PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 29214257-0 2018 Piceatannol attenuates behavioral disorder and neurological deficits in aging mice via activating the Nrf2 pathway. 3,3',4,5'-tetrahydroxystilbene 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 102-106 33335015-11 2021 Piceatannol, but not resveratrol, induced heme oxygenase-1 (HO1) expression, which was blocked by knockdown of the transcription factor NRF2, but not by SIRT1 knockdown. 3,3',4,5'-tetrahydroxystilbene 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 136-140 33335015-14 2021 Our results suggest that the therapeutic dose of piceatannol protects cells against mitochondrial ROS more than does resveratrol via SIRT1- and NRF2/HO1-dependent mechanisms. 3,3',4,5'-tetrahydroxystilbene 49-60 nuclear factor, erythroid derived 2, like 2 Mus musculus 144-148 33335015-15 2021 The activation of NRF2/HO1 could be an advantage of piceatannol compared with resveratrol for cytoprotection. 3,3',4,5'-tetrahydroxystilbene 52-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 18-22 33335015-18 2021 In addition to the SIRT1-dependent pathway, piceatannol exerted NRF2/HO1-mediated anti-oxidative and anti-apoptotic effects, which could be an advantage of piceatannol compared with resveratrol. 3,3',4,5'-tetrahydroxystilbene 44-55 nuclear factor, erythroid derived 2, like 2 Mus musculus 64-68 33335015-18 2021 In addition to the SIRT1-dependent pathway, piceatannol exerted NRF2/HO1-mediated anti-oxidative and anti-apoptotic effects, which could be an advantage of piceatannol compared with resveratrol. 3,3',4,5'-tetrahydroxystilbene 156-167 nuclear factor, erythroid derived 2, like 2 Mus musculus 64-68 32886103-0 2020 Piceatannol inhibits pyroptosis and suppresses oxLDL-induced lipid storage in macrophages by regulating miR-200a/Nrf2/GSDMD axis. 3,3',4,5'-tetrahydroxystilbene 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 113-117 32886103-3 2020 Our study identified miR-200a/Nrf2/GSDMD signaling pathway as critical mediators in the effect of piceatannol on macrophages. 3,3',4,5'-tetrahydroxystilbene 98-109 nuclear factor, erythroid derived 2, like 2 Mus musculus 30-34 32886103-7 2020 Moreover, we investigated the role of miR-200a/Nrf2 signaling pathway in the effect of piceatannol. 3,3',4,5'-tetrahydroxystilbene 87-98 nuclear factor, erythroid derived 2, like 2 Mus musculus 47-51 32886103-8 2020 The results declared that after transfection of si-miR-200a or si-Nrf2 plasmids, the effects of piceatannol on macrophages were converted, including lipid storage and pyroptosis. 3,3',4,5'-tetrahydroxystilbene 96-107 nuclear factor, erythroid derived 2, like 2 Mus musculus 66-70 32886103-10 2020 Collectively, our findings demonstrate that piceatannol exerts anti-atherosclerotic activity on RAW264.7 cells by regulating miR-200a/Nrf2/GSDMD signaling. 3,3',4,5'-tetrahydroxystilbene 44-55 nuclear factor, erythroid derived 2, like 2 Mus musculus 134-138 29214257-8 2018 Furthermore, western blotting results revealed that piceatannol treatment noticeably reversed the suppression of Nrf2 nuclear translocation and increased the expressions of HO-1 and NOQ1 in mice with aging induced by d-gal. 3,3',4,5'-tetrahydroxystilbene 52-63 nuclear factor, erythroid derived 2, like 2 Mus musculus 113-117 29214257-9 2018 Furthermore, piceatannol activated the Nrf2 pathway in natural aging mice, whereas treatment with the Nrf2 inhibitor brusatol reversed the increased expressions of Nrf2, HO-1, and NOQ1. 3,3',4,5'-tetrahydroxystilbene 13-24 nuclear factor, erythroid derived 2, like 2 Mus musculus 39-43 28933476-0 2017 Piceatannol inhibits the IL-1beta-induced inflammatory response in human osteoarthritic chondrocytes and ameliorates osteoarthritis in mice by activating Nrf2. 3,3',4,5'-tetrahydroxystilbene 0-11 nuclear factor, erythroid derived 2, like 2 Mus musculus 154-158 28933476-6 2017 Mechanistically, we found that piceatannol inhibited IL-1beta-induced nuclear factor kappa B (NF-kappaB) activation by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway. 3,3',4,5'-tetrahydroxystilbene 31-42 nuclear factor, erythroid derived 2, like 2 Mus musculus 179-183 23712764-7 2013 The observed cytoprotective effect was much higher when HT22 neuronal cells were pretreated with piceatannol for 6 or 12 h prior to glutamate treatment than when pretreated for 0.5 h. Piceatannol also increased HO-1 expression and HO activity via its activation of nuclear factor-E2-related factor 2 (Nrf2). 3,3',4,5'-tetrahydroxystilbene 97-108 nuclear factor, erythroid derived 2, like 2 Mus musculus 301-305 23712764-7 2013 The observed cytoprotective effect was much higher when HT22 neuronal cells were pretreated with piceatannol for 6 or 12 h prior to glutamate treatment than when pretreated for 0.5 h. Piceatannol also increased HO-1 expression and HO activity via its activation of nuclear factor-E2-related factor 2 (Nrf2). 3,3',4,5'-tetrahydroxystilbene 184-195 nuclear factor, erythroid derived 2, like 2 Mus musculus 301-305 23712764-9 2013 Taken together, our results suggest that piceatannol, similar to resveratrol, is capable of protecting HT22 neuronal cells against glutamate-induced cell death, at least in part, by inducing Nrf2-dependent HO-1 expression. 3,3',4,5'-tetrahydroxystilbene 41-52 nuclear factor, erythroid derived 2, like 2 Mus musculus 191-195