PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
26113114-3	2015	OBJECTIVE: We investigated whether pharmacological modulation of SPHK1 activity, using a novel synthetic SPHK1 activator, (S)-methyl 2-(hexanamide)-3-(4-hydroxyphenyl) propanoate (MHP), stimulates CAMP expression.	methyl 2-(hexanamide)-3-(4-hydroxyphenyl)propanoate	122-178	sphingosine kinase 1	Homo sapiens	65-70	
26113114-3	2015	OBJECTIVE: We investigated whether pharmacological modulation of SPHK1 activity, using a novel synthetic SPHK1 activator, (S)-methyl 2-(hexanamide)-3-(4-hydroxyphenyl) propanoate (MHP), stimulates CAMP expression.	methyl 2-(hexanamide)-3-(4-hydroxyphenyl)propanoate	122-178	sphingosine kinase 1	Homo sapiens	105-110	
26113114-7	2015	Next, we found that exogenous MHP significantly stimulated CAMP mRNA and protein production in KC, increases that were significantly suppressed by siRNA directed against SPHK1, but not by a scrambled control siRNA.	methyl 2-(hexanamide)-3-(4-hydroxyphenyl)propanoate	30-33	sphingosine kinase 1	Homo sapiens	170-175	
26113114-9	2015	Conversely, pretreatment with a specific inhibitor of SPHK1 decreased MHP-induced nuclear translocation of NF-kappaB, and significantly attenuated the MHP-mediated increase in CAMP production.	methyl 2-(hexanamide)-3-(4-hydroxyphenyl)propanoate	70-73	sphingosine kinase 1	Homo sapiens	54-59