PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 32587297-5 2020 The nucleoside analogs (DAC, 5AC and zebularine) were the most potent DHAs and increased the enzymatic activity of SIRT6 without showing any significant increase in other sirtuin isoforms. Nucleosides 4-14 sirtuin 6 Homo sapiens 115-120 32587297-6 2020 ChIP-Seq analysis of bone marrow cells derived from six acute myeloid leukemia (AML) patients and treated with the nucleoside analog DAC induced genome-wide acetylation changes in H3K9, the physiological substrate for SIRT6. Nucleosides 115-125 sirtuin 6 Homo sapiens 218-223 32587297-9 2020 To our knowledge, this is the first report to identify the nucleoside analogs DHAs as activators of SIRT6. Nucleosides 59-69 sirtuin 6 Homo sapiens 100-105