PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27519632-2 2017 However, recent evidence has demonstrated that 11OHA4 is the precursor to the potent androgenic 11-oxygenated steroids, 11-ketotestosterone and 11-ketodihydrotestosterone, that bind and activate the human androgen receptor similarly to testosterone and DHT. 11-ketotestosterone 120-139 androgen receptor Homo sapiens 205-222 33974560-2 2021 Studies have identified 11-ketotestosterone (11KT) as a potent AR agonist, but it is unknown if 11KT is present at physiologically-relevant concentrations in CRPC patients to drive AR activation. 11-ketotestosterone 24-43 androgen receptor Homo sapiens 63-65 27345701-2 2017 Androstenedione (A4), 11beta-hydroxyandrostenedione (11OHA4) and 11beta-hydroxytestosterone (11OHT) are metabolised to potent androgen receptor (AR) agonists, dihydrotestosterone (DHT), 11-ketotestosterone (11KT) and 11-ketodihydrotestosterone (11KDHT). 11-ketotestosterone 186-205 androgen receptor Homo sapiens 126-143 16107211-0 2005 Molecular cloning and characterization of a nuclear androgen receptor activated by 11-ketotestosterone. 11-ketotestosterone 83-102 androgen receptor Homo sapiens 52-69 16107211-9 2005 However, comparison of the trans-activation potential of the stickleback androgen receptor with the human androgen receptor, in both human HepG2 cells and zebrafish ZFL cells, revealed preferential activation by 11-ketotestosterone of the stickleback receptor, but not of the human receptor. 11-ketotestosterone 212-231 androgen receptor Homo sapiens 73-90 16107211-9 2005 However, comparison of the trans-activation potential of the stickleback androgen receptor with the human androgen receptor, in both human HepG2 cells and zebrafish ZFL cells, revealed preferential activation by 11-ketotestosterone of the stickleback receptor, but not of the human receptor. 11-ketotestosterone 212-231 androgen receptor Homo sapiens 106-123 33974560-2 2021 Studies have identified 11-ketotestosterone (11KT) as a potent AR agonist, but it is unknown if 11KT is present at physiologically-relevant concentrations in CRPC patients to drive AR activation. 11-ketotestosterone 45-49 androgen receptor Homo sapiens 63-65