PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 16807468-11 2006 Also, 5"-nucleotidase opposes the action of nucleoside kinases by catalysing the conversion of nucleotides back to nucleosides. Nucleosides 115-126 5'-nucleotidase ecto Homo sapiens 6-21 21873433-1 2011 The 5"-nucleotidase (NT5) family of enzyme dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. Nucleosides 108-119 5'-nucleotidase ecto Homo sapiens 4-19 21873433-1 2011 The 5"-nucleotidase (NT5) family of enzyme dephosphorylates non-cyclic nucleoside monophosphates to produce nucleosides and inorganic phosphates. Nucleosides 108-119 5'-nucleotidase ecto Homo sapiens 21-24 17980347-1 2008 Powerful capillary electrophoresis (CE) methods were developed for monitoring the reaction of ecto-5"-nucleotidase (ecto-5"-NT, CD73), a (patho)biochemically important enzyme that hydrolyzes nucleoside-5"-monophosphates to the corresponding nucleosides. Nucleosides 241-252 5'-nucleotidase ecto Homo sapiens 94-114 17980347-1 2008 Powerful capillary electrophoresis (CE) methods were developed for monitoring the reaction of ecto-5"-nucleotidase (ecto-5"-NT, CD73), a (patho)biochemically important enzyme that hydrolyzes nucleoside-5"-monophosphates to the corresponding nucleosides. Nucleosides 241-252 5'-nucleotidase ecto Homo sapiens 116-126 17980347-1 2008 Powerful capillary electrophoresis (CE) methods were developed for monitoring the reaction of ecto-5"-nucleotidase (ecto-5"-NT, CD73), a (patho)biochemically important enzyme that hydrolyzes nucleoside-5"-monophosphates to the corresponding nucleosides. Nucleosides 241-252 5'-nucleotidase ecto Homo sapiens 128-132 19927594-8 1996 Finally, the presence of a suitable substrate for the phosphotransferase activity of cytosolic 5"-nucleotidase caused a stimulation of the rate of formation of the nucleoside. Nucleosides 164-174 5'-nucleotidase ecto Homo sapiens 95-110 15240122-5 2004 This is in agreement with the observation that 5"-nucleotidase/deoxycytidine kinase ratio might be an important factor in predicting resistance to NAs. Nucleosides 147-150 5'-nucleotidase ecto Homo sapiens 47-62 11896543-1 2002 The relative levels of the deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK), and the 5"-nucleotidase (5"-NT) are of importance for the effect of many nucleoside analogues used in the treatment of hematological malignancies. Nucleosides 157-167 5'-nucleotidase ecto Homo sapiens 92-107 8645738-1 1996 Cytosolic 5"-nucleotidase, acting preferentially on IMP, GMP and their deoxyderivatives, can also behave as a phosphotransferase, operating a transfer of phosphate from a nucleoside monophosphate donor to a nucleoside acceptor which, besides a natural nucleoside, can be also an analog. Nucleosides 171-181 5'-nucleotidase ecto Homo sapiens 10-25 8645738-1 1996 Cytosolic 5"-nucleotidase, acting preferentially on IMP, GMP and their deoxyderivatives, can also behave as a phosphotransferase, operating a transfer of phosphate from a nucleoside monophosphate donor to a nucleoside acceptor which, besides a natural nucleoside, can be also an analog. Nucleosides 207-217 5'-nucleotidase ecto Homo sapiens 10-25 8790720-6 1996 Alternative routes for phosphorylation of nucleoside analogs are also reviewed, such as the phosphotransfer capacity of 5"-nucleotidase and protein kinases. Nucleosides 42-52 5'-nucleotidase ecto Homo sapiens 120-135 9675011-1 1998 Human 5"-nucleotidase (5"-NT, EC 3.1.3.5) is an enzyme that hydrolyzes nucleotides such as AMP or IMP (inosine 5"-monophosphate) into inorganic phosphate and the respective nucleoside. Nucleosides 173-183 5'-nucleotidase ecto Homo sapiens 6-21 9636049-10 1998 The nucleoside analogue was also greater than 1000-fold more potent against c-N-I than the membrane ecto-5"-nucleotidase (e-N). Nucleosides 4-14 5'-nucleotidase ecto Homo sapiens 100-120 9636049-10 1998 The nucleoside analogue was also greater than 1000-fold more potent against c-N-I than the membrane ecto-5"-nucleotidase (e-N). Nucleosides 4-14 5'-nucleotidase ecto Homo sapiens 122-125 9113412-1 1997 CD73 (ecto-5"-nucleotidase), a glycosyl phosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes, catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides. Nucleosides 269-280 5'-nucleotidase ecto Homo sapiens 0-4 9113412-1 1997 CD73 (ecto-5"-nucleotidase), a glycosyl phosphatidylinositol (GPI) anchored purine salvage enzyme expressed on the surface of human T and B lymphocytes, catalyzes the conversion of purine and pyrimidine ribo- and deoxyribonucleoside monophosphates to the corresponding nucleosides. Nucleosides 269-280 5'-nucleotidase ecto Homo sapiens 6-26 9361795-12 1997 2.5"-Nucleotidase (5"-NT) is an enzyme that hydrolyzes nucleotides such as AMP or IMP into inorganic phosphate and the respective nucleoside. Nucleosides 130-140 5'-nucleotidase ecto Homo sapiens 2-17 1430786-3 1992 Existing assays for nucleoside phosphorylation effected by 5"-nucleotidase require a radiolabeled nucleoside as the phosphate acceptor and separation of the substrate-nucleoside from product-nucleotide has been accomplished either by a filter binding method or HPLC. Nucleosides 20-30 5'-nucleotidase ecto Homo sapiens 59-74 7494863-7 1995 Finally, alternative pathways for nucleoside analogue phosphorylation are surveyed, such as the phosphotransfer capacity of 5"-nucleotidase. Nucleosides 34-44 5'-nucleotidase ecto Homo sapiens 124-139 1445204-10 1992 The control patterns of these five fluxes indicate that, in the presence of extracellular adenosine and inosine, the intracellular metabolism of adenine derivatives would be highly dependent on the extracellular and intracellular concentrations of both nucleosides, on the ectoenzymes (5"-nucleotidase and adenosine deaminase) and on the transporter. Nucleosides 253-264 5'-nucleotidase ecto Homo sapiens 286-301 1430786-0 1992 A novel non-radioactive method for detection of nucleoside analog phosphorylation by 5"-nucleotidase. Nucleosides 48-58 5'-nucleotidase ecto Homo sapiens 85-100 1430786-1 1992 Cytosolic 5"-nucleotidase has been implicated in the phosphorylation of certain nucleosides of therapeutic interest. Nucleosides 80-91 5'-nucleotidase ecto Homo sapiens 10-25 1430786-3 1992 Existing assays for nucleoside phosphorylation effected by 5"-nucleotidase require a radiolabeled nucleoside as the phosphate acceptor and separation of the substrate-nucleoside from product-nucleotide has been accomplished either by a filter binding method or HPLC. Nucleosides 98-108 5'-nucleotidase ecto Homo sapiens 59-74 1430786-3 1992 Existing assays for nucleoside phosphorylation effected by 5"-nucleotidase require a radiolabeled nucleoside as the phosphate acceptor and separation of the substrate-nucleoside from product-nucleotide has been accomplished either by a filter binding method or HPLC. Nucleosides 98-108 5'-nucleotidase ecto Homo sapiens 59-74 3000575-10 1986 The monophosphate donor specificity, divalent metal, high salt requirement, and nucleoside acceptor specificity of this enzyme activity paralleled that of a 5"-nucleotidase (EC 3.1.3.5) which catalyzes inosine phosphorylation. Nucleosides 80-90 5'-nucleotidase ecto Homo sapiens 157-172 1535254-1 1992 Ecto-5"-nucleotidase (ecto-5"-NUC, EC 3.1.3.5., CD73) is a plasma membrane enzyme, which catalyzes the hydrolytic dephosphorylation of purine nucleotides to the corresponding nucleosides so that they can pass through the plasma membrane. Nucleosides 175-186 5'-nucleotidase ecto Homo sapiens 0-20 1535254-1 1992 Ecto-5"-nucleotidase (ecto-5"-NUC, EC 3.1.3.5., CD73) is a plasma membrane enzyme, which catalyzes the hydrolytic dephosphorylation of purine nucleotides to the corresponding nucleosides so that they can pass through the plasma membrane. Nucleosides 175-186 5'-nucleotidase ecto Homo sapiens 22-33 1535254-1 1992 Ecto-5"-nucleotidase (ecto-5"-NUC, EC 3.1.3.5., CD73) is a plasma membrane enzyme, which catalyzes the hydrolytic dephosphorylation of purine nucleotides to the corresponding nucleosides so that they can pass through the plasma membrane. Nucleosides 175-186 5'-nucleotidase ecto Homo sapiens 48-52 1601953-1 1992 The enzyme 5"-nucleotidase (5"-ribonucleotide phosphohydrolase, EC 3.1.3.5) catalyzes a critical reaction in intermediary metabolism, the phosphohydrolysis of nucleoside 5"-monophosphates to their corresponding nucleosides. Nucleosides 211-222 5'-nucleotidase ecto Homo sapiens 11-26 34697820-3 2021 CD39 catalyzes the extracellular hydrolysis of nucleoside tri- and diphosphates, mainly adenosine 5"-triphosphate (ATP) and ADP, yielding adenosine monophosphate, which is further hydrolyzed by ecto-5"-nucleotidase (CD73) to produce adenosine. Nucleosides 47-57 5'-nucleotidase ecto Homo sapiens 194-214 34697820-3 2021 CD39 catalyzes the extracellular hydrolysis of nucleoside tri- and diphosphates, mainly adenosine 5"-triphosphate (ATP) and ADP, yielding adenosine monophosphate, which is further hydrolyzed by ecto-5"-nucleotidase (CD73) to produce adenosine. Nucleosides 47-57 5'-nucleotidase ecto Homo sapiens 216-220 2553165-7 1989 The size and distribution of the 27.2 antigen on T cell subsets suggested that it might be the enzyme ecto-5" nucleotidase (NT), a phosphatidylinositol-linked enzyme that catalyzes dephosphorylation of monophosphate nucleotides to their respective nucleosides. Nucleosides 248-259 5'-nucleotidase ecto Homo sapiens 102-122 6320196-6 1984 Variations in substrate specificity, pH optima, kinetics, and sensitivity to inactivation by Pb2+ indicated the existence of multiple 5"-nucleotidase isozymes in normal erythrocytes: PyrNase and deoxyribonucleotidase(s) that might function physiologically in the conversion of DNA-derived nucleotides to diffusible nucleosides. Nucleosides 315-326 5'-nucleotidase ecto Homo sapiens 134-149 33052071-9 2021 Chimeric CD39-CD73-ECD proteins were superior in converting triphosphate and diphosphate nucleotides into nucleosides when compared with ALP-ECD and HAP-ECD. Nucleosides 106-117 5'-nucleotidase ecto Homo sapiens 14-18 6100584-9 1983 For uptake of purine nucleotides sequential action of ecto-5"-nucleotidase (ecto-5"-NT), nucleoside carrier and intracellular metabolism is necessary. Nucleosides 89-99 5'-nucleotidase ecto Homo sapiens 54-74 6100584-9 1983 For uptake of purine nucleotides sequential action of ecto-5"-nucleotidase (ecto-5"-NT), nucleoside carrier and intracellular metabolism is necessary. Nucleosides 89-99 5'-nucleotidase ecto Homo sapiens 76-86 33909515-6 2021 EXPERT OPINION: : Considerable advances have been reported in the design of nucleotide/nucleoside-based CD73 inhibitors, after the X-ray crystal structure of the enzyme in complex with the non-hydrolyzable ADP analog, adenosine (alpha,beta)-methylene diphosphate (AMPCP), was reported. Nucleosides 87-97 5'-nucleotidase ecto Homo sapiens 104-108 32970317-1 2021 PURPOSE: Purine metabolism involves various intracellular and extracellular enzymes, including cN-II and CD73 that dephosphorylate intracellular and extracellular nucleoside monophosphates into their corresponding nucleosides. Nucleosides 214-225 5'-nucleotidase ecto Homo sapiens 105-109 38755-6 1979 The results suggest that the enzyme which degrades nucleoside-5"-phosphate to nucleoside and inorganic phosphate is not acid phosphatase but 5"-nucleotidase. Nucleosides 51-61 5'-nucleotidase ecto Homo sapiens 141-156 27233214-7 2016 In contrast to RPMI1640, X-Vivo15 resulted in a significant down-regulation of the cell-surface-located ectonucleotidases CD39 (Ecto-Apyrase) and CD73 (Ecto-5"-Nucleotidase), critical for the extracellular nucleotides-hydrolysis to nucleosides, explaining the loss of inhibition mediated by dGTP and GTP, but not Guanosine. Nucleosides 232-243 5'-nucleotidase ecto Homo sapiens 152-172 32973513-2 2020 The products are subsequently hydrolyzed by ecto-5"-nucleotidase (ecto-5"-NT) to nucleosides. Nucleosides 81-92 5'-nucleotidase ecto Homo sapiens 44-64 27906612-1 2016 The 5"-nucleotidase cN-II has been shown to be associated with the sensitivity to nucleoside analogues, the survival of cytarabine treated leukemia patients and to cell proliferation. Nucleosides 82-92 5'-nucleotidase ecto Homo sapiens 4-19 32556945-7 2020 Immortalized cells upregulated the CD39/NTPDase1 enzyme and downregulated CD73/NT5E and adenosine deaminase (ADA), which had a direct impact on their nucleotide/nucleoside metabolism profile. Nucleosides 161-171 5'-nucleotidase ecto Homo sapiens 79-83 30176535-0 2018 CD73 inhibition by purine cytotoxic nucleoside analogue-based diphosphonates. Nucleosides 36-46 5'-nucleotidase ecto Homo sapiens 0-4 28529533-3 2017 Furthermore, cellular response to this nucleoside is highly dependent on its extracellular concentration that is regulated by ecto-enzymes such as CD39 and CD73. Nucleosides 39-49 5'-nucleotidase ecto Homo sapiens 156-160 23992316-5 2013 In districts, such as brain, which are dependent on salvage nucleotide synthesis, nucleosides are produced through the action of the ecto-5"-nucleotidase, the last component of a series of plasma-membrane bound enzyme proteins, catalyzing the successive dephosphorylation of released nucleoside-triphosphates. Nucleosides 82-93 5'-nucleotidase ecto Homo sapiens 133-153 23377281-3 2013 Using whole-exome sequencing, we identify mutations in the cytosolic 5"-nucleotidase II gene (NT5C2), which encodes a 5"-nucleotidase enzyme that is responsible for the inactivation of nucleoside-analog chemotherapy drugs, in 20/103 (19%) relapse T cell ALLs and 1/35 (3%) relapse B-precursor ALLs. Nucleosides 185-195 5'-nucleotidase ecto Homo sapiens 69-84 23377281-3 2013 Using whole-exome sequencing, we identify mutations in the cytosolic 5"-nucleotidase II gene (NT5C2), which encodes a 5"-nucleotidase enzyme that is responsible for the inactivation of nucleoside-analog chemotherapy drugs, in 20/103 (19%) relapse T cell ALLs and 1/35 (3%) relapse B-precursor ALLs. Nucleosides 185-195 5'-nucleotidase ecto Homo sapiens 118-133 23220537-1 2013 Clinical and preclinical observations have lead to the hypothesis that 5"-nucleotidase cN-II could constitute a therapeutic target in oncology, either per se or to increase the activity of cytotoxic nucleoside analogs. Nucleosides 199-209 5'-nucleotidase ecto Homo sapiens 71-86 25080434-5 2014 Extracellular nucleotides and adenosine were shown to be rapidly metabolized on tumor cell surfaces via sequential ecto-5"-nucleotidase (CD73/NT5E) and adenosine deaminase reactions with subsequent cellular uptake of nucleoside metabolites and their intracellular interconversion into ADP/ATP. Nucleosides 217-227 5'-nucleotidase ecto Homo sapiens 137-141 24749746-3 2014 Using mass spectrometry, we measured nucleoside production by subsets of human CD4(+) CD39(+) and CD4(+) CD39(-)CD73(+) T cells or CD19(+) B cells isolated from blood of 30 volunteers and 14 cancer patients. Nucleosides 37-47 5'-nucleotidase ecto Homo sapiens 112-116