PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
18600530-1	2008	Resistance toward nucleoside analogues is often due to decreased activities of the activating enzymes deoxycytidine kinase (dCK) and/or deoxyguanosine kinase (dGK).	Nucleosides	18-28	Diacyl glycerol kinase	Drosophila melanogaster	159-162	
18600530-2	2008	With small interfering RNA (siRNA), dCK and dGK were downregulated by approximately 70% in CEM cells and tested against six nucleoside analogues using the methyl thiazol tetrazolium assay.	Nucleosides	124-134	Diacyl glycerol kinase	Drosophila melanogaster	44-47	
11896543-1	2002	The relative levels of the deoxycytidine kinase (dCK), deoxyguanosine kinase (dGK), and the 5"-nucleotidase (5"-NT) are of importance for the effect of many nucleoside analogues used in the treatment of hematological malignancies.	Nucleosides	157-167	Diacyl glycerol kinase	Drosophila melanogaster	78-81	
9776315-1	1998	The kinetic properties of recombinant human mitochondrial deoxyguanosine kinase (dGK, EC 2.7.1.113) for 2"-deoxyguanosine and the clinically important nucleoside analogs 2-chloro-2"-deoxyadenosine (CdA), 9-beta-D-arabinofuranosylguanine (araG) and 2",2",-difluorodeoxyguanosine (dFdG) were determined.	Nucleosides	151-161	Diacyl glycerol kinase	Drosophila melanogaster	81-84	
9614068-2	1998	We overexpressed dGK as a fusion protein to the green fluorescent protein in the human pancreatic cancer cell lines PanC-1 and MIA PaCa-2 to determine the importance of dGK-mediated nucleoside analog phosphorylation.	Nucleosides	182-192	Diacyl glycerol kinase	Drosophila melanogaster	169-172	
9614068-7	1998	Our data imply that the dGK activity is rate-limiting for the efficacy of nucleoside analogs in the cell lines investigated.	Nucleosides	74-84	Diacyl glycerol kinase	Drosophila melanogaster	24-27	
9463485-2	1998	Its role in activation of pharmacologically used nucleoside analogs is not well understood, because of the low levels of dGK found in tissue extracts and its inactivation during purification.	Nucleosides	49-59	Diacyl glycerol kinase	Drosophila melanogaster	121-124	
9463485-10	1998	The broad specificity of dGK described here may change our understanding of the mechanisms responsible for the efficacy and mitochondrial toxicity of several nucleoside analogs.	Nucleosides	158-168	Diacyl glycerol kinase	Drosophila melanogaster	25-28	
25182642-8	2014	These results suggest that downregulation of mitochondrial TK2 and dGK may lead to decreased mitochondrial DNA precursor pools and eventually mtDNA depletion, which has significant implications for the regulation of mitochondrial nucleotide biosynthesis and for antiviral therapy using nucleoside analogs.	Nucleosides	286-296	Diacyl glycerol kinase	Drosophila melanogaster	67-70	
26252632-1	2015	Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies.	Nucleosides	86-96	Diacyl glycerol kinase	Drosophila melanogaster	37-40	
26252632-1	2015	Mitochondrial deoxyguanosine kinase (dGK), is an enzyme responsible for activation of nucleoside analogs (NAs) to phosphorylated compounds which exert profound cytotoxicity, especially in hematological malignancies.	Nucleosides	106-109	Diacyl glycerol kinase	Drosophila melanogaster	37-40	
24976398-6	2014	The results suggest that down-regulation of mitochondrial TK2 and dGK may be a mechanism of mitochondrial toxicity caused by antiviral and anticancer nucleoside analogs.	Nucleosides	150-160	Diacyl glycerol kinase	Drosophila melanogaster	66-69