PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
9160673-4	1997	In order to prevent this TNF alpha associated HCMV reactivation patients were additionally treated with pentoxifylline (PTX), a methylxanthine derivative that has been shown to suppress TNF alpha induction.	methylxanthine	128-142	tumor necrosis factor	Homo sapiens	186-195	
10321674-1	1999	OBJECTIVE: To evaluate the influence of the methylxanthine derivative, pentoxifylline, on plasma levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-1, and IL-6 in prematurely delivered infants with generalized bacterial infections and to assess the effect of this immunomodulating drug on the clinical outcome in newborns with sepsis.	methylxanthine	44-58	tumor necrosis factor	Homo sapiens	107-140	
9067700-4	1997	Pentoxifylline is a methylxanthine derivative suppressing the release of TNF alpha.	methylxanthine	20-34	tumor necrosis factor	Homo sapiens	73-82	
8655288-0	1995	Methylxanthines with adenosine alter TNF alpha-primed PMN activation.	methylxanthine	0-15	tumor necrosis factor	Homo sapiens	37-46	
9172017-1	1996	Pentoxifylline (PTX) is a methylxanthine drug known to inhibit the production of tumor necrosis factor-alpha (TNF alpha), which plays a key role in inflammation.	methylxanthine	26-40	tumor necrosis factor	Homo sapiens	81-108	
9172017-1	1996	Pentoxifylline (PTX) is a methylxanthine drug known to inhibit the production of tumor necrosis factor-alpha (TNF alpha), which plays a key role in inflammation.	methylxanthine	26-40	tumor necrosis factor	Homo sapiens	110-119	
8865286-1	1996	Pentoxifylline (PTXF) is a methylxanthine derivative which modifies leukocyte function and inhibits tumor necrosis factor (TNF)-alpha release.	methylxanthine	27-41	tumor necrosis factor	Homo sapiens	100-133	
8409522-3	1993	Pentoxifylline, a methylxanthine derivative used in the treatment of vascular disorders, currently has been found to suppress the production of tumor necrosis factor alpha by human and murine leukocytes.	methylxanthine	18-32	tumor necrosis factor	Homo sapiens	144-171	
7835945-1	1994	Pentoxifylline (PTX) is a methylxanthine compound known to inhibit the production of tumour necrosis factor-alpha (TNF-alpha), which is an important inflammatory mediator.	methylxanthine	26-40	tumor necrosis factor	Homo sapiens	115-124	
1385797-1	1992	Pentoxifylline (PTX) is a methylxanthine compound known to inhibit the production of tumour necrosis factor-alpha (TNF-alpha) by monocytic cells.	methylxanthine	26-40	tumor necrosis factor	Homo sapiens	115-124	
7682199-4	1993	Pentoxifylline, a methylxanthine derivative with phosphodiesterase inhibitory activity, selectively inhibited LPS-induced TNF alpha release with an IC50 of 100 microM.	methylxanthine	18-32	tumor necrosis factor	Homo sapiens	122-131	
7678547-3	1993	Pentoxifylline, a substituted methylxanthine approved for treatment of intermittent claudication, has been shown in preclinical studies to down-regulate TNF RNA expression as well as TNF activity.	methylxanthine	30-44	tumor necrosis factor	Homo sapiens	153-156	
7678547-3	1993	Pentoxifylline, a substituted methylxanthine approved for treatment of intermittent claudication, has been shown in preclinical studies to down-regulate TNF RNA expression as well as TNF activity.	methylxanthine	30-44	tumor necrosis factor	Homo sapiens	183-186	
2460096-3	1988	In this study, we present data demonstrating pentoxifylline, a methylxanthine, is efficacious in suppressing LPS-induced MO-derived TNF at the level of both TNF mRNA accumulation and TNF supernatant bioactivity.	methylxanthine	63-77	tumor necrosis factor	Homo sapiens	132-135	
2460096-5	1988	Furthermore, additional methylxanthines and dibutyryl cAMP have similar effects on TNF expression.	methylxanthine	24-39	tumor necrosis factor	Homo sapiens	83-86