PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21978950-3 2011 Utilizing a parallel synthetic approach, 50 various functionalized tetrahydro-beta-carboline derivatives were prepared and assessed for activities related to cancer chemoprevention and cancer treatment: induction of quinone reductase 1 (QR1) and inhibition of aromatase, nitric oxide (NO) production, tumor necrosis factor (TNF)-alpha-induced NFkappaB activity, and MCF7 breast cancer cell proliferation. tryptoline 67-92 tumor necrosis factor Homo sapiens 301-334