PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
10447750-5	1999	Inhibition of the antigen presenting capacity by piceatannol, a protein tyrosine kinase (PTK) syk inhibitor, indicates that this is an active process resulting from immunoglobulin E (IgE)-antigen-FcepsilonRI engagement which involves tyrosines found in the immunoreceptor tyrosine-based activation motif (ITAM) embedded in the cytoplasmic tail of the FcepsilonRI beta and gamma chains.	3,3',4,5'-tetrahydroxystilbene	49-60	spleen tyrosine kinase	Mus musculus	94-97	
10754332-9	2000	Although piceatannol, a reportedly selective inhibitor of Syk, also prevented degranulation and activation of p38 MAPK, no fMLP-induced phosphorylation of Syk could be observed, raising doubts about the specificity of the inhibitor.	3,3',4,5'-tetrahydroxystilbene	9-20	spleen tyrosine kinase	Mus musculus	58-61	
9732296-4	1998	The Syk inhibitor piceatannol blocks the Syk homologue ZAP-70, which is expressed by TAM2D2 cells, with the same dose dependence as the inhibition of invasion.	3,3',4,5'-tetrahydroxystilbene	18-29	spleen tyrosine kinase	Mus musculus	4-7	
9732296-4	1998	The Syk inhibitor piceatannol blocks the Syk homologue ZAP-70, which is expressed by TAM2D2 cells, with the same dose dependence as the inhibition of invasion.	3,3',4,5'-tetrahydroxystilbene	18-29	spleen tyrosine kinase	Mus musculus	41-44	
9396765-7	1997	Pharmacologic exposure to piceatannol, a known Syk family kinase inhibitor, inhibits natural cytotoxicity.	3,3',4,5'-tetrahydroxystilbene	26-37	spleen tyrosine kinase	Mus musculus	47-50	
35230826-9	2022	Targeting this subset with ANP loaded with the drug piceatannol, a spleen tyrosine kinase (Syk) inhibitor, mitigated the effects of polymicrobial sepsis by reducing tissue inflammation while fully preserving neutrophilic host-defense function.	3,3',4,5'-tetrahydroxystilbene	52-63	spleen tyrosine kinase	Mus musculus	67-89	
35230826-9	2022	Targeting this subset with ANP loaded with the drug piceatannol, a spleen tyrosine kinase (Syk) inhibitor, mitigated the effects of polymicrobial sepsis by reducing tissue inflammation while fully preserving neutrophilic host-defense function.	3,3',4,5'-tetrahydroxystilbene	52-63	spleen tyrosine kinase	Mus musculus	91-94	
19017976-4	2008	Pretreatment of mDC with the Syk inhibitor piceatannol blocked B7-DC XAb-induced Ag uptake with a concomitant loss of tumor protection in mice.	3,3',4,5'-tetrahydroxystilbene	43-54	spleen tyrosine kinase	Mus musculus	29-32	
28680194-2	2017	Indeed, we found that overexpression of myeloid differentiation primary response gene 88 (MyD88), an adaptor molecule that drives TLR signaling, induced IRAK1 expression and that piceatannol, a Syk inhibitor, successfully suppressed the MyD88-dependent upregulation of IRAK1 under LPS treatment conditions.	3,3',4,5'-tetrahydroxystilbene	179-190	spleen tyrosine kinase	Mus musculus	194-197	
28680194-4	2017	According to our measurements of IRAK1 mRNA levels, the transcriptional upregulation of IRAK1 was induced by LPS treatment between 4 and 60 min, and this can be suppressed in Syk knockout cells, providing an effect similar that that seen under piceatannol treatment.	3,3',4,5'-tetrahydroxystilbene	244-255	spleen tyrosine kinase	Mus musculus	175-178	
27186801-1	2016	Piceatannol is a polyphenolic analog of resveratrol that selectively inhibits the non-receptor tyrosine kinase-Syk.	3,3',4,5'-tetrahydroxystilbene	0-11	spleen tyrosine kinase	Mus musculus	111-114	
24212132-5	2013	We treated mice with piceatannol, a Syk inhibitor, and consequently the infarct volume and swelling were suppressed by piceatannol.	3,3',4,5'-tetrahydroxystilbene	21-32	spleen tyrosine kinase	Mus musculus	36-39	
24212132-5	2013	We treated mice with piceatannol, a Syk inhibitor, and consequently the infarct volume and swelling were suppressed by piceatannol.	3,3',4,5'-tetrahydroxystilbene	119-130	spleen tyrosine kinase	Mus musculus	36-39	
24212132-6	2013	The levels of phospho-Syk, MMP9 and ICAM-1 were downregulated, and the level of Claudin5 was uplegurated in piceatannol-treated groups.	3,3',4,5'-tetrahydroxystilbene	108-119	spleen tyrosine kinase	Mus musculus	22-25	
16751367-7	2006	Pretreatment of the cells with Src-family or Syk-family selective tyrosine kinase inhibitors, PP2 or piceatannol, respectively, inhibited the formation of microtubules and reduced the amount of tyrosine phosphorylated proteins in gamma-tubulin complexes, suggesting that Src and Syk family kinases are involved in the initial stages of microtubule formation.	3,3',4,5'-tetrahydroxystilbene	101-112	spleen tyrosine kinase	Mus musculus	45-48	
16751367-7	2006	Pretreatment of the cells with Src-family or Syk-family selective tyrosine kinase inhibitors, PP2 or piceatannol, respectively, inhibited the formation of microtubules and reduced the amount of tyrosine phosphorylated proteins in gamma-tubulin complexes, suggesting that Src and Syk family kinases are involved in the initial stages of microtubule formation.	3,3',4,5'-tetrahydroxystilbene	101-112	spleen tyrosine kinase	Mus musculus	279-282