PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33335015-11	2021	Piceatannol, but not resveratrol, induced heme oxygenase-1 (HO1) expression, which was blocked by knockdown of the transcription factor NRF2, but not by SIRT1 knockdown.	3,3',4,5'-tetrahydroxystilbene	0-11	heme oxygenase 1	Mus musculus	60-63	
23712764-0	2013	Involvement of heme oxygenase-1 expression in neuroprotection by piceatannol, a natural analog and a metabolite of resveratrol, against glutamate-mediated oxidative injury in HT22 neuronal cells.	3,3',4,5'-tetrahydroxystilbene	65-76	heme oxygenase 1	Mus musculus	15-31	
33335015-11	2021	Piceatannol, but not resveratrol, induced heme oxygenase-1 (HO1) expression, which was blocked by knockdown of the transcription factor NRF2, but not by SIRT1 knockdown.	3,3',4,5'-tetrahydroxystilbene	0-11	heme oxygenase 1	Mus musculus	42-58	
33335015-12	2021	HO1 knockdown partially blocked the reduction of ROS by piceatannol.	3,3',4,5'-tetrahydroxystilbene	56-67	heme oxygenase 1	Mus musculus	0-3	
33335015-13	2021	Furthermore, the anti-apoptotic action of piceatannol was abolished by HO1 knockdown.	3,3',4,5'-tetrahydroxystilbene	42-53	heme oxygenase 1	Mus musculus	71-74	
33335015-14	2021	Our results suggest that the therapeutic dose of piceatannol protects cells against mitochondrial ROS more than does resveratrol via SIRT1- and NRF2/HO1-dependent mechanisms.	3,3',4,5'-tetrahydroxystilbene	49-60	heme oxygenase 1	Mus musculus	149-152	
33335015-15	2021	The activation of NRF2/HO1 could be an advantage of piceatannol compared with resveratrol for cytoprotection.	3,3',4,5'-tetrahydroxystilbene	52-63	heme oxygenase 1	Mus musculus	23-26	
33335015-18	2021	In addition to the SIRT1-dependent pathway, piceatannol exerted NRF2/HO1-mediated anti-oxidative and anti-apoptotic effects, which could be an advantage of piceatannol compared with resveratrol.	3,3',4,5'-tetrahydroxystilbene	44-55	heme oxygenase 1	Mus musculus	69-72	
33335015-18	2021	In addition to the SIRT1-dependent pathway, piceatannol exerted NRF2/HO1-mediated anti-oxidative and anti-apoptotic effects, which could be an advantage of piceatannol compared with resveratrol.	3,3',4,5'-tetrahydroxystilbene	156-167	heme oxygenase 1	Mus musculus	69-72	
29214257-8	2018	Furthermore, western blotting results revealed that piceatannol treatment noticeably reversed the suppression of Nrf2 nuclear translocation and increased the expressions of HO-1 and NOQ1 in mice with aging induced by d-gal.	3,3',4,5'-tetrahydroxystilbene	52-63	heme oxygenase 1	Mus musculus	173-177	
28933476-6	2017	Mechanistically, we found that piceatannol inhibited IL-1beta-induced nuclear factor kappa B (NF-kappaB) activation by activating the nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway.	3,3',4,5'-tetrahydroxystilbene	31-42	heme oxygenase 1	Mus musculus	185-201