PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 21083985-3 2010 PVSMCs were stimulated by PDGF-BB and were treated with three different doses of piceatannol, a Syk selective inhibitor. 3,3',4,5'-tetrahydroxystilbene 81-92 spleen associated tyrosine kinase Rattus norvegicus 96-99 30106055-6 2018 Piceatannol (34.62 mg/kg), a Syk inhibitor, was intraperitoneally injected as a control. 3,3',4,5'-tetrahydroxystilbene 0-11 spleen associated tyrosine kinase Rattus norvegicus 29-32 29401630-7 2018 The anti-osteoclastogenesis effect of tetrandrine nearly disappeared when it was used in combination with the Syk inhibitor piceatannol or in constitutively activated Syk-overexpressing cells. 3,3',4,5'-tetrahydroxystilbene 124-135 spleen associated tyrosine kinase Rattus norvegicus 110-113 26138128-12 2015 Syk inhibitor piceatannol reduced brain edema at 24 hours after SAH. 3,3',4,5'-tetrahydroxystilbene 14-25 spleen associated tyrosine kinase Rattus norvegicus 0-3 21189061-5 2011 Notably, Syk inhibitor piceatannol significantly inhibited those biological effects induced by PDGF-BB. 3,3',4,5'-tetrahydroxystilbene 23-34 spleen associated tyrosine kinase Rattus norvegicus 9-12 21083985-10 2010 After piceatannol treatment, both Syk mRNA and protein expression decreased and the proliferation of PVSMCs was inhibited in a dose-dependent manner. 3,3',4,5'-tetrahydroxystilbene 6-17 spleen associated tyrosine kinase Rattus norvegicus 34-37 17303097-5 2007 These effects of PDGF-BB were inhibited by piceatannol, an inhibitor of Syk. 3,3',4,5'-tetrahydroxystilbene 43-54 spleen associated tyrosine kinase Rattus norvegicus 72-75 20384866-10 2010 Further, while inhibition of Syk with piceatannol blocked phagocytosis as expected, it did not inhibit serotonin secretion. 3,3',4,5'-tetrahydroxystilbene 38-49 spleen associated tyrosine kinase Rattus norvegicus 29-32 19023180-5 2008 PDGF-BB-induced dephosphorylation of cofilin was inhibited by pretreatment with piceatannol (a spleen tyrosine kinase [Syk] inhibitor), PP2 (a Src inhibitor), or SP600125 (a c-Jun N-terminal kinase [JNK] inhibitor), but not by PD98059, an inhibitor of extracellular signal-regulated kinase 1/2. 3,3',4,5'-tetrahydroxystilbene 80-91 spleen associated tyrosine kinase Rattus norvegicus 119-122 17442668-4 2007 Ang II-induced Syk phosphorylation was inhibited by piceatannol and dominant negative but not wild type Syk mutant. 3,3',4,5'-tetrahydroxystilbene 52-63 spleen associated tyrosine kinase Rattus norvegicus 15-18 17679556-4 2007 PDGF-BB (10 ng/mL) induced the migration and proliferation of RASMCs, which were significantly inhibited by PP2 (10 microM) and piceatannol (30 microM), inhibitors of Src and Syk, respectively. 3,3',4,5'-tetrahydroxystilbene 128-139 spleen associated tyrosine kinase Rattus norvegicus 175-178 11341783-6 2001 The Syk-selective inhibitor piceatannol and the Src family-selective tyrosine kinase inhibitor PP1 dose-dependently inhibited FcepsilonRI-mediated degranulation, whereas neither compound inhibited the Ag(+)-mediated degranulation. 3,3',4,5'-tetrahydroxystilbene 28-39 spleen associated tyrosine kinase Rattus norvegicus 4-7 12490796-4 2002 Piceatannol blocks Syk and ZAP-70, tyrosine kinases involved in immune cell activation. 3,3',4,5'-tetrahydroxystilbene 0-11 spleen associated tyrosine kinase Rattus norvegicus 19-22 12490796-16 2002 CONCLUSIONS: These results are the first to show that piceatannol, when combined with subtherapeutic dosages of CsA, prevents graft rejection, suggesting that targeting Syk and Zap could be useful for preventing graft rejection. 3,3',4,5'-tetrahydroxystilbene 54-65 spleen associated tyrosine kinase Rattus norvegicus 169-172 17409631-3 2007 ET-1-induced contraction of aortic strips was inhibited by piceatannol, PD98059, and SB203580, inhibitors of Syk, extracellular signal-regulated kinase 1/2 (ERK1/2), and p38 mitogen-activated protein kinase (MAPK), respectively. 3,3',4,5'-tetrahydroxystilbene 59-70 spleen associated tyrosine kinase Rattus norvegicus 109-112 17409631-5 2007 ET-1 dose-dependently enhanced the activity of Syk and this was inhibited by piceatannol in both rat aortic strip and rat aortic smooth muscle cells. 3,3',4,5'-tetrahydroxystilbene 77-88 spleen associated tyrosine kinase Rattus norvegicus 47-50 15489638-7 2004 Alpha-MSH and the Syk kinase inhibitor piceatannol blocked these processes. 3,3',4,5'-tetrahydroxystilbene 39-50 spleen associated tyrosine kinase Rattus norvegicus 18-21 12225366-6 2002 Piceatannol inhibited tyrosine-phosphorylation of Syk and decreased both adhesion and krox-20/egr-2 mRNA level. 3,3',4,5'-tetrahydroxystilbene 0-11 spleen associated tyrosine kinase Rattus norvegicus 50-53 10731700-6 2000 Furthermore, Syk is significantly tyrosine-phosphorylated in response to angiotensin II in JTC-27 cells, and angiotensin II-induced MAP kinase activation is blocked by the treatment of cells with a Syk-selective inhibitor, piceatannol. 3,3',4,5'-tetrahydroxystilbene 223-234 spleen associated tyrosine kinase Rattus norvegicus 13-16 10731700-6 2000 Furthermore, Syk is significantly tyrosine-phosphorylated in response to angiotensin II in JTC-27 cells, and angiotensin II-induced MAP kinase activation is blocked by the treatment of cells with a Syk-selective inhibitor, piceatannol. 3,3',4,5'-tetrahydroxystilbene 223-234 spleen associated tyrosine kinase Rattus norvegicus 198-201 7961959-0 1994 Inhibition of mast cell Fc epsilon R1-mediated signaling and effector function by the Syk-selective inhibitor, piceatannol. 3,3',4,5'-tetrahydroxystilbene 111-122 spleen associated tyrosine kinase Rattus norvegicus 86-89 7961959-4 1994 Piceatannol preferentially inhibits the activity of Syk as compared with Lyn when added to in vitro assays with isolated enzymes. 3,3',4,5'-tetrahydroxystilbene 0-11 spleen associated tyrosine kinase Rattus norvegicus 52-55 7961959-5 1994 Treatment of RBL-2H3 cells with piceatannol strongly inhibits the antigen-stimulated activation of Syk measured in anti-Syk and anti-phosphotyrosine immune complex kinase assays at concentrations that have no effect on receptor subunit phosphorylation and maintain or increase the activity of Lyn in anti-phosphotyrosine immune complex kinase assays. 3,3',4,5'-tetrahydroxystilbene 32-43 spleen associated tyrosine kinase Rattus norvegicus 99-102 7961959-5 1994 Treatment of RBL-2H3 cells with piceatannol strongly inhibits the antigen-stimulated activation of Syk measured in anti-Syk and anti-phosphotyrosine immune complex kinase assays at concentrations that have no effect on receptor subunit phosphorylation and maintain or increase the activity of Lyn in anti-phosphotyrosine immune complex kinase assays. 3,3',4,5'-tetrahydroxystilbene 32-43 spleen associated tyrosine kinase Rattus norvegicus 120-123 7961959-6 1994 In cells metabolically labeled with [32P]orthophosphate, piceatannol inhibits the antigen-stimulated tyrosine phosphorylation of Syk and most other proteins. 3,3',4,5'-tetrahydroxystilbene 57-68 spleen associated tyrosine kinase Rattus norvegicus 129-132 7961959-10 1994 Receptor-mediated Syk activation on the other hand is highly sensitive to piceatannol, is essential to Fc epsilon R1-mediated cellular responses, and, based on the increased phosphorylation of Lyn in piceatannol-treated cells, may be involved in terminating Lyn activity. 3,3',4,5'-tetrahydroxystilbene 74-85 spleen associated tyrosine kinase Rattus norvegicus 18-21 7961959-10 1994 Receptor-mediated Syk activation on the other hand is highly sensitive to piceatannol, is essential to Fc epsilon R1-mediated cellular responses, and, based on the increased phosphorylation of Lyn in piceatannol-treated cells, may be involved in terminating Lyn activity. 3,3',4,5'-tetrahydroxystilbene 200-211 spleen associated tyrosine kinase Rattus norvegicus 18-21