1 of hippocampus in a calcium-dependent manner. Calcium 77-84 carbonic anhydrase 1 Homo sapiens 53-56 8544487-5 1995 Transients of intracellular calcium concentration and membrane potential associated with evoked neural activity in hippocampal areas CA1 and CA3 were recorded. Calcium 28-35 carbonic anhydrase 1 Homo sapiens 133-136 7716524-0 1995 Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Calcium 49-56 carbonic anhydrase 1 Homo sapiens 81-84 7716524-1 1995 The temporal and spatial profile of activity-evoked changes in membrane potential and intracellular calcium concentration in the dendrites of hippocampal CA1 pyramidal neurons was examined with simultaneous somatic and dendritic patch-pipette recording and calcium imaging experiments. Calcium 100-107 carbonic anhydrase 1 Homo sapiens 154-157 7716524-1 1995 The temporal and spatial profile of activity-evoked changes in membrane potential and intracellular calcium concentration in the dendrites of hippocampal CA1 pyramidal neurons was examined with simultaneous somatic and dendritic patch-pipette recording and calcium imaging experiments. Calcium 257-264 carbonic anhydrase 1 Homo sapiens 154-157 7870309-12 1994 In conclusion, the data presented show that calcium influxes through N-methyl-D-aspartate receptor channels result in long-term suppression of GABAA receptor function in CA1 pyramidal cells. Calcium 44-51 carbonic anhydrase 1 Homo sapiens 170-173 8027781-3 1994 Lucifer yellow staining of CA1 pyramidal neurons revealed that dye coupling was increased 2.3 times in hippocampal slices made hyperexcitable by perfusion with calcium-free artificial cerebrospinal fluid (aCSF). Calcium 160-167 carbonic anhydrase 1 Homo sapiens 27-30 8083757-2 1994 After selectively loading presynaptic structures in area CA1 with the calcium indicator fura-2, we simultaneously recorded a presynaptic calcium transient ([Ca]t) and the corresponding field excitatory postsynaptic potential (fEPSP) evoked by a single stimulus given to the Schaffer collateral-commissural (SCC) pathway. Calcium 70-77 carbonic anhydrase 1 Homo sapiens 57-60 8027781-8 1994 These observations indicate an apparent increase in electrotonic coupling during calcium-free induced spontaneous rhythmic field burst activity in the CA1 area of the hippocampus and that electrotonic coupling may contribute substantially to the synchronization of neuronal firing underlying seizure-like events. Calcium 81-88 carbonic anhydrase 1 Homo sapiens 151-154 8185949-0 1994 Adenosine inhibits evoked synaptic transmission primarily by reducing presynaptic calcium influx in area CA1 of hippocampus. Calcium 82-89 carbonic anhydrase 1 Homo sapiens 105-108 8207497-1 1994 Transient ischemia-induced perturbations in calcium homeostasis have been proposed to lead to pathological activation of the cysteine protease calpain I and subsequent delayed neuronal death in the CA1 region of hippocampus. Calcium 44-51 carbonic anhydrase 1 Homo sapiens 198-201 8069668-0 1994 Block of induction and maintenance of calcium-induced LTP by inhibition of protein kinase C in postsynaptic neuron in hippocampal CA1 region. Calcium 38-45 carbonic anhydrase 1 Homo sapiens 130-133 7905515-1 1994 We examined the relationship between presynaptic calcium levels and postsynaptic potentials during normal synaptic transmission, paired-pulse facilitation (PPF), and long-term potentiation (LTP) in CA3-CA1 synapses of hippocampus. Calcium 49-56 carbonic anhydrase 1 Homo sapiens 202-205 8313384-2 1994 CAI, a carboxyamido-triazole with a halogenated benzophenone tail, is a novel inhibitor of receptor-operated calcium influx and arachidonic acid release which inhibits malignant proliferation, invasion, and metastasis. Calcium 109-116 carbonic anhydrase 1 Homo sapiens 0-3 8313384-3 1994 The focus of this investigation was structural analysis of CAI and to determine if the inhibition of calcium influx and arachidonic acid release by CAI and its antiproliferative activity were mediated through the same chemical domains. Calcium 101-108 carbonic anhydrase 1 Homo sapiens 148-151 8313384-6 1994 Only CAI and Group I compounds inhibited stimulated calcium influx, arachidonic acid release, and proliferation. Calcium 52-59 carbonic anhydrase 1 Homo sapiens 5-8 8313384-10 1994 This investigation provides the first evidence for a coordinate link between calcium influx, calcium-mediated arachidonic acid release, and malignant proliferation and metastasis and constitutes the initial analysis of structurally important domains of the CAI molecule. Calcium 77-84 carbonic anhydrase 1 Homo sapiens 257-260 8313384-10 1994 This investigation provides the first evidence for a coordinate link between calcium influx, calcium-mediated arachidonic acid release, and malignant proliferation and metastasis and constitutes the initial analysis of structurally important domains of the CAI molecule. Calcium 93-100 carbonic anhydrase 1 Homo sapiens 257-260 7906405-0 1993 Metabotropic glutamate receptors and calcium signalling in dendrites of hippocampal CA1 neurones. Calcium 37-44 carbonic anhydrase 1 Homo sapiens 84-87 7901336-4 1993 In membranes prepared from area CA1, AC was stimulated by calcium in the presence of calmodulin, and the effect of calcium/calmodulin on AC in membranes was blocked by the calmodulin antagonists N-(6-aminohexyl)-5-chloro-1- naphthalenesulfonamide (W-7) and trifluoperazine (TFP). Calcium 58-65 carbonic anhydrase 1 Homo sapiens 32-35 8225943-1 1993 The proposed involvement of free intracellular calcium concentration ([Ca]i) in neuronal plasticity is examined. Calcium 47-54 carbonic anhydrase 1 Homo sapiens 71-75 8225943-2 1993 While it is generally believed that a rise of [Ca]i is necessary for the triggering of long-term modification of synaptic connections, there are many unresolved issues related to this dogma; it is not entirely clear what is the source of the elevated calcium, how much of a calcium rise is sufficient to produce the synaptic potentiation, where and for how long, and what are the relevant chemical consequences of the transient rise of [Ca]i. Calcium 251-258 carbonic anhydrase 1 Homo sapiens 47-51 8225943-2 1993 While it is generally believed that a rise of [Ca]i is necessary for the triggering of long-term modification of synaptic connections, there are many unresolved issues related to this dogma; it is not entirely clear what is the source of the elevated calcium, how much of a calcium rise is sufficient to produce the synaptic potentiation, where and for how long, and what are the relevant chemical consequences of the transient rise of [Ca]i. Calcium 274-281 carbonic anhydrase 1 Homo sapiens 47-51 8395581-19 1993 The open probability changed e-fold per 14.8 mV change in membrane potential with a calcium concentration at the cytoplasmic membrane face ([Ca]i) of 100 nM. Calcium 84-91 carbonic anhydrase 1 Homo sapiens 141-145 1385374-6 1992 Further examination of possible signal transduction that might be associated with crosslinking CD7 and/or FcRmu receptors indicated a marked reduction in the magnitude and duration of intracellular calcium (Ca++)i released in response to PHA. Calcium 198-205 carbonic anhydrase 1 Homo sapiens 207-213 8390310-0 1993 Interleukin-2 modulates calcium currents in dissociated hippocampal CA1 neurons. Calcium 24-31 carbonic anhydrase 1 Homo sapiens 68-71 1525675-0 1992 Interleukin-1 beta depresses calcium currents in CA1 hippocampal neurons at pathophysiological concentrations. Calcium 29-36 carbonic anhydrase 1 Homo sapiens 49-52 1321817-3 1992 Tg caused an irreversible change such that even after it was removed Cai was dependent on the ambient calcium concentration, consistent with the hypothesis that Ca2+ entry is controlled by the state of the intracellular stores. Calcium 102-109 carbonic anhydrase 1 Homo sapiens 69-72 1799868-2 1991 When slices were superfused with hypoxic medium at 37 degrees C, 35 degrees C, 33 degrees C or 31 degrees C, latencies of acute increase of calcium accumulation, which was accompanied by a large negative shift of extracellular DC potentials, were delayed in a dose-dependent manner: mean latencies in field CA1 were 130 s, 182 s, 232 s and 277 s after hypoxia, respectively. Calcium 140-147 carbonic anhydrase 1 Homo sapiens 307-310 1584457-2 1992 In the CA1 region, tissue calcium ions began to increase 24 h after reperfusion, accompanied by changes in tissue pH and ATP. Calcium 26-33 carbonic anhydrase 1 Homo sapiens 7-10 1315607-2 1992 Postsynaptic responses in CA1 zone of hippocampal tissue slices were blocked either by the combined administration of 6,7-dinitroquinoxaline-2,3-dione (DNQX) and 3-((+-)-2-carboxypiperazine-4-yl)-propyl-1-phosphonic acid (CPP) or by lowering extracellular calcium concentration ([Ca2+]o). Calcium 256-263 carbonic anhydrase 1 Homo sapiens 26-29 1295670-1 1992 Intra- and extra-cellular concentrations of calcium were measured in hippocampal neurons of areas CA1 and CA3 during 8 min ischaemia and short-term (up to 60 min) recovery. Calcium 44-51 carbonic anhydrase 1 Homo sapiens 98-101 1295670-6 1992 It is postulated that (i) large increases in [Ca2+]i in cerebral neurones during ischaemia are related to the high density of pathways on neurones that allow calcium entry; (ii) differences in the amount of calcium accumulated during periods of oxygen deprivation between neurones of the Ca1 and CA3 regions are linked to the level of glutamatergic input (and hence excitatory synapses) that the two areas receive; (iii) restitution of blood flow and consequent rapid restoration of ATP synthesis permit reactivation of calcium-eliminating mechanisms. Calcium 207-214 carbonic anhydrase 1 Homo sapiens 288-291 1295670-6 1992 It is postulated that (i) large increases in [Ca2+]i in cerebral neurones during ischaemia are related to the high density of pathways on neurones that allow calcium entry; (ii) differences in the amount of calcium accumulated during periods of oxygen deprivation between neurones of the Ca1 and CA3 regions are linked to the level of glutamatergic input (and hence excitatory synapses) that the two areas receive; (iii) restitution of blood flow and consequent rapid restoration of ATP synthesis permit reactivation of calcium-eliminating mechanisms. Calcium 207-214 carbonic anhydrase 1 Homo sapiens 288-291 1456064-2 1992 The rest level of Neu intracellular free calcium ([Ca]i) measured by Ca(2+)-sensitive probe Quin 2/AM was calculated to be 200 +/- s 19 nmol.L-1. Calcium 41-48 carbonic anhydrase 1 Homo sapiens 51-55 1376873-1 1992 The calcium binding protein calbindin D28k (CaBP) is localized in the granule cells of the dentate gyrus, in pyramidal neurons of the CA1 and CA2 subfields of the Ammon"s horn as well as in distinct groups of local circuit neurons in both parts of the human hippocampal formation. Calcium 4-11 carbonic anhydrase 1 Homo sapiens 134-137 1647342-0 1991 Effects of calcium and potassium extracellular ionic concentration changes on the hippocampal CA1 activity of purinergic drugs. Calcium 11-18 carbonic anhydrase 1 Homo sapiens 94-97 1999483-4 1991 The isometric contractions and electrophysiologic properties of all myocardial specimens were recorded by standard techniques and [Ca++]i was measured with the bioluminescent calcium indicator aequorin. Calcium 175-182 carbonic anhydrase 1 Homo sapiens 131-137 2060032-2 1991 Preliminary experiments have confirmed that the addition of EGTA (5 x 10(-3); 10(-2) M) to BWW medium decreased the intracellular calcium concentration ((Ca++)i) of spermatozoa, as measured in cells loaded with a fluorescent Ca++ indicator, Quin-2. Calcium 130-137 carbonic anhydrase 1 Homo sapiens 154-160 1717356-0 1991 Effects of calcium channel agonist and antagonists on calcium-dependent events in CA1 hippocampal neurons. Calcium 11-18 carbonic anhydrase 1 Homo sapiens 82-85 1717356-1 1991 The effects of a variety of calcium channel modulators on different calcium-dependent events in CA1 pyramidal hippocampal neurons were analysed using intracellular recordings in an in vitro slice preparation. Calcium 28-35 carbonic anhydrase 1 Homo sapiens 96-99 1717356-13 1991 Our results provide evidence that different classes of agents which act on calcium channels can be used to discriminate between different calcium-dependent responses in CA1 hippocampal neurons. Calcium 75-82 carbonic anhydrase 1 Homo sapiens 169-172 1668390-2 1991 In the CA1 region of the hippocampus, the induction of LTP is likely to require a rise in postsynaptic calcium levels. Calcium 103-110 carbonic anhydrase 1 Homo sapiens 7-10 2342403-2 1990 Lithium has been shown to block the metabolism of the intracellular second messenger inositol-1,4,5-trisphosphate which is involved in the rise in ionic intracellular calcium [( Ca++]i) which triggers neurotransmitter release and other cellular changes in secretory cells. Calcium 167-174 carbonic anhydrase 1 Homo sapiens 178-184 2245327-4 1990 Following 3-min ischemia, however, abnormal calcium accumulation was recognized only in the hippocampal CA1 sector and part of the striatum. Calcium 44-51 carbonic anhydrase 1 Homo sapiens 104-107 2245327-9 1990 The abnormal calcium accumulation was found in the dorsolateral part of striatum, the hippocampal CA1 sector, the thalamus, the medial geniculate body, the substantia nigra and the inferior colliculus. Calcium 13-20 carbonic anhydrase 1 Homo sapiens 98-101 1972782-0 1990 Postsynaptic NMDA receptor-mediated calcium accumulation in hippocampal CA1 pyramidal cell dendrites. Calcium 36-43 carbonic anhydrase 1 Homo sapiens 72-75 1972782-1 1990 In the CA1 hippocampal region, intracellular calcium is a putative second messenger for the induction of long-term potentiation (LTP), a persistent increase of synaptic transmission produced by high frequency afferent fibre stimulation. Calcium 45-52 carbonic anhydrase 1 Homo sapiens 7-10 2158012-2 1990 In a separate report, we demonstrated that in vitro ischemia inhibits protein synthesis in the CA1 pyramidal neurons of the hippocampal slice via a mechanism involving extracellular calcium and N-methyl-D-aspartate (NMDA) receptor activation during the ischemic episode. Calcium 182-189 carbonic anhydrase 1 Homo sapiens 95-98 1974094-5 1990 Attempts to decrease the [Ca]i with the calcium chelator quin-2 at low [Ca]e seemed to elevate the proportion of strongly labelled S-phase cells, whereas an increased [Ca]i obtained with the ionophore A23187 caused a dramatic decrease in the proportion of S-phase cells that showed strong 3H-thymidine incorporation. Calcium 40-47 carbonic anhydrase 1 Homo sapiens 26-30 2168058-5 1990 In field CA1, LTP induction appears to be triggered by a postsynaptic influx of calcium through NMDA receptor-linked channels. Calcium 80-87 carbonic anhydrase 1 Homo sapiens 9-12 1974094-5 1990 Attempts to decrease the [Ca]i with the calcium chelator quin-2 at low [Ca]e seemed to elevate the proportion of strongly labelled S-phase cells, whereas an increased [Ca]i obtained with the ionophore A23187 caused a dramatic decrease in the proportion of S-phase cells that showed strong 3H-thymidine incorporation. Calcium 40-47 carbonic anhydrase 1 Homo sapiens 168-172 34880499-5 2022 Two-photon calcium imaging of CA3 axonal projections to CA1 combined with simultaneous local field potential recordings revealed that CA3 projections that encode behaviourally informative sensory stimuli were selectively recruited during the memory replay events that underlie hippocampal memory consolidation5. Calcium 11-18 carbonic anhydrase 1 Homo sapiens 56-59 34790098-4 2021 In this study, CDK5 KD astrocytes transplanted in CA3 remained at the injection site without proliferation, regulated calcium in the CA1 hippocampal region after excitotoxicity by glutamate in ex vivo hippocampal slices, improving synapsin and PSD95 clustering. Calcium 118-125 carbonic anhydrase 1 Homo sapiens 133-136 34882093-2 2021 A relatively non-standard form of synaptic plasticity driven by dendritic calcium spikes, or plateau potentials, has been reported to underlie place field formation in rodent hippocampal CA1 neurons. Calcium 74-81 carbonic anhydrase 1 Homo sapiens 187-190 34790098-8 2021 In summary, induction of calcium homeostasis at the CA1 hippocampal area by CDK5 KD astrocytes transplanted in the CA3 area highlights the role of astrocytes as a cell therapy target due to CDK5-KD astrocyte-mediated synaptic clustering, calcium spreading regulation between both areas, and recovery of the intracellular astrocyte-neuron calcium imbalance and plasticity impairment generated by glutamate excitotoxicity. Calcium 25-32 carbonic anhydrase 1 Homo sapiens 52-55 35355012-3 2022 Here we used wireless calcium imaging to longitudinally monitor the activity of dorsal CA1 hippocampal neurons in freely flying bats performing highly reproducible flights in a familiar environment. Calcium 22-29 carbonic anhydrase 1 Homo sapiens 87-90 35228668-5 2022 Modelling NMDA-EPSCs with mutant properties in a CA1 neuron revealed that the effect of GRIN2A mutations can lead to abnormal temporal integration and spine calcium dynamics during trains of concerted synaptic activity. Calcium 157-164 carbonic anhydrase 1 Homo sapiens 49-52 2565567-1 1989 Reduction of external calcium and magnesium from 1.5 to 1.2 mM intensified potassium-induced interictal bursts, increased the likelihood of electrographic seizure occurrence in CA1, and rendered seizure initiation independent of N-methyl-D-aspartate (NMDA) receptor activation. Calcium 22-29 carbonic anhydrase 1 Homo sapiens 177-180 2559374-0 1989 Elevation of intracellular calcium content in area CA1 of hippocampus is not directly correlated with the development of long-term potentiation. Calcium 27-34 carbonic anhydrase 1 Homo sapiens 51-54 2686633-4 1989 Intracellular calcium concentration [( Ca]i) was measured in single H7CM cells using the fluorescent calcium indicator fura-2. Calcium 14-21 carbonic anhydrase 1 Homo sapiens 39-43 2686633-4 1989 Intracellular calcium concentration [( Ca]i) was measured in single H7CM cells using the fluorescent calcium indicator fura-2. Calcium 101-108 carbonic anhydrase 1 Homo sapiens 39-43 2686633-7 1989 The initial calcium peak was followed by a recovery phase during which oscillations of [Ca]i occurred. Calcium 12-19 carbonic anhydrase 1 Homo sapiens 88-92 2556936-13 1989 These experiments suggest that although the carbachol-induced increase in Isc is dependent on the increase in [Ca]i, the hormone may activate a second process that increases the sensitivity of the calcium-activated transport process to changes in [Ca]i. Calcium 197-204 carbonic anhydrase 1 Homo sapiens 248-252 2488296-6 1989 This revision of the calcium hypothesis suggests that there is a complex interaction between the amount of [Ca2+]i perturbation and the duration of such deregulation of Ca2+ homeostasis and it proposes that a small disturbance in Ca2+ homeostasis with a sustained increase in [Ca+]i over a long period has similar cell injuring consequences as that produced by a large increase in [Ca2+]i over a shorter period. Calcium 21-28 carbonic anhydrase 1 Homo sapiens 277-282 2473078-1 1989 Human lung mast cells were examined by digital video microscopy for changes in cytosolic free ionized calcium [( Ca++]i) after stimulation with anti-IgE antibody or specific antigens. Calcium 102-109 carbonic anhydrase 1 Homo sapiens 113-119 2560950-3 1989 Features of LPT in Schaffer collateral-CA1 neuron are calcium-dependency, input-specificity, cooperativity and sensitivity to blockers of N-methyl-D-aspartate (NMDA) receptors. Calcium 54-61 carbonic anhydrase 1 Homo sapiens 39-42 2537541-1 1989 To examine mechanisms that might be responsible for limiting transmission at excitatory synapses in hippocampus, we analyzed the relationship between extracellular calcium concentrations (1-6 mM) and postsynaptic responses in field CA1 of hippocampal slices using low stimulation intensities and a paired-pulse paradigm. Calcium 164-171 carbonic anhydrase 1 Homo sapiens 232-235 2924160-1 1989 We used two approaches to test the possibility that changes in presynaptic calcium currents might be responsible for the long-term potentiation (LTP) effect induced by high-frequency stimulation in area CA1 of hippocampal slices. Calcium 75-82 carbonic anhydrase 1 Homo sapiens 203-206 2537401-4 1989 In fura-2-loaded, differentiated U-937 cells, PAF induced immediate and concentration-dependent calcium mobilization [( Ca++]i) that was inhibited by CV3988, but not by calcium channel blockers. Calcium 96-103 carbonic anhydrase 1 Homo sapiens 120-126 2537401-5 1989 Addition of an increasing concentration of calcium chelator, ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid, to the medium inhibited a large fraction (approximately 75%) of PAF receptor-induced [Ca++]i mobilization thus suggesting the majority of [Ca++]i mobilization was originated from extracellular milieu and a small portion (approximately 25%) was originated from intracellular sources. Calcium 43-50 carbonic anhydrase 1 Homo sapiens 213-219 2537401-5 1989 Addition of an increasing concentration of calcium chelator, ethylene glycol bis(beta-aminoethyl ether)-N,N"-tetraacetic acid, to the medium inhibited a large fraction (approximately 75%) of PAF receptor-induced [Ca++]i mobilization thus suggesting the majority of [Ca++]i mobilization was originated from extracellular milieu and a small portion (approximately 25%) was originated from intracellular sources. Calcium 43-50 carbonic anhydrase 1 Homo sapiens 266-272 2802914-17 1989 In the hippocampal subiculum-CA1 regions, the abnormal calcium stains preceded the alteration of ATP and tissue pH. Calcium 55-62 carbonic anhydrase 1 Homo sapiens 29-32 3021291-1 1986 A transient increase in extracellular calcium concentration causes a long-lasting enhancement of radiatum fibers evoked excitatory postsynaptic potential and population spike responses of CA1 pyramidal neurons which resembles long-term potentiation (LTP). Calcium 38-45 carbonic anhydrase 1 Homo sapiens 188-191 2446907-3 1987 Since [Ca]i shows only a marginal increase the calcium load must be buffered. Calcium 47-54 carbonic anhydrase 1 Homo sapiens 7-11 3627566-1 1987 Calcium was localized in neurons and glial cells of the CA1 region of hippocampus and in neurons of parietal cortex with the oxalate-pyroantimonate electron cytochemical method following recovery from 5-min ischemia of gerbil brain. Calcium 0-7 carbonic anhydrase 1 Homo sapiens 56-59 2456632-6 1988 Compared with a control group not subjected to carotid ligation, neurons of the two vehicle groups and the low-dose calcium blocker group were almost nonexistent in the CA1 region. Calcium 116-123 carbonic anhydrase 1 Homo sapiens 169-172 2840609-2 1988 When high calcium was applied in the presence of 100 microM NDGA, induction of potentiation in the dentate gyrus was blocked, while in CA1 there was an initial potentiation which was not maintained on return to control medium. Calcium 10-17 carbonic anhydrase 1 Homo sapiens 135-138 3123378-3 1987 Secondly, these inhibitors were demonstrated as exerting their effect on two levels: they affected the events controlled by both second messengers implicated in T cell activation, namely rise of intracellular free calcium concentration [( Ca++]i) and protein kinase C (PKC) activation. Calcium 214-221 carbonic anhydrase 1 Homo sapiens 239-245 6122492-6 1982 Perfusion with a medium containing a high calcium - low magnesium concentration (4 mM Ca+2 and 1 mM Mg+2) produced a differential effect on CA1 and dentate evoked potentials. Calcium 42-49 carbonic anhydrase 1 Homo sapiens 140-143 3533598-0 1986 Effects of GABA and bicuculline on N-methyl-D-aspartate- and quisqualate-induced reductions in extracellular free calcium in area CA1 of the hippocampal slice. Calcium 114-121 carbonic anhydrase 1 Homo sapiens 130-133 3533598-1 1986 Decreases in extracellular free calcium ([Ca2+]o) and concomitant field potentials were recorded from the dendritic and cell body layers of the CA1 field in transverse hippocampal slices. Calcium 32-39 carbonic anhydrase 1 Homo sapiens 144-147 3918108-4 1985 An increase in cytosolic free calcium concentrations [( Ca++]i) is one of the signals involved in cellular activation by lectins. Calcium 30-37 carbonic anhydrase 1 Homo sapiens 56-62 6431312-1 1984 It has been suggested that the late hyperpolarisation following synaptic activation of hippocampal CA1 pyramidal neurons is activated by calcium influx. Calcium 137-144 carbonic anhydrase 1 Homo sapiens 99-102 6139775-4 1983 In addition, if intraterminal calcium [( Ca]i) was raised by a train of EPSCs, small depolarizations with little additional Ca entry elicited release which depended strongly on pulse amplitude. Calcium 30-37 carbonic anhydrase 1 Homo sapiens 41-45 6884463-0 1983 Spontaneous epileptiform activity of CA1 hippocampal neurons in low extracellular calcium solutions. Calcium 82-89 carbonic anhydrase 1 Homo sapiens 37-40 3088111-6 1986 At such high concentrations of 9.3, small transient increases in cytoplasmic free calcium ((Ca++)i) were detected in quin 2-loaded Jurkat cells. Calcium 82-89 carbonic anhydrase 1 Homo sapiens 92-98 3088111-7 1986 This increase in (Ca++)i was the result of release of internal stores of calcium. Calcium 73-80 carbonic anhydrase 1 Homo sapiens 18-24 3484612-4 1986 From these data was derived the working hypothesis that the value of [Ca]i during the contracture plateau is a steady-state value due to influx through a sodium-dependent mechanism and calcium uptake or efflux via a sodium-independent mechanism. Calcium 185-192 carbonic anhydrase 1 Homo sapiens 70-74 3699450-1 1986 Long-term potentiation (LTP) of the CA1 population spike in the hippocampal slice was produced by a tetanic stimulus in the stratum radiatum or by doubling the calcium concentration in the medium to 4 mM for 10 min. Calcium 160-167 carbonic anhydrase 1 Homo sapiens 36-39 4019579-1 1985 We have used aequorin as an indicator for the intracellular free calcium ion concentration [( Ca++]i) of Swiss 3T3 fibroblasts. Calcium 65-72 carbonic anhydrase 1 Homo sapiens 94-100 4019579-8 1985 The primary source of calcium for these transients was intracellular, since the magnitude of the serum-induced rise in [Ca++]i was reduced by only 30% in the absence of exogenous calcium. Calcium 22-29 carbonic anhydrase 1 Homo sapiens 120-126 6122492-8 1982 Frequency potentiation of CA1 responses and habituation of dentate responses were depressed or eliminated by the high calcium medium. Calcium 118-125 carbonic anhydrase 1 Homo sapiens 26-29 6122492-9 1982 The opposing influence of extracellular calcium on CA1 and dentate evoked potentials indicates a fundamental difference in the process of transmitter release in these systems, a characteristic that may contribute to the production of frequency potentiation and habituation. Calcium 40-47 carbonic anhydrase 1 Homo sapiens 51-54 209170-9 1978 The quelling effect of nerve stimulation on transmitter release is explained by the hypothesis that a low [Ca]o a reversed electrochemical gradient for calcium occurs and nerve stimulation causes an increased calcium conductance leading to calcium efflux which in turn temporarily reduces [Ca]i and transmitter release. Calcium 152-159 carbonic anhydrase 1 Homo sapiens 290-294 7444438-0 1980 Epileptiform burst afterhyperolarization: calcium-dependent potassium potential in hippocampal CA1 pyramidal cells. Calcium 42-49 carbonic anhydrase 1 Homo sapiens 95-98 745059-0 1978 The role of sodium-calcium exchange in controlling [Ca]i in smooth muscle [proceedings]. Calcium 19-26 carbonic anhydrase 1 Homo sapiens 52-56 209170-9 1978 The quelling effect of nerve stimulation on transmitter release is explained by the hypothesis that a low [Ca]o a reversed electrochemical gradient for calcium occurs and nerve stimulation causes an increased calcium conductance leading to calcium efflux which in turn temporarily reduces [Ca]i and transmitter release. Calcium 209-216 carbonic anhydrase 1 Homo sapiens 290-294 209170-9 1978 The quelling effect of nerve stimulation on transmitter release is explained by the hypothesis that a low [Ca]o a reversed electrochemical gradient for calcium occurs and nerve stimulation causes an increased calcium conductance leading to calcium efflux which in turn temporarily reduces [Ca]i and transmitter release. Calcium 209-216 carbonic anhydrase 1 Homo sapiens 290-294 33421771-4 2021 RECENT FINDINGS: We recently revealed the presence of social memory engrams in hippocampal ventral CA1 neurons, using optogenetic manipulation and calcium (Ca2+) imaging. Calcium 147-154 carbonic anhydrase 1 Homo sapiens 99-102 33711021-6 2021 Epileptiform discharges were blocked by addition of the calcium-channel blocker Cd2+ and disappeared in CA1 after a surgical cut between CA3 and CA1. Calcium 56-63 carbonic anhydrase 1 Homo sapiens 104-107 33711021-6 2021 Epileptiform discharges were blocked by addition of the calcium-channel blocker Cd2+ and disappeared in CA1 after a surgical cut between CA3 and CA1. Calcium 56-63 carbonic anhydrase 1 Homo sapiens 145-148 33013341-3 2020 To address this question, we have developed a model of CA1 pyramidal neuron that takes into consideration muscarinic receptor activation in response to changes in extracellular concentration of acetylcholine and its effects on cellular excitability and downstream intracellular calcium dynamics. Calcium 278-285 carbonic anhydrase 1 Homo sapiens 55-58 32937911-5 2020 We used Darea for comparing glutamate receptor and calcium channel distributions between hippocampal CA3-CA1 spine synapses on apical and basal dendrites, which differ in signaling pathways involved in synaptic plasticity. Calcium 51-58 carbonic anhydrase 1 Homo sapiens 105-108 33013341-7 2020 The result of this work is a compartmental model with calibrated mechanisms for simulating the intracellular calcium dynamics of CA1 pyramidal cells with a focus on those related to release from calcium stores in the endoplasmic reticulum. Calcium 109-116 carbonic anhydrase 1 Homo sapiens 129-132 31376934-5 2019 Using this miniscope, we demonstrate the optogenetic silencing of hippocampal CA1 neurons using two laser light sources-one stimulating a calcium sensor (i.e., jGCaAMP7c) and the other serving as an optogenetic silencer (i.e., Jaws). Calcium 138-145 carbonic anhydrase 1 Homo sapiens 78-81 31827590-14 2019 Therefore, the certain value of diastolic Cansr/Ca i can be the better "threshold" for Ca waves and Ca2+ alternans. Calcium 100-104 carbonic anhydrase 1 Homo sapiens 48-52 32095522-3 2020 Using subcellular calcium imaging from CA1 pyramidal neurons in ex vivo hippocampal networks, we discovered that neighboring spines are activated serially along dendrites toward or away from cell bodies. Calcium 18-25 carbonic anhydrase 1 Homo sapiens 39-42 31461656-1 2019 The excitability of CA1 hippocampal pyramidal cells is mediated by a slow AHP (sAHP) that responds to calcium increases by Cav1 calcium channels and ryanodine receptors (RyR). Calcium 102-109 carbonic anhydrase 1 Homo sapiens 20-23 31099020-1 2019 KEY POINTS: Calcium (Ca2+ ) entry mediated by NMDA receptors is considered central to the induction of activity-dependent synaptic plasticity in hippocampal area CA1; this description does not, however, take into account the potential contribution of endoplasmic reticulum (ER) Ca2+ stores. Calcium 12-19 carbonic anhydrase 1 Homo sapiens 162-165 30100870-6 2018 In this article we present a computational model of calcium dynamics at the postsynaptic spine of a CA1 pyramidal neuron, as well as a methodology that enables its implementation in multi-scale, large-scale simulations. Calcium 52-59 carbonic anhydrase 1 Homo sapiens 100-103 29709925-9 2018 Conclusion Cytotoxicity caused by glutamate-mediated calcium influx in the neurons of the CA1 region was recently reported in the pathogenesis of TGA. Calcium 53-60 carbonic anhydrase 1 Homo sapiens 90-93 29750314-15 2018 CA1 and S100P may regulate the process of MIO by modulation of calcification and dysregulation of calcium binding. Calcium 98-105 carbonic anhydrase 1 Homo sapiens 0-3 29029315-8 2018 We also found a Pb2+-induced impairment of calcium influx in Schaffer collateral-CA1 synaptic terminals. Calcium 43-50 carbonic anhydrase 1 Homo sapiens 81-84 28989592-3 2017 Ionized serum calcium (Ca (I)) will be increased in true hypercalcemia. Calcium 14-21 carbonic anhydrase 1 Homo sapiens 23-29 28440411-7 2017 Glial fibrillary acidic protein-immunoreactive astrocytes and ionized calcium binding adaptor molecule 1-immunoreactive microglia were activated in the CA1 and polymorphic layer of the dentate gyrus of the group without treadmill exercise. Calcium 70-77 carbonic anhydrase 1 Homo sapiens 152-155 27922063-7 2016 Stimulation of hippocampal CA1 pyramidal neurons with five action potentials fired at 100 Hz resulted in a single dendritic calcium transient with a 2-fold faster rise and 7-fold faster decay time (t1/2 of 40 ms) than GCaMP6f, indicating that tracking high frequency action potentials may be limited by calcium dynamics. Calcium 124-131 carbonic anhydrase 1 Homo sapiens 27-30 27922063-7 2016 Stimulation of hippocampal CA1 pyramidal neurons with five action potentials fired at 100 Hz resulted in a single dendritic calcium transient with a 2-fold faster rise and 7-fold faster decay time (t1/2 of 40 ms) than GCaMP6f, indicating that tracking high frequency action potentials may be limited by calcium dynamics. Calcium 303-310 carbonic anhydrase 1 Homo sapiens 27-30 24191047-3 2013 Optogenetic stimulation of CA3 pyramidal cells at 1 Hz led to strong and reliable depression of postsynaptic calcium transients in CA1. Calcium 109-116 carbonic anhydrase 1 Homo sapiens 131-134 25058697-1 2014 We use a computational model of a hippocampal CA1 pyramidal cell to demonstrate that spine head calcium provides an instantaneous readout at each synapse of the postsynaptic weighted sum of all presynaptic activity impinging on the cell. Calcium 96-103 carbonic anhydrase 1 Homo sapiens 46-49 26074766-5 2015 We also found that acute inhibition of calcium signaling in astrocytes by intracellular calcium chelation rapidly potentiates excitatory synaptic transmission and short-term plasticity of Shaffer collateral CA1 synapses, i.e., paired-pulse facilitation and responses to tetanic and prolonged repetitive stimulation. Calcium 39-46 carbonic anhydrase 1 Homo sapiens 207-210 26074766-5 2015 We also found that acute inhibition of calcium signaling in astrocytes by intracellular calcium chelation rapidly potentiates excitatory synaptic transmission and short-term plasticity of Shaffer collateral CA1 synapses, i.e., paired-pulse facilitation and responses to tetanic and prolonged repetitive stimulation. Calcium 88-95 carbonic anhydrase 1 Homo sapiens 207-210 26074766-6 2015 These data reveal that calcium signaling of astrocytes is plastic and down-regulates basal transmission and short-term plasticity of hippocampal CA1 glutamatergic synapses. Calcium 23-30 carbonic anhydrase 1 Homo sapiens 145-148 24465987-2 2014 At synapses onto neurons in region CA1 of the hippocampus (and many other synapses), NMDA receptors provide the relevant source of calcium. Calcium 131-138 carbonic anhydrase 1 Homo sapiens 35-38 24298157-6 2014 We also show that LTP consolidation at CA1 synapses requires a rise in intracellular calcium concentration during the early phase of expression, indicating that calcium influx through the GluA2-lacking AMPA receptors drives their replacement by GluA2-containing receptors during LTP consolidation. Calcium 85-92 carbonic anhydrase 1 Homo sapiens 39-42 24298157-6 2014 We also show that LTP consolidation at CA1 synapses requires a rise in intracellular calcium concentration during the early phase of expression, indicating that calcium influx through the GluA2-lacking AMPA receptors drives their replacement by GluA2-containing receptors during LTP consolidation. Calcium 161-168 carbonic anhydrase 1 Homo sapiens 39-42 22758919-3 2012 In hippocampal CA1 pyramidal neurons, small-amplitude (1 mV) long-lasting (seconds) afterdepolarizations have been reported and are thought to depend on calcium-activated nonselective (CAN) currents recently identified as transient receptor potential (TRP) channels. Calcium 153-160 carbonic anhydrase 1 Homo sapiens 15-18 23357314-0 2013 Differences of calcium binding proteins immunoreactivities in the young hippocampal CA1 region from the adult following transient ischemic damage. Calcium 15-22 carbonic anhydrase 1 Homo sapiens 84-87 22838845-2 2012 In vitro assays demonstrate that carbonic anhydrase I (CA1) promotes calcium precipitation. Calcium 69-76 carbonic anhydrase 1 Homo sapiens 33-53 22838845-2 2012 In vitro assays demonstrate that carbonic anhydrase I (CA1) promotes calcium precipitation. Calcium 69-76 carbonic anhydrase 1 Homo sapiens 55-58 21616637-3 2011 Here I explore these intersections with a multilevel model that embeds molecular events following synaptic calcium influx into a multicompartmental electrical model of a CA1 hippocampal neuron. Calcium 107-114 carbonic anhydrase 1 Homo sapiens 170-173 22307057-5 2012 The extent and time course of impairment has been be linked to senescence of calcium (Ca2+) regulation and Ca2+-dependent synaptic plasticity mechanisms in region CA1. Calcium 77-84 carbonic anhydrase 1 Homo sapiens 163-166 20882545-0 2012 Astrocyte calcium signals at Schaffer collateral to CA1 pyramidal cell synapses correlate with the number of activated synapses but not with synaptic strength. Calcium 10-17 carbonic anhydrase 1 Homo sapiens 52-55 20882545-2 2012 At hippocampal Schaffer collateral to CA1 pyramidal cell synapses, such activity-induced astrocyte calcium transients modulate neuronal excitability, synaptic activity, and LTP induction threshold by calcium-dependent release of gliotransmitters. Calcium 99-106 carbonic anhydrase 1 Homo sapiens 38-41 20882545-2 2012 At hippocampal Schaffer collateral to CA1 pyramidal cell synapses, such activity-induced astrocyte calcium transients modulate neuronal excitability, synaptic activity, and LTP induction threshold by calcium-dependent release of gliotransmitters. Calcium 200-207 carbonic anhydrase 1 Homo sapiens 38-41 22172932-6 2012 High voltage-gated calcium current (I(HVA)) in hippocampal CA3 neurons was decreased by hypertonicity, whereas the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA)-induced current in hippocampal CA1 neurons was unaffected. Calcium 19-26 carbonic anhydrase 1 Homo sapiens 211-214 21677174-5 2011 To address this, we developed a system to map astrocyte calcium responses along apical dendrites of CA1 pyramidal neurons in hippocampal slices using single-neuron stimulation with channelrhodopsin-2. Calcium 56-63 carbonic anhydrase 1 Homo sapiens 100-103 22027000-2 2011 This mutant has shown to bind calcium more tightly than the wild-type (WT) at Ca1 and to possess Ca2. Calcium 30-37 carbonic anhydrase 1 Homo sapiens 78-81 21677174-8 2011 Stimulation of single neurons caused calcium responses in populations of astrocytes along the apical axis of CA1 cell dendrites. Calcium 37-44 carbonic anhydrase 1 Homo sapiens 109-112 21145005-3 2010 In this study, we demonstrate that the depletion of calcium from the ER of hippocampal CA1 pyramidal neurons induces a persistent, perisomatic increase in the density of functional h channels resulting in a reduction in intrinsic excitability and an increase in the optimal response frequency. Calcium 52-59 carbonic anhydrase 1 Homo sapiens 87-90 21370042-4 2011 When RNA editing fails in a neuron, calcium influx through AMPA receptors may cause neuron death by glutamate excitotoxicity, as in the case of vulnerable hippocampal CA1 pyramidal neurons that die after transient forebrain ischemia. Calcium 36-43 carbonic anhydrase 1 Homo sapiens 167-170 21532170-4 2011 Here we used functional multineuron calcium imaging (fMCI), an optical recording technique with high temporal and spatial resolution, to visualize the activity of neuron populations in hippocampus CA1 region under ischemia-like conditions ex vivo. Calcium 36-43 carbonic anhydrase 1 Homo sapiens 197-200