PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 15240695-5 2004 TNF-induced Syk activation was abolished by piceatannol (Syk-selective inhibitor), which led to the suppression of TNF-induced activation of c- JNK, p38 MAPK, and p44/p42 MAPK. 3,3',4,5'-tetrahydroxystilbene 44-55 tumor necrosis factor Homo sapiens 0-3 15779068-6 2005 Genistein, piceatannol, and TAS diminished secretion of TNF-alpha, and IL-8. 3,3',4,5'-tetrahydroxystilbene 11-22 tumor necrosis factor Homo sapiens 56-65 15240695-5 2004 TNF-induced Syk activation was abolished by piceatannol (Syk-selective inhibitor), which led to the suppression of TNF-induced activation of c- JNK, p38 MAPK, and p44/p42 MAPK. 3,3',4,5'-tetrahydroxystilbene 44-55 tumor necrosis factor Homo sapiens 115-118 28535046-0 2017 Inhibitory Effect of Piceatannol on TNF-alpha-Mediated Inflammation and Insulin Resistance in 3T3-L1 Adipocytes. 3,3',4,5'-tetrahydroxystilbene 21-32 tumor necrosis factor Homo sapiens 36-45 28535046-4 2017 Piceatannol also partially improved the malfunction of insulin-stimulated glucose uptake, which was reduced by TNF-alpha in 3T3-L1 adipocytes. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 111-120 12444159-0 2002 Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 21-24 12444159-5 2002 The treatment of human myeloid cells with piceatannol suppressed TNF-induced DNA binding activity of NF-kappaB. 3,3',4,5'-tetrahydroxystilbene 42-53 tumor necrosis factor Homo sapiens 65-68 12444159-7 2002 The effect of piceatannol was not restricted to myeloid cells, as TNF-induced NF-kappaB activation was also suppressed in lymphocyte and epithelial cells. 3,3',4,5'-tetrahydroxystilbene 14-25 tumor necrosis factor Homo sapiens 66-69 12444159-9 2002 Piceatannol abrogated the expression of TNF-induced NF-kappaB-dependent reporter gene and of matrix metalloprotease-9, cyclooxygenase-2, and cyclin D1. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 40-43 12444159-10 2002 When examined for the mechanism, we found that piceatannol inhibited TNF-induced IkappaBalpha phosphorylation, p65 phosphorylation, p65 nuclear translocation, and IkappaBalpha kinase activation, but had no significant effect on IkappaBalpha degradation. 3,3',4,5'-tetrahydroxystilbene 47-58 tumor necrosis factor Homo sapiens 69-72 35235887-6 2022 The molecular mechanism of piceatannol was studied in the TNFalpha/IFNgamma-induced HaCaT cell line. 3,3',4,5'-tetrahydroxystilbene 27-38 tumor necrosis factor Homo sapiens 58-66 35235887-10 2022 Piceatannol decreased phosphorylation of JAK-STAT protein in the TNFalpha/IFNgamma-induced HaCaT cell line. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 65-73 28535046-1 2017 Piceatannol, a bioactive component in grape and blueberry, was examined for its potential in decreasing the inflammatory activities in adipocytes using a cocultured adipocyte and macrophage system, and suppressing tumor necrosis factor-alpha (TNF-alpha)-mediated inflammation and the related insulin resistance using a 3T3-L1 adipocyte model. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 214-241 28535046-1 2017 Piceatannol, a bioactive component in grape and blueberry, was examined for its potential in decreasing the inflammatory activities in adipocytes using a cocultured adipocyte and macrophage system, and suppressing tumor necrosis factor-alpha (TNF-alpha)-mediated inflammation and the related insulin resistance using a 3T3-L1 adipocyte model. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 243-252 28535046-2 2017 Piceatannol at 10 muM significantly reduced the release of inflammatory cytokines of TNF-alpha and monocyte chemoattractant protein-1 (MCP-1) by 19 and 31% in the cocultured system, respectively. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 85-94 28535046-3 2017 Pretreatment with piceatannol also inhibited TNF-alpha-induced expression of interleukin-6 (IL-6) and MCP-1 at both mRNA and protein levels in the 3T3-L1 adipocytes. 3,3',4,5'-tetrahydroxystilbene 18-29 tumor necrosis factor Homo sapiens 45-54 23726836-6 2013 Furthermore, piceatannol obviously suppressed TNF-alpha-induced IkappaB phosphorylation and the downstream NF-kappaB activation, suggesting that Syk is an upstream key regulator in the activation of PI3K/IKK/IkappaB-mediated signaling. 3,3',4,5'-tetrahydroxystilbene 13-24 tumor necrosis factor Homo sapiens 46-55 23255946-14 2013 Overall, these data suggest that piceatannol inhibits TNF-alpha-induced invasion by suppression of MMP-9 activation via the Akt-mediated NF-kappaB pathway in DU145 prostate cancer cells. 3,3',4,5'-tetrahydroxystilbene 33-44 tumor necrosis factor Homo sapiens 54-63 23255946-0 2013 Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-alpha-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-kappaB pathway. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 49-76 22705645-0 2012 Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFalpha-mediated NFkappaB activation in piceatannol-treated human leukemia U937 cells. 3,3',4,5'-tetrahydroxystilbene 136-147 tumor necrosis factor Homo sapiens 95-103 23255946-5 2013 However, treatment with piceatannol reversed TNF-alpha- and MMP-9-induced gelatin zymography and its gene expression. 3,3',4,5'-tetrahydroxystilbene 24-35 tumor necrosis factor Homo sapiens 45-54 23255946-6 2013 In addition, a Matrigel invasion assay determined that piceatannol reduces the TNF-alpha-induced invasion of DU145 cells. 3,3',4,5'-tetrahydroxystilbene 55-66 tumor necrosis factor Homo sapiens 79-88 23255946-12 2013 Furthermore, TNF-alpha-induced Akt phosphorylation was significantly downregulated in the presence of piceatannol. 3,3',4,5'-tetrahydroxystilbene 102-113 tumor necrosis factor Homo sapiens 13-22 22705645-1 2012 To address the mechanism of piceatannol in inhibiting TNFalpha-mediated pathway, studies on piceatannol-treated human leukemia U937 cells were conducted. 3,3',4,5'-tetrahydroxystilbene 28-39 tumor necrosis factor Homo sapiens 54-62 22705645-2 2012 Piceatannol treatment reduced TNFalpha shedding and NFkappaB activation and decreased the release of soluble TNFalpha into the culture medium of U937 cells. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 30-38 22705645-2 2012 Piceatannol treatment reduced TNFalpha shedding and NFkappaB activation and decreased the release of soluble TNFalpha into the culture medium of U937 cells. 3,3',4,5'-tetrahydroxystilbene 0-11 tumor necrosis factor Homo sapiens 109-117 22705645-4 2012 Over-expression of ADAM17 abrogated the ability of piceatannol to suppress TNFalpha-mediated NFkappaB activation. 3,3',4,5'-tetrahydroxystilbene 51-62 tumor necrosis factor Homo sapiens 75-83 22705645-12 2012 Consequently, piceatannol suppresses TNFalpha shedding, leading to inhibition of TNFalpha/NFkappaB pathway. 3,3',4,5'-tetrahydroxystilbene 14-25 tumor necrosis factor Homo sapiens 37-45 22705645-12 2012 Consequently, piceatannol suppresses TNFalpha shedding, leading to inhibition of TNFalpha/NFkappaB pathway. 3,3',4,5'-tetrahydroxystilbene 14-25 tumor necrosis factor Homo sapiens 81-89 19631264-3 2009 The treatment of cells with piceatannol inhibited cell proliferation by reducing extracellular signal-regulated kinase (ERK) 1/2 and JNK activity in cultured VSMC in the presence of tumor necrosis factor-alpha (TNF-alpha). 3,3',4,5'-tetrahydroxystilbene 28-39 tumor necrosis factor Homo sapiens 182-209 19631264-3 2009 The treatment of cells with piceatannol inhibited cell proliferation by reducing extracellular signal-regulated kinase (ERK) 1/2 and JNK activity in cultured VSMC in the presence of tumor necrosis factor-alpha (TNF-alpha). 3,3',4,5'-tetrahydroxystilbene 28-39 tumor necrosis factor Homo sapiens 211-220 19631264-6 2009 The effect of piceatannol was not restricted to cell proliferation, as TNF-alpha-induced invasion and migration was also suppressed in VSMC. 3,3',4,5'-tetrahydroxystilbene 14-25 tumor necrosis factor Homo sapiens 71-80 19631264-7 2009 Moreover, piceatannol treatment strongly decreased matrix metalloproteinase-9 (MMP-9) expression and promoter activity in a dose-dependent manner in response to TNF-alpha. 3,3',4,5'-tetrahydroxystilbene 10-21 tumor necrosis factor Homo sapiens 161-170 19631264-9 2009 Overall, these results demonstrate that piceatannol inhibits proliferation and migration of VSMC treated with TNF-alpha. 3,3',4,5'-tetrahydroxystilbene 40-51 tumor necrosis factor Homo sapiens 110-119