PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
21946100-2	2011	We previously showed that mouse J774 macrophages cultivated for a prolonged period of time with toxic concentrations of the fluoroquinolone ciprofloxacin overexpress the efflux transporter Mrp4 and display a reduced accumulation of this antibiotic, but no change in the accumulation of moxifloxacin, a closely related molecule (Antimicrob.	Ciprofloxacin	140-153	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	189-193	
26852845-3	2016	We used positron emission tomography imaging to study the influence of norUDCA on hepatic disposition of the model Mrp4 substrate [(18)F]ciprofloxacin in wild-type and Mdr2((-/-)) mice, a model of cholestasis.	Ciprofloxacin	137-150	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	115-119	
26852845-9	2016	In conclusion, our data suggest that changes in hepatic [(18)F]ciprofloxacin disposition in mice after norUDCA treatment were caused by induction of basolateral Mrp4 in hepatocytes.	Ciprofloxacin	63-76	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	161-165	
33865975-2	2021	Ciprofloxacin is a known substrate of the ATP-binding cassette (ABC) transporters breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4).	Ciprofloxacin	0-13	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	126-167	
33865975-2	2021	Ciprofloxacin is a known substrate of the ATP-binding cassette (ABC) transporters breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4).	Ciprofloxacin	0-13	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	169-173	
22162766-0	2011	Characterization of Abcc4 gene amplification in stepwise-selected mouse J774 macrophages resistant to the topoisomerase II inhibitor ciprofloxacin.	Ciprofloxacin	133-146	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	20-25	
22162766-1	2011	Exposure of J774 mouse macrophages to stepwise increasing concentrations of ciprofloxacin, an antibiotic inhibiting bacterial topoisomerases, selects for resistant cells that overexpress the efflux transporter Abcc4 (Marquez et al.	Ciprofloxacin	76-89	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	210-215	
22162766-6	2011	Abcc4 expression progressively increased upon selection rounds, with exponential changes observed between cells exposed to 150 and 200 microM of ciprofloxacin, accompanied by a commensurate decrease in ciprofloxacin accumulation.	Ciprofloxacin	145-158	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	0-5	
22162766-6	2011	Abcc4 expression progressively increased upon selection rounds, with exponential changes observed between cells exposed to 150 and 200 microM of ciprofloxacin, accompanied by a commensurate decrease in ciprofloxacin accumulation.	Ciprofloxacin	202-215	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Mus musculus	0-5