PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 10477278-10 1999 Using labelled dihydrosphingosine and dihydrosphingosine-1-P (DHS-1-P), we found that overexpression of YSR2 significantly increased ceramide formation, whereas deletion of YSR2, YSR3, or both, accumulated DHS-1-P, and deletion of YSR2 decreased ceramide formation. safingol 15-33 sphinganine kinase LCB3 Saccharomyces cerevisiae S288C 104-108