PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 23255946-12 2013 Furthermore, TNF-alpha-induced Akt phosphorylation was significantly downregulated in the presence of piceatannol. 3,3',4,5'-tetrahydroxystilbene 102-113 AKT serine/threonine kinase 1 Homo sapiens 31-34 23877152-6 2013 Piceatannol attenuated the H-ras-induced phosphorylation of Akt in a time- and dose-dependent manner, whereas resveratrol, at the same concentrations, did not exert an inhibitory effect. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 60-63 23255946-0 2013 Piceatannol inhibits MMP-9-dependent invasion of tumor necrosis factor-alpha-stimulated DU145 cells by suppressing the Akt-mediated nuclear factor-kappaB pathway. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 119-122 23255946-14 2013 Overall, these data suggest that piceatannol inhibits TNF-alpha-induced invasion by suppression of MMP-9 activation via the Akt-mediated NF-kappaB pathway in DU145 prostate cancer cells. 3,3',4,5'-tetrahydroxystilbene 33-44 AKT serine/threonine kinase 1 Homo sapiens 124-127 22705645-0 2012 Suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression and TNFalpha-mediated NFkappaB activation in piceatannol-treated human leukemia U937 cells. 3,3',4,5'-tetrahydroxystilbene 136-147 AKT serine/threonine kinase 1 Homo sapiens 15-18 22705645-6 2012 Piceatannol treatment induced p38 MAPK phosphorylation but inactivation of Akt and ERK. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 75-78 22480333-0 2012 Piceatannol suppresses breast cancer cell invasion through the inhibition of MMP-9: involvement of PI3K/AKT and NF-kappaB pathways. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 104-107 22705645-7 2012 In contrast to p38 MAPK inhibitor or restoration of ERK activation, transfection of constitutive active Akt abolished the effect of piceatannol on beta-TrCP, Sp1 and ADAM17 expression. 3,3',4,5'-tetrahydroxystilbene 132-143 AKT serine/threonine kinase 1 Homo sapiens 104-107 22705645-9 2012 Inactivation of Akt resulted in Foxp3 down-regulation and reduced miR-183 expression in piceatannol-treated cells. 3,3',4,5'-tetrahydroxystilbene 88-99 AKT serine/threonine kinase 1 Homo sapiens 16-19 22705645-11 2012 Taken together, our data indicate that suppression of Akt/Foxp3-mediated miR-183 expression blocks Sp1-mediated ADAM17 expression in piceatannol-treated U937 cells. 3,3',4,5'-tetrahydroxystilbene 133-144 AKT serine/threonine kinase 1 Homo sapiens 54-57 22480333-6 2012 Piceatannol attenuated phosphoinisitide-3-kinase (PI3K) and phosphorylation of AKT and mammalian target of rapamycin (mTOR), whereas phosphatase and tensin homologue (PTEN) was increased. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 79-82 22480333-9 2012 These results proposed piceatannol as a potential anti-invasive agent by inhibiting MMP-9 involved in PI3K/AKT and NF-kappaB pathways. 3,3',4,5'-tetrahydroxystilbene 23-34 AKT serine/threonine kinase 1 Homo sapiens 107-110 20951127-6 2011 Furthermore, piceatannol significantly repressed LPS-induced PI3K/Akt phosphorylation and the downstream IKK/IkappaB activation, suggesting that Syk is an upstream key regulator in the activation of PI3K/Akt-mediated signaling. 3,3',4,5'-tetrahydroxystilbene 13-24 AKT serine/threonine kinase 1 Homo sapiens 66-69 22298784-8 2012 Piceatannol dose-dependently inhibited differentiation mixture-induced phosphorylation of insulin receptor (IR)/insulin receptor substrate-1 (IRS-1)/Akt pathway in the early phase of adipogenesis. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 149-152 22567414-7 2012 Immunoblot analyses showed that exposure of different-stage CaP cells to piceatannol also resulted in cell-type-specific downregulation of mTOR and its upstream and downstream effector proteins, AKT and eIF-4E-BP1. 3,3',4,5'-tetrahydroxystilbene 73-84 AKT serine/threonine kinase 1 Homo sapiens 195-198 22567414-8 2012 We propose that the observed AKT and mTOR changes are new targets of piceatannol possibly contributing to its inhibitory activities on proliferation of CaP cells. 3,3',4,5'-tetrahydroxystilbene 69-80 AKT serine/threonine kinase 1 Homo sapiens 29-32 20951127-6 2011 Furthermore, piceatannol significantly repressed LPS-induced PI3K/Akt phosphorylation and the downstream IKK/IkappaB activation, suggesting that Syk is an upstream key regulator in the activation of PI3K/Akt-mediated signaling. 3,3',4,5'-tetrahydroxystilbene 13-24 AKT serine/threonine kinase 1 Homo sapiens 204-207 12393431-6 2003 Expression of kinase-deficient Syk or pretreatment with piceatannol markedly suppressed IL-2-stimulated activation of PI 3-kinase and Akt, demonstrating that Syk is upstream of PI 3-kinase and Akt. 3,3',4,5'-tetrahydroxystilbene 56-67 AKT serine/threonine kinase 1 Homo sapiens 134-137 12393431-6 2003 Expression of kinase-deficient Syk or pretreatment with piceatannol markedly suppressed IL-2-stimulated activation of PI 3-kinase and Akt, demonstrating that Syk is upstream of PI 3-kinase and Akt. 3,3',4,5'-tetrahydroxystilbene 56-67 AKT serine/threonine kinase 1 Homo sapiens 193-196 12393431-7 2003 However, constitutively active PI 3-kinase reversed this loss of Akt function caused by kinase-deficient Syk or piceatannol. 3,3',4,5'-tetrahydroxystilbene 112-123 AKT serine/threonine kinase 1 Homo sapiens 65-68 32824997-8 2020 Piceatannol was proposed to bind with VEGF, thus attenuating VEGF in activating VEGF receptor and blocking VEGF-mediated downstream signaling, including expressions of phosphorylated eNOS, Erk and Akt. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 197-200 32368141-0 2020 Piceatannol Suppresses the Proliferation and Induced Apoptosis of Osteosarcoma Cells Through PI3K/AKT/mTOR Pathway. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 98-101 31277394-0 2019 Piceatannol Protects Human Retinal Pigment Epithelial Cells against Hydrogen Peroxide Induced Oxidative Stress and Apoptosis through Modulating PI3K/Akt Signaling Pathway. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 149-152 31277394-6 2019 LY294002 (PI3K inhibitor) dramatically blocked piceatannol-mediated increasing of Nrf2 nuclear translocation, HO-1 expression, and cytoprotective activity, indicating the involvement of PI3K/Akt pathway in the cytoprotective effect of piceatannol. 3,3',4,5'-tetrahydroxystilbene 47-58 AKT serine/threonine kinase 1 Homo sapiens 191-194 31277394-6 2019 LY294002 (PI3K inhibitor) dramatically blocked piceatannol-mediated increasing of Nrf2 nuclear translocation, HO-1 expression, and cytoprotective activity, indicating the involvement of PI3K/Akt pathway in the cytoprotective effect of piceatannol. 3,3',4,5'-tetrahydroxystilbene 235-246 AKT serine/threonine kinase 1 Homo sapiens 191-194 14982949-3 2004 We found that Src inhibitor PP2 and Syk inhibitor piceatannol inhibited phagocytosis, macrophage-inflammatory protein-1alpha (MIP-1alpha) release, as well as phosphorylation of extracellular-regulated kinase (ERK) and Akt, consistent with Src/Syk involvement early in FcgammaR signaling. 3,3',4,5'-tetrahydroxystilbene 50-61 AKT serine/threonine kinase 1 Homo sapiens 218-221 32538768-0 2020 Piceatannol inhibits proliferation and induces apoptosis of bladder cancer cells through regulation of the PTEN/AKT signal pathway. 3,3',4,5'-tetrahydroxystilbene 0-11 AKT serine/threonine kinase 1 Homo sapiens 112-115 32538768-8 2020 PIC significantly inhibits the proliferation of EJ cells and enhances their apoptosis through a mechanism related to the activation of PTEN/Akt signaling pathway. 3,3',4,5'-tetrahydroxystilbene 0-3 AKT serine/threonine kinase 1 Homo sapiens 140-143