PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33140501-2	2021	5-Fluorouracil (5-FU) is an anticancer nucleoside analog that both inhibits thymidylate synthase (TS) and causes DNA damage via the misincorporation of FdUTP and dUTP into DNA under the conditions of dTTP depletion.	Nucleosides	39-49	thymidylate synthetase	Homo sapiens	76-96	
4027943-4	1985	The results of the nucleoside incorporation were consistent with a thymidylate synthetase block; however, other explanations are offered.	Nucleosides	19-29	thymidylate synthetase	Homo sapiens	67-89	
2840503-9	1988	These new nucleosides were studied in comparison with the corresponding 2"-deoxy-erythro-pentofuranosyl derivatives, for their inhibitory activity against cellular thymidylate synthase (TS) and [3H]TdR incorporation into DNA, cytotoxicity against HL-60 cells, and antiviral activity against herpes simplex types 1 and 2 (HSV-1 and -2).	Nucleosides	10-21	thymidylate synthetase	Homo sapiens	164-184	
10598557-4	1999	Dipyridamole inhibits nucleoside transport and in vitro studies have demonstrated that dipyridamole can prevent thymidine salvage rescue from antifolate thymidylate synthase inhibitors.	Nucleosides	22-32	thymidylate synthetase	Homo sapiens	153-173	
27017552-6	2016	Nucleoside protection assays establish compound 8 a dual inhibitor of thymidylate synthase (TS) and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICARFTase) targeting both de novo thymidylate and purine nucleotide biosynthesis, which is further verified by the molecular modeling studies.	Nucleosides	0-10	thymidylate synthetase	Homo sapiens	70-90	
27126991-2	2016	TFT was originally synthesized in the 1960s and is a nucleoside analogue that impedes DNA synthesis by inhibition of thymidylate synthase.	Nucleosides	53-63	thymidylate synthetase	Homo sapiens	117-137	
2195987-6	1990	The ITR highly overestimated the cytotoxicity of 5-fluoro-2"-deoxyuridine: the irreversible inhibition of thymidylate synthase by this nucleoside resulted in an ED50 value 100-fold lower than that observed with the clonogenic assay.	Nucleosides	135-145	thymidylate synthetase	Homo sapiens	106-126