PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21497499-7	2012	Additionally, piceatannol inhibited the phosphorylation of signal transducer and activator of transcription (STAT) 3.	3,3',4,5'-tetrahydroxystilbene	14-25	signal transducer and activator of transcription 3	Homo sapiens	59-116	
29731870-7	2018	Piceatannol treatment induced the dose-dependent decline in the enhancement of STAT3 phosphorylation induced by IGF-1, indicating that the JAK1/STAT3 pathway may be implicated in the elevated expression of MMP-11 induced by IGF-1 in SGC-7901 cells.	3,3',4,5'-tetrahydroxystilbene	0-11	signal transducer and activator of transcription 3	Homo sapiens	79-84	
29731870-7	2018	Piceatannol treatment induced the dose-dependent decline in the enhancement of STAT3 phosphorylation induced by IGF-1, indicating that the JAK1/STAT3 pathway may be implicated in the elevated expression of MMP-11 induced by IGF-1 in SGC-7901 cells.	3,3',4,5'-tetrahydroxystilbene	0-11	signal transducer and activator of transcription 3	Homo sapiens	144-149	
21497499-10	2012	Interleukin-6 treatment was also shown to enhance the secretion of uPA and VEGF, STAT3 phosphorylation and the migration of DU145 cells; these increases were suppressed by piceatannol.	3,3',4,5'-tetrahydroxystilbene	172-183	signal transducer and activator of transcription 3	Homo sapiens	81-86	
21497499-11	2012	These results demonstrate that the inhibition of IL-6/STAT3 signaling may constitute a mechanism by which piceatannol regulates the expression of proteins involved in regulating the migration and invasion of DU145 cells.	3,3',4,5'-tetrahydroxystilbene	106-117	signal transducer and activator of transcription 3	Homo sapiens	54-59	
19796718-6	2010	Most importantly, the induction of Cxcl5, Cxcl12 and Tnfsf11 in osteoblasts by PC-3-conditioned medium was abrogated by the Stat3/5 inhibitor piceatannol, whereas the selective blockade of Stat1 and Erk activation had no effect.	3,3',4,5'-tetrahydroxystilbene	142-153	signal transducer and activator of transcription 3	Homo sapiens	124-131	
21681336-8	2011	Compared with the control group, after treatment of HeLa cells with STAT3 inhibitor Piceatannol for 24, 48, 72, and 96 h, the cell viability decreased by 23.8%, 29.7%, 37.3% and 45.4% (all P < 0.05), respectively, while increase of c-SRC content could not reverse the inhibitory effect.	3,3',4,5'-tetrahydroxystilbene	84-95	signal transducer and activator of transcription 3	Homo sapiens	68-73	
21187490-10	2010	In addition, using HepG2 cells, AG490 and piceatannol, which are signal transducer and activator of transcription 3 (STAT3) inhibitors, each increased the amount of GPC3 mRNA expressed.	3,3',4,5'-tetrahydroxystilbene	42-53	signal transducer and activator of transcription 3	Homo sapiens	65-115	
21187490-10	2010	In addition, using HepG2 cells, AG490 and piceatannol, which are signal transducer and activator of transcription 3 (STAT3) inhibitors, each increased the amount of GPC3 mRNA expressed.	3,3',4,5'-tetrahydroxystilbene	42-53	signal transducer and activator of transcription 3	Homo sapiens	117-122	
17341611-5	2006	Besides small peptides and oligonucleotides, numerous small molecules have been identified as blockers of STAT3 activation, including synthetic molecules (e.g., AG 490, decoy peptides, and oligonucleotides) and plant polyphenols (e.g., curcumin, resveratrol, flavopiridol, indirubin, magnolol, piceatannol, parthenolide, EGCG, and cucurbitacin).	3,3',4,5'-tetrahydroxystilbene	294-305	signal transducer and activator of transcription 3	Homo sapiens	106-111	
16920889-6	2007	Inhibition of JAK1/STAT-3 pathways by piceatannol or ERK1/2 by the MAPK/ERK kinase 1/2 inhibitor U0126 blunted the increase in total protein synthesis.	3,3',4,5'-tetrahydroxystilbene	38-49	signal transducer and activator of transcription 3	Homo sapiens	19-25	
12538484-8	2003	We demonstrate by phosphoprotein immunoblotting analysis and electrophoretic mobility shift analysis that piceatannol and AG490 inhibit the constitutive activity of STAT3 in 2F7 and U266, respectively.	3,3',4,5'-tetrahydroxystilbene	106-117	signal transducer and activator of transcription 3	Homo sapiens	165-170	
16427785-11	2006	Piceatannol-a specific blocker of STAT3 phosphorylation-inhibited CT-1 induced MCP-1 induction completely.	3,3',4,5'-tetrahydroxystilbene	0-11	signal transducer and activator of transcription 3	Homo sapiens	34-39	
15665043-6	2005	The STAT3 inhibitor piceatannol decreased both OSM-induced VEGF release and synergy between OSM and IL-1beta, without affecting responses to IL-1beta alone.	3,3',4,5'-tetrahydroxystilbene	20-31	signal transducer and activator of transcription 3	Homo sapiens	4-9	
11431352-10	2001	Additionally, piceatannol, an inhibitor of STAT3 activation, down-regulates the expression of Bcl-2.	3,3',4,5'-tetrahydroxystilbene	14-25	signal transducer and activator of transcription 3	Homo sapiens	43-48	
10777558-1	2000	Selective inhibition of STAT3 and STAT5 by piceatannol.	3,3',4,5'-tetrahydroxystilbene	43-54	signal transducer and activator of transcription 3	Homo sapiens	24-29	
10777558-4	2000	Piceatannol, previously reported as a Syk/ZAP70-specific kinase inhibitor, selectively inhibits the tyrosine phosphorylation of STAT3 and STAT5, but not of STAT1 and STAT2.	3,3',4,5'-tetrahydroxystilbene	0-11	signal transducer and activator of transcription 3	Homo sapiens	128-133	
10777558-6	2000	Last, the IFNalpha-induced serine phosphorylation of STAT1 and STAT3 is not inhibited by piceatannol but is sensitive to the Src kinase-specific inhibitor PP2.	3,3',4,5'-tetrahydroxystilbene	89-100	signal transducer and activator of transcription 3	Homo sapiens	63-68