PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 27995330-0 2017 Piceatannol attenuates homocysteine-induced endoplasmic reticulum stress and endothelial cell damage via heme oxygenase-1 expression. 3,3',4,5'-tetrahydroxystilbene 0-11 heme oxygenase 1 Homo sapiens 105-121 31277394-4 2019 Moreover, piceatannol treatment induced NF-E2-related factor 2 (Nrf2) signaling activation, which was evidenced by increased transcription of anti-oxidant genes, glutamate-cysteine ligase catalytic subunit (GCLc), SOD, and HO-1. 3,3',4,5'-tetrahydroxystilbene 10-21 heme oxygenase 1 Homo sapiens 223-227 31277394-5 2019 Knockdown of Nrf2 through targeted siRNA alleviated piceatannol-mediated HO-1 transcription, and significantly abolished piceatannol-mediated cytoprotection. 3,3',4,5'-tetrahydroxystilbene 52-63 heme oxygenase 1 Homo sapiens 73-77 31277394-6 2019 LY294002 (PI3K inhibitor) dramatically blocked piceatannol-mediated increasing of Nrf2 nuclear translocation, HO-1 expression, and cytoprotective activity, indicating the involvement of PI3K/Akt pathway in the cytoprotective effect of piceatannol. 3,3',4,5'-tetrahydroxystilbene 47-58 heme oxygenase 1 Homo sapiens 110-114 27995330-8 2017 Interestingly, the inhibitory effects of Pic on Hcy-induced apoptosis, ROS generation and ER stress were abolished by down-regulation of HO-1 expression, while mimicked by treatment of ECs with the HO-1 inducer hemin. 3,3',4,5'-tetrahydroxystilbene 41-44 heme oxygenase 1 Homo sapiens 137-141 27995330-8 2017 Interestingly, the inhibitory effects of Pic on Hcy-induced apoptosis, ROS generation and ER stress were abolished by down-regulation of HO-1 expression, while mimicked by treatment of ECs with the HO-1 inducer hemin. 3,3',4,5'-tetrahydroxystilbene 41-44 heme oxygenase 1 Homo sapiens 198-202 27995330-9 2017 Overall, these results suggest that Pic may protect ECs against Hcy-induced apoptosis, oxidative stress and ER stress via Nrf2-dependent HO-1 expression. 3,3',4,5'-tetrahydroxystilbene 36-39 heme oxygenase 1 Homo sapiens 137-141 25815690-0 2015 Resveratrol analog piceatannol restores the palmitic acid-induced impairment of insulin signaling and production of endothelial nitric oxide via activation of anti-inflammatory and antioxidative heme oxygenase-1 in human endothelial cells. 3,3',4,5'-tetrahydroxystilbene 19-30 heme oxygenase 1 Homo sapiens 195-211 25815690-9 2015 The results of the present study suggested that Pic may have the potential to prevent PA-induced impairment of insulin signaling and eNOS function, by inducing the expression of the anti-inflammatory and antioxidant, HO-1. 3,3',4,5'-tetrahydroxystilbene 48-51 heme oxygenase 1 Homo sapiens 217-221 26163109-6 2015 Moreover, the HO-1 inducers, resveratrol and piceatannol decrease the expression of miR-183, resulting in attenuated osteoclastogenesis. 3,3',4,5'-tetrahydroxystilbene 45-56 heme oxygenase 1 Homo sapiens 14-18 20558128-0 2010 Piceatannol induces heme oxygenase-1 expression in human mammary epithelial cells through activation of ARE-driven Nrf2 signaling. 3,3',4,5'-tetrahydroxystilbene 0-11 heme oxygenase 1 Homo sapiens 20-36 20558128-3 2010 In the present study, we found that piceatannol treatment (30 microM) significantly upregulated the expression of the antioxidant enzyme heme oxygenase-1 (HO-1) and its mRNA transcript at 6h and 3h, respectively in human breast epithelial (MCF10A) cells. 3,3',4,5'-tetrahydroxystilbene 36-47 heme oxygenase 1 Homo sapiens 137-153 20558128-3 2010 In the present study, we found that piceatannol treatment (30 microM) significantly upregulated the expression of the antioxidant enzyme heme oxygenase-1 (HO-1) and its mRNA transcript at 6h and 3h, respectively in human breast epithelial (MCF10A) cells. 3,3',4,5'-tetrahydroxystilbene 36-47 heme oxygenase 1 Homo sapiens 155-159 20558128-6 2010 Upregulation of HO-1 expression by piceatannol through direct binding of Nrf2 to antioxidant response element (ARE) was verified by the chromatin immunoprecipitation (ChIP) assay. 3,3',4,5'-tetrahydroxystilbene 35-46 heme oxygenase 1 Homo sapiens 16-20 20558128-7 2010 siRNA knock down of Nrf2 gene abolished piceatannol-induced HO-1 expression. 3,3',4,5'-tetrahydroxystilbene 40-51 heme oxygenase 1 Homo sapiens 60-64 20558128-8 2010 In addition, piceatannol-induced activation of Nrf2 and/or HO-1 expression was abrogated by the pharmacological inhibitor (LY294002) as well as the kinase-dead form of Akt. 3,3',4,5'-tetrahydroxystilbene 13-24 heme oxygenase 1 Homo sapiens 59-63 20558128-9 2010 In an attempt to elucidate the molecular mechanisms underlying cytoprotective or chemoprotective activity exerted by piceatannol, we examined its effect on the signaling pathways responsible for induction of HO-1 expression. 3,3',4,5'-tetrahydroxystilbene 117-128 heme oxygenase 1 Homo sapiens 208-212 20558128-12 2010 The thiol reducing agents, dithiothreitol (100 microM) or beta-mercaptoethanol (1.4 microM), attenuated piceatannol-induced Nrf2 activation and HO-1 expression. 3,3',4,5'-tetrahydroxystilbene 104-115 heme oxygenase 1 Homo sapiens 144-148 20558128-13 2010 It is hence likely that piceatannol modifies specific cysteine residues of Keap1, which allows Nrf2 to translocate into the nucleus and bind to ARE, leading to enhancement of the expression of HO-1. 3,3',4,5'-tetrahydroxystilbene 24-35 heme oxygenase 1 Homo sapiens 193-197 20558128-14 2010 The characteristic catechol moiety of piceatannol appears to be critical for induction of Nrf2 activation and subsequent upregulation of HO-1. 3,3',4,5'-tetrahydroxystilbene 38-49 heme oxygenase 1 Homo sapiens 137-141 16243536-0 2006 Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. 3,3',4,5'-tetrahydroxystilbene 0-11 heme oxygenase 1 Homo sapiens 36-52 16243536-3 2006 In this study, we examined the ability of piceatannol to upregulate HO-1 expression in endothelial cells. 3,3',4,5'-tetrahydroxystilbene 42-53 heme oxygenase 1 Homo sapiens 68-72 16243536-4 2006 We found piceatannol at micromolar (10-50 microM) concentrations dramatically increased HO-1 protein levels in a time-dependent manner. 3,3',4,5'-tetrahydroxystilbene 9-20 heme oxygenase 1 Homo sapiens 88-92 16243536-5 2006 Piceatannol was similarly potent in the induction of HO-1 as hemin, arsenate, and 15d-PGJ2, and was more potent than some other phytochemicals including curcumin, EGCG, baicalein, and quercetin. 3,3',4,5'-tetrahydroxystilbene 0-11 heme oxygenase 1 Homo sapiens 53-57 16243536-8 2006 Piceatannol-mediated HO-1 induction was abrogated in the presence of N-acetylcysteine and glutathione, but not by other antioxidants. 3,3',4,5'-tetrahydroxystilbene 0-11 heme oxygenase 1 Homo sapiens 21-25 16243536-9 2006 Induction of HO-1 by piceatannol was further enhanced by using buthionine sulfoximine. 3,3',4,5'-tetrahydroxystilbene 21-32 heme oxygenase 1 Homo sapiens 13-17 16243536-13 2006 Treating ECs with zinc protoporphyrin, an HO-1 inhibito blocked the anti-inflammatory effect of piceatannol. 3,3',4,5'-tetrahydroxystilbene 96-107 heme oxygenase 1 Homo sapiens 42-46 16243536-14 2006 In summary, this study identified piceatannol as a novel phytochemical inducer of HO-1 expression and identified the mechanisms involved in this process. 3,3',4,5'-tetrahydroxystilbene 34-45 heme oxygenase 1 Homo sapiens 82-86